Associations of PON1 and Genetic Ancestry with Obesity in Early Childhood

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Huen, Karen ^a   Harley, Kim ^a   Beckman, Kenneth ^b   Eskenazi, Brenda ^a   Holland, Nina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; ARYLDIALKYLPHOSPHATASE; PON1 PROTEIN, HUMAN;

AFRICAN AMERICAN; AMERICAN INDIAN; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; ETHNIC DIFFERENCE; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PLESIOMORPHY; PON1 GENE; PRESCHOOL CHILD; PREVALENCE; UNITED STATES; WAIST CIRCUMFERENCE; ADOLESCENT; ADULT; ALLELE; EPIDEMIOLOGY; ETHNOLOGY; GENETICS; INHERITANCE; MEXICAN AMERICAN; ONSET AGE;

ADOLESCENT; ADULT; AGE OF ONSET; ALLELES; ARYLDIALKYLPHOSPHATASE; BODY MASS INDEX; CALIFORNIA; CHILD; CHILD, PRESCHOOL; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INHERITANCE PATTERNS; MALE; MEXICAN AMERICANS; OBESITY; POLYMORPHISM, GENETIC; PREVALENCE; WAIST CIRCUMFERENCE;

EID: 84877049549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062565     Document Type: Article

References (65)

1. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM, (2010) Prevalence of high body mass index in US children and adolescents, 2007-2008. Jama 303: 242-249.
2. Ogden CL, Carroll MD, Flegal KM, (2008) High body mass index for age among US children and adolescents, 2003-2006. Jama 299: 2401-2405.
3. Kimm SY, Barton BA, Obarzanek E, McMahon RP, Kronsberg SS, et al. (2002) Obesity development during adolescence in a biracial cohort: the NHLBI Growth and Health Study. Pediatrics 110: e54.
4. Lighthall D, (2001) The poor health of farm workers. West J Med 175: 223-224.
5. Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, et al. (2011) Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 365: 1876-1885.
6. Rankinen T, Bray MS, Hagberg JM, Perusse L, Roth SM, et al. (2006) The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc 38: 1863-1888.
7. Zhao J, Grant SF, (2011) Genetics of childhood obesity. J Obes 2011: 845148.
8. Heindel JJ, vom Saal FS, (2009) Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity. Mol Cell Endocrinol 304: 90-96.
9. Loos RJ, (2009) Recent progress in the genetics of common obesity. Br J Clin Pharmacol 68: 811-829.
10. Sisson SB, Church TS, Martin CK, Tudor-Locke C, Smith SR, et al. (2009) Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001-2006. Int J Pediatr Obes 4: 353-359.
11. Rankinen T, Rice T, Teran-Garcia M, Rao DC, Bouchard C, (2010) FTO genotype is associated with exercise training-induced changes in body composition. Obesity (Silver Spring) 18: 322-326.
12. Haworth CM, Carnell S, Meaburn EL, Davis OS, Plomin R, et al. (2008) Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring) 16: 2663-2668.
13. Bueno AC, Espineira AR, Fernandes-Rosa FL, de Souza RM, de Castro M, et al. (2010) Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age. Eur J Endocrinol 162: 53-60.
14. Bouchard C, (2009) Childhood obesity: are genetic differences involved? Am J Clin Nutr 89: 1494S-1501S.
15. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753.
16. Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, et al. (2008) Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. Jama 299: 1265-1276.
17. Koncsos P, Seres I, Harangi M, Illyes I, Jozsa L, et al. (2010) Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels. Pediatr Res 67: 309-313.
18. Li HL, Liu DP, Liang CC, (2003) Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med 81: 766-779.
19. Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, et al. (2003) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 23: 434-439.
20. Seres I, Bajnok L, Harangi M, Sztanek F, Koncsos P, et al. (2010) Alteration of PON1 activity in adult and childhood obesity and its relation to adipokine levels. Adv Exp Med Biol 660: 129-142.
21. Bajnok L, Csongradi E, Seres I, Varga Z, Jeges S, et al. (2008) Relationship of adiponectin to serum paraoxonase 1. Atherosclerosis 197: 363-367.
22. Ferretti G, Bacchetti T, Moroni C, Savino S, Liuzzi A, et al. (2005) Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females. J Clin Endocrinol Metab 90: 1728-1733.
23. Ferretti G, Bacchetti T, Masciangelo S, Bicchiega V (2009) HDL-paraoxonase and Membrane Lipid Peroxidation: A Comparison Between Healthy and Obese Subjects. Obesity (Silver Spring).
24. Veiga L, Silva-Nunes J, Melao A, Oliveira A, Duarte L, et al. (2011) Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women. Eur J Endocrinol 164: 213-218.
25. Martinez-Salazar MF, Almenares-Lopez D, Garcia-Jimenez S, Sanchez-Aleman MA, Juantorena-Ugas A, et al. (2011) Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study. Genes Nutr 6: 361-368.
26. Andersen HR, Wohlfahrt-Veje C, Dalgard C, Christiansen L, Main KM, et al. (2012) Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PLoS One 7: e36830.
27. Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG, (2003) Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect 111: 1403-1409.
28. Holland N, Furlong C, Bastaki M, Richter R, Bradman A, et al. (2006) Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environ Health Perspect 114 985-991: PMC1513322.
29. Rojas-Garcia AE, Solis-Heredia MJ, Pina-Guzman B, Vega L, Lopez-Carrillo L, et al. (2005) Genetic polymorphisms and activity of PON1 in a Mexican population. Toxicol Appl Pharmacol 205: 282-289.
30. Cossrow N, Falkner B, (2004) Race/ethnic issues in obesity and obesity-related comorbidities. J Clin Endocrinol Metab 89: 2590-2594.
31. Ziv E, Burchard EG, (2003) Human population structure and genetic association studies. Pharmacogenomics 4: 431-441.
32. Lee YL, Teitelbaum S, Wolff MS, Wetmur JG, Chen J, (2010) Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City. J Genet 89: 417-423.
33. Fernandez JR, Shriver MD, Beasley TM, Rafla-Demetrious N, Parra E, et al. (2003) Association of African genetic admixture with resting metabolic rate and obesity among women. Obes Res 11: 904-911.
34. Tang H, Jorgenson E, Gadde M, Kardia SL, Rao DC, et al. (2006) Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Genet 119: 624-633.
35. Harley KG, Huen K, Schall RA, Holland NT, Bradman A, et al. (2011) Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PLoS One 6: e23923.
36. Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, et al. (2000) Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 10: 453-460.
37. Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, et al. (2000) Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arterioscler Thromb Vasc Biol 20: 2441-2447.
38. Richter RJ, Jarvik GP, Furlong CE, (2010) Paraoxonase 1 status as a risk factor for disease or exposure. Adv Exp Med Biol 660: 29-35.
39. Eskenazi B, Bradman A, Gladstone E, Jaramillo S, Birch K, et al. (2003) CHAMACOS, a longitudinal birth cohort study: lessons from the fields. J Childrens Healt 1: 3-27.
40. Warner ML, Harley K, Bradman A, Vargas G, Eskenazi B (2006) Soda consumption and overweight status of 2-year-old mexican-american children in california. Obesity (Silver Spring) 141966-1974, PMID: 17135613.
41. Rosas LG, Guendelman S, Harley K, Fernald LC, Neufeld L, et al. (2011) Factors associated with overweight and obesity among children of Mexican descent: results of a binational study. J Immigr Minor Health 13: 169-180.
42. Rosas LG, Harley KG, Guendelman S, Fernald LC, Mejia F, et al. (2010) Maternal perception of child weight among Mexicans in California and Mexico. Matern Child Health J 14: 886-894.
43. National Center for Health Statistics (2005) CDC Growth Charts, United States.
44. Ogden CL, Flegal KM (2010) Changes in terminology for childhood overweight and obesity. Natl Health Stat Report: 1-5.
45. ISBER (2012) 2012 Best Practices for Repositories: Collection, Storage, Retrieval, and Distribution of Biological Materials for Research. Biopreservation and Biobanking 10: 79-161.
46. Richter RJ, Furlong CE, (1999) Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 9: 745-753.
47. Connelly PW, Maguire GF, Picardo CM, Teiber JF, Draganov D, (2008) Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma. J Lipid Res 49: 245-250.
48. Kujiraoka T, Oka T, Ishihara M, Egashira T, Fujioka T, et al. (2000) A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration. J Lipid Res 41: 1358-1363.
49. Huen K, Richter R, Furlong C, Eskenazi B, Holland N, (2009) Validation of PON1 enzyme activity assays for longitudinal studies. Clin Chim Acta 402: 67-74.
50. Tsai HJ, Choudhry S, Naqvi M, Rodriguez-Cintron W, Burchard EG, et al. (2005) Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations. Hum Genet 118: 424-433.
51. Choudhry S, Taub M, Mei R, Rodriguez-Santana J, Rodriguez-Cintron W, et al. (2008) Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet 123: 455-468.
52. Fejerman L, Romieu I, John EM, Lazcano-Ponce E, Huntsman S, et al. (2010) European ancestry is positively associated with breast cancer risk in Mexican women. Cancer Epidemiol Biomarkers Prev 19: 1074-1082.
53. Lai CQ, Tucker KL, Choudhry S, Parnell LD, Mattei J, et al. (2009) Population admixture associated with disease prevalence in the Boston Puerto Rican health study. Hum Genet 125: 199-209.
54. Huen K, Barcellos L, Beckman K, Rose S, Eskenazi B, et al. (2011) Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children. Environ Mol Mutagen 52: 105-116.
55. Huen K, Harley K, Bradman A, Eskenazi B, Holland N, (2010) Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes. Toxicol Appl Pharmacol 244: 181-189.
56. Fejerman L, John EM, Huntsman S, Beckman K, Choudhry S, et al. (2008) Genetic ancestry and risk of breast cancer among U.S. Latinas. Cancer Res 68: 9723-9728.
57. Falush D, Stephens M, Pritchard JK, (2003) Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics 164: 1567-1587.
58. Hubisz MJ, Falush D, Stephens M, Pritchard JK, (2009) Inferring weak population structure with the assistance of sample group information. Mol Ecol Resour 9: 1322-1332.
59. Pritchard JK, Stephens M, Donnelly P, (2000) Inference of population structure using multilocus genotype data. Genetics 155: 945-959.
60. Rothman K, Greenland S (1998) Modern Epidemiology. Philadelphia: Lippincott-Raven.
61. Huen K, Harley K, Brooks J, Hubbard A, Bradman A, et al. (2009) Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1 Polymorphisms Environmental Health Perspectives. 117: 1632-1638.
62. Paragh G, Seres I, Harangi M, Pocsai Z, Asztalos L, et al. (2009) Discordance in human paraoxonase-1 gene between phenotypes and genotypes in chronic kidney disease. Nephron Clin Pract 113: c46-53.
63. Aviram M, Kaplan M, Rosenblat M, Fuhrman B (2005) Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol: 263-300.
64. Mackness MI, Durrington PN, Mackness B, (2000) How high-density lipoprotein protects against the effects of lipid peroxidation. Curr Opin Lipidol 11: 383-388.
65. Silventoinen K, Rokholm B, Kaprio J, Sorensen TI, (2010) The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond) 34: 29-40.