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Volumn 20, Issue 19, 2014, Pages 5023-5031

Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma

(26)  Omuro, Antonio a   Beal, Kathryn a   Gutin, Philip a   Karimi, Sasan a   Correa, Denise D a   Kaley, Thomas J a   DeAngelis, Lisa M a   Chan, Timothy A a   Gavrilovic, Igor T a   Nolan, Craig a   Hormigo, Adilia a,b   Lassman, Andrew B a,c   Mellinghoff, Ingo a   Grommes, Christian a   Reiner, Anne S a   Panageas, Katherine S a   Baser, Raymond E a   Tabar, Viviane a   Pentsova, Elena a   Sanchez, Juan a,f   more..


Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; DACARBAZINE; MONOCLONAL ANTIBODY;

EID: 84908519521     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0822     Document Type: Article
Times cited : (86)

References (46)
  • 2
    • 84891785971 scopus 로고    scopus 로고
    • Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
    • Gilbert MR, Wang M, Aldape KD, Stupp R, Hegi ME, Jaeckle KA, et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol 2013;31:4085-91.
    • (2013) J Clin Oncol , vol.31 , pp. 4085-4091
    • Gilbert, M.R.1    Wang, M.2    Aldape, K.D.3    Stupp, R.4    Hegi, M.E.5    Jaeckle, K.A.6
  • 3
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008;359:492-507.
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 4
    • 84891791656 scopus 로고    scopus 로고
    • Net clinical benefit analysis of radiation therapy oncology group 0525: A phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma
    • Armstrong TS, Wefel JS, Wang M, Gilbert MR, Won M, Bottomley A, et al. Net clinical benefit analysis of radiation therapy oncology group 0525: a phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma. J Clin Oncol 2013;31:4076-84.
    • (2013) J Clin Oncol , vol.31 , pp. 4076-4084
    • Armstrong, T.S.1    Wefel, J.S.2    Wang, M.3    Gilbert, M.R.4    Won, M.5    Bottomley, A.6
  • 5
    • 84887102623 scopus 로고    scopus 로고
    • Glioblastoma and other malignant gliomas: A clinical review
    • Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA 2013;310:1842-50.
    • (2013) JAMA , vol.310 , pp. 1842-1850
    • Omuro, A.1    DeAngelis, L.M.2
  • 7
    • 68649114787 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    • Gutin PH, Iwamoto FM, Beal K, Mohile NA, Karimi S, Hou BL, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 2009;75:156-63.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 156-163
    • Gutin, P.H.1    Iwamoto, F.M.2    Beal, K.3    Mohile, N.A.4    Karimi, S.5    Hou, B.L.6
  • 8
    • 0036720401 scopus 로고    scopus 로고
    • Relative cerebral blood volume measurements in intracranial mass lesions: Interobserver and intraobserver reproducibility study
    • Wetzel SG, Cha S, Johnson G, Lee P, Law M, Kasow DL, et al. Relative cerebral blood volume measurements in intracranial mass lesions: interobserver and intraobserver reproducibility study. Radiology 2002;224:797-803.
    • (2002) Radiology , vol.224 , pp. 797-803
    • Wetzel, S.G.1    Cha, S.2    Johnson, G.3    Lee, P.4    Law, M.5    Kasow, D.L.6
  • 9
    • 35148852821 scopus 로고    scopus 로고
    • Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomas
    • Young R, Babb J, Law M, Pollack E, Johnson G. Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomas. J Magn Reson Imaging 2007;26:1053-1063.
    • (2007) J Magn Reson Imaging , vol.26 , pp. 1053-1063
    • Young, R.1    Babb, J.2    Law, M.3    Pollack, E.4    Johnson, G.5
  • 10
    • 0036210301 scopus 로고    scopus 로고
    • Intracranial mass lesions: Dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging
    • Cha S, Knopp EA, Johnson G, Wetzel SG, Litt AW, Zagzag D. Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology 2002;223:11-29.
    • (2002) Radiology , vol.223 , pp. 11-29
    • Cha, S.1    Knopp, E.A.2    Johnson, G.3    Wetzel, S.G.4    Litt, A.W.5    Zagzag, D.6
  • 11
    • 60149093752 scopus 로고    scopus 로고
    • Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
    • Barajas RF, Chang JS, Sneed PK, Segal MR, McDermott MW, Cha S. Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol 2009;30:367-372.
