메뉴 건너뛰기




Volumn 9, Issue 6, 2014, Pages 304-316

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Author keywords

Dissolution; Drug solubility; Particle technology; Poorly water soluble drug; Solubility enhancement

Indexed keywords

POLYMER; SOLID LIPID NANOPARTICLE;

EID: 84919921268     PISSN: 18180876     EISSN: 2221285X     Source Type: Journal    
DOI: 10.1016/j.ajps.2014.05.005     Document Type: Review
Times cited : (773)

References (83)
  • 1
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: the correlation of invitro drug product dissolution and invivo bioavailability
    • Amidon G.L., Lennernas H., Shah V.P., et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of invitro drug product dissolution and invivo bioavailability. Pharm Res 1995, 12:413-420.
    • (1995) Pharm Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3
  • 2
    • 84877259367 scopus 로고    scopus 로고
    • Strategies to address low drug solubility in discovery and development
    • Williams H.D., Trevaskis N.L., Charman S.A., et al. Strategies to address low drug solubility in discovery and development. Pharmacol Rev 2013, 65:315-499.
    • (2013) Pharmacol Rev , vol.65 , pp. 315-499
    • Williams, H.D.1    Trevaskis, N.L.2    Charman, S.A.3
  • 3
    • 79957789430 scopus 로고    scopus 로고
    • Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs
    • Krishnaiah Y.S.R. Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs. J Bioequiv Bioavailab 2010, 2:28-36.
    • (2010) J Bioequiv Bioavailab , vol.2 , pp. 28-36
    • Krishnaiah, Y.S.R.1
  • 4
    • 80054697161 scopus 로고    scopus 로고
    • Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications
    • Kawabata Y., Wada K., Nakatani M., et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 2011, 420:1-10.
    • (2011) Int J Pharm , vol.420 , pp. 1-10
    • Kawabata, Y.1    Wada, K.2    Nakatani, M.3
  • 5
    • 1842559836 scopus 로고    scopus 로고
    • Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs
    • Hu J., Johnston K.P., Williams R.O. Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Dev Ind Pharm 2004, 30:233-245.
    • (2004) Drug Dev Ind Pharm , vol.30 , pp. 233-245
    • Hu, J.1    Johnston, K.P.2    Williams, R.O.3
  • 6
    • 0035073301 scopus 로고    scopus 로고
    • Modeling and comparison of dissolution profiles
    • Costa P., Sousa Lobo J.M. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001, 13:123-133.
    • (2001) Eur J Pharm Sci , vol.13 , pp. 123-133
    • Costa, P.1    Sousa Lobo, J.M.2
  • 7
    • 77953429362 scopus 로고    scopus 로고
    • Biopharmaceutical classification system: scientific basis for biowaiver extensions
    • Wagh M.P., Patel J.S. Biopharmaceutical classification system: scientific basis for biowaiver extensions. Int J Pharm Pharm Sci 2010, 2:12-19.
    • (2010) Int J Pharm Pharm Sci , vol.2 , pp. 12-19
    • Wagh, M.P.1    Patel, J.S.2
  • 8
    • 0035997323 scopus 로고    scopus 로고
    • Biopharmaceutics classification system: the scientific basis for biowaiver extensions
    • Yu L.X., Amidon G.L., Polli J.E., et al. Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharm Res 2002, 19:921-925.
    • (2002) Pharm Res , vol.19 , pp. 921-925
    • Yu, L.X.1    Amidon, G.L.2    Polli, J.E.3
  • 9
    • 84876766388 scopus 로고    scopus 로고
    • Drug carrier systems for solubility enhancement of BCS class II drugs: a critical review
    • Kumar S., Bhargava D., Thakkar A., et al. Drug carrier systems for solubility enhancement of BCS class II drugs: a critical review. Crit Rev Ther Drug Carrier Syst 2013, 30:217-256.
