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Volumn 5, Issue 15, 2014, Pages 6252-6266

The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells

Author keywords

Aggregates; Autophagy; HSPB8; Multiple myeloma; Resistance; Velcade

Indexed keywords

BORTEZOMIB; CASPASE; CHYMOTRYPSIN; ETOPOSIDE; GAMMA GLUTAMYLTRANSFERASE; HEAT SHOCK PROTEIN 22; MELPHALAN; STAUROSPORINE; THAPSIGARGIN; TRYPSIN; TUNICAMYCIN; ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN; HSPB8 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84906277696     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2193     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 0036083396 scopus 로고    scopus 로고
    • The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction
    • Glickman MH and Ciechanover A. The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev. 2002; 82(2):373-428.
    • (2002) Physiol Rev. , vol.82 , Issue.2 , pp. 373-428
    • Glickman, M.H.1    Ciechanover, A.2
  • 3
    • 3242807547 scopus 로고    scopus 로고
    • Post-proteasomal antigen processing for major histocompatibility complex class I presentation
    • Rock KL, York IA and Goldberg AL. Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004; 5(7):670-677.
    • (2004) Nat Immunol. , vol.5 , Issue.7 , pp. 670-677
    • Rock, K.L.1    York, I.A.2    Goldberg, A.L.3
  • 4
    • 0031973765 scopus 로고    scopus 로고
    • The ubiquitinproteasome pathway in cancer
    • Spataro V, Norbury C and Harris AL. The ubiquitinproteasome pathway in cancer. Br J Cancer. 1998; 77(3):448-455.
    • (1998) Br J Cancer. , vol.77 , Issue.3 , pp. 448-455
    • Spataro, V.1    Norbury, C.2    Harris, A.L.3
  • 8
    • 33745728140 scopus 로고    scopus 로고
    • Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132
    • Crawford LJ, Walker B, Ovaa H, Chauhan D, Anderson KC, Morris TC and Irvine AE. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006; 66(12):6379-6386.
    • (2006) Cancer Res. , vol.66 , Issue.12 , pp. 6379-6386
    • Crawford, L.J.1    Walker, B.2    Ovaa, H.3    Chauhan, D.4    Anderson, K.C.5    Morris, T.C.6    Irvine, A.E.7
  • 9
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schroder M and Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005; 74:739-789.
    • (2005) Annu Rev Biochem. , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 11
    • 79952781038 scopus 로고    scopus 로고
    • Multiple myeloma
    • Palumbo A and Anderson K. Multiple myeloma. N Engl J Med. 2011; 364(11):1046-1060.
    • (2011) N Engl J Med. , vol.364 , Issue.11 , pp. 1046-1060
    • Palumbo, A.1    Anderson, K.2
  • 12
    • 0026585927 scopus 로고
    • Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials
    • Gregory WM, Richards MA and Malpas JS. Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials. J Clin Oncol. 1992; 10(2):334-342.
    • (1992) J Clin Oncol. , vol.10 , Issue.2 , pp. 334-342
    • Gregory, W.M.1    Richards, M.A.2    Malpas, J.S.3
  • 16
    • 0141953292 scopus 로고    scopus 로고
    • Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
    • Chauhan D, Li G, Shringarpure R, Podar K, Ohtake Y, Hideshima T and Anderson KC. Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res. 2003; 63(19):6174-6177.
    • (2003) Cancer Res. , vol.63 , Issue.19 , pp. 6174-6177
    • Chauhan, D.1    Li, G.2    Shringarpure, R.3    Podar, K.4    Ohtake, Y.5    Hideshima, T.6    Anderson, K.C.7
  • 21
    • 67049107847 scopus 로고    scopus 로고
    • Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line
    • Lu S, Yang J, Chen Z, Gong S, Zhou H, Xu X and Wang J. Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. Exp Hematol. 2009; 37(7):831-837.
    • (2009) Exp Hematol. , vol.37 , Issue.7 , pp. 831-837
    • Lu, S.1    Yang, J.2    Chen, Z.3    Gong, S.4    Zhou, H.5    Xu, X.6    Wang, J.7
  • 23