    • (2009) AJNR Am J Neuroradiol , vol.30 , pp. 367-372
    • Barajas, R.F.1    Chang, J.S.2    Sneed, P.K.3    Segal, M.R.4    McDermott, M.W.5    Cha, S.6
  • 12
    • 79959322515 scopus 로고    scopus 로고
    • Percentage signal recovery derived from MR dynamic susceptibility contrast imaging is useful to differentiate common enhancing malignant lesions of the brain
    • Mangla R, Kolar B, Zhu T, Zhong J, Almast J, Ekholm S. Percentage signal recovery derived from MR dynamic susceptibility contrast imaging is useful to differentiate common enhancing malignant lesions of the brain. AJNR Am J Neuroradiol 2011;32:1004-10.
    • (2011) AJNR Am J Neuroradiol , vol.32 , pp. 1004-1010
    • Mangla, R.1    Kolar, B.2    Zhu, T.3    Zhong, J.4    Almast, J.5    Ekholm, S.6
  • 13
    • 34247270951 scopus 로고    scopus 로고
    • Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomas
    • Law M, Young R, Babb J, Pollack E, Johnson G. Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomas. AJNR Am J Neuroradiol 2007;28:761-6.
    • (2007) AJNR Am J Neuroradiol , vol.28 , pp. 761-766
    • Law, M.1    Young, R.2    Babb, J.3    Pollack, E.4    Johnson, G.5
  • 14
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 17
    • 34547840273 scopus 로고    scopus 로고
    • Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines
    • Correa DD, Maron L, Harder H, Klein M, Armstrong CL, Calabrese P, et al. Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. Ann Oncol 2007;18:1145-51.
    • (2007) Ann Oncol , vol.18 , pp. 1145-1151
    • Correa, D.D.1    Maron, L.2    Harder, H.3    Klein, M.4    Armstrong, C.L.5    Calabrese, P.6
  • 18
    • 58149472908 scopus 로고    scopus 로고
    • Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy
    • Correa DD, Rocco-Donovan M, DeAngelis LM, Dolgoff-Kaspar R, Iwamoto F, Yahalom J, et al. Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. J Neurooncol 2009;91:315-21.
    • (2009) J Neurooncol , vol.91 , pp. 315-321
    • Correa, D.D.1    Rocco-Donovan, M.2    DeAngelis, L.M.3    Dolgoff-Kaspar, R.4    Iwamoto, F.5    Yahalom, J.6
  • 19
    • 0025281789 scopus 로고
    • Response criteria for phase II studies of supratentorial malignant glioma
    • Macdonald DR, Cascino TL, Schold SC Jr, Cairncross JG. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 1990;8:1277-80.
    • (1990) J Clin Oncol , vol.8 , pp. 1277-1280
    • Macdonald, D.R.1    Cascino, T.L.2    Schold, S.C.3    Cairncross, J.G.4
  • 20
    • 77951625266 scopus 로고    scopus 로고
    • Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group
    • Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 2010;28:1963-72.
    • (2010) J Clin Oncol , vol.28 , pp. 1963-1972
    • Wen, P.Y.1    Macdonald, D.R.2    Reardon, D.A.3    Cloughesy, T.F.4    Sorensen, A.G.5    Galanis, E.6
  • 21
    • 79951486845 scopus 로고    scopus 로고
    • Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab
    • Pope WB, Xia Q, Paton VE, Das A, Hambleton J, Kim HJ, et al. Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab. Neurology 2011;76:432-7.
    • (2011) Neurology , vol.76 , pp. 432-437
    • Pope, W.B.1    Xia, Q.2    Paton, V.E.3    Das, A.4    Hambleton, J.5    Kim, H.J.6
  • 22
    • 79959213028 scopus 로고    scopus 로고
    • The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma
    • Vredenburgh JJ, Desjardins A, Reardon DA, Peters KB, Herndon JE II, Marcello J, et al. The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma. Clin Cancer Res 2011;17:4119-24.
    • (2011) Clin Cancer Res , vol.17 , pp. 4119-4124
    • Vredenburgh, J.J.1    Desjardins, A.2    Reardon, D.A.3    Peters, K.B.4    Herndon, J.E.5    Marcello, J.6
  • 23
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai A, Tran A, Nghiemphu PL, Pope WB, Solis OE, Selch M, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 2011;29:142-8.