    • (2013) Crit Rev Ther Drug Carrier Syst , vol.30 , pp. 217-256
    • Kumar, S.1    Bhargava, D.2    Thakkar, A.3
  • 10
    • 84865398523 scopus 로고    scopus 로고
    • Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability
    • Onoue S., Kojo Y., Aoki Y., et al. Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. Drug Metab Pharmacokinet 2012, 27:379-387.
    • (2012) Drug Metab Pharmacokinet , vol.27 , pp. 379-387
    • Onoue, S.1    Kojo, Y.2    Aoki, Y.3
  • 11
    • 33644881395 scopus 로고    scopus 로고
    • Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000
    • Urbanetz N.A. Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000. Eur J Pharm Sci 2006, 28:67-76.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 67-76
    • Urbanetz, N.A.1
  • 12
    • 34547864243 scopus 로고    scopus 로고
    • Drug delivery strategies for poorly water-soluble drugs
    • Fahr A., Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007, 4:403-416.
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 403-416
    • Fahr, A.1    Liu, X.2
  • 13
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system
    • Pouton C.W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006, 29:278-287.
    • (2006) Eur J Pharm Sci , vol.29 , pp. 278-287
    • Pouton, C.W.1
  • 14
    • 15744392762 scopus 로고    scopus 로고
    • Pharmaceutical powder technology-from art to science: the challenge of the FDA's process analytical technology initiative
    • Leuenberger H., Lanz M. Pharmaceutical powder technology-from art to science: the challenge of the FDA's process analytical technology initiative. Adv Powder Technol 2005, 16:3-25.
    • (2005) Adv Powder Technol , vol.16 , pp. 3-25
    • Leuenberger, H.1    Lanz, M.2
  • 15
    • 84873703839 scopus 로고    scopus 로고
    • Special issue on pharmaceutical powders: towards developing understanding of the influence of materials and processes on product performance
    • Davé R.N., Bilgili E., Jallo L., et al. Special issue on pharmaceutical powders: towards developing understanding of the influence of materials and processes on product performance. Powder Technol 2013, 236:1-4.
    • (2013) Powder Technol , vol.236 , pp. 1-4
    • Davé, R.N.1    Bilgili, E.2    Jallo, L.3
  • 16
    • 34548061596 scopus 로고    scopus 로고
    • Estimating drug solubility in the gastrointestinal tract
    • Dressman J.B., Vertzoni M., Goumas K., et al. Estimating drug solubility in the gastrointestinal tract. Adv Drug Deliv Rev 2007, 59:591-602.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 591-602
    • Dressman, J.B.1    Vertzoni, M.2    Goumas, K.3
  • 17
    • 84874752995 scopus 로고    scopus 로고
    • Drug solubility: importance and enhancement techniques
    • Savjani K.T., Gajjar A.K., Savjani J.K. Drug solubility: importance and enhancement techniques. ISRN Pharm 2012, 1-10. 10.5402/2012/195727.
    • (2012) ISRN Pharm , pp. 1-10
    • Savjani, K.T.1    Gajjar, A.K.2    Savjani, J.K.3
  • 18
    • 85009518892 scopus 로고    scopus 로고
    • Recent advancements in mechanical reduction methods: Particulate systems
    • Leleux J., Williams R.O. Recent advancements in mechanical reduction methods: Particulate systems. Drug Dev Ind Pharm 2013, 3109:1-12.
    • (2013) Drug Dev Ind Pharm , vol.3109 , pp. 1-12
    • Leleux, J.1    Williams, R.O.2
  • 19
    • 33747373878 scopus 로고    scopus 로고
    • A century of dissolution research: from noyes and whitney to the biopharmaceutics classification system
    • Dokoumetzidis A., Macheras P. A century of dissolution research: from noyes and whitney to the biopharmaceutics classification system. Int J Pharm 2006, 321:1-11.
    • (2006) Int J Pharm , vol.321 , pp. 1-11
    • Dokoumetzidis, A.1    Macheras, P.2
  • 20
    • 84870342804 scopus 로고    scopus 로고
    • Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q(10) as naked nanocrystals
    • Sun J., Wang F., Sui Y., et al. Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q(10) as naked nanocrystals. Int J Nanomed 2012, 7:5733-5744.
