Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1

Cell Reports

Volumn 9, Issue 6, 2014, Pages 2011-2017

  Hentges, Pierre ^a   Waller, Helen ^a   Reis, Clara C ^b   Ferreira, MiguelGodinho ^b   Doherty, Aidan J ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 1; NUCLEAR PROTEIN; PLASMID DNA; PROTEIN XLF1; UNCLASSIFIED DRUG; SCHIZOSACCHAROMYCES POMBE PROTEIN; XLF1 PROTEIN, S POMBE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CONTROLLED STUDY; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; HOMOLOGOUS RECOMBINATION; IN VITRO STUDY; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SCHIZOSACCHAROMYCES; CHEMISTRY; DOWN REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

EUKARYOTA; SCHIZOSACCHAROMYCETACEAE;

CDC2 PROTEIN KINASE; DNA END-JOINING REPAIR; DOWN-REGULATION; HOMOLOGOUS RECOMBINATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 84919835722     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.11.044     Document Type: Article

References (22)

1. Almeida H., Godinho Ferreira M. Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells. Nucleic Acids Res. 2013, 41:3056-3067.
2. Aylon Y., Liefshitz B., Kupiec M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 2004, 23:4868-4875.
3. Cavero S., Chahwan C., Russell P. Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe. Genetics 2007, 175:963-967.
4. Chiruvella K.K., Liang Z., Wilson T.E. Repair of double-strand breaks by end joining. Cold Spring Harb. Perspect. Biol. 2013, 5:a012757.
5. Clerici M., Mantiero D., Guerini I., Lucchini G., Longhese M.P. The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep. 2008, 9:810-818.
6. Dischinger S., Krapp A., Xie L., Paulson J.R., Simanis V. Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network. J.Cell Sci. 2008, 121:843-853.
7. Ferreira M.G., Cooper J.P. Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes Dev. 2004, 18:2249-2254.
8. Ferretti L.P., Lafranchi L., Sartori A.A. Controlling DNA-end resection: a new task for CDKs. Front. Genet. 2013, 4:99.
9. Frank-Vaillant M., Marcand S. NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway. Genes Dev. 2001, 15:3005-3012.
10. Hentges P., Ahnesorg P., Pitcher R.S., Bruce C.K., Kysela B., Green A.J., Bianchi J., Wilson T.E., Jackson S.P., Doherty A.J. Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J.Biol. Chem. 2006, 281:37517-37526.
11. Huertas P., Cortés-Ledesma F., Sartori A.A., Aguilera A., Jackson S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 2008, 455:689-692.
12. Ira G., Pellicioli A., Balijja A., Wang X., Fiorani S., Carotenuto W., Liberi G., Bressan D., Wan L., Hollingsworth N.M., et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 2004, 431:1011-1017.
13. Kegel A., Sjöstrand J.O., Aström S.U. Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr. Biol. 2001, 11:1611-1617.
14. Kinoshita E., Kinoshita-Kikuta E., Takiyama K., Koike T. Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol. Cell. Proteomics 2006, 5:749-757.
15. Limbo O., Chahwan C., Yamada Y., de Bruin R.A.M., Wittenberg C., Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 2007, 28:134-146.
16. Manolis K.G., Nimmo E.R., Hartsuiker E., Carr A.M., Jeggo P.A., Allshire R.C. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J. 2001, 20:210-221.
17. Matsuzaki K., Terasawa M., Iwasaki D., Higashide M., Shinohara M. Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection. Genes Cells. 2012, 17:473-493.
18. Moreno S., Hayles J., Nurse P. Regulation of p34cdc2 protein kinase during mitosis. Cell 1989, 58:361-372.
19. Symington L.S., Gautier J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 2011, 45:247-271.
20. Valencia M., Bentele M., Vaze M.B., Herrmann G., Kraus E., Lee S.E., Schär P., Haber J.E. NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature 2001, 414:666-669.
21. Walworth N.C., Bernards R. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 1996, 271:353-356.
22. Zhang Y., Shim E.Y., Davis M., Lee S.E. Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks. DNA Repair (Amst.) 2009, 8:1235-1241.