    • (2011) J Clin Oncol , vol.29 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3    Pope, W.B.4    Solis, O.E.5    Selch, M.6
  • 26
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007;11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    Di Tomaso, E.3    Zhang, W.T.4    Duda, D.G.5    Cohen, K.S.6
  • 27
    • 84866063199 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy for glioblastoma: Strategy for poor-risk patients or hope for the future?
    • Hingorani M, Colley WP, Dixit S, Beavis AM. Hypofractionated radiotherapy for glioblastoma: strategy for poor-risk patients or hope for the future? Br J Radiol 2012;85:e770-81.
    • (2012) Br J Radiol , vol.85 , pp. e770-e781
    • Hingorani, M.1    Colley, W.P.2    Dixit, S.3    Beavis, A.M.4
  • 28
    • 0030956096 scopus 로고    scopus 로고
    • Hypofractionated radiation induces a decrease in cell proliferation but no histological damage to organotypic multicellular spheroids of human glioblastomas
    • Kaaijk P, Troost D, Sminia P, Hulshof MC, van der Kracht AH, Leenstra S, et al. Hypofractionated radiation induces a decrease in cell proliferation but no histological damage to organotypic multicellular spheroids of human glioblastomas. Eur J Cancer 1997;33:645-51.
    • (1997) Eur J Cancer , vol.33 , pp. 645-651
    • Kaaijk, P.1    Troost, D.2    Sminia, P.3    Hulshof, M.C.4    Van Der Kracht, A.H.5    Leenstra, S.6
  • 29
    • 2442659387 scopus 로고    scopus 로고
    • Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial
    • Roa W, Brasher PM, Bauman G, Anthes M, Bruera E, Chan A, et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 2004;22:1583-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1583-1588
    • Roa, W.1    Brasher, P.M.2    Bauman, G.3    Anthes, M.4    Bruera, E.5    Chan, A.6
  • 31
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
    • Malmstrom A, Gronberg BH, Marosi C, Stupp R, Frappaz D, Schultz H, et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol 2012;13:916-26.
    • (2012) Lancet Oncol , vol.13 , pp. 916-926
    • Malmstrom, A.1    Gronberg, B.H.2    Marosi, C.3    Stupp, R.4    Frappaz, D.5    Schultz, H.6
  • 32
    • 0038639357 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: Outcome and prognostic factors
    • Chang EL, Yi W, Allen PK, Levin VA, Sawaya RE, Maor MH. Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys 2003;56:519-28.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 519-528
    • Chang, E.L.1    Yi, W.2    Allen, P.K.3    Levin, V.A.4    Sawaya, R.E.5    Maor, M.H.6
  • 33
    • 84863560794 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: A review of ten-year single institutional experience
    • Cao JQ, Fisher BJ, Bauman GS, Megyesi JF, Watling CJ, Macdonald DR. Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience. J Neurooncol 2012;107:395-405.
    • (2012) J Neurooncol , vol.107 , pp. 395-405
    • Cao, J.Q.1    Fisher, B.J.2    Bauman, G.S.3    Megyesi, J.F.4    Watling, C.J.5    Macdonald, D.R.6
  • 34
    • 84878275261 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy and stereotactic boost with concurrent and adjuvant temozolamide for glioblastoma in good performance status elderly patients - Early results of a phase II trial
    • Floyd SR, Kasper EM, Uhlmann EJ, Fonkem E, Wong ET, Mahadevan A. Hypofractionated radiotherapy and stereotactic boost with concurrent and adjuvant temozolamide for glioblastoma in good performance status elderly patients - early results of a phase II trial. Front Oncol 2012;2:122.
    • (2012) Front Oncol , vol.2 , pp. 122
    • Floyd, S.R.1    Kasper, E.M.2    Uhlmann, E.J.3    Fonkem, E.4    Wong, E.T.5    Mahadevan, A.6
  • 35
    • 0347624471 scopus 로고    scopus 로고
    • The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: Preliminary results of a prospective trial
    • Sultanem K, Patrocinio H, Lambert C, Corns R, Leblanc R, Parker W, et al. The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: preliminary results of a prospective trial. Int J Radiat Oncol Biol Phys 2004;58:247-52.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 247-252
    • Sultanem, K.1    Patrocinio, H.2    Lambert, C.3    Corns, R.4    Leblanc, R.5    Parker, W.6
  • 36
    • 84866740043 scopus 로고    scopus 로고
    • Phase II trial of hypofractionated IMRT with temozolomide for patients with newly diagnosed glioblastoma multiforme
    • Reddy K, Damek D, Gaspar LE, Ney D, Waziri A, Lillehei K, et al. Phase II trial of hypofractionated IMRT with temozolomide for patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2012;84:655-60.