    • (2012) Int J Nanomed , vol.7 , pp. 5733-5744
    • Sun, J.1    Wang, F.2    Sui, Y.3
  • 21
    • 69749103682 scopus 로고    scopus 로고
    • Nanocrystal technology, drug delivery and clinical applications
    • Junghanns J.A., Müller R.H. Nanocrystal technology, drug delivery and clinical applications. Int J Nanomed 2008, 3:295-309.
    • (2008) Int J Nanomed , vol.3 , pp. 295-309
    • Junghanns, J.A.1    Müller, R.H.2
  • 22
    • 0037312695 scopus 로고    scopus 로고
    • Nanosizing: a formulation approach for poorly-water-soluble compounds
    • Merisko-Liversidge E., Liversidge G.G., Cooper E.R. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci 2003, 18:113-120.
    • (2003) Eur J Pharm Sci , vol.18 , pp. 113-120
    • Merisko-Liversidge, E.1    Liversidge, G.G.2    Cooper, E.R.3
  • 23
    • 84864951526 scopus 로고    scopus 로고
    • Solubility: Particle size reduction is a promising approach to improve the bioavailability of lipophillic drugs
    • Rawat N., Kumar M.S., Mahadevan N. Solubility: Particle size reduction is a promising approach to improve the bioavailability of lipophillic drugs. Int J Recent Adv Pharm Res 2011, 1:8-18.
    • (2011) Int J Recent Adv Pharm Res , vol.1 , pp. 8-18
    • Rawat, N.1    Kumar, M.S.2    Mahadevan, N.3
  • 24
    • 1342281182 scopus 로고    scopus 로고
    • Micron-size drug particles: common and novel micronization techniques
    • Rasenack N., Muller B.W. Micron-size drug particles: common and novel micronization techniques. Pharm Dev Technol 2004, 9:1-13.
    • (2004) Pharm Dev Technol , vol.9 , pp. 1-13
    • Rasenack, N.1    Muller, B.W.2
  • 25
    • 0344172594 scopus 로고    scopus 로고
    • Micronization of pharmaceutical substances in a spiral jet mill
    • Midoux N., Hošek P., Pailleres L., et al. Micronization of pharmaceutical substances in a spiral jet mill. Powder Technol 1999, 104:113-120.
    • (1999) Powder Technol , vol.104 , pp. 113-120
    • Midoux, N.1    Hošek, P.2    Pailleres, L.3
  • 26
    • 33344478634 scopus 로고    scopus 로고
    • Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
    • Jinno J., Kamada N., Miyake M., et al. Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs. J Control Release 2006, 111:56-64.
    • (2006) J Control Release , vol.111 , pp. 56-64
    • Jinno, J.1    Kamada, N.2    Miyake, M.3
  • 27
    • 79960185799 scopus 로고    scopus 로고
    • Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
    • Han X., Ghoroi C., To D., et al. Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles. Int J Pharm 2011, 415:185-195.
    • (2011) Int J Pharm , vol.415 , pp. 185-195
    • Han, X.1    Ghoroi, C.2    To, D.3
  • 28
    • 0029080002 scopus 로고
    • Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. absolute oral bioavailability of nanocrystalline danazol in beagle dogs
    • Liversidge G.G., Cundy K.C. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int J Pharm 1995, 125:91-97.
    • (1995) Int J Pharm , vol.125 , pp. 91-97
    • Liversidge, G.G.1    Cundy, K.C.2
  • 29
    • 79952165879 scopus 로고    scopus 로고
    • The role of configurational entropy in amorphous systems
    • Graeser K.A., Patterson J.E., Zeitler J.A., et al. The role of configurational entropy in amorphous systems. Pharmaceutics 2010, 2:224-244.
    • (2010) Pharmaceutics , vol.2 , pp. 224-244
    • Graeser, K.A.1    Patterson, J.E.2    Zeitler, J.A.3
  • 30
    • 34047252848 scopus 로고    scopus 로고
    • Preparation of glasssolutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling
    • Patterson J.E., James M.B., Forster A.H., et al. Preparation of glasssolutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling. Int J Pharm 2007, 336:22-34.
