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Volumn 15, Issue 4, 2014, Pages 551-566

Current Role of Anti-Angiogenic Strategies for Glioblastoma

Author keywords

Angiogenesis; Bevacizumab; Glioblastoma; Treatment; Vascular endothelial growth factor (VEGF)

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; AFLIBERCEPT; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; BORTEZOMIB; CARMUSTINE; CEDIRANIB; CILENGITIDE; CORTICOSTEROID; CRIZOTINIB; DASATINIB; ENZASTAURIN; ERLOTINIB; ETOPOSIDE; EVEROLIMUS; IRINOTECAN; LOMUSTINE; NELFINAVIR; PLACEBO; PLERIXAFOR; PROTEIN TYROSINE KINASE INHIBITOR; RAMUCIRUMAB; SORAFENIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; TRC 105; TREBANANIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER;

EID: 84919932068     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-014-0308-2     Document Type: Review
Times cited : (24)

References (59)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • PID: 15758009, COI: 1:CAS:528:DC%2BD2MXit1Wksbk%3D
    • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–96.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3    Weller, M.4    Fisher, B.5    Taphoorn, M.J.B.6
  • 2
    • 84887102623 scopus 로고    scopus 로고
    • Glioblastoma and other malignant gliomas: a clinical review
    • PID: 24193082, COI: 1:CAS:528:DC%2BC3sXhsl2gu7nM
    • Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA. 2013;310:1842–50.
    • (2013) JAMA , vol.310 , pp. 1842-1850
    • Omuro, A.1    DeAngelis, L.M.2
  • 4
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • PID: 1279432, COI: 1:CAS:528:DyaK38XmsV2gsb8%3D
    • Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 1992;359:845–8.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 5
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • PID: 15136787, COI: 1:CAS:528:DC%2BD2cXktlCrt78%3D
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004;3:391–400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 6
    • 0032941495 scopus 로고    scopus 로고
    • Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
    • PID: 9988225, COI: 1:CAS:528:DyaK1MXht1Cqt78%3D
    • Schmidt NO, Westphal M, Hagel C, Ergun S, Stavrou D, Rosen EM, et al. Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis. Int J Cancer. 1999;84:10–8.
    • (1999) Int J Cancer , vol.84 , pp. 10-18
    • Schmidt, N.O.1    Westphal, M.2    Hagel, C.3    Ergun, S.4    Stavrou, D.5    Rosen, E.M.6
  • 7
    • 0026439870 scopus 로고
    • Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas
    • PID: 1434531, COI: 1:STN:280:DyaK3s%2FmtV2jsg%3D%3D
    • Plate KH, Breier G, Farrell CL, Risau W. Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Lab Investig. 1992;67:529–34.
    • (1992) Lab Investig , vol.67 , pp. 529-534
    • Plate, K.H.1    Breier, G.2    Farrell, C.L.3    Risau, W.4
  • 8
    • 0028941001 scopus 로고
    • Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF
    • PID: 7714613, COI: 1:CAS:528:DyaK2MXmt1eru7o%3D
    • Tsai JC, Goldman CK, Gillespie GY. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg. 1995;82:864–73.
    • (1995) J Neurosurg , vol.82 , pp. 864-873
    • Tsai, J.C.1    Goldman, C.K.2    Gillespie, G.Y.3
  • 9
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology
    • PID: 7680247, COI: 1:CAS:528:DyaK3sXitFSnsLs%3D
    • Goldman CK, Kim J, Wong WL, King V, Brock T, Gillespie GY. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell. 1993;4:121–33.
    • (1993) Mol Biol Cell , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3    King, V.4    Brock, T.5    Gillespie, G.Y.6
  • 10
    • 47949114114 scopus 로고    scopus 로고
    • Integrins in angiogenesis and lymphangiogenesis
    • PID: 18497750, COI: 1:CAS:528:DC%2BD1cXovV2lsr0%3D
    • Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008;8:604–17.
    • (2008) Nat Rev Cancer , vol.8 , pp. 604-617
    • Avraamides, C.J.1    Garmy-Susini, B.2    Varner, J.A.3
  • 11
    • 17844397949 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
    • PID: 15831231, COI: 1:CAS:528:DC%2BD2MXjvV2qsLg%3D
    • Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005;7:122–33.
