Gene age predicts the strength of purifying selection acting on gene expression variation in humans

American Journal of Human Genetics

Volumn 95, Issue 6, 2014, Pages 660-674

  Popadin, Konstantin Y ^a,b,c   Gutierrez Arcelus, Maria ^a,b,d   Lappalainen, Tuuli ^a,b,d,e,f   Buil, Alfonso ^a,b,d   Steinberg, Julia ^g,h   Nikolaev, Sergey I ^a,b   Lukowski, Samuel W ^a,b   Bazykin, Georgii A ^c,i   Seplyarskiy, Vladimir B ^c,i   Ioannidis, Panagiotis ^a,b,d   Zdobnov, Evgeny M ^a,b,d   Dermitzakis, Emmanouil T ^a,b,d,j   Antonarakis, Stylianos E ^a,b  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b Institute of Genetics and Genomics in Geneva (IGE3)   (Switzerland)

^c INSTITUTE FOR INFORMATION TRANSMISSION PROBLEMS   (Russian Federation)

^d SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^e NEW YORK GENOME CENTER   (United States)

^f Och Spine at New York Presbyterian Hospitals   (United States)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ MOSCOW STATE UNIVERSITY   (Russian Federation)

^j KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN;

ALLELE; ARTICLE; CELL METABOLISM; CLASSIFICATION; EMBRYO DEVELOPMENT; ENVIRONMENTAL FACTOR; FIBROBLAST; GENE AGE; GENE EXPRESSION; GENE PRODUCT; GENETIC CODE; GENETIC REGULATION; GENETIC VARIABILITY; HAPLOINSUFFICIENCY; HERITABILITY; HUMAN; HUMAN CELL; HUMAN GENOME; LIFESPAN; LYMPHOBLASTOID CELL LINE; MOLECULAR GENETICS; NEWBORN; PRIMATE; PURIFYING SELECTION; QUANTITATIVE TRAIT LOCUS; T LYMPHOCYTE; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; ZEBRA FISH; AGE; ANTIBODY SPECIFICITY; CELL LINE; FEMALE; FETUS BLOOD; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GENOME; MALE; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; UMBILICAL CORD;

DANIO RERIO; PRIMATES;

AGE FACTORS; CELL LINE; FEMALE; FETAL BLOOD; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOME; HUMANS; INFANT, NEWBORN; LOGISTIC MODELS; MALE; ORGAN SPECIFICITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; QUANTITATIVE TRAIT LOCI; TRANSCRIPTION INITIATION SITE; UMBILICAL CORD;

EID: 84919665521     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2014.11.003     Document Type: Article

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