    • (2007) Int J Pharm , vol.336 , pp. 22-34
    • Patterson, J.E.1    James, M.B.2    Forster, A.H.3
  • 31
    • 84860666097 scopus 로고    scopus 로고
    • High pressure homogenization of pharmaceutical solids
    • Kluge J., Muhrer G., Mazzotti M. High pressure homogenization of pharmaceutical solids. J Supercrit Fluid 2012, 66:380-388.
    • (2012) J Supercrit Fluid , vol.66 , pp. 380-388
    • Kluge, J.1    Muhrer, G.2    Mazzotti, M.3
  • 32
    • 28444461830 scopus 로고    scopus 로고
    • Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation
    • Keck C.M., Müller R.H. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm 2006, 62:3-16.
    • (2006) Eur J Pharm Biopharm , vol.62 , pp. 3-16
    • Keck, C.M.1    Müller, R.H.2
  • 33
    • 0342897023 scopus 로고    scopus 로고
    • Nanosuspensions for the formulation of poorly soluble drugs: I. preparation by a size-reduction technique
    • Müller R.H., Peters K. Nanosuspensions for the formulation of poorly soluble drugs: I. preparation by a size-reduction technique. Int J Pharm 1998, 160:229-237.
    • (1998) Int J Pharm , vol.160 , pp. 229-237
    • Müller, R.H.1    Peters, K.2
  • 34
    • 21844461846 scopus 로고    scopus 로고
    • Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine
    • Hecq J., Deleers M., Fanara D., et al. Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. Int J Pharm 2005, 299:167-177.
    • (2005) Int J Pharm , vol.299 , pp. 167-177
    • Hecq, J.1    Deleers, M.2    Fanara, D.3
  • 37
    • 84919931827 scopus 로고    scopus 로고
    • Drug particle engineering of poorly water soluble drugs
    • Koshy P., Pacharane S., Chaudhry A., et al. Drug particle engineering of poorly water soluble drugs. Der Pharm Let 2010, 2:65-76.
    • (2010) Der Pharm Let , vol.2 , pp. 65-76
    • Koshy, P.1    Pacharane, S.2    Chaudhry, A.3
  • 39
    • 0036849433 scopus 로고    scopus 로고
    • A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: Spray-freezing into liquid
    • Rogers T.L., Nelsen A.C., Hu J., et al. A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: Spray-freezing into liquid. Eur J Pharm Biopharm 2002, 54:271-280.
    • (2002) Eur J Pharm Biopharm , vol.54 , pp. 271-280
    • Rogers, T.L.1    Nelsen, A.C.2    Hu, J.3
  • 40
    • 0037333353 scopus 로고    scopus 로고
    • Enhanced aqueous dissolution of a poorly water soluble drug by novel particleengineering technology: Spray-freezing into liquidwith atmospheric freeze-drying
    • Rogers T.L., Nelsen A.C., Sarkari M., et al. Enhanced aqueous dissolution of a poorly water soluble drug by novel particleengineering technology: Spray-freezing into liquidwith atmospheric freeze-drying. Pharm Res 2003, 20:485-493.
    • (2003) Pharm Res , vol.20 , pp. 485-493
    • Rogers, T.L.1    Nelsen, A.C.2    Sarkari, M.3
  • 41
    • 0242334090 scopus 로고    scopus 로고
    • Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems
    • Hu J., Johnston K.P., Williams R.O. Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems. Eur J Pharm Sci 2003, 20:295-303.
    • (2003) Eur J Pharm Sci , vol.20 , pp. 295-303
    • Hu, J.1    Johnston, K.P.2    Williams, R.O.3
  • 42
    • 33749649133 scopus 로고    scopus 로고
    • Cryogenic liquids, nanoparticles, and microencapsulation
    • Purvis T., Vaughn J.M., Rogers T.L., et al. Cryogenic liquids, nanoparticles, and microencapsulation. Int J Pharm 2006, 324:43-50.
