메뉴 건너뛰기




Volumn 230, Issue 4, 2015, Pages 791-801

Role of acinus in regulating retinoic acid-responsive gene Pre-mRNA splicing

Author keywords

[No Author keywords available]

Indexed keywords

ACINUS L PROTEIN; ACINUS S PROTEIN; ISOPROTEIN; LIGAND; MESSENGER RNA PRECURSOR; PROTEIN; PROTEIN BCL X; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; RNA ISOFORM; UNCLASSIFIED DRUG; ACIN1 PROTEIN, HUMAN; NUCLEAR PROTEIN; RETINOIC ACID RECEPTOR; RNA PRECURSOR; TRANSCRIPTION FACTOR;

EID: 84919770512     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24804     Document Type: Article
Times cited : (16)

References (53)
  • 2
    • 8644237368 scopus 로고    scopus 로고
    • Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene
    • Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Hunt ME, Sugrue SP. 2004. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol Cell Biol 24:10223-10235.
    • (2004) Mol Cell Biol , vol.24 , pp. 10223-10235
    • Alpatov, R.1    Munguba, G.C.2    Caton, P.3    Joo, J.H.4    Shi, Y.5    Hunt, M.E.6    Sugrue, S.P.7
  • 3
    • 40749155486 scopus 로고    scopus 로고
    • Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene
    • Alpatov R, Shi Y, Munguba GC, Moghimi B, Joo JH, Bungert J, Sugrue SP. 2008. Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. Mol Cell Biol 28:1584-1595.
    • (2008) Mol Cell Biol , vol.28 , pp. 1584-1595
    • Alpatov, R.1    Shi, Y.2    Munguba, G.C.3    Moghimi, B.4    Joo, J.H.5    Bungert, J.6    Sugrue, S.P.7
  • 4
    • 0028019317 scopus 로고
    • Hyperplasia and tumours in lung, breast and other tissues in mice carrying a RAR beta4-like transgene
    • Berard J, Gaboury L, Landers M, De Repentigny Y, Houle B, Kothary R, Bradley WE. 1994. Hyperplasia and tumours in lung, breast and other tissues in mice carrying a RAR beta4-like transgene. EMBO J 13:5570-5580.
    • (1994) EMBO J , vol.13 , pp. 5570-5580
    • Berard, J.1    Gaboury, L.2    Landers, M.3    De Repentigny, Y.4    Houle, B.5    Kothary, R.6    Bradley, W.E.7
  • 5
    • 0030994024 scopus 로고    scopus 로고
    • Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation
    • Boise LH, Thompson CB. 1997. Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc Natl Acad Sci USA 94:3759-3764.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3759-3764
    • Boise, L.H.1    Thompson, C.B.2
  • 7
    • 0029794132 scopus 로고    scopus 로고
    • A decade of molecular biology of retinoic acid receptors
    • Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954.
    • (1996) FASEB J , vol.10 , pp. 940-954
    • Chambon, P.1
  • 8
    • 34548015212 scopus 로고    scopus 로고
    • Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation
    • Chan CB, Liu X, Tang X, Fu H, Ye K. 2007. Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation. Cell Death Differ 14:1688-1699.
    • (2007) Cell Death Differ , vol.14 , pp. 1688-1699
    • Chan, C.B.1    Liu, X.2    Tang, X.3    Fu, H.4    Ye, K.5
  • 9
    • 79957784833 scopus 로고    scopus 로고
    • Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly
    • Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. 2011. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci USA 108:8233-8238.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8233-8238
    • Cho, S.1    Hoang, A.2    Sinha, R.3    Zhong, X.Y.4    Fu, X.D.5    Krainer, A.R.6    Ghosh, G.7
  • 11
    • 13244253805 scopus 로고    scopus 로고
    • Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta
    • Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW. 2005. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. Mol Cell 17:429-439.
    • (2005) Mol Cell , vol.17 , pp. 429-439
    • Dowhan, D.H.1    Hong, E.P.2    Auboeuf, D.3    Dennis, A.P.4    Wilson, M.M.5    Berget, S.M.6    O'Malley, B.W.7
  • 12
    • 35648938726 scopus 로고    scopus 로고
    • Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
    • Du YC, Lewis BC, Hanahan D, Varmus H. 2007. Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS Biol 5:e276.
    • (2007) PLoS Biol , vol.5 , pp. e276
    • Du, Y.C.1    Lewis, B.C.2    Hanahan, D.3    Varmus, H.4
  • 13
