Targeted delivery of lovastatin and tocotrienol to fracture site promotes fracture healing in osteoporosis model: Micro-computed tomography and biomechanical evaluation

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Ibrahim, Nurul 'Izzah ^a   Khamis, Mohd Fadhli ^b   Yunoh, Mohd Faridz Mod ^c   Abdullah, Shahrum ^c   Mohamed, Norazlina ^a   Shuid, Ahmad Nazrun ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

^b SCHOOL OF HEALTH SCIENCES   (Malaysia)

^c UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOTRIENOL; CONJUGATED ESTROGEN; MEVINOLIN; POLYGLACTIN; POLYLACTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE PLATE; BONE SCREW; CALLUS; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; FRACTURE FIXATION; FRACTURE HEALING; FRAGILITY FRACTURE; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; RAT; SINGLE DRUG DOSE; TIBIA FRACTURE; ANIMAL; COMBINATION DRUG THERAPY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HUMAN; POSTMENOPAUSE OSTEOPOROSIS; PROCEDURES; RADIOGRAPHY; SPRAGUE DAWLEY RAT; TENSILE STRENGTH; TIBIAL FRACTURES; TREATMENT OUTCOME;

RATTUS;

ANIMALS; BIOMECHANICAL PHENOMENA; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG THERAPY, COMBINATION; FEMALE; FRACTURE HEALING; HUMANS; LOVASTATIN; OSTEOPOROSIS, POSTMENOPAUSAL; RATS; RATS, SPRAGUE-DAWLEY; TENSILE STRENGTH; TIBIAL FRACTURES; TOCOTRIENOLS; TREATMENT OUTCOME; X-RAY MICROTOMOGRAPHY;

EID: 84919683732     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115595     Document Type: Article

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