Diffusion magnetic resonance monitors intramyocellular lipid droplet size in vivo

Magnetic Resonance in Medicine

Volumn 73, Issue 1, 2015, Pages 59-69

  Cao, Peng ^a   Fan, Shu Juan ^a   Wang, Anna M ^a   Xie, Victor B ^a   Qiao, Zhongwei ^a   Brittenham, Gary M ^b   Wu, Ed X ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b University of Hong Kong ^*  (United States)

Author keywords

Diffusion magnetic resonance spectroscopy; Fasting; Intracellular lipid; Intramyocellular lipid; Obesity; Streptozotocininduced diabetes

Indexed keywords

ANALOG TO DIGITAL CONVERSION; DROPS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETISM; MAMMALS; METABOLISM; MORPHOLOGY; MUSCLE; NUTRITION; SURFACE DIFFUSION;

APPARENT DIFFUSION COEFFICIENT; DIFFUSION WEIGHTING; ENERGY METABOLISM; FASTING; LIPID SYNTHESIS; MOLECULAR DIFFUSION; OBESITY; RESTRICTED DIFFUSION;

MAGNETIC RESONANCE;

CREATINE; FAT DROPLET; INTRAMYOCELLULAR LIPID; LIPID; STREPTOZOCIN; TAURINE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; DIFFUSION COEFFICIENT; DIFFUSION MAGNETIC RESONANCE SPECTROSCOPY; EX VIVO STUDY; HINDLIMB; IN VIVO STUDY; LIPID DIET; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANTARIS MUSCLE; RAT; SOLEUS MUSCLE; SPRAGUE DAWLEY RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SWINE; TIME; TRANSMISSION ELECTRON MICROSCOPY; ALGORITHM; ANIMAL; CELL CULTURE; CELL TRACKING; CHEMISTRY; COMPUTER ASSISTED DIAGNOSIS; CYTOLOGY; DIFFUSION WEIGHTED IMAGING; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE CELL; ULTRASTRUCTURE;

ALGORITHMS; ANIMALS; CELL TRACKING; CELLS, CULTURED; DIFFUSION MAGNETIC RESONANCE IMAGING; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIPID DROPLETS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE FIBERS, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84919871669     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25116     Document Type: Article

References (47)