    • (2006) Int J Pharm , vol.324 , pp. 43-50
    • Purvis, T.1    Vaughn, J.M.2    Rogers, T.L.3
  • 43
    • 34548023425 scopus 로고    scopus 로고
    • Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
    • Blagden N., De Matas M., Gavan P., et al. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev 2007, 59:617-630.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 617-630
    • Blagden, N.1    De Matas, M.2    Gavan, P.3
  • 44
    • 79954493298 scopus 로고    scopus 로고
    • Particle engineering techniques to enhance dissolution of poorly water soluble drugs
    • Deerle D., Patel J., Yeole D., et al. Particle engineering techniques to enhance dissolution of poorly water soluble drugs. Int J Cur Pharm Res 2010, 2:10-15.
    • (2010) Int J Cur Pharm Res , vol.2 , pp. 10-15
    • Deerle, D.1    Patel, J.2    Yeole, D.3
  • 45
    • 33746899402 scopus 로고    scopus 로고
    • Use of a glutaric acid cocrystal to improve oral bioavailability of a low solubility API
    • McNamara D.P., Childs S.L., Giordano J., et al. Use of a glutaric acid cocrystal to improve oral bioavailability of a low solubility API. Pharm Res 2006, 23:1888-1897.
    • (2006) Pharm Res , vol.23 , pp. 1888-1897
    • McNamara, D.P.1    Childs, S.L.2    Giordano, J.3
  • 46
    • 84899741816 scopus 로고    scopus 로고
    • Development and characterization of lecithin stabilized glibenclamide nanocrystals for enhanced solubility and drug delivery
    • Sajeev Kumar B., Saraswathi R., Venkates Kumar K., et al. Development and characterization of lecithin stabilized glibenclamide nanocrystals for enhanced solubility and drug delivery. Drug Deliv 2014, 21:173-184.
    • (2014) Drug Deliv , vol.21 , pp. 173-184
    • Sajeev Kumar, B.1    Saraswathi, R.2    Venkates Kumar, K.3
  • 47
    • 84870172693 scopus 로고    scopus 로고
    • Solvent-free drug crystal engineering for drug nano-& micro suspensions
    • da Fonseca Antunes A.B., De Geest B.G., Vervaet C., et al. Solvent-free drug crystal engineering for drug nano-& micro suspensions. Eur J Pharm Sci 2013, 48:121-129.
    • (2013) Eur J Pharm Sci , vol.48 , pp. 121-129
    • da Fonseca Antunes, A.B.1    De Geest, B.G.2    Vervaet, C.3
  • 48
    • 45849115831 scopus 로고    scopus 로고
    • Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms
    • Tang B., Cheng G., Gu J., et al. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today 2008, 13:606-612.
    • (2008) Drug Discov Today , vol.13 , pp. 606-612
    • Tang, B.1    Cheng, G.2    Gu, J.3
  • 49
    • 52949125231 scopus 로고    scopus 로고
    • A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs
    • Yi T., Wan J., Xu H., et al. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J Pharm Biopharm 2008, 70:439-444.
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 439-444
    • Yi, T.1    Wan, J.2    Xu, H.3
  • 50
    • 84861029109 scopus 로고    scopus 로고
    • Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier
    • Kim D.W., Kang J.H., Oh D.H., et al. Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier. J Microencapsul 2012, 29:323-330.
    • (2012) J Microencapsul , vol.29 , pp. 323-330
    • Kim, D.W.1    Kang, J.H.2    Oh, D.H.3
  • 51
    • 67449116319 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS)
    • Balakrishnan P., Lee B., Oh D.H., et al. Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS). Eur J Pharm Biopharm 2009, 72:539-545.
    • (2009) Eur J Pharm Biopharm , vol.72 , pp. 539-545
    • Balakrishnan, P.1    Lee, B.2    Oh, D.H.3
  • 52
    • 79551483231 scopus 로고    scopus 로고
    • Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability
    • Chen Y., Chen C., Zheng J., et al. Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability. Biol Pharm Bull 2011, 34:278-286.
