-
1
-
-
79953240916
-
Modern natural products drug discovery and its relevance to biodiversity conservation
-
Kingston DGI (2011) Modern natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod 74(3):496-511.
-
(2011)
J Nat Prod
, vol.74
, Issue.3
, pp. 496-511
-
-
Kingston, D.G.I.1
-
2
-
-
84863825873
-
Charting, navigating, and populating natural product chemical space for drug discovery
-
Lachance H, Wetzel S, Kumar K, Waldmann H (2012) Charting, navigating, and populating natural product chemical space for drug discovery. J Med Chem 55(13):5989-6001.
-
(2012)
J Med Chem
, vol.55
, Issue.13
, pp. 5989-6001
-
-
Lachance, H.1
Wetzel, S.2
Kumar, K.3
Waldmann, H.4
-
3
-
-
84897443754
-
New horizons for old drugs and drug leads
-
Cragg GM, Grothaus PG, Newman DJ (2014) New horizons for old drugs and drug leads. J Nat Prod 77(3):703-723.
-
(2014)
J Nat Prod
, vol.77
, Issue.3
, pp. 703-723
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
4
-
-
84871292787
-
Regulation of fungal secondary metabolism
-
Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11(1):21-32.
-
(2013)
Nat Rev Microbiol
, vol.11
, Issue.1
, pp. 21-32
-
-
Brakhage, A.A.1
-
5
-
-
84865674915
-
Recasting natural product research
-
Sheridan C (2012) Recasting natural product research. Nat Biotechnol 30(5):385-387.
-
(2012)
Nat Biotechnol
, vol.30
, Issue.5
, pp. 385-387
-
-
Sheridan, C.1
-
6
-
-
84902253019
-
Recreational drug discovery: Natural products as lead structures for the synthesis of smart drugs
-
Appendino G, Minassi A, Taglialatela-Scafati O (2014) Recreational drug discovery: Natural products as lead structures for the synthesis of smart drugs. Nat Prod Rep 31(7):880-904.
-
(2014)
Nat Prod Rep
, vol.31
, Issue.7
, pp. 880-904
-
-
Appendino, G.1
Minassi, A.2
Taglialatela-Scafati, O.3
-
7
-
-
84905380808
-
All natural: The renaissance of natural products chemistry
-
Molinski TF (2014) All natural: The renaissance of natural products chemistry. Org Lett 16(15):3849-3855.
-
(2014)
Org Lett
, vol.16
, Issue.15
, pp. 3849-3855
-
-
Molinski, T.F.1
-
8
-
-
84899477796
-
Synthesis and patterning of tunable multiscale materials with engineered cells
-
Chen AY, et al. (2014) Synthesis and patterning of tunable multiscale materials with engineered cells. Nat Mater 13(5):515-523.
-
(2014)
Nat Mater
, vol.13
, Issue.5
, pp. 515-523
-
-
Chen, A.Y.1
-
9
-
-
84879324704
-
Natural product and material chemistries - Separated forever?
-
Kunz H, Müllen K (2013) Natural product and material chemistries - separated forever? J Am Chem Soc 135(24):8764-8769.
-
(2013)
J Am Chem Soc
, vol.135
, Issue.24
, pp. 8764-8769
-
-
Kunz, H.1
Müllen, K.2
-
10
-
-
84900329578
-
Dopa/Catechol-tethered polymers: Bioadhesives and biomimetic adhesive materials
-
Moulay S (2014) Dopa/Catechol-tethered polymers: Bioadhesives and biomimetic adhesive materials. Pol Rev 54(3):436-513.
-
(2014)
Pol Rev
, vol.54
, Issue.3
, pp. 436-513
-
-
Moulay, S.1
-
11
-
-
80052483777
-
The Pictet-Spengler reaction in nature and in organic chemistry
-
Stöckigt J, Antonchick AP, Wu F, Waldmann H (2011) The Pictet-Spengler reaction in nature and in organic chemistry. Angew Chem Int Ed Engl 50(37):8538-8564.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, Issue.37
, pp. 8538-8564
-
-
Stöckigt, J.1
Antonchick, A.P.2
Wu, F.3
Waldmann, H.4
-
12
-
-
84884233005
-
Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway
-
Chen Q, et al. (2013) Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew Chem Int Ed Engl 52(38):9980-9984.
