Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone

Journal of Bone and Mineral Research

Volumn 19, Issue 9, 2004, Pages 1441-1451

  Dai, Xu Ming ^a   Zong, Xiao Hua ^a   Akhter, Mohammed P ^b   Stanley, E Richard ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone development; Bone mineralization; Colony stimulating factor 1; Osteoblast; Osteoclast

Indexed keywords

ALCIAN BLUE; ALIZARIN RED S; CALCEIN; COLONY STIMULATING FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; BIOASSAY; BIOMECHANICS; BONE BOWING; BONE DEVELOPMENT; BONE DISEASE; BONE MATRIX; BONE MINERALIZATION; BONE STRENGTH; BONE TRANSPLANTATION; CELL LABELING; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FEMUR; HISTOLOGY; LAMELLAR BODY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; STAINING; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; X RAY MICROANALYSIS; ANIMAL; BONE; GENETICS; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; ULTRASTRUCTURE;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONE MATRIX; CALCIFICATION, PHYSIOLOGIC; FEMUR; MALE; MICE; OSTEOBLASTS; OSTEOCLASTS; RECEPTORS, COLONY-STIMULATING FACTOR;

EID: 15544373018     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040514     Document Type: Article

References (64)

1. Baron R 2003 General principles of bone biology. In: Favus MJ (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. American Society for Bone and Mineral Research, Washingon, DC, USA, pp. 1-8.
2. Robey PG, Boskey AL 2003 Extracellular matrix and biomineralization of bone. In: Favus MJ (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. American Society for Bone and Mineral Research, Washington, DC, pp. 38-46.
3. Martin RB, Boardman DL 1993 The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech 26:1047-1054.
4. Landis WJ 1995 The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone 16:533-544.
5. Rho JY, Kuhn-Spearing L, Zioupos P 1998 Mechanical properties and the hierarchical structure of bone. Med Eng Phys 20:92-102.
6. Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Prenger MC, Phipps RJ 2002 Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography. J Bone Miner Res 17:1139-1147.
7. Watts NB 2002 Bone quality: Getting closer to a definition. J Bone Miner Res 17:1148-1150.
8. Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Gross MC, Phipps RJ 2003 Architecture is one of the determinants of bone strength. J Bone Miner Res 18:385.
9. Jee WSS 2001 Integrated bone tissue physiology: Anatomy and physiology. In: Cowin SC (ed.) Bone Mechanics Handbook. CRC Press, Boca Raton, FL, USA, pp. 1.1-1.68.
10. Weiner S, Wagner HD 1998 The material bone: Structure-mechanical function relations. Annu Rev Mater Sci 28:271-298.
11. Lucchinetti E 2001 Composite models of bone properties. In: Cowin SC (ed.) Bone Mechanics Handbook, 2nd ed. CRC Press, Boca Raton, pp. 12.1-12.19.
12. Weiner S, Traub W, Wagner HD 1999 Lamellar bone: Structure-function relations. J Struct Biol 126:241-255.
13. Marotti G, Muglia MA, Palumbo C 1995 Collagen texture and osteocyte distribution in lamellar bone. Ital J Anat Embryol 100(Suppl 1):95-102.
14. Palumbo C, Palazzini S, Zaffe D, Marotti G 1990 Osteocyte differentiation in the tibia of newborn rabbit: An ultrastructural study of the formation of cytoplasmic processes. Acta Anat (Basel) 137:350-358.
15. Nijweide PJ, Burger EH, Klein-Nulend J 2002 The osteocyte. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology, 2nd ed. Academic Press, San Diego, CA, USA, pp. 93-107.
16. Gorski JP 1998 Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms. Crit Rev Oral Biol Med 9:201-223.
17. Ferretti M, Palumbo C, Contri M, Marotti G 2002 Static and dynamic osteogenesis: Two different types of bone formation. Anat Embryol (Berl) 206:21-29.