    • 84897147399 scopus 로고    scopus 로고
    • Nuclear receptors, RXR and the big bang
    • Evans R, Mangelsdorf D. 2014. Nuclear receptors, RXR and the big bang. Cell 157:255-266.
    • (2014) Cell , vol.157 , pp. 255-266
    • Evans, R.1    Mangelsdorf, D.2
  • 14
    • 0032239750 scopus 로고    scopus 로고
    • A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
    • Ge H, Si Y, Wolffe AP. 1998. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol Cell 2:751-759.
    • (1998) Mol Cell , vol.2 , pp. 751-759
    • Ge, H.1    Si, Y.2    Wolffe, A.P.3
  • 15
    • 0642318054 scopus 로고    scopus 로고
    • Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4
    • Hayashi K, Goodison S, Urquidi V, Tarin D, Lotan D, Lotan R, Tahara E. 2003. Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4. Int J Oncol 22:623-629.
    • (2003) Int J Oncol , vol.22 , pp. 623-629
    • Hayashi, K.1    Goodison, S.2    Urquidi, V.3    Tarin, D.4    Lotan, D.5    Lotan, R.6    Tahara, E.7
  • 17
    • 36249025726 scopus 로고    scopus 로고
    • Acinus-provoked protein kinase C delta isoform activation is essential for apoptotic chromatin condensation
    • Hu Y, Liu Z, Yang SJ, Ye K. 2007. Acinus-provoked protein kinase C delta isoform activation is essential for apoptotic chromatin condensation. Cell Death Differ 14:2035-2046.
    • (2007) Cell Death Differ , vol.14 , pp. 2035-2046
    • Hu, Y.1    Liu, Z.2    Yang, S.J.3    Ye, K.4
  • 18
    • 27144446343 scopus 로고    scopus 로고
    • Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation
    • Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K. 2005. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J 24:3543-3554.
    • (2005) EMBO J , vol.24 , pp. 3543-3554
    • Hu, Y.1    Yao, J.2    Liu, Z.3    Liu, X.4    Fu, H.5    Ye, K.6
  • 19
    • 33744951870 scopus 로고    scopus 로고
    • Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis
    • Joselin AP, Schulze-Osthoff K, Schwerk C. 2006. Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. J Biol Chem 281:12475-12484.
    • (2006) J Biol Chem , vol.281 , pp. 12475-12484
    • Joselin, A.P.1    Schulze-Osthoff, K.2    Schwerk, C.3
  • 20
    • 0037059798 scopus 로고    scopus 로고
    • Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors
    • Jung DJ, Na SY, Na DS, Lee JW. 2002. Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. J Biol Chem 277:1229-1234.
    • (2002) J Biol Chem , vol.277 , pp. 1229-1234
    • Jung, D.J.1    Na, S.Y.2    Na, D.S.3    Lee, J.W.4
  • 21
    • 0026705751 scopus 로고
    • Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
    • Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-774.
    • (1992) Nature , vol.358 , pp. 771-774
    • Kliewer, S.A.1    Umesono, K.2    Noonan, D.J.3    Heyman, R.A.4    Evans, R.M.5
  • 23
    • 0039550795 scopus 로고    scopus 로고
    • A human papillomavirus E2 transcriptional activator. The interactions with cellular splicing factors and potential function in pre-mRNA processing
    • Lai MC, Teh BH, Tarn WY. 1999. A human papillomavirus E2 transcriptional activator. The interactions with cellular splicing factors and potential function in pre-mRNA processing. J Biol Chem 274:11832-11841.
    • (1999) J Biol Chem , vol.274 , pp. 11832-11841
    • Lai, M.C.1    Teh, B.H.2    Tarn, W.Y.3
  • 24
    • 27744511919 scopus 로고    scopus 로고
    • Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations
    • Lavery DN, McEwan IJ. 2005. Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations. Biochem J 391:449-464.
    • (2005) Biochem J , vol.391 , pp. 449-464
    • Lavery, D.N.1    McEwan, I.J.2
  • 25
    • 84869118124 scopus 로고    scopus 로고
    • Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD
    • Leu S, Lin YM, Wu CH, Ouyang P. 2012. Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. J Cell Sci 125:3164-3172.
    • (2012) J Cell Sci , vol.125 , pp. 3164-3172
    • Leu, S.1    Lin, Y.M.2    Wu, C.H.3    Ouyang, P.4
  • 26
    • 0037570621 scopus 로고    scopus 로고
    • Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification
    • Li X, Wong J, Tsai SY, Tsai MJ, O'Malley BW. 2003. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol 23:3763-3773.