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, Issue.38
, pp. 9980-9984
-
-
Chen, Q.1
-
13
-
-
77952542213
-
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms
-
Koketsu K, Watanabe K, Suda H, Oguri H, Oikawa H (2010) Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms. Nat Chem Biol 6(6):408-410.
-
(2010)
Nat Chem Biol
, vol.6
, Issue.6
, pp. 408-410
-
-
Koketsu, K.1
Watanabe, K.2
Suda, H.3
Oguri, H.4
Oikawa, H.5
-
14
-
-
84880132566
-
Reticulatins A and B and hyrtioreticulin F from the marine sponge Hyrtios reticulatus
-
Imada K, et al. (2013) Reticulatins A and B and hyrtioreticulin F from the marine sponge Hyrtios reticulatus. Tetrahedron 69(34):7051-7055.
-
(2013)
Tetrahedron
, vol.69
, Issue.34
, pp. 7051-7055
-
-
Imada, K.1
-
15
-
-
79953050469
-
N-containing compounds of macromycetes
-
Jiang MY, Feng T, Liu JK (2011) N-containing compounds of macromycetes. Nat Prod Rep 28(4):783-808.
-
(2011)
Nat Prod Rep
, vol.28
, Issue.4
, pp. 783-808
-
-
Jiang, M.Y.1
Feng, T.2
Liu, J.K.3
-
16
-
-
33846304653
-
New procedure to mask the 2,3-π bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton
-
Takayama H, et al. (2006) New procedure to mask the 2,3-π bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton. Org Lett 8(25):5705-5708.
-
(2006)
Org Lett
, vol.8
, Issue.25
, pp. 5705-5708
-
-
Takayama, H.1
-
17
-
-
79751478725
-
Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action
-
Ge HM, et al. (2011) Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem Commun (Camb) 47(8):2321-2323.
-
(2011)
Chem Commun (Camb)
, vol.47
, Issue.8
, pp. 2321-2323
-
-
Ge, H.M.1
-
18
-
-
33644915823
-
Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019
-
Ding G, et al. (2006) Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. J Nat Prod 69(2):302-304.
-
(2006)
J Nat Prod
, vol.69
, Issue.2
, pp. 302-304
-
-
Ding, G.1
-
19
-
-
37049081146
-
Useful approach to find the plausible biosynthetic precursors of secondary metabolites using P-450 inhibitors: Postulated intermediates of chaetoglobosin A
-
Oikawa H, Murakami Y, Ichihara A (1992) Useful approach to find the plausible biosynthetic precursors of secondary metabolites using P-450 inhibitors: Postulated intermediates of chaetoglobosin A. J Chem Soc, Perk Trans 1(21):2949-2953.
-
(1992)
J Chem Soc, Perk Trans
, vol.1
, Issue.21
, pp. 2949-2953
-
-
Oikawa, H.1
Murakami, Y.2
Ichihara, A.3
-
20
-
-
0030590449
-
The biosynthesis of the Streptomyces antibiotic bicyclomycin
-
Bradley EL, et al. (1996) The biosynthesis of the Streptomyces antibiotic bicyclomycin. Tetrahedron Lett 37(38):6935-6938.
-
(1996)
Tetrahedron Lett
, vol.37
, Issue.38
, pp. 6935-6938
-
-
Bradley, E.L.1
-
21
-
-
38049168553
-
Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis
-
Ge HM, et al. (2008) Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis. Chem Eur J 14(1):376-381.
-
(2008)
Chem Eur J
, vol.14
, Issue.1
, pp. 376-381
-
-
Ge, H.M.1
-
22
-
-
84872614505
-
Hopeahainol A attenuates memory deficits by targeting β-amyloid in APP/PS1 transgenic mice
-
Zhu X, et al. (2013) Hopeahainol A attenuates memory deficits by targeting β-amyloid in APP/PS1 transgenic mice. Aging Cell 12(1):85-92.
