-
1
-
-
84862005859
-
Prevalence of obesity in the United States, 2009–2010
-
PID: 22617494
-
Ogden CL, Carroll MD, Kit BK, Flegal KM (2012) Prevalence of obesity in the United States, 2009–2010. NCHS Data Brief 82:1–8
-
(2012)
NCHS Data Brief
, vol.82
, pp. 1-8
-
-
Ogden, C.L.1
Carroll, M.D.2
Kit, B.K.3
Flegal, K.M.4
-
2
-
-
70350245011
-
Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
-
COI: 1:CAS:528:DC%2BD1MXht1OrtrrK, PID: 19805654
-
Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645
-
(2009)
Circulation
, vol.120
, pp. 1640-1645
-
-
Alberti, K.G.1
Eckel, R.H.2
Grundy, S.M.3
-
3
-
-
62849107573
-
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
-
Prospective Studies Collaboration, Whitlock G, Lewington S et al (2009) Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 73:1083–1096
-
(2009)
Lancet
, vol.73
, pp. 1083-1096
-
-
Prospective Studies Collaboration1
Whitlock, G.2
Lewington, S.3
-
4
-
-
33747739430
-
Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
-
COI: 1:CAS:528:DC%2BD28XosFGhs7s%3D, PID: 16735483
-
Meigs JB, Wilson PW, Fox CS et al (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91:2906–2912
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 2906-2912
-
-
Meigs, J.B.1
Wilson, P.W.2
Fox, C.S.3
-
5
-
-
74949084667
-
Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
-
PID: 20038741
-
Arnlöv J, Ingelsson E, Sundström J, Lind L (2010) Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121(2):230–236
-
(2010)
Circulation
, vol.121
, Issue.2
, pp. 230-236
-
-
Arnlöv, J.1
Ingelsson, E.2
Sundström, J.3
Lind, L.4
-
6
-
-
21544462572
-
Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence
-
PID: 15983333
-
Ford ES (2005) Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 28:1769–1778
-
(2005)
Diabetes Care
, vol.28
, pp. 1769-1778
-
-
Ford, E.S.1
-
7
-
-
0024160877
-
Role of insulin resistance in human disease
-
COI: 1:STN:280:DyaL1M%2Flt12msQ%3D%3D, PID: 3056758
-
Reaven G (1988) Role of insulin resistance in human disease. Diabetes 37:1595–1607
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.1
-
8
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
COI: 1:STN:280:DC%2BD3M3kvFejsA%3D%3D, PID: 11333990
-
Tuomilehto J, Lindström J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindström, J.2
Eriksson, J.G.3
-
9
-
-
84864283300
-
Muscles, exercise and obesity: skeletal muscle as a secretory organ
-
COI: 1:CAS:528:DC%2BC38XhtVOmtLrJ, PID: 22473333
-
Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457–465
-
(2012)
Nat Rev Endocrinol
, vol.8
, pp. 457-465
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
10
-
-
84862776702
-
A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
PID: 22237023
-
Boström P, Wu J, Jedrychowski MP et al (2012) A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Boström, P.1
Wu, J.2
Jedrychowski, M.P.3
-
11
-
-
84865512723
-
Is irisin a human exercise gene?
-
COI: 1:CAS:528:DC%2BC38Xht1yntbrK, PID: 22932392
-
Timmons JA, Baar K, Davidsen PK, Atherton PJ (2012) Is irisin a human exercise gene? Nature 488:E9–E10
-
(2012)
Nature
, vol.488
, pp. E9-E10
-
-
Timmons, J.A.1
Baar, K.2
Davidsen, P.K.3
Atherton, P.J.4
-
12
-
-
84869497609
-
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
-
COI: 1:CAS:528:DC%2BC38XhsVSlt7bK, PID: 23018146
-
Huh JY, Panagiotou G, Mougios V et al (2012) FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61:1725–1738
-
(2012)
Metabolism
, vol.61
, pp. 1725-1738
-
-
Huh, J.Y.1
Panagiotou, G.2
Mougios, V.3
-
13
-
-
84888879117
-
Circulating irisin in relation to insulin resistance and the metabolic syndrome
-
Hee Park K, Zaichenko L, Brinkoetter M et al (2013) Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 98:4899–4907
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 4899-4907
-
-
Hee Park, K.1
Zaichenko, L.2
Brinkoetter, M.3
-
14
-
-
84871587312
-
Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index
-
COI: 1:CAS:528:DC%2BC3sXitlejsLc%3D, PID: 23219488
-
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides 39:125–130
-
(2013)
Peptides
, vol.39
, pp. 125-130
-
-
Stengel, A.1
Hofmann, T.2
Goebel-Stengel, M.3
Elbelt, U.4
Kobelt, P.5
Klapp, B.F.6
-
15
-
-
84879915581
-
Lower circulating irisin is associated with type 2 diabetes mellitus
-
PID: 23619195
-
