A finite element inverse analysis to assess functional improvement during the fracture healing process

Journal of Biomechanics

Volumn 43, Issue 3, 2010, Pages 557-562

  Weis, Jared A ^a,b   Miga, Michael I ^b   Granero Moltó, Froilán ^a   Spagnoli, Anna ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Biomechanical testing; Finite element analysis; Fracture healing; Material properties; Micro CT

Indexed keywords

BIOMECHANICAL TESTING; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; MATERIAL PROPERTY; MICRO CT;

BIOMECHANICS; COMPUTERIZED TOMOGRAPHY; FRACTURE; FRACTURE TESTING; FUNCTIONALLY GRADED MATERIALS; INVERSE PROBLEMS; MAMMALS; MATERIALS PROPERTIES;

FINITE ELEMENT METHOD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MATURATION; BONE STRUCTURE; CALLUS; CONTROLLED STUDY; ELASTOGRAPHY; FEMALE; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; FUNCTIONAL ASSESSMENT; LOAD CARRYING CAPACITY; MOUSE; MUSCLE RIGIDITY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROCESS MODEL; SENSITIVITY ANALYSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; TIBIA FRACTURE; VALIDATION PROCESS; WEIGHT BEARING; YOUNG MODULUS;

ANIMALS; COMPUTER SIMULATION; ELASTIC MODULUS; FEMALE; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; MICE; MODELS, BIOLOGICAL; RECOVERY OF FUNCTION; STRESS, MECHANICAL; TIBIAL FRACTURES;

EID: 74449083765     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.09.051     Document Type: Article

References (29)