18. Yoshida H, Hayashi S-I, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S-I 1990 The murine mutation "osteopetrosis" (op) is a mutation in the coding region of the macrophage colony stimulating factor (Csfm) gene. Nature 345:442-444.
19. Wiktor-Jedrzejczak W, Bartocci A, Ferrante AW Jr, Ahmed-Ansari A, Sell KW, Pollard JW, Stanley ER 1990 Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 87:4828-4832.
20. Cecchini MG, Hofstetter W, Halasy J, Wetterwald A, Felix R 1997 Role of CSF-1 in bone and bone marrow development. Mol Reprod Dev 46:75-83.
21. Tsurukai T, Udagawa N, Matsuzaki K, Takahashi N, Suda T 2000 Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis. J Bone Miner Metab 18:177-184.
22. Dai X-M, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, Kapp S, Sylvestre V, Stanley ER 2002 Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99:111-120.
23. Luna LG 1992 Agents and methods for specimen processing. In: Luna LG (ed.) Histopathologic Methods and Color Atlas of Special Stains and Tissue Artifacts. American Histolabs, Inc., Gaithersburg, MD, USA, pp. 28-57.
24. Cole AA, Walters LM 1987 Tartrate-resistant acid phosphatase in bone and cartilage following decalcification and cold-embedding in plastic. J Histochem Cytochem 35:203-206.
25. Akhter MP, Cullen DM, Gong G, Recker RR 2001 Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice. Bone 29:121-125.
26. Baumeister T, Avallone EA 1986 Marks' Standard Handbook for Mechanical Engineers, 9th ed. McGraw-Hill, New York, NY, USA.
27. Lufkin T, Mark M, Hart CP, Dolle P, LeMeur M, Chambon P 1992 Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature 359:835-841.
28. Nishino I, Amizuka N, Ozawa H 2001 Histochemical examination of osteoblastic activity in op/op mice with or without injection of recombinant M-CSF. J Bone Miner Metab 19:267-276.
29. Vignery A, Baron R 1980 Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec 196:191-200.
30. Clement-Lacroix P, Ormandy C, Lepescheux L, Ammann P, Damotte D, Goffin V, Bouchard B, Amling M, Gaillard-Kelly M, Binart N, Baron R, Kelly PA 1999 Osteoblasts are a new target for prolactin: Analysis of bone formation in prolactin receptor knockout mice. Endocrinology 140:96-105.
31. Sodek J, Berkman FA 1987 Bone cell cultures. Methods Enzymol 145:303-324.
32. Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, Civitelli R 2000 Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151:931-944.
33. Li W, Stanley ER 1991 Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response. EMBO J 10:277-288.
34. Kratochwil K, von der Mark K, Kollar EJ, Jaenisch R, Mooslehner K, Schwarz M, Haase K, Gmachl I, Harbers K 1989 Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner. Cell 57:807-816.
35. Jochum W, David JP, Elliott C, Wutz A, Plenk H Jr, Matsuo K, Wagner EF 2000 Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6:980-984.
36. Baron R 1999 Anatomy and ultrastructure of bone. In: Favus MJ (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed. Lippincott, Williams & Wilkins, Philadelphia, PA, USA, pp. 3-10.
37. Kaufman MH 1999 Differentiation of the skeletal system. In: Kaufman MH (ed.) The Altas of Mouse Development, 3rd ed. Academic Press, London, UK, pp. 495-507.
38. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G 2002 Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305-317.
39. Morgan C, Pollard JW, Stanley ER 1987 Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. J Cell Physiol 130:420-427.
40. Scheven BA, Kawilarang-De Haas EW, Wassenaar AM, Nijweide PJ 1986 Differentiation kinetics of osteoclasts in the periosteum of embryonic bones in vivo and in vitro. Anat Rec 214:418-423.