    • (2005) Neuro Oncol , vol.7 , pp. 122-133
    • Brat, D.J.1    Bellail, A.C.2    Van Meir, E.G.3
  • 12
    • 0031737425 scopus 로고    scopus 로고
    • Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
    • PID: 9811337, COI: 1:CAS:528:DyaK1cXns1Ohu7Y%3D
    • Stratmann A, Risau W, Plate KH. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol. 1998;153:1459–66.
    • (1998) Am J Pathol , vol.153 , pp. 1459-1466
    • Stratmann, A.1    Risau, W.2    Plate, K.H.3
  • 13
    • 79952184099 scopus 로고    scopus 로고
    • Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma
    • PID: 20607353, COI: 1:CAS:528:DC%2BC3MXit1ygtLY%3D
    • Reynes G, Vila V, Martin M, Parada A, Fleitas T, Reganon E, et al. Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma. J Neurooncol. 2011;102:35–41.
    • (2011) J Neurooncol , vol.102 , pp. 35-41
    • Reynes, G.1    Vila, V.2    Martin, M.3    Parada, A.4    Fleitas, T.5    Reganon, E.6
  • 14
    • 84887449396 scopus 로고    scopus 로고
    • The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer
    • PID: 23818211
    • Hemmerle T, Neri D. The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer. Int J Cancer. 2014;134:467–77.
    • (2014) Int J Cancer , vol.134 , pp. 467-477
    • Hemmerle, T.1    Neri, D.2
  • 15
    • 0037942860 scopus 로고    scopus 로고
    • Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin
    • PID: 12828859
    • De Bouard S, Guillamo JS, Christov C, Lefevre N, Brugieres P, Gola E, et al. Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin. Hum Gene Ther. 2003;14:883–95.
    • (2003) Hum Gene Ther , vol.14 , pp. 883-895
    • De Bouard, S.1    Guillamo, J.S.2    Christov, C.3    Lefevre, N.4    Brugieres, P.5    Gola, E.6
  • 16
    • 79951664438 scopus 로고    scopus 로고
    • Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor
    • PID: 21163810, COI: 1:CAS:528:DC%2BC3MXhvFOitbc%3D
    • Crocker M, Ashley S, Giddings I, Petrik V, Hardcastle A, Aherne W, et al. Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor. Neuro Oncol. 2011;13:99–108.
    • (2011) Neuro Oncol , vol.13 , pp. 99-108
    • Crocker, M.1    Ashley, S.2    Giddings, I.3    Petrik, V.4    Hardcastle, A.5    Aherne, W.6
  • 18
    • 78650098659 scopus 로고    scopus 로고
    • Glioblastoma stem-like cells give rise to tumour endothelium
    • PID: 21102433, COI: 1:CAS:528:DC%2BC3cXhsVGhsr3J
    • Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, et al. Glioblastoma stem-like cells give rise to tumour endothelium. Nature. 2010;468:829–33.
    • (2010) Nature , vol.468 , pp. 829-833
    • Wang, R.1    Chadalavada, K.2    Wilshire, J.3    Kowalik, U.4    Hovinga, K.E.5    Geber, A.6
  • 19
    • 85028151366 scopus 로고    scopus 로고
    • Stark-Vance V. Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma. Neurooncology. 2005;7(3):369. Meeting Abstracts.
    • Stark-Vance V. Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma. Neurooncology. 2005;7(3):369. Meeting Abstracts.
  • 21
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant gliomas
    • PID: 17317837, COI: 1:CAS:528:DC%2BD2sXhvF2htr8%3D
    • Vredenburgh JJ, Desjardins A, Herndon II JE, Dowell JM, Reardon D, Quinn J, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant gliomas. Clin Cancer Res. 2007;13:1253–9.
    • (2007) Clin Cancer Res , vol.13 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.3    Dowell, J.M.4    Reardon, D.5    Quinn, J.6
  • 22
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
    • PID: 19897538, COI: 1:CAS:528:DC%2BC3cXjt1eqsw%3D%3D
    • Cohen MH, Shen YL, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist. 2009;14:1131–8.
    • (2009) Oncologist , vol.14 , pp. 1131-1138
    • Cohen, M.H.1    Shen, Y.L.2    Keegan, P.3    Pazdur, R.4
  • 23
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • PID: 19720927, COI: 1:CAS:528:DC%2BD1MXhtlGgtbbM
    • Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27:4733–40.