Liu JJ, Wong MD, Toy WC et al (2013) Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complicat 27:365–369
-
(2013)
J Diabetes Complicat
, vol.27
, pp. 365-369
-
-
Liu, J.J.1
Wong, M.D.2
Toy, W.C.3
-
16
-
-
84876222786
-
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
-
COI: 1:CAS:528:DC%2BC3sXmtFegsr0%3D, PID: 23436919
-
Moreno-Navarrete JM, Ortega F, Serrano M et al (2013) Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 98:E769–E778
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. E769-E778
-
-
Moreno-Navarrete, J.M.1
Ortega, F.2
Serrano, M.3
-
17
-
-
84876736157
-
Serum irisin levels in new-onset type 2 diabetes
-
COI: 1:CAS:528:DC%2BC3sXhvFSqtbc%3D, PID: 23369227
-
Choi YK, Kim MK, Bae KH et al (2013) Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 100:96–101
-
(2013)
Diabetes Res Clin Pract
, vol.100
, pp. 96-101
-
-
Choi, Y.K.1
Kim, M.K.2
Bae, K.H.3
-
18
-
-
84876744461
-
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity
-
Staiger H, Böhm A, Scheler M et al (2013) Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity. PLoS One 25(8):e61903
-
(2013)
PLoS One
, vol.25
, Issue.8
, pp. e61903
-
-
Staiger, H.1
Böhm, A.2
Scheler, M.3
-
19
-
-
40749087319
-
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
-
COI: 1:CAS:528:DC%2BD1cXhvVOktLc%3D, PID: 18039816
-
Staiger H, Stančáková A, Zilinskaite J et al (2008) A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 57:514–517
-
(2008)
Diabetes
, vol.57
, pp. 514-517
-
-
Staiger, H.1
Stančáková, A.2
Zilinskaite, J.3
-
20
-
-
43249095915
-
SNP rs7754840 of CDKAL1 is associated with impaired insulin secretion in non-diabetic offspring of type 2 diabetic subjects (the EUGENE2 study) and in a large sample of men with normal glucose tolerance
-
PID: 18285412
-
Stancáková A, Pihlajamäki J, Kuusisto J et al (2008) SNP rs7754840 of CDKAL1 is associated with impaired insulin secretion in non-diabetic offspring of type 2 diabetic subjects (the EUGENE2 study) and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924–1930
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1924-1930
-
-
Stancáková, A.1
Pihlajamäki, J.2
Kuusisto, J.3
-
21
-
-
84862089177
-
Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-h postload plasma glucose levels
-
COI: 1:CAS:528:DC%2BC38Xmt1Chsbk%3D, PID: 22357182
-
Marini MA, Succurro E, Frontoni S et al (2012) Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-h postload plasma glucose levels. Diabetes Care 35:868–872
-
(2012)
Diabetes Care
, vol.35
, pp. 868-872
-
-
Marini, M.A.1
Succurro, E.2
Frontoni, S.3
-
22
-
-
0037622751
-
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients
-
COI: 1:CAS:528:DC%2BD3sXlslaiurw%3D, PID: 12843189
-
Marini MA, Frontoni S, Mineo D et al (2003) The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab 88:3368–3371
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3368-3371
-
-
Marini, M.A.1
Frontoni, S.2
Mineo, D.3
-
23
-
-
70350574189
-
Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis
-
COI: 1:CAS:528:DC%2BD1MXhtlyrur7P, PID: 19410252
-
Succurro E, Marini MA, Arturi F et al (2009) Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis. Atherosclerosis 207:245–249
-
(2009)
Atherosclerosis
, vol.207
, pp. 245-249
-
-
Succurro, E.1
Marini, M.A.2
Arturi, F.3
-
24
-
-
84880640561
-
Insulin clearance is associated with carotid artery intima–media thickness
-
COI: 1:CAS:528:DC%2BC3sXhtFCrsr%2FK, PID: 23880204
-
Marini MA, Frontoni S, Succurro E et al (2013) Insulin clearance is associated with carotid artery intima–media thickness. Atherosclerosis 229:453–458
-
(2013)
Atherosclerosis
, vol.229
, pp. 453-458
-
-
Marini, M.A.1
Frontoni, S.2
Succurro, E.3
-
25
-
-
33846031943
-
Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
-
COI: 1:CAS:528:DC%2BD2sXhsFWqtb4%3D, PID: 17192339
-
Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA (2007) Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care 30:89–94
-
(2007)
Diabetes Care
, vol.30
, pp. 89-94
-
-
Abdul-Ghani, M.A.1
Matsuda, M.2
Balas, B.3
DeFronzo, R.A.4
-
27
-
-
0019721421
-
Decreased insulin removal contributes to hyperinsulinemia in obesity
-
COI: 1:STN:280:DyaL3M3msVGqug%3D%3D, PID: 7021583
-
Faber OK, Christensen K, Kehlet H, Madsbad S, Binder C (1981) Decreased insulin removal contributes to hyperinsulