PH-responsive modulation of insulin aggregation and structural transformation of the aggregates

Biochimie

Volumn 109, Issue , 2015, Pages 49-59

  Smirnova, Ekaterina ^a   Safenkova, Irina ^a   Stein Margolina, Vita ^a   Shubin, Vladimir ^a   Polshakov, Vladimir ^b   Gurvits, Bella ^a  

^a BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

^b LOMONOSOV MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Arginine; Atomic force microscope; Insulin; pH regulation; Protein aggregation

Indexed keywords

ARGININE; GUANIDINE; LYSINE; RECOMBINANT HUMAN INSULIN; INSULIN; PROTEIN AGGREGATE; RECOMBINANT PROTEIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; CIRCULAR DICHROISM; DYNAMIC LIGHT SCATTERING; FLUORESCENCE SPECTROSCOPY; LIGHT SCATTERING; MODULATION; MOLECULAR WEIGHT; PH; PROTEIN AGGREGATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSMISSION ELECTRON MICROSCOPY; TURBIDIMETRY; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTOMETRY; SPECTROFLUOROMETRY;

ARGININE; CIRCULAR DICHROISM; HUMANS; HYDROGEN-ION CONCENTRATION; INSULIN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; NEPHELOMETRY AND TURBIDIMETRY; PROTEIN AGGREGATES; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

EID: 84919755015     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.12.006     Document Type: Article

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