    • (2009) J Clin Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3    Mikkelsen, T.4    Schiff, D.5    Abrey, L.E.6
  • 24
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • PID: 19114704, COI: 1:CAS:528:DC%2BD1MXjsVCjs7o%3D
    • Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27:740–5.
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3    Duic, P.4    Royce, C.5    Stroud, I.6
  • 26
    • 79959213028 scopus 로고    scopus 로고
    • The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma
    • PID: 21531816, COI: 1:CAS:528:DC%2BC3MXnsFKgurc%3D
    • Vredenburgh JJ, Desjardins A, Reardon DA, Peters KB, Herndon II JE, Marcello J, et al. The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma. Clin Cancer Res. 2011;17:4119–24.
    • (2011) Clin Cancer Res , vol.17 , pp. 4119-4124
    • Vredenburgh, J.J.1    Desjardins, A.2    Reardon, D.A.3    Peters, K.B.4    Herndon, J.E.5    Marcello, J.6
  • 27
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • PID: 21135282, COI: 1:CAS:528:DC%2BC3MXhvVahtb0%3D
    • Lai A, Tran A, Nghiemphu PL, Pope WB, Solis OE, Selch M, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol. 2011;29:142–8.
    • (2011) J Clin Oncol , vol.29 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3    Pope, W.B.4    Solis, O.E.5    Selch, M.6
  • 28
    • 85028167493 scopus 로고    scopus 로고
    • Omuro A, Beal K, Karimi S, Chan T, Panageas K, Nayak L, et al. Phase II study of bevacizumab (BEV), temozolomide (TMZ), and hypofractionated stereotactic radiotherapy (HFSRT) for newly diagnosed glioblastoma (GBM). J Clin Oncol. 2010;28(15 Suppl):2036. Meeting Abstracts.
    • Omuro A, Beal K, Karimi S, Chan T, Panageas K, Nayak L, et al. Phase II study of bevacizumab (BEV), temozolomide (TMZ), and hypofractionated stereotactic radiotherapy (HFSRT) for newly diagnosed glioblastoma (GBM). J Clin Oncol. 2010;28(15 Suppl):2036. Meeting Abstracts.
  • 29
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • PID: 24552318, COI: 1:CAS:528:DC%2BC2cXjt1alu7s%3D, Landmark trial investigating bevacizumab for newly diagnosed glioblastoma.
    • Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370:709–22. Landmark trial investigating bevacizumab for newly diagnosed glioblastoma.
    • (2014) N Engl J Med , vol.370 , pp. 709-722
    • Chinot, O.L.1    Wick, W.2    Mason, W.3    Henriksson, R.4    Saran, F.5    Nishikawa, R.6
  • 30
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • PID: 24552317, COI: 1:CAS:528:DC%2BC2cXjt1alu7o%3D, Companion article to Chinot et al above. Also a landmark trial for bevacizumab in newly diagnosed glioblastoma.
    • Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370:699–708. Companion article to Chinot et al above. Also a landmark trial for bevacizumab in newly diagnosed glioblastoma.
    • (2014) N Engl J Med , vol.370 , pp. 699-708
    • Gilbert, M.R.1    Dignam, J.J.2    Armstrong, T.S.3    Wefel, J.S.4    Blumenthal, D.T.5    Vogelbaum, M.A.6
  • 31
    • 85026569322 scopus 로고    scopus 로고
    • A randomized phase II study of bevacizumab vs bevacizumab plus lomustine vs lomustine single agent in recurrent glioblastoma: the Dutch BELOB study. J Clin Oncol
    • Taal W, Oosterkamp HM, Walenkamp AME, Beerepoot LV, Hanse M, Buter J, et al. A randomized phase II study of bevacizumab vs bevacizumab plus lomustine vs lomustine single agent in recurrent glioblastoma: the Dutch BELOB study. J Clin Oncol. 2013;31(Suppl): [Abstract 2001].