    • (2003) Mol Cell Biol , vol.23 , pp. 3763-3773
    • Li, X.1    Wong, J.2    Tsai, S.Y.3    Tsai, M.J.4    O'Malley, B.W.5
  • 27
    • 0033575702 scopus 로고    scopus 로고
    • Purification and characterization of human RNPS1: A general activator of pre-mRNA splicing
    • Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR. 1999. Purification and characterization of human RNPS1: A general activator of pre-mRNA splicing. EMBO J 18:4560-4570.
    • (1999) EMBO J , vol.18 , pp. 4560-4570
    • Mayeda, A.1    Badolato, J.2    Kobayashi, R.3    Zhang, M.Q.4    Gardiner, E.M.5    Krainer, A.R.6
  • 28
    • 0345829926 scopus 로고    scopus 로고
    • Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents
    • Mercatante DR, Mohler JL, Kole R. 2002. Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents. J Biol Chem 277:49374-49382.
    • (2002) J Biol Chem , vol.277 , pp. 49374-49382
    • Mercatante, D.R.1    Mohler, J.L.2    Kole, R.3
  • 29
    • 0033638283 scopus 로고    scopus 로고
    • Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
    • Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. 2000. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell 6:307-316.
    • (2000) Mol Cell , vol.6 , pp. 307-316
    • Monsalve, M.1    Wu, Z.2    Adelmant, G.3    Puigserver, P.4    Fan, M.5    Spiegelman, B.M.6
  • 30
    • 84861323734 scopus 로고    scopus 로고
    • The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex
    • Murachelli AG, Ebert J, Basquin C, Le Hir H, Conti E. 2012. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nat Struct Mol Biol 19:378-386.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 378-386
    • Murachelli, A.G.1    Ebert, J.2    Basquin, C.3    Le Hir, H.4    Conti, E.5
  • 31
    • 0026566674 scopus 로고
    • RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon
    • Nagpal S, Zelent A, Chambon P. 1992. RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. Proc Natl Acad Sci USA 89:2718-2722.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2718-2722
    • Nagpal, S.1    Zelent, A.2    Chambon, P.3
  • 32
    • 0030805125 scopus 로고    scopus 로고
    • Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases
    • Olopade OI, Adeyanju MO, Safa AR, Hagos F, Mick R, Thompson CB, Recant WM. 1997. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J Sci Am 3:230-237.
    • (1997) Cancer J Sci Am , vol.3 , pp. 230-237
    • Olopade, O.I.1    Adeyanju, M.O.2    Safa, A.R.3    Hagos, F.4    Mick, R.5    Thompson, C.B.6    Recant, W.M.7
  • 33
    • 0036674269 scopus 로고    scopus 로고
    • Large-scale proteomic analysis of the human spliceosome
    • Rappsilber J, Ryder U, Lamond AI, Mann M. 2002. Large-scale proteomic analysis of the human spliceosome. Genome Res 12:1231-1245.
    • (2002) Genome Res , vol.12 , pp. 1231-1245
    • Rappsilber, J.1    Ryder, U.2    Lamond, A.I.3    Mann, M.4
  • 35
    • 0242384920 scopus 로고    scopus 로고
    • Transcriptional activators control splicing and 3′-end cleavage levels
    • Rosonina E, Bakowski MA, McCracken S, Blencowe BJ. 2003. Transcriptional activators control splicing and 3′-end cleavage levels. J Biol Chem 278:43034-43040.
    • (2003) J Biol Chem , vol.278 , pp. 43034-43040
    • Rosonina, E.1    Bakowski, M.A.2    McCracken, S.3    Blencowe, B.J.4
  • 36
    • 0033539067 scopus 로고    scopus 로고
    • Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
    • Sahara S, Aoto M, Eguchi MY, Imamoto N, Yoneda Y, Tsujimoto Y. 1999. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401:168-173.
    • (1999) Nature , vol.401 , pp. 168-173
    • Sahara, S.1    Aoto, M.2    Eguchi, M.Y.3    Imamoto, N.4    Yoneda, Y.5    Tsujimoto, Y.6
  • 38
    • 1642540255 scopus 로고    scopus 로고
    • Human RNPS1 and its associated factors: A versatile alternative pre-mRNA splicing regulator in vivo
    • Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A. 2004. Human RNPS1 and its associated factors: A versatile alternative pre-mRNA splicing regulator in vivo. Mol Cell Biol 24:1174-1187.
    • (2004) Mol Cell Biol , vol.24 , pp. 1174-1187