1. Barnes S.L., Lyshchik A., Washington M.K., Gore J.C., and Miga M.I. Development of a mechanical testing assay for fibrotic murine liver. Medical Physics 34 11 (2007) 4439-4450
2. Bourne B.C., and van der Meulen M.C. Finite element models predict cancellous apparent modulus when tissue modulus is scaled from specimen CT-attenuation. Journal of Biomechanics 37 5 (2004) 613-621
3. Cattermole H.C., Fordham J.N., Muckle D.S., and Cunningham J.L. Dual-energy X-ray absorptiometry as a measure of healing in fractures treated by intramedullary nailing. Journal of Orthopaedic Trauma 10 8 (1996) 563-568
4. Choi K., Kuhn J.L., Ciarelli M.J., and Goldstein S.A. The elastic moduli of human subchondral, trabecular, and cortical bone tissue and the size-dependency of cortical bone modulus. Journal of Biomechanics 23 11 (1990) 1103-1113
5. Ciprian S., Iochum S., Kohlmann R., Dautel G., Dap F., and Blum A. MR imaging accuracy in the prediction of bone graft healing potential in scaphoid non-union. Journal De Radiologie 85 10 (2004) 1699-1706
6. Colnot C., Thompson Z., Miclau T., Werb Z., and Helms J.A. Altered fracture repair in the absence of MMP9. Development 130 17 (2003) 4123-4133
7. Einhorn T.A. Enhancement of fracture-healing. Journal of Bone Joint Surgery American. 77 6 (1995) 940-956
8. Einhorn T.A. The cell and molecular biology of fracture healing. Clinical Orthopaedics and Related Research 355 (1998) S7-S21
9. Gerstenfeld L.C., Wronski T.J., Hollinger J.O., and Einhorn T.A. Application of histomorphometric methods to the study of bone repair. Journal of Bone and Mineral Research 20 10 (2005) 1715-1722
10. Greenleaf J.F., Fatemi M., and Insana M. Selected methods for imaging elastic properties of biological tissues. Annual Review of Biomedical Engineering 5 (2003) 57-78
11. Grigoryan M., Lynch J.A., Fierlinger A.L., Guermazi A., Fan B., MacLean D.B., MacLean A., and Genant H.K. Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography. Academic Radiology 10 11 (2003) 1267-1273
12. Hiltunen A., Vuorio E., and Aro H.T. A standardized experimental fracture in the Mouse Tibia. Journal of Orthopaedic Research 11 2 (1993) 305-312
13. Hsu W.K., Feeley B.T., Krenek L., Stout D.B., Chatziioannou A.F., and Lieberman J.R. The use of F-18-fluoride and F-18-FDG PET scans to assess fracture healing in a rat femur model. European Journal of Nuclear Medicine and Molecular Imaging 34 8 (2007) 1291-1301
14. Jamsa T., Jalovaara P., Peng Z., Vaananen H.K., and Tuukkanen J. Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia. Bone 23 2 (1998) 155-161
15. Lynch J.A., Grigoryan M., Fierlinger A., Guermazi A., Zaim S., MacLean D.B., and Genant H.K. Measurement of changes in trabecular bone at fracture sites using X-ray CT and automated image registration and processing. Journal of Orthopaedic Research 22 2 (2004) 362-367
16. Marsh D. Concepts of fracture union, delayed union, and nonunion. Clinical Orthopaedics and Related Research 355 (1998) S22-S30
17. Miga M.I., Rothney M.P., and Ou J.J. Modality independent elastography (MIE): Potential applications in dermoscopy. Medical Physics 32 5 (2005) 1308-1320
18. Ophir J., Cespedes I., Ponnekanti H., Yazdi Y., and Li X. Elastography-a quantitative method for imaging the elasticity of biological tissues. Ultrasonic Imaging 13 2 (1991) 111-134
19. Ou J.J., Ong R.E., Yankeelov T.E., and Miga M.I. Evaluation of 3D modality-independent elastography for breast imaging: A simulation study. Physics in Medicine and Biology 53 1 (2008) 147-163
20. Reynolds D.G., Hock C., Shaikh S., Jacobson J., Zhang X., Rubery P.T., Beck C.A., O'Keefe R.J., Lerner A.L., Schwarz E.M., and Awad H.A. Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. Journal of Biomechanics 40 14 (2007) 3178-3186
21. Samani A., and Plewes D. An inverse problem solution for measuring the elastic modulus of intact ex vivo breast tissue tumours. Physics in Medicine and Biology 52 5 (2007) 1247-1260
22. Saran N., and Hamdy R.C. DEXA as a predictor of fixator removal in distraction osteogenesis. Clinical Orthopaedics and Related Research 466 12 (2008) 2955-2961
23. Schmidhammer R., Zandieh S., Mittermayr R., Pelinka L.E., Leixnering M., Hopf R., Kroepfl A., and Redl H. Assessment of bone union/nonunion in an experimental model using microcomputed technology. Journal of Trauma-Injury Infection and Critical Care 61 1 (2006) 199-205
24. Schriefer J.L., Robling A.G., Warden S.J., Fournier A.J., Mason J.J., and Turner C.H. A comparison of mechanical properties derived from multiple skeletal sites in mice. Journal of Biomechanics 38 3 (2005) 467-475
25. Severns A.E., Lee Y.P., Nelson S.D., Johnson E.E., and Kabo J.M. Metabolic measurement techniques to assess bone fracture healing-A preliminary study. Clinical Orthopaedics and Related Research 424 (2004) 231-238
26. Shefelbine S.J., Simon U., Claes L., Gold A., Gabet Y., Bab I., Muller R., and Augat P. Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis. Bone 36 3 (2005) 480-488
27. Sullivan J.M., Charron G., and Paulsen K.D. A three-dimensional mesh generator for arbitrary multiple material domains. Finite Elements in Analysis and Design 25 3-4 (1997) 219-241
28. van Lenthe G.H., Voide R., Boyd S.K., and Muller R. Tissue modulus calculated from beam theory is biased by bone size and geometry: implications for the use of three-point bending tests to determine bone tissue modulus. Bone 43 4 (2008) 717-723
29. Washington C.W., and Miga M.I. Modality independent elastography (MIE): A new approach to elasticity imaging. IEEE Transactions on Medical Imaging 23 9 (2004) 1117-1128