    • 52049086674 scopus 로고    scopus 로고
    • Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/ leukemia cells derived from Jurkat line
    • Lu S, Chen Z, Yang J, Chen L, Gong S, Zhou H, Guo L and Wang J. Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/ leukemia cells derived from Jurkat line. Exp Hematol. 2008; 36(10):1278-1284.
    • (2008) Exp Hematol. , vol.36 , Issue.10 , pp. 1278-1284
    • Lu, S.1    Chen, Z.2    Yang, J.3    Chen, L.4    Gong, S.5    Zhou, H.6    Guo, L.7    Wang, J.8
  • 24
    • 47949089799 scopus 로고    scopus 로고
    • Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line
    • Lu S, Yang J, Song X, Gong S, Zhou H, Guo L, Song N, Bao X, Chen P and Wang J. Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. J Pharmacol Exp Ther. 2008; 326(2):423-431.
    • (2008) J Pharmacol Exp Ther. , vol.326 , Issue.2 , pp. 423-431
    • Lu, S.1    Yang, J.2    Song, X.3    Gong, S.4    Zhou, H.5    Guo, L.6    Song, N.7    Bao, X.8    Chen, P.9    Wang, J.10
  • 25
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • Catley L, Weisberg E, Kiziltepe T, Tai YT, Hideshima T, Neri P, Tassone P, Atadja P, Chauhan D, Munshi NC and Anderson KC. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood. 2006; 108(10):3441-3449.
    • (2006) Blood. , vol.108 , Issue.10 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3    Tai, Y.T.4    Hideshima, T.5    Neri, P.6    Tassone, P.7    Atadja, P.8    Chauhan, D.9    Munshi, N.C.10    Anderson, K.C.11
  • 26
    • 38349105324 scopus 로고    scopus 로고
    • HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy
    • Carra S, Seguin SJ, Lambert H and Landry J. HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J Biol Chem. 2008; 283(3):1437-1444.
    • (2008) J Biol Chem. , vol.283 , Issue.3 , pp. 1437-1444
    • Carra, S.1    Seguin, S.J.2    Lambert, H.3    Landry, J.4
  • 27
    • 38949184241 scopus 로고    scopus 로고
    • HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy
    • Carra S, Seguin SJ and Landry J. HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy. 2008; 4(2):237-239.
    • (2008) Autophagy. , vol.4 , Issue.2 , pp. 237-239
    • Carra, S.1    Seguin, S.J.2    Landry, J.3
  • 28
    • 0034717110 scopus 로고    scopus 로고
    • Regulation of [Ca(2+)](i) homeostasis in MRP1 overexpressing cells
    • Filipeanu CM, Nelemans A, Veldman RJ, de Zeeuw D and Kok JW. Regulation of [Ca(2+)](i) homeostasis in MRP1 overexpressing cells. FEBS Lett. 2000; 474(1):107-110.
    • (2000) FEBS Lett. , vol.474 , Issue.1 , pp. 107-110
    • Filipeanu, C.M.1    Nelemans, A.2    Veldman, R.J.3    de Zeeuw, D.4    Kok, J.W.5
  • 29
    • 0036206470 scopus 로고    scopus 로고
    • Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistanceassociated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT)
    • Guo A, Marinaro W, Hu P and Sinko PJ. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistanceassociated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002; 30(4):457-463.
    • (2002) Drug Metab Dispos. , vol.30 , Issue.4 , pp. 457-463
    • Guo, A.1    Marinaro, W.2    Hu, P.3    Sinko, P.J.4
  • 30
    • 38149082008 scopus 로고    scopus 로고
    • Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells
    • Fuchs D, Berges C, Opelz G, Daniel V and Naujokat C. Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells. J Cell Biochem. 2008; 103(1):270-283.
    • (2008) J Cell Biochem. , vol.103 , Issue.1 , pp. 270-283
    • Fuchs, D.1    Berges, C.2    Opelz, G.3    Daniel, V.4    Naujokat, C.5
  • 33
    • 28844435438 scopus 로고    scopus 로고
    • No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib
    • Politou M, Karadimitris A, Terpos E, Kotsianidis I, Apperley JF and Rahemtulla A. No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib. Leuk Res. 2006; 30(2):240-241.