    • Sakashita, E.1    Tatsumi, S.2    Werner, D.3    Endo, H.4    Mayeda, A.5
  • 41
    • 0026287921 scopus 로고
    • Mouse and human retinoic acid receptor beta 2 promoters: Sequence comparison and localization of retinoic acid responsiveness
    • Shen S, Kruyt FA, den Hertog J, van der Saag PT, Kruijer W. 1991. Mouse and human retinoic acid receptor beta 2 promoters: Sequence comparison and localization of retinoic acid responsiveness. DNA Seq 2:111-119.
    • (1991) DNA Seq , vol.2 , pp. 111-119
    • Shen, S.1    Kruyt, F.A.2    den Hertog, J.3    van der Saag, P.T.4    Kruijer, W.5
  • 43
    • 0033587758 scopus 로고    scopus 로고
    • Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization
    • Sommer KM, Chen LI, Treuting PM, Smith LT, Swisshelm K. 1999. Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc Natl Acad Sci USA 96:8651-8656.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8651-8656
    • Sommer, K.M.1    Chen, L.I.2    Treuting, P.M.3    Smith, L.T.4    Swisshelm, K.5
  • 44
    • 0033625059 scopus 로고    scopus 로고
    • Murine RARbeta4 displays reduced transactivation activity, lower affinity for retinoic acid, and no anti-AP1 activity
    • Soprano DR, Scanlon E, Shukri M, Zhang ZP, Soprano KJ. 2000. Murine RARbeta4 displays reduced transactivation activity, lower affinity for retinoic acid, and no anti-AP1 activity. J Cell Biochem 77:604-614.
    • (2000) J Cell Biochem , vol.77 , pp. 604-614
    • Soprano, D.R.1    Scanlon, E.2    Shukri, M.3    Zhang, Z.P.4    Soprano, K.J.5
  • 45
    • 28344456363 scopus 로고    scopus 로고
    • Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
    • Tange TO, Shibuya T, Jurica MS, Moore MJ. 2005. Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA 11:1869-1883.
    • (2005) RNA , vol.11 , pp. 1869-1883
    • Tange, T.O.1    Shibuya, T.2    Jurica, M.S.3    Moore, M.J.4
  • 46
    • 42149131529 scopus 로고    scopus 로고
    • Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs
    • Vucetic Z, Zhang Z, Zhao J, Wang F, Soprano KJ, Soprano DR. 2008. Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs. Mol Cell Biol 28:2549-2558.
    • (2008) Mol Cell Biol , vol.28 , pp. 2549-2558
    • Vucetic, Z.1    Zhang, Z.2    Zhao, J.3    Wang, F.4    Soprano, K.J.5    Soprano, D.R.6
  • 47
    • 84919735562 scopus 로고    scopus 로고
    • Role of the SAP Motif and the C-terminal RS- and RD/E-rich region in the sub-nuclear localization of Acinus isoforms
    • in press).
    • Wang F, Wendling, KS, Soprano KJ, Soprano DR. 2014. Role of the SAP Motif and the C-terminal RS- and RD/E-rich region in the sub-nuclear localization of Acinus isoforms. J Cell Biochem (in press).
    • (2014) J Cell Biochem
    • Wang, F.1    Wendling, K.S.2    Soprano, K.J.3    Soprano, D.R.4
  • 49
    • 0032814423 scopus 로고    scopus 로고
    • Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein
    • Yoshida T, Makino Y, Tamura T. 1999. Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein. FEBS Lett 457:251-254.
    • (1999) FEBS Lett , vol.457 , pp. 251-254
    • Yoshida, T.1    Makino, Y.2    Tamura, T.3
  • 51
    • 52649127884 scopus 로고    scopus 로고
    • Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection
    • Zhou A, Ou AC, Cho A, Benz EJ, Jr, Huang SC. 2008. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection. Mol Cell Biol 28:5924-5936.
    • (2008) Mol Cell Biol , vol.28 , pp. 5924-5936
    • Zhou, A.1    Ou, A.C.2    Cho, A.3    Benz, E.J.4    Huang, S.C.5
  • 52
    • 0037068447 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of the human spliceosome
    • Zhou Z, Licklider LJ, Gygi SP, Reed R. 2002. Comprehensive proteomic analysis of the human spliceosome. Nature 419:182-185.
    • (2002) Nature , vol.419 , pp. 182-185
    • Zhou, Z.1    Licklider, L.J.2    Gygi, S.P.3    Reed, R.4
  • 53
    • 0034671932 scopus 로고    scopus 로고
    • Pre-mRNA splicing in the absence of an SR protein RS domain
    • Zhu J, Kraine AR. 2000. Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev 14:3166-3178.
    • (2000) Genes Dev , vol.14 , pp. 3166-3178
    • Zhu, J.1    Kraine, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.