-
(2013)
Aging Cell
, vol.12
, Issue.1
, pp. 85-92
-
-
Zhu, X.1
-
23
-
-
84861209852
-
Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis
-
Davison J, et al. (2012) Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci USA 109(20):7642-7647.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.20
, pp. 7642-7647
-
-
Davison, J.1
-
24
-
-
84894427871
-
Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism
-
Wang M, Beissner M, Zhao H (2014) Aryl-aldehyde formation in fungal polyketides: Discovery and characterization of a distinct biosynthetic mechanism. Chem Biol 21(2):257-263.
-
(2014)
Chem Biol
, vol.21
, Issue.2
, pp. 257-263
-
-
Wang, M.1
Beissner, M.2
Zhao, H.3
-
25
-
-
79953328952
-
Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases
-
Yuasa HJ, Ball HJ (2011) Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases. J Mol Evol 72(2):160-168.
-
(2011)
J Mol Evol
, vol.72
, Issue.2
, pp. 160-168
-
-
Yuasa, H.J.1
Ball, H.J.2
-
26
-
-
29344449110
-
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus
-
Gibson M, Nur-e-alam M, Lipata F, Oliveira MA, Rohr J (2005) Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus. J Am Chem Soc 127(50):17594-17595.
-
(2005)
J Am Chem Soc
, vol.127
, Issue.50
, pp. 17594-17595
-
-
Gibson, M.1
Nur-e-alam, M.2
Lipata, F.3
Oliveira, M.A.4
Rohr, J.5
-
27
-
-
84877731561
-
Epicoccolides: Antimicrobial and antifungal polyketides from an endophytic fungus Epicoccum sp. associated with Theobroma cacao
-
Talontsi FM, Dittrich B, Schüffler A, Sun H, Laatsch H (2013) Epicoccolides: Antimicrobial and antifungal polyketides from an endophytic fungus Epicoccum sp. associated with Theobroma cacao. Eur J Org Chem (15):3174-3180.
-
(2013)
Eur J Org Chem
, Issue.15
, pp. 3174-3180
-
-
Talontsi, F.M.1
Dittrich, B.2
Schüffler, A.3
Sun, H.4
Laatsch, H.5
-
28
-
-
84893061095
-
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum
-
El Amrani M, et al. (2014) Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. J Nat Prod 77(1):49-56.
-
(2014)
J Nat Prod
, vol.77
, Issue.1
, pp. 49-56
-
-
El Amrani, M.1
-
29
-
-
49049114068
-
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia
-
Yuan D, et al. (2008) Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. J Nat Prod 71(7):1271-1274.
-
(2008)
J Nat Prod
, vol.71
, Issue.7
, pp. 1271-1274
-
-
Yuan, D.1
-
30
-
-
84881261151
-
Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba, contributes to antioxidant activity
-
Ye YH, et al. (2013) Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba, contributes to antioxidant activity. Appl Microbiol Biotechnol 97(16):7131-7139.
-
(2013)
Appl Microbiol Biotechnol
, vol.97
, Issue.16
, pp. 7131-7139
-
-
Ye, Y.H.1
-
31
-
-
84873057263
-
Antifungal screening of endophytic fungi from Ginkgo biloba for discovery of potent anti-phytopathogenic fungicides
-
Xiao Y, et al. (2013) Antifungal screening of endophytic fungi from Ginkgo biloba for discovery of potent anti-phytopathogenic fungicides. FEMS Microbiol Lett 339(2):130-136.
-
(2013)
FEMS Microbiol Lett
, vol.339
, Issue.2
, pp. 130-136
-
-
Xiao, Y.1
-
32
-
-
78651172117
-
The biosynthesis of flavipin. I. Incorporation of acetate and methionine
-
Pettersson G (1965) The biosynthesis of flavipin. I. Incorporation of acetate and methionine. Acta Chem Scand 19:35-40.
-
(1965)
Acta Chem Scand
, vol.19
, pp. 35-40
-
-
Pettersson, G.1
-
33
-
-
0013835695
-
The biosynthesis of flavipin. II. Incorporation of aromatic precursors
-
Pettersson G (1965) The biosynthesis of flavipin. II. Incorporation of aromatic precursors. Acta Chem Scand 19(7):1724-1732.