    • (2011) Biol Pharm Bull , vol.34 , pp. 278-286
    • Chen, Y.1    Chen, C.2    Zheng, J.3
  • 53
    • 80051519201 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of curcumin via a solid lipid-based self-emulsifying drug delivery system using a spray-drying technique
    • Yan Y., Kim J.A., Kwak M.K., et al. Enhanced oral bioavailability of curcumin via a solid lipid-based self-emulsifying drug delivery system using a spray-drying technique. Biol Pharm Bull 2011, 34:1179-1186.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1179-1186
    • Yan, Y.1    Kim, J.A.2    Kwak, M.K.3
  • 54
    • 84885607851 scopus 로고    scopus 로고
    • Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration
    • Agarwal V., Alayoubi A., Siddiqui A., et al. Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration. Drug Dev Ind Pharm 2013, 39:1681-1689.
    • (2013) Drug Dev Ind Pharm , vol.39 , pp. 1681-1689
    • Agarwal, V.1    Alayoubi, A.2    Siddiqui, A.3
  • 55
    • 84909986317 scopus 로고    scopus 로고
    • Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate
    • Kanaujia P., Ng W.K., Tan R.B. Solid self-emulsifying drug delivery system (S-SEDDS) for improved dissolution rate of fenofibrate. J Microencapsul 2013, 31:293-298.
    • (2013) J Microencapsul , vol.31 , pp. 293-298
    • Kanaujia, P.1    Ng, W.K.2    Tan, R.B.3
  • 56
    • 80053940463 scopus 로고    scopus 로고
    • Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets
    • Kang M.J., Jung S.Y., Song W.H., et al. Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets. Drug Dev Ind Pharm 2011, 37:1298-1305.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 1298-1305
    • Kang, M.J.1    Jung, S.Y.2    Song, W.H.3
  • 57
    • 34548134519 scopus 로고    scopus 로고
    • Cyclodextrins as pharmaceutical solubilizers
    • Brewster M.E., Loftsson T. Cyclodextrins as pharmaceutical solubilizers. Adv Drug Deliv Rev 2007, 59:645-666.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 645-666
    • Brewster, M.E.1    Loftsson, T.2
  • 58
    • 80053087179 scopus 로고    scopus 로고
    • Oral formulation strategies to improve solubility of poorly water-soluble drugs
    • Singh A., Worku Z.A., Van den Mooter G. Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opin Drug Deliv 2011, 8:1361-1378.
    • (2011) Expert Opin Drug Deliv , vol.8 , pp. 1361-1378
    • Singh, A.1    Worku, Z.A.2    Van den Mooter, G.3
  • 59
    • 35248822616 scopus 로고    scopus 로고
    • The utility of cyclodextrins for enhancing oral bioavailability
    • Carrier R.L., Miller L.A., Ahmed I. The utility of cyclodextrins for enhancing oral bioavailability. J Control Release 2007, 123:78-99.
    • (2007) J Control Release , vol.123 , pp. 78-99
    • Carrier, R.L.1    Miller, L.A.2    Ahmed, I.3
  • 60
    • 58149234269 scopus 로고    scopus 로고
    • Cyclodextrins as drug carrier molecule: a review
    • Rasheed A., Kumar A., Sravanthi V. Cyclodextrins as drug carrier molecule: a review. Sci Pharm 2008, 76:567-598.
    • (2008) Sci Pharm , vol.76 , pp. 567-598
    • Rasheed, A.1    Kumar, A.2    Sravanthi, V.3
  • 61
    • 0032966667 scopus 로고    scopus 로고
    • Improvement of the invitrodissolution of praziquantel by complexation with alpha-, beta- and gamma-cyclodextrins
    • Becket G., Schep L.J., Tan M.Y. Improvement of the invitrodissolution of praziquantel by complexation with alpha-, beta- and gamma-cyclodextrins. Int J Pharm 1999, 179:65-71.