    • (2001) 2013;31(Suppl): [Abstract
    • Taal, W.1    Oosterkamp, H.M.2    Walenkamp, A.M.E.3    Beerepoot, L.V.4    Hanse, M.5    Buter, J.6
  • 32
    • 84903745672 scopus 로고    scopus 로고
    • Randomized phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomide-chemoradiation for unresectable glioblastoma: final results of the TEMAVIR study from ANOCEFdagger
    • PID: 24723487, COI: 1:STN:280:DC%2BC2cnis1GgsQ%3D%3D
    • Chauffert B, Feuvret L, Bonnetain F, Taillandier L, Frappaz D, Taillia H, et al. Randomized phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomide-chemoradiation for unresectable glioblastoma: final results of the TEMAVIR study from ANOCEFdagger. Ann Oncol. 2014;25:1442–7.
    • (2014) Ann Oncol , vol.25 , pp. 1442-1447
    • Chauffert, B.1    Feuvret, L.2    Bonnetain, F.3    Taillandier, L.4    Frappaz, D.5    Taillia, H.6
  • 33
    • 84886020146 scopus 로고    scopus 로고
    • Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma
    • PID: 23634286, COI: 1:CAS:528:DC%2BC3sXlsV2lu74%3D
    • Lou E, Peters KB, Sumrall AL, Desjardins A, Reardon DA, Lipp ES, et al. Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma. Cancer Med. 2013;2:185–95.
    • (2013) Cancer Med , vol.2 , pp. 185-195
    • Lou, E.1    Peters, K.B.2    Sumrall, A.L.3    Desjardins, A.4    Reardon, D.A.5    Lipp, E.S.6
  • 34
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • PID: 18182667, COI: 1:CAS:528:DC%2BD1cXitVWitbY%3D
    • Sathornsumetee S, Cao Y, Marcello JE, Herndon II JE, McLendon RE, Desjardins A, et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol. 2008;26:271–8.
    • (2008) J Clin Oncol , vol.26 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3    Herndon, J.E.4    McLendon, R.E.5    Desjardins, A.6
  • 35
    • 84908519521 scopus 로고    scopus 로고
    • Phase II study of bevacizumab, temozolomide and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma, Clinical Cancer Research:
    • Omuro A, Beal K, Gutin P, Karimi S, Correa DD, Kaley TJ, DeAngelis LM, Chan TA, et al. Phase II study of bevacizumab, temozolomide and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma. Clinical Cancer Research. 2014. doi: 10.1158/1078-0432
    • (2014) et al
    • Omuro, A.1    Beal, K.2    Gutin, P.3    Karimi, S.4    Correa, D.D.5    Kaley, T.J.6    DeAngelis, L.M.7    Chan, T.A.8
  • 36
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • PID: 16530701, COI: 1:CAS:528:DC%2BD28XivFWjtL4%3D
    • Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 2006;9:157–73.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3    Forrest, W.F.4    Soriano, R.H.5    Wu, T.D.6
  • 37
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • PID: 20129251, COI: 1:CAS:528:DC%2BC3cXkvFKgsL4%3D
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17:98–110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 38
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • PID: 19915670
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One. 2009;4:e7752.
    • (2009) PLoS One , vol.4 , pp. e7752
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6
  • 40
    • 84907510882 scopus 로고    scopus 로고
    • Correlation of molecular subtypes with survival in AVAglio (bevacizumab [Bv] and radiotherapy [RT] and temozolomide [T] for newly diagnosed glioblastoma [GB])
    • Phillips H, Sandmann T, Li C, Cloughesy TF, Chinot OL, Wick W, et al. Correlation of molecular subtypes with survival in AVAglio (bevacizumab [Bv] and radiotherapy [RT] and temozolomide [T] for newly diagnosed glioblastoma [GB]). ASCO Meet Abstr. 2014;32(15 Suppl):2001.
    • (2014) ASCO Meet Abstr , vol.32 , Issue.15 Suppl , pp. 2001
    • Phillips, H.1    Sandmann, T.2    Li, C.3    Cloughesy, T.F.4    Chinot, O.L.5    Wick, W.6
  • 41
    • 85028153202 scopus 로고    scopus 로고
    • RA-013. Diffusion and perfusion magnetic resonance imaging in newly diagnosed glioblastoma following treatment with bevacizumab, temozolomide and hypo-fractionated stereotactic radiotherapy
    • Daras M, Abrey L, Sanchez J, Beal K, Gutin P, Kaley T, et al. RA-013. Diffusion and perfusion magnetic resonance imaging in newly diagnosed glioblastoma following treatment with bevacizumab, temozolomide and hypo-fractionated stereotactic radiotherapy. Neurooncology. 2013;15 Suppl 3:iii191–205.
