Interaction between paraoxonase 1 polymorphism and prenatal pesticide exposure on metabolic markers in children using a multiplex approach

Reproductive Toxicology

Volumn 51, Issue , 2015, Pages 22-30

  Jørgensen, Anne ^a,b   Nellemann, Christine ^c   Wohlfahrt Veje, Christine ^b   Jensen, Tina Kold ^a   Main, Katharina M ^b   Andersen, Helle Raun ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Rigshospitalet   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Environmental obesogens; Glucagon; Leptin; PAI 1; Pesticides, Prenatal exposure, PON1 genotype

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; C PEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PESTICIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; AIR POLLUTANT; ARYLDIALKYLPHOSPHATASE; BIOLOGICAL MARKER; PON1 PROTEIN, HUMAN; SERPINE1 PROTEIN, HUMAN;

ABDOMINAL CIRCUMFERENCE; ALLELE; ARTICLE; BODY FAT; BODY MASS; CARDIOMETABOLIC RISK; CHILD; CONTROLLED STUDY; CORRELATIONAL STUDY; DIASTOLIC BLOOD PRESSURE; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FAT CONTENT; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; IMMUNOASSAY; INSULIN BLOOD LEVEL; LIPID STORAGE; PON1 GENE; PRENATAL EXPOSURE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SKINFOLD; ADVERSE EFFECTS; AIR POLLUTANT; BLOOD; CHEMICALLY INDUCED; EPIDEMIOLOGY; GENETICS; MALE; MATERNAL EXPOSURE; OCCUPATIONAL EXPOSURE; PREGNANCY; TOXICITY;

AIR POLLUTANTS, OCCUPATIONAL; ALLELES; ARYLDIALKYLPHOSPHATASE; BIOMARKERS; CHILD; FEMALE; GLUCAGON; HUMANS; INSULIN; LEPTIN; MALE; MATERNAL EXPOSURE; OCCUPATIONAL EXPOSURE; PESTICIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84919765885     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.11.005     Document Type: Article

References (54)