-
(1965)
Acta Chem Scand
, vol.19
, Issue.7
, pp. 1724-1732
-
-
Pettersson, G.1
-
34
-
-
84887419508
-
Organocatalytic enantioselective decarboxylative aldol reaction of malonic acid half thioesters with aldehydes
-
Bae HY, Sim JH, Lee JW, List B, Song CE (2013) Organocatalytic enantioselective decarboxylative aldol reaction of malonic acid half thioesters with aldehydes. Angew Chem Int Ed Engl 52(46):12143-12147.
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, Issue.46
, pp. 12143-12147
-
-
Bae, H.Y.1
Sim, J.H.2
Lee, J.W.3
List, B.4
Song, C.E.5
-
35
-
-
84872077444
-
Organocatalytic enantioselective decarboxylative Michael addition of β-ketoacids to α,β-unsaturated ketones
-
Kang YK, Lee HJ, Moon HW, Kim DY (2013) Organocatalytic enantioselective decarboxylative Michael addition of β-ketoacids to α,β-unsaturated ketones. RSC Adv 3(5):1332-1335.
-
(2013)
RSC Adv
, vol.3
, Issue.5
, pp. 1332-1335
-
-
Kang, Y.K.1
Lee, H.J.2
Moon, H.W.3
Kim, D.Y.4
-
36
-
-
78650726697
-
A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5
-
Lai WG, Farah N, Moniz GA, Wong YN (2011) A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5. Drug Metab Dispos 39(1):61-70.
-
(2011)
Drug Metab Dispos
, vol.39
, Issue.1
, pp. 61-70
-
-
Lai, W.G.1
Farah, N.2
Moniz, G.A.3
Wong, Y.N.4
-
37
-
-
84890587379
-
Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri
-
0
-
Costa SP, et al. (2014) Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri. J Hazard Mater 265(0):133-141.
-
(2014)
J Hazard Mater
, vol.265
, pp. 133-141
-
-
Costa, S.P.1
-
38
-
-
79955604151
-
Biochemical characterization of a peroxidase isolated from Caribbean plant: Euphorbia cotinifolia
-
Kumar R, Singh KA, Singh VK, Jagannadham MV (2011) Biochemical characterization of a peroxidase isolated from Caribbean plant: Euphorbia cotinifolia. Process Biochem 46(6):1350-1357.
-
(2011)
Process Biochem
, vol.46
, Issue.6
, pp. 1350-1357
-
-
Kumar, R.1
Singh, K.A.2
Singh, V.K.3
Jagannadham, M.V.4
-
39
-
-
84903470523
-
Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes
-
Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K (2014) Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes. Proc Natl Acad Sci USA 111(25):9259-9264.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.25
, pp. 9259-9264
-
-
Wang, H.1
Fewer, D.P.2
Holm, L.3
Rouhiainen, L.4
Sivonen, K.5
-
40
-
-
84873886920
-
Genome streamlining and chemical defense in a coral reef symbiosis
-
Kwan JC, et al. (2012) Genome streamlining and chemical defense in a coral reef symbiosis. Proc Natl Acad Sci USA 109(50):20655-20660.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.50
, pp. 20655-20660
-
-
Kwan, J.C.1
-
41
-
-
84896918327
-
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora
-
Ziemert N, et al. (2014) Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci USA 111(12):E1130-E1139.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.12
, pp. E1130-E1139
-
-
Ziemert, N.1
-
42
-
-
84879514195
-
Deciphering the cryptic genome: Genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
-
Wiemann P, et al. (2013) Deciphering the cryptic genome: Genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites. PLoS Pathog 9(6):e1003475.
-
(2013)
PLoS Pathog
, vol.9
, Issue.6
, pp. e1003475
-
-
Wiemann, P.1
-
43
-
-
84900501387
-
Mycoplasma pneumoniae in children: Carriage, pathogenesis, and antibiotic resistance
-
Meyer Sauteur PM, van Rossum AM, Vink C (2014) Mycoplasma pneumoniae in children: Carriage, pathogenesis, and antibiotic resistance. Curr Opin Infect Dis 27(3):220-227.
-
(2014)
Curr Opin Infect Dis
, vol.27
, Issue.3
, pp. 220-227
-
-
Meyer Sauteur, P.M.1
Van Rossum, A.M.2
Vink, C.3
|