    • (2013) Neurooncology , vol.15 , pp. iii191-iii205
    • Daras, M.1    Abrey, L.2    Sanchez, J.3    Beal, K.4    Gutin, P.5    Kaley, T.6
  • 42
    • 79955866104 scopus 로고    scopus 로고
    • Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma
    • PID: 21330401, COI: 1:STN:280:DC%2BC3MrgvFarug%3D%3D
    • Pope WB, Lai A, Mehta R, Kim HJ, Qiao J, Young JR, et al. Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. Am J Neuroradiol. 2011;32:882–9.
    • (2011) Am J Neuroradiol , vol.32 , pp. 882-889
    • Pope, W.B.1    Lai, A.2    Mehta, R.3    Kim, H.J.4    Qiao, J.5    Young, J.R.6
  • 43
    • 84887419886 scopus 로고    scopus 로고
    • Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
    • PID: 24190997, COI: 1:CAS:528:DC%2BC3sXhvFCis7fI
    • Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A. 2013;110:19059–64.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 19059-19064
    • Batchelor, T.T.1    Gerstner, E.R.2    Emblem, K.E.3    Duda, D.G.4    Kalpathy-Cramer, J.5    Snuderl, M.6
  • 44
    • 36048955738 scopus 로고    scopus 로고
    • Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18 F] fluorothymidine positron emission tomography: a pilot study
    • Chen W, Delaloye S, Silverman DH, Geist C, Czernin J, Sayre J, et al. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18 F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol. 2007;25:4714–21.
    • (2007) J Clin Oncol , vol.25 , pp. 4714-4721
    • Chen, W.1    Delaloye, S.2    Silverman, D.H.3    Geist, C.4    Czernin, J.5    Sayre, J.6
  • 45
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • PID: 17222792, COI: 1:CAS:528:DC%2BD2sXhtFClsLc%3D
    • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83–95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3    Zhang, W.T.4    Duda, D.G.5    Cohen, K.S.6
  • 46
    • 68649114787 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    • PID: 19167838, COI: 1:CAS:528:DC%2BD1MXhtVegsLjO
    • Gutin PH, Iwamoto FM, Beal K, Mohile NA, Karimi S, Hou BL, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2009;75:156–63.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 156-163
    • Gutin, P.H.1    Iwamoto, F.M.2    Beal, K.3    Mohile, N.A.4    Karimi, S.5    Hou, B.L.6
  • 47
    • 79952698481 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system
    • PID: 20399573, COI: 1:CAS:528:DC%2BC3MXjs1SmtL8%3D
    • Levin VA, Bidaut L, Hou P, Kumar AJ, Wefel JS, Bekele BN, et al. Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys. 2011;79:1487–95.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 1487-1495
    • Levin, V.A.1    Bidaut, L.2    Hou, P.3    Kumar, A.J.4    Wefel, J.S.5    Bekele, B.N.6
  • 49
    • 84919343233 scopus 로고    scopus 로고
    • Thomas AA, BC, DeAngelis LM, Omuro AM. Emerging therapies for glioblastoma. JAMA Neurology. 2014:[Pub pending].
    • Thomas AA, BC, DeAngelis LM, Omuro AM. Emerging therapies for glioblastoma. JAMA Neurology. 2014:[Pub pending].
  • 50
    • 84891527003 scopus 로고    scopus 로고
    • A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07)
    • COI: 1:CAS:528:DC%2BC2cXit1Wqtw%3D%3D
    • Hutterer M, Nowosielski M, Haybaeck J, Embacher S, Stockhammer F, Gotwald T, et al. A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07). Neurooncology. 2014;16:92–102.
    • (2014) Neurooncology , vol.16 , pp. 92-102
    • Hutterer, M.1    Nowosielski, M.2    Haybaeck, J.3    Embacher, S.4    Stockhammer, F.5    Gotwald, T.6
  • 51
    • 84869155416 scopus 로고    scopus 로고
    • A phase I/II trial of vandetanib for patients with recurrent malignant glioma
    • COI: 1:CAS:528:DC%2BC38XhslWktL7E
    • Kreisl TN, McNeill KA, Sul J, Iwamoto FM, Shih J, Fine HA. A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neurooncology. 2012;14:1519–26.