41. Aubin JE, Triffitt JT 2002 Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology, 2nd ed. Academic Press, San Diego, CA, USA, pp. 59-81.
42. Takahashi N, Udagawa N, Takami M, Suda T 2002 Cells of bone: Osteoclast generation. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology, 2nd ed., vol. 1. Academic Press, San Diego, CA, USA, pp. 109-126.
43. Frost HM 1964 Dynamics of bone remodeling. In: Brown EL (ed.) Bone Biodynamics. Littel, Boston, MA, USA, pp. 315-333.
44. Teitelbaum SL 2000 Bone resorption by osteoclasts. Science 289:1504-1508.
45. Boskey AL 2001 Bone mineralization. In: Cowin SC (ed.) Bone Mechnics Handbook. CRC Press, Boca Raton, FL, USA, pp. 5.1-5.33.
46. Jeansonne BG, Feagin FF, McMinn RW, Shoemaker RL, Rehm WS 1979 Cell-to-cell communication of osteoblasts. J Dent Res 58:1415-1423.
47. Palumbo C, Palazzini S, Marotti G 1990 Morphological study of intercellular junctions during osteocyte differentiation. Bone 11:401-406.
48. Howard GA, Bottemiller BL, Turner RT, Rader JI, Baylink DJ 1981 Parathyroid hormone stimulates bone formation and resorption in organ culture: Evidence for a coupling mechanism. Proc Natl Acad Sci USA 78:3204-3208.
49. Mohan S, Baylink DJ 1991 The role of IGF-II in the coupling of bone formation to resorption. In: Spencer EM (ed.) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, NY, USA, pp. 169-184.
50. Mohan S, Baylink DJ 1996 Insulin-like growth factor system components and the coupling of bone formation to resorption. Horm Res 45:59-62.
51. Dallas SL, Park-Snyder S, Miyazono K, Twardzik D, Mundy GR, Bonewald LF 1994 Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. J Biol Chem 269:6815-6821.
52. Pfeilschifter J, Bonewald L, Mundy GR 1990 Characterization of the latent transforming growth factor beta complex in bone. J Bone Miner Res 5:49-58.
53. Baylink DJ, Farley J, Howard GA, Drivdahl R, Puzas E, Masuda T, Ivey J, Gruber H 1982 Coupling factor. Adv Exp Med Biol 151:409-421.
54. Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsbrun M 1986 Growth factors in bone matrix. J Biol Chem 261:12665-12674.
55. Oursler MJ 1994 Osteoclast synthesis and secretion and activation of latent transforming growth factor beta. J Bone Miner Res 9:443-452.
56. Canalis E, McCarthy T, Centrella M 1988 Growth factors and the regulation of bone remodeling. J Clin Invest 81:277-281.
57. Everts V, Delaisse JM, Korper W, Jansen DC, Tigchelaar-Gutter W, Saftig P, Beertsen W 2002 The bone lining cell: Its role in cleaning Howship's lacunae and initiating bone formation. J Bone Miner Res 17:77-90.
58. Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE 2002 Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. J Bone Miner Res 17:915-922.
59. Sheu TJ, Schwartz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE 2003 A phage display technique indentifies a novel regulator of cell differentiation. J Biol Chem 278:438-443.
60. Key LL Jr, Ries WL 2002 Osteopetrosis. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology, 2nd ed., vol. 2. Academic Press, San Diego, CA, USA, pp. 1217-1227.
61. Feng X, Takeshita S, Namba N, Wei S, Teitelbaum SL, Ross FP 2002 Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function. Endocrinology 143:4868-4874.
62. Cecchini MG, Dominguez MG, Mocci S, Wetterwald A, Felix R, Fleisch H, Chisholm O, Hofstetter W, Pollard JW, Stanley ER 1994 Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120:1357-1372.
63. Mackie EJ 2003 Osteoblasts: Novel roles in orchestration of skeletal architecture. Int J Biochem Cell Biol 35:1301-1305.
64. Corral DA, Amling M, Priemel M, Loyer E, Fuchs S, Ducy P, Baron R, Karsenty G 1998 Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci USA 95:13835-13840.