1. Grun F., Blumberg B. Endocrine disrupters as obesogens. Mol Cell Endocrinol 2009, 304:19-29.
2. Newbold R.R. Impact of environmental endocrine disrupting chemicals on the development of obesity. Hormones 2010, 9:206-217.
3. Decherf S., Demeneix B.A. The obesogen hypothesis: a shift of focus from the periphery to the hypothalamus. J Toxicol Environ Health B Crit Rev 2011, 14:423-448.
4. Heindel J.J. Endocrine disruptors and the obesity epidemic. Toxicol Sci 2003, 76:247-249.
5. Casals-Casas C., Feige J.N., Desvergne B. Interference of pollutants with PPARs: endocrine disruption meets metabolism. Int J Obes 2008, 32(Suppl 6):S53-S61.
6. Frontera M., Dickins B., Plagge A., Kelsey G. Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. Adv Exp Med Biol 2008, 626:41-61.
7. Heindel J.J., vom Saal F.S. Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity. Mol Cell Endocrinol 2009, 304:90-96.
8. Korner J., Woods S.C., Woodworth K.A. Regulation of energy homeostasis and health consequences in obesity. Am J Med 2009, 122:S12-S18.
9. Khan S.M., Hamnvik O.P., Brinkoetter M., Mantzoros C.S. Leptin as a modulator of neuroendocrine function in humans. Yonsei Med J 2012, 53:671-679.
10. Ouchi N., Parker J.L., Lugus J.J., Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011, 11:85-97.
11. Tateya S., Kim F., Tamori Y. Recent advances in obesity-induced inflammation and insulin resistance. Front Endocrinol 2013, 4:93.
12. Smits M.M., Woudstra P., Utzschneider K.M., Tong J., Gerchman F., Faulenbach M., et al. Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis. Ann Epidemiol 2013, 23:415-421.
13. Grun F., Blumberg B. Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Rev Endocr Metab Disord 2007, 8:161-171.
14. Newbold R.R., Padilla-Banks E., Jefferson W.N., Heindel J.J. Effects of endocrine disruptors on obesity. Int J Androl 2008, 31:201-208.
15. Lassiter T.L., Brimijoin S. Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos. Neurotoxicol Teratol 2008, 30:125-130.
16. Newbold R.R., Padilla-Banks E., Snyder R.J., Jefferson W.N. Perinatal exposure to environmental estrogens and the development of obesity. Mol Nutr Food Res 2007, 51:912-917.
17. Boberg J., Metzdorff S., Wortziger R., Axelstad M., Brokken L., Vinggaard A.M., et al. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 2008, 250:75-81.
18. Vickers M.H., Krechowec S.O., Breier B.H. Is later obesity programmed in utero. Curr Drug Targets 2007, 8:923-934.
19. Tang-Peronard J.L., Andersen H.R., Jensen T.K., Heitmann B.L. Endocrine-disrupting chemicals and obesity development in humans: a review. Obes Rev 2011, 12:622-636.
20. Warner M., Aguilar Schall R., Harley K.G., Bradman A., Barr D., Eskenazi B. In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort. Environ Health Perspect 2013, 121:631-636.
21. Halldorsson T.I., Rytter D., Haug L.S., Bech B.H., Danielsen I., Becher G., et al. Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environ Health Perspect 2012, 120:668-673.
22. Wohlfahrt-Veje C., Main K.M., Schmidt I.M., Boas M., Jensen T.K., Grandjean P., et al. Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study. Environ Health 2011, 10:79.
23. Andersen H.R., Wohlfahrt-Veje C., Dalgard C., Christiansen L., Main K.M., Nellemann C., et al. Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PLoS One 2012, 7:e36830.
24. Costa L.G., Giordano G., Cole T.B., Marsillach J., Furlong C.E. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology 2013, 307:115-122.
25. Aharoni S., Aviram M., Fuhrman B. Paraoxonase 1 (PON1) reduces macrophage inflammatory responses. Atherosclerosis 2013, 228:353-361.
26. Rosenblat M., Aviram M. Paraoxonases role in the prevention of cardiovascular diseases. Biofactors 2009, 35:98-104.
27. Durrington P.N., Mackness B., Mackness M.I. Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol 2001, 21:473-480.
28. Andersen H.R., Schmidt I.M., Grandjean P., Jensen T.K., Budtz-Jorgensen E., Kjaerstad M.B., et al. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environ Health Perspect 2008, 116:566-572.
29. Linnet K. Evaluation of regression procedures for methods comparison studies. Clin Chem 1993, 39:424-432.
30. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1:307-310.
31. Nysom K., Molgaard C., Hutchings B., Michaelsen K.F. Body mass index of 0 to 45-y-old Danes: reference values and comparison with published European reference values. Int J Obes Relat Metab Disord. 2001, 25:177-184.
32. Castaneda T.R., Tong J., Datta R., Culler M., Tschop M.H. Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol 2010, 31:44-60.
33. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
34. Vettor R., Milan G., Rossato M., Federspil G. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005, 22(Suppl 2):3-10.
35. Klok M.D., Jakobsdottir S., Drent M.L. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007, 8:21-34.
36. Murphy M.J., Metcalf B.S., Voss L.D., Jeffery A.N., Kirkby J., Mallam K.M., et al. Girls at five are intrinsically more insulin resistant than boys: The Programming Hypotheses Revisited--The EarlyBird Study (EarlyBird 6). Pediatrics 2004, 113:82-86.
37. Elshal M.F., McCoy J.P. Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA. Methods 2006, 38:317-323.
38. Liu M.Y., Xydakis A.M., Hoogeveen R.C., Jones P.H., Smith E.O., Nelson K.W., et al. Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system. Clin Chem 2005, 51:1102-1109.
39. Loo B.M., Marniemi J., Jula A. Evaluation of multiplex immunoassays, used for determination of adiponectin, resistin, leptin, and ghrelin from human blood samples, in comparison to ELISA assays. Scand J Clin Lab Invest 2011, 71:221-226.
40. Adigun A.A., Wrench N., Seidler F.J., Slotkin T.A. Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environ Health Perspect 2010, 118:210-215.
41. Slotkin T.A. Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity. Reprod Toxicol 2011, 31:297-301.
42. Kelly A.S., Steinberger J., Kaiser D.R., Olson T.P., Bank A.J., Dengel D.R. Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. J Cardiometab Syndr 2006, 1:248-252.
43. D'Alessio D. The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab 2011, 13(Suppl 1):126-132.
44. Kohler H.P., Grant P.J. Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med 2000, 342:1792-1801.
45. Festa A., D'Agostino R., Tracy R.P., Haffner S.M. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 2002, 51:1131-1137.
46. Huen K., Harley K., Beckman K., Eskenazi B., Holland N. Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One 2013, 8:e62565.
47. Ruperez A.I., Lopez-Guarnido O., Gil F., Olza J., Gil-Campos M., Leis R., et al. Paraoxonase 1 activities and genetic variation in childhood obesity. Br J Nutr 2013, 110:1-9.
48. Bourguignon J.P., Rasier G., Lebrethon M.C., Gerard A., Naveau E., Parent A.S. Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance. Mol Cell Endocrinol 2010, 324:110-120.
49. Jirtle R.L., Skinner M.K. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007, 8:253-262.
50. Almen M.S., Jacobsson J.A., Moschonis G., Benedict C., Chrousos G.P., Fredriksson R., et al. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics 2012, 99:132-137.
51. Manikkam M., Haque M.M., Guerrero-Bosagna C., Nilsson E.E., Skinner M.K. Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline. PLoS One 2014, 9:e102091.
52. Skinner M.K., Manikkam M., Tracey R., Guerrero-Bosagna C., Haque M., Nilsson E.E. Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med 2013, 11:228.
53. Berkowitz G.S., Wetmur J.G., Birman-Deych E., Obel J., Lapinski R.H., Godbold J.H., et al. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 2004, 112:388-391.
54. Engel S.M., Wetmur J., Chen J., Zhu C., Barr D.B., Canfield R.L., et al. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect 2011, 119:1182-1188.