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 655-660
    • Reddy, K.1    Damek, D.2    Gaspar, L.E.3    Ney, D.4    Waziri, A.5    Lillehei, K.6
  • 37
    • 58149337555 scopus 로고    scopus 로고
    • Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: A safety and efficacy analysis
    • Panet-Raymond V, Souhami L, Roberge D, Kavan P, Shakibnia L, Muanza T, et al. Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis. Int J Radiat Oncol Biol Phys 2009;73:473-8.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 473-478
    • Panet-Raymond, V.1    Souhami, L.2    Roberge, D.3    Kavan, P.4    Shakibnia, L.5    Muanza, T.6
  • 38
    • 84855449737 scopus 로고    scopus 로고
    • Concurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma
    • Tsien CI, Brown D, Normolle D, Schipper M, Piert M, Junck L, et al. Concurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma. Clin Cancer Res 2012;18:273-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 273-279
    • Tsien, C.I.1    Brown, D.2    Normolle, D.3    Schipper, M.4    Piert, M.5    Junck, L.6
  • 40
    • 77951003656 scopus 로고    scopus 로고
    • Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States
    • Grossman SA, Ye X, Piantadosi S, Desideri S, Nabors LB, Rosenfeld M, et al. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin Cancer Res 2010;16:2443-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 2443-2449
    • Grossman, S.A.1    Ye, X.2    Piantadosi, S.3    Desideri, S.4    Nabors, L.B.5    Rosenfeld, M.6
  • 41
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • Sathornsumetee S, Cao Y, Marcello JE, Herndon JE II, McLendon RE, Desjardins A, et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 2008;26:271-8.
    • (2008) J Clin Oncol , vol.26 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3    Herndon, J.E.4    McLendon, R.E.5    Desjardins, A.6
  • 42
    • 79955866104 scopus 로고    scopus 로고
    • Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma
    • Pope WB, Lai A, Mehta R, Kim HJ, Qiao J, Young JR, et al. Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. AJNR Am J Neuroradiol 2011;32:882-9.
    • (2011) AJNR Am J Neuroradiol , vol.32 , pp. 882-889
    • Pope, W.B.1    Lai, A.2    Mehta, R.3    Kim, H.J.4    Qiao, J.5    Young, J.R.6
  • 43
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9:157-73.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3    Forrest, W.F.4    Soriano, R.H.5    Wu, T.D.6
  • 44
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE 2009;4:e7752.
    • (2009) PLoS ONE , vol.4 , pp. e7752
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6
  • 45
    • 84907510882 scopus 로고    scopus 로고
    • Correlation of molecular subtypes with survival in AVAglio (bevacizumab [Bv] and radiotherapy [RT] and temozolomide [T] for newly diagnosed glioblastoma [GB])
    • Philips H, Sandmann T, Li C, Cloughesy TF, Chinot OL, Wick W, et al. Correlation of molecular subtypes with survival in AVAglio (bevacizumab [Bv] and radiotherapy [RT] and temozolomide [T] for newly diagnosed glioblastoma [GB]). ASCO Meeting Abstracts 2014;32:2001.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 2001
    • Philips, H.1    Sandmann, T.2    Li, C.3    Cloughesy, T.F.4    Chinot, O.L.5    Wick, W.6
  • 46
    • 84898748271 scopus 로고    scopus 로고
    • Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III trial comparing chemoradiation (CRT) with and without BEV in patients with newly diagnosed glioblastoma (GBM)
    • Sulman EP, Won M, Blumenthal DT, Vogelbaum MA, Colman H, Jenkins RB, et al. Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III trial comparing chemoradiation (CRT) with and without BEV in patients with newly diagnosed glioblastoma (GBM). ASCO Meeting Abstracts 2013;31:LBA2010.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. LBA2010
    • Sulman, E.P.1    Won, M.2    Blumenthal, D.T.3    Vogelbaum, M.A.4    Colman, H.5    Jenkins, R.B.6


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