Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats

Addiction Biology

Volumn 20, Issue 1, 2015, Pages 56-68

  Cohen, Ami ^a   Treweek, Jennifer ^a   Edwards, Scott ^a   Leão, Rodrigo Molini ^a   Schulteis, Gery ^b,c   Koob, George F ^a   George, Olivier ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c University of California at San Diego   (United States)

Author keywords

addiction; emotion; stress; tobacco; withdrawal

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; N,N BIS (2 METHOXYETHYL) 3 (4 METHOXY 2 METHYLPHENYL) 2,5 DIMETHYL PYRAZOLO(1,5ALPHA)PYRIMIDIN 7 AMINE; NICOTINE TARTRATE; UNCLASSIFIED DRUG; CORTICOTROPIN RELEASING FACTOR RECEPTOR; N,N-BIS(2-METHOXYETHYL)-3-(4-METHOXY-2-METHYLPHENYL)-2,5-DIMETHYL-PYRAZOLO(1,5-A)PYRIMIDIN-7-AMINE; NICOTINE; NICOTINIC AGENT; PYRIMIDINE DERIVATIVE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; ELEVATED PLUS MAZE TEST; FLUID INTAKE; FOOD INTAKE; HYPERALGESIA; HYPERSENSITIVITY; LOCOMOTION; MALE; NONHUMAN; PAIN THRESHOLD; RAT; SMOKING CESSATION; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; HYPERALGESIA; MALE; NICOTINE; NICOTINIC AGONISTS; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE DISORDER;

EID: 84919846266     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12077     Document Type: Article

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