    • (2006) Leuk Res. , vol.30 , Issue.2 , pp. 240-241
    • Politou, M.1    Karadimitris, A.2    Terpos, E.3    Kotsianidis, I.4    Apperley, J.F.5    Rahemtulla, A.6
  • 35
    • 84878322959 scopus 로고    scopus 로고
    • Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance
    • Kraus M, Bader J, Overkleeft H and Driessen C. Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance. Blood Cancer J. 2013; 3:e103.
    • (2013) Blood Cancer J. , vol.3
    • Kraus, M.1    Bader, J.2    Overkleeft, H.3    Driessen, C.4
  • 36
    • 0032499199 scopus 로고    scopus 로고
    • A proteolytic system that compensates for loss of proteasome function
    • Glas R, Bogyo M, McMaster JS, Gaczynska M and Ploegh HL. A proteolytic system that compensates for loss of proteasome function. Nature. 1998; 392(6676):618-622.
    • (1998) Nature. , vol.392 , Issue.6676 , pp. 618-622
    • Glas, R.1    Bogyo, M.2    McMaster, J.S.3    Gaczynska, M.4    Ploegh, H.L.5
  • 38
    • 79952016563 scopus 로고    scopus 로고
    • Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagylysosome and ER stress
    • Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, Naito M, Itoh M and Tomoda A. Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagylysosome and ER stress. Int J Oncol. 2011; 38(3):643-654.
    • (2011) Int J Oncol. , vol.38 , Issue.3 , pp. 643-654
    • Kawaguchi, T.1    Miyazawa, K.2    Moriya, S.3    Ohtomo, T.4    Che, X.F.5    Naito, M.6    Itoh, M.7    Tomoda, A.8
  • 40
    • 0037040541 scopus 로고    scopus 로고
    • Molecular chaperones in the cytosol: from nascent chain to folded protein
    • Hartl FU and Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002; 295(5561):1852-1858.
    • (2002) Science. , vol.295 , Issue.5561 , pp. 1852-1858
    • Hartl, F.U.1    Hayer-Hartl, M.2
  • 41
    • 4344578534 scopus 로고    scopus 로고
    • The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator
    • Alberti S, Bohse K, Arndt V, Schmitz A and Hohfeld J. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2004; 15(9):4003-4010.
    • (2004) Mol Biol Cell. , vol.15 , Issue.9 , pp. 4003-4010
    • Alberti, S.1    Bohse, K.2    Arndt, V.3    Schmitz, A.4    Hohfeld, J.5
  • 42
    • 79959939343 scopus 로고    scopus 로고
    • BAG3 and friends: co-chaperones in selective autophagy during aging and disease
    • Behl C. BAG3 and friends: co-chaperones in selective autophagy during aging and disease. Autophagy. 2011; 7(7):795-798.
    • (2011) Autophagy. , vol.7 , Issue.7 , pp. 795-798
    • Behl, C.1
  • 43
    • 84861362268 scopus 로고    scopus 로고
    • NF-kappaB regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex
    • Nivon M, Abou-Samra M, Richet E, Guyot B, Arrigo AP and Kretz-Remy C. NF-kappaB regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex. J Cell Sci. 2012; 125(Pt 5):1141-1151.
    • (2012) J Cell Sci. , vol.125 , Issue.PT. 5 , pp. 1141-1151
    • Nivon, M.1    Abou-Samra, M.2    Richet, E.3    Guyot, B.4    Arrigo, A.P.5    Kretz-Remy, C.6
  • 46
    • 21244489544 scopus 로고    scopus 로고
    • HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells
    • Carra S, Sivilotti M, Chavez Zobel AT, Lambert H and Landry J. HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Hum Mol Genet. 2005; 14(12):1659-1669.
    • (2005) Hum Mol Genet. , vol.14 , Issue.12 , pp. 1659-1669
    • Carra, S.1    Sivilotti, M.2    Chavez Zobel, A.T.3    Lambert, H.4    Landry, J.5
  • 48
    • 0043193876 scopus 로고    scopus 로고
    • Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
    • Lee AH, Iwakoshi NN, Anderson KC and Glimcher LH. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A. 2003; 100(17):9946-9951.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.17 , pp. 9946-9951
    • Lee, A.H.1    Iwakoshi, N.N.2    Anderson, K.C.3    Glimcher, L.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.