Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules

Investigational New Drugs

Volumn 32, Issue 5, 2014, Pages 838-850

  Raja, Vijay J ^a   Lim, Kuan Hon ^b   Leong, Chee Onn ^c   Kam, Toh Seok ^d   Bradshaw, Tracey D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM MALAYSIA CAMPUS   (Malaysia)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Aneuploidy; Apoptosis; Blebbing; Cell cycle; Multipolar spindles; Tubulin

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CCNB1 PROTEIN, HUMAN; CYCLIN B1; INDOLE ALKALOID; JERANTININE A; MCL1 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN MCL 1; TUBULIN;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MICROTUBULE; TABERNAEMONTANA; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN B1; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INDOLE ALKALOIDS; M PHASE CELL CYCLE CHECKPOINTS; MICROTUBULES; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TABERNAEMONTANA; TUBULIN;

EID: 84919691001     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-014-0126-1     Document Type: Article

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