    • (1999) Int J Pharm , vol.179 , pp. 65-71
    • Becket, G.1    Schep, L.J.2    Tan, M.Y.3
  • 62
    • 1442310829 scopus 로고    scopus 로고
    • Solubility enhancement of celecoxib using β-cyclodextrin inclusion complexes
    • Rawat S., Jain S.K. Solubility enhancement of celecoxib using β-cyclodextrin inclusion complexes. Eur J Pharm Biopharm 2004, 57:263-267.
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 263-267
    • Rawat, S.1    Jain, S.K.2
  • 63
    • 0037258407 scopus 로고    scopus 로고
    • Direct formation of nanospheres from amphiphilic β-cyclodextrin inclusion complexes
    • Memişoğlu E., Bochot A., Özalp M., et al. Direct formation of nanospheres from amphiphilic β-cyclodextrin inclusion complexes. Pharm Res 2003, 20:117-125.
    • (2003) Pharm Res , vol.20 , pp. 117-125
    • Memişoğlu, E.1    Bochot, A.2    Özalp, M.3
  • 65
    • 0032778659 scopus 로고    scopus 로고
    • Polymeric micelles-a new generation of colloidal drug carriers
    • Jones M., Leroux J. Polymeric micelles-a new generation of colloidal drug carriers. Eur J Pharm Biopharm 1999, 48:101-111.
    • (1999) Eur J Pharm Biopharm , vol.48 , pp. 101-111
    • Jones, M.1    Leroux, J.2
  • 66
    • 1942486331 scopus 로고    scopus 로고
    • Micelles from lipid derivativesofwater-soluble polymers as delivery systems forpoorly soluble drugs
    • Lukyanov A.N., Torchilin V.P. Micelles from lipid derivativesofwater-soluble polymers as delivery systems forpoorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273-1289.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1273-1289
    • Lukyanov, A.N.1    Torchilin, V.P.2
  • 67
    • 9944229543 scopus 로고    scopus 로고
    • Targeted polymeric micelles for delivery of poorly soluble drugs
    • Torchilin V. Targeted polymeric micelles for delivery of poorly soluble drugs. Cell Mol Life Sci 2004, 61:2549-2559.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2549-2559
    • Torchilin, V.1
  • 68
    • 28544450961 scopus 로고    scopus 로고
    • Block copolymer micelles: preparation, characterization and application in drug delivery
    • Gaucher G., Dufresne M., Sant V.P., et al. Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release 2005, 109:169-188.
    • (2005) J Control Release , vol.109 , pp. 169-188
    • Gaucher, G.1    Dufresne, M.2    Sant, V.P.3
  • 69
    • 0030590446 scopus 로고    scopus 로고
    • Polymeric micelles as new drug carriers
    • Kwon G.S., Okano T. Polymeric micelles as new drug carriers. Adv Drug Deliv Rev 1996, 21:107-116.
    • (1996) Adv Drug Deliv Rev , vol.21 , pp. 107-116
    • Kwon, G.S.1    Okano, T.2
  • 70
    • 33846443159 scopus 로고    scopus 로고
    • Hydrotropic polymeric micelles for enhanced paclitaxel solubility: Invitro and invivo characterization
    • Lee S.C., Huh K.M., Lee J., et al. Hydrotropic polymeric micelles for enhanced paclitaxel solubility: Invitro and invivo characterization. Biomacromolecules 2007, 8:202-208.
    • (2007) Biomacromolecules , vol.8 , pp. 202-208
    • Lee, S.C.1    Huh, K.M.2    Lee, J.3
  • 71
    • 70449711530 scopus 로고    scopus 로고
    • Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs
    • Shin H., Alani A.W., Rao D.A., et al. Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. J Control Release 2009, 140:294-300.
    • (2009) J Control Release , vol.140 , pp. 294-300
    • Shin, H.1    Alani, A.W.2    Rao, D.A.3
  • 72
    • 0032580499 scopus 로고    scopus 로고
    • Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B
    • Yu B., Okano T., Kataoka K., et al. Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B. J Control Release 1998, 53:131-136.