1. Martin S, Parton RG. Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006;7:373-378.
2. Boesch C, Machann J, Vermathen P, Schick F. Role of proton MR for the study of muscle lipid metabolism. NMR Biomed 2006;19:968-988.
3. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 2008;453:657-661.
4. Thiele C, Spandl J. Cell biology of lipid droplets. Curr Opin Cell Biol 2008;20:378-385.
5. Ducharme NA, Bickel PE. Lipid droplets in lipogenesis and lipolysis. Endocrinology 2008;149:942-949.
6. Meex RC, Schrauwen P, Hesselink MK. Modulation of myocellular fat stores: lipid droplet dynamics in health and disease. Am J Physiol Regul Integr Comp Physiol 2009;297:R913-R924.
7. Beller M, Thiel K, Thul PJ, Jackle H. Lipid droplets: a dynamic organelle moves into focus. FEBS Lett 2010;584:2176-2182.
8. Suzuki M, Shinohara Y, Ohsaki Y, Fujimoto T. Lipid droplets: size matters. J Electron Microsc (Tokyo) 2011;60(Suppl 1):S101-S116.
9. Coen PM, Goodpaster BH. Role of intramyocelluar lipids in human health. Trends Endocrinol Metab 2012;23:391-398.
10. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997;46:983-988.
11. Krssak M, Falk Petersen K, Dresner A, Di Pietro L, Vogel SM, Rothman DL, Roden M, Shulman GI. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 1999;42:113-116.
12. Jacob S, Machann J, Rett K, et al. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999;48:1113-1119.
13. Perseghin G, Scifo P, De Cobelli F, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999;48:1600-1606.
14. Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S. Assessment of skeletal muscle triglyceride content by (1) H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002;51:1022-1027.
15. Kelley DE, Goodpaster BH, Storlien L. Muscle triglyceride and insulin resistance. Annu Rev Nutr 2002;22:325-346.
16. Machann J, Haring H, Schick F, Stumvoll M. Intramyocellular lipids and insulin resistance. Diabetes Obes Metab 2004;6:239-248.
17. Moro C, Bajpeyi S, Smith SR. Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab 2008;294:E203-E213.
18. Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 2011;121:2102-2110.
19. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993;29:158-167.
20. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1HMR-spectroscopy. Magn Reson Med 1997;37:484-493.
21. Steidle G, Machann J, Claussen CD, Schick F. Separation of intraand extramyocellular lipid signals in proton MR spectra by determination of their magnetic field distribution. J Magn Reson 2002;154:228-235.
22. Szczepaniak LS, Dobbins RL, Stein DT, McGarry JD. Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo. Magn Reson Med 2002;47:607-610.
23. Newcomer BR, Lawrence JC, Buchthal S, den Hollander JA. Highresolution chemical shift imaging for the assessment of intramuscular lipids. Magn Reson Med 2007;57:848-858.
24. Ren J, Sherry AD, Malloy CR. 1H MRS of intramyocellular lipids in soleus muscle at 7 T: spectral simplification by using long echo times without water suppression. Magn Reson Med 2010;64:662-671.
25. Wietek BM, Machann J, Mader I, Thamer C, Haring HU, Claussen CD, Stumvoll M, Schick F. Muscle type dependent increase in intramyocellular lipids during prolonged fasting of human subjects: a proton MRS study. Horm Metab Res 2004;36:639-644.
26. Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurancetrained athletes. J Clin Endocrinol Metab 2001;86:5755-5761.
27. Schrauwen-Hinderling VB, Schrauwen P, Hesselink MK, van Engelshoven JM, Nicolay K, Saris WH, Kessels AG, Kooi ME. The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab 2003;88:1610-1616.
28. He J, Goodpaster BH, Kelley DE. Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res 2004;12:761-769.
29. Hesselink MK, Mensink M, Schrauwen P. Intramyocellular lipids and insulin sensitivity: does size really matter? Obes Res 2004;12:741-742.
30. Fraenkel M, Weiss R, Leizerman I, Anaby D, Golomb E, Leibowitz G, Kaiser N. Scanning electron microscopic analysis of intramyocellular lipid droplets in an animal model of type 2 diabetes. Obesity (Silver Spring) 2008;16:695-699.
31. Lally JS, Snook LA, Han XX, Chabowski A, Bonen A, Holloway GP. Subcellular lipid droplet distribution in red and white muscles in the obese Zucker rat. Diabetologia 2012;55:479-488.
32. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401-407.
33. Van Zijl PC, Moonen CT, Faustino P, Pekar J, Kaplan O, Cohen JS. Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy. Proc Natl Acad Sci U S A 1991;88:3228-3232.
34. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 1995;8:333-344.
35. Assaf Y, Cohen Y. Assignment of the water slow-diffusing component in the central nervous system using q-space diffusion MRS: implications for fiber tract imaging. Magn Reson Med 2000;43:191-199.
36. Lahrech H, Zoula S, Farion R, Remy C, Decorps M. In vivo measurement of the size of lipid droplets in an intracerebral glioma in the rat. Magn Reson Med 2001;45:409-414.
37. Lehnert A, Machann J, Helms G, Claussen CD, Schick F. Diffusion characteristics of large molecules assessed by proton MRS on a whole-body MR system. Magn Reson Imaging 2004;22:39-46.
38. Xiao L, Wu EX. Diffusion-weighted magnetic resonance spectroscopy: a novel approach to investigate intrymocellular lipids. Magn Reson Med 2011;66:937-944.
39. Brandejsky V, Kreis R, Boesch C. Restricted or severely hindered diffusion of intramyocellular lipids in human skeletal muscle shown by in vivo proton MR spectroscopy. Magn Reson Med 2012;67:310-316.
40. Moonen CT, van Zijl PC, Le Bihan D, Des Pres D. In vivo NMR diffusion spectroscopy: 31P application to phosphorus metabolites in muscle. Magn Reson Med 1990;13:467-477.
41. Nicolay K, van der Toorn A, Dijkhuizen RM. In vivo diffusion spectroscopy. An overview. NMR Biomed 1995;8:365-374.
42. Price WS. Pulsed-field gradient nuclear magnetic resonance as a tool for studying translational diffusion. 1. Basic theory. Concept Magn Reson 1997;9:299-336.
43. Murday JS, Cotts R. Self-diffusion coefficient of liquid lithium. J Chem Phys 1968;48:4938-4945.
44. Garasanin T, Cosgrove T, Marteaux L, Kretschmer A, Goodwin A, Zick K. NMR self-diffusion studies on PDMS oil-in-water emulsion. Langmuir 2002;18:10298-10304.
45. Stearns SB, Tepperman HM, Tepperman J. Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocindiabetic and control rats. J Lipid Res 1979;20:654-662.
46. Whiting PH, Middleton B, Thomas N, Hawthorne J. Studies on a stable, mild diabetes induced by streptozotocin in rats. Br J Exp Pathol 1982;63:408-413.
47. Fieber W, Hafner V, Normand V. Oil droplet size determination in complex flavor delivery systems by diffusion NMR spectroscopy. J Colloid Interface Sci 2011;356:422-428.