    • (2012) Neurooncology , vol.14 , pp. 1519-1526
    • Kreisl, T.N.1    McNeill, K.A.2    Sul, J.3    Iwamoto, F.M.4    Shih, J.5    Fine, H.A.6
  • 52
    • 72449155176 scopus 로고    scopus 로고
    • EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma
    • PID: 19945857, COI: 1:CAS:528:DC%2BD1MXhs1WgtLfJ
    • Brandes AA, Stupp R, Hau P, Lacombe D, Gorlia T, Tosoni A, et al. EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma. Eur J Cancer. 2010;46:348–54.
    • (2010) Eur J Cancer , vol.46 , pp. 348-354
    • Brandes, A.A.1    Stupp, R.2    Hau, P.3    Lacombe, D.4    Gorlia, T.5    Tosoni, A.6
  • 53
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, vs lomustine alone in patients with recurrent glioblastoma
    • PID: 23940216, COI: 1:CAS:528:DC%2BC3sXhs1ahur7O
    • Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, vs lomustine alone in patients with recurrent glioblastoma. J Clin Oncol. 2013;31:3212–8.
    • (2013) J Clin Oncol , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3    Nabors, L.B.4    Campone, M.5    Wick, A.6
  • 54
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study
    • PID: 21606416
    • de Groot JF, Lamborn KR, Chang SM, Gilbert MR, Cloughesy TF, Aldape K, et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol. 2011;29:2689–95.
    • (2011) J Clin Oncol , vol.29 , pp. 2689-2695
    • de Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3    Gilbert, M.R.4    Cloughesy, T.F.5    Aldape, K.6
  • 55
    • 85028158759 scopus 로고    scopus 로고
    • Stupp R HM, Gorlia T, Erridge S, Grujicic D, Steinbach JP, Wick W, et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study. J Clin Oncol. 2013;31(Suppl l):LBA2009.
    • Stupp R HM, Gorlia T, Erridge S, Grujicic D, Steinbach JP, Wick W, et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study. J Clin Oncol. 2013;31(Suppl l):LBA2009.
  • 56
    • 77956061453 scopus 로고    scopus 로고
    • Rebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade glioma
    • PID: 20151176, COI: 1:CAS:528:DC%2BC3cXhtVGmtLfP
    • Zuniga RM, Torcuator R, Jain R, Anderson J, Doyle T, Schultz L, et al. Rebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade glioma. J Neurooncol. 2010;99:237–42.
    • (2010) J Neurooncol , vol.99 , pp. 237-242
    • Zuniga, R.M.1    Torcuator, R.2    Jain, R.3    Anderson, J.4    Doyle, T.5    Schultz, L.6
  • 57
    • 84867900118 scopus 로고    scopus 로고
    • Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients
    • PID: 23037712, COI: 1:CAS:528:DC%2BC38XhsFOntLbO
    • Reardon DA, Herndon II JE, Peters KB, Desjardins A, Coan A, Lou E, et al. Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients. Br J Cancer. 2012;107:1481–7.
    • (2012) Br J Cancer , vol.107 , pp. 1481-1487
    • Reardon, D.A.1    Herndon, J.E.2    Peters, K.B.3    Desjardins, A.4    Coan, A.5    Lou, E.6
  • 58
    • 84875709160 scopus 로고    scopus 로고
    • Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma
    • COI: 1:CAS:528:DC%2BC3sXhsVOnurY%3D
    • Omuro A, Chan TA, Abrey LE, Khasraw M, Reiner AS, Kaley TJ, et al. Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma. Neurooncology. 2013;15:242–50.
    • (2013) Neurooncology , vol.15 , pp. 242-250
    • Omuro, A.1    Chan, T.A.2    Abrey, L.E.3    Khasraw, M.4    Reiner, A.S.5    Kaley, T.J.6
  • 59
    • 0035503538 scopus 로고    scopus 로고
    • Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    • PID: 11691802, COI: 1:CAS:528:DC%2BD3MXotlaku70%3D
    • Takahashi N, Haba A, Matsuno F, Seon BK. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res. 2001;61:7846–54.
    • (2001) Cancer Res , vol.61 , pp. 7846-7854
    • Takahashi, N.1    Haba, A.2    Matsuno, F.3    Seon, B.K.4


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