    • (1998) J Control Release , vol.53 , pp. 131-136
    • Yu, B.1    Okano, T.2    Kataoka, K.3
  • 73
    • 5444237082 scopus 로고    scopus 로고
    • Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability
    • Mohammed A., Weston N., Coombes A., et al. Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability. Int J Pharm 2004, 285:23-34.
    • (2004) Int J Pharm , vol.285 , pp. 23-34
    • Mohammed, A.1    Weston, N.2    Coombes, A.3
  • 74
    • 9644268054 scopus 로고    scopus 로고
    • Development and characterization of a novel cremophor® EL free liposome-based paclitaxel (LEP-ETU) formulation
    • Zhang J.A., Anyarambhatla G., Ma L., et al. Development and characterization of a novel cremophor® EL free liposome-based paclitaxel (LEP-ETU) formulation. Eur J Pharm Biopharm 2005, 59:177-187.
    • (2005) Eur J Pharm Biopharm , vol.59 , pp. 177-187
    • Zhang, J.A.1    Anyarambhatla, G.2    Ma, L.3
  • 75
    • 0022365706 scopus 로고
    • Preservation of freeze-dried liposomes by trehalose
    • Crowe L.M., Crowe J.H., Rudolph A., et al. Preservation of freeze-dried liposomes by trehalose. Arch Biochem Biophys 1985, 242:240-247.
    • (1985) Arch Biochem Biophys , vol.242 , pp. 240-247
    • Crowe, L.M.1    Crowe, J.H.2    Rudolph, A.3
  • 76
    • 84874971767 scopus 로고    scopus 로고
    • The effects of lyophilization on the physico-chemical stability of sirolimus liposomes
    • Ghanbarzadeh S., Valizadeh H., Zakeri-Milani P. The effects of lyophilization on the physico-chemical stability of sirolimus liposomes. Adv Pharm Bull 2013, 3:25-29.
    • (2013) Adv Pharm Bull , vol.3 , pp. 25-29
    • Ghanbarzadeh, S.1    Valizadeh, H.2    Zakeri-Milani, P.3
  • 77
    • 34347405909 scopus 로고    scopus 로고
    • Liposome formulation of paclitaxel with enhanced solubility and stability
    • Yang T., Cui F., Choi M., et al. Liposome formulation of paclitaxel with enhanced solubility and stability. Drug Deliv 2007, 14:301-308.
    • (2007) Drug Deliv , vol.14 , pp. 301-308
    • Yang, T.1    Cui, F.2    Choi, M.3
  • 78
    • 34248638766 scopus 로고    scopus 로고
    • Enhanced solubility and stability of PEGylated liposomal paclitaxel: invitro and invivo evaluation
    • Yang T., Cui F., Choi M., et al. Enhanced solubility and stability of PEGylated liposomal paclitaxel: invitro and invivo evaluation. Int J Pharm 2007, 338:317-326.
    • (2007) Int J Pharm , vol.338 , pp. 317-326
    • Yang, T.1    Cui, F.2    Choi, M.3
  • 79
    • 51049120877 scopus 로고    scopus 로고
    • Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives
    • Üner M., Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomed 2007, 2:289-300.
    • (2007) Int J Nanomed , vol.2 , pp. 289-300
    • Üner, M.1    Yener, G.2
  • 80
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art
    • Müller R.H., Mäder K., Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. Eur J Pharm Biopharm 2000, 50:161-177.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 81
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: production, characterization and applications
    • Mehnert W., Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 2001, 47:165-196.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 82
    • 10044223246 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs
    • Hu L., Tang X., Cui F. Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs. J Pharm Pharmacol 2004, 56:1527-1535.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1527-1535
    • Hu, L.1    Tang, X.2    Cui, F.3
  • 83
    • 80052099308 scopus 로고    scopus 로고
    • Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables
    • Das S., Ng W.K., Kanaujia P., et al. Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. Colloids Surf B Biointerfaces 2011, 88:483-489.
    • (2011) Colloids Surf B Biointerfaces , vol.88 , pp. 483-489
    • Das, S.1    Ng, W.K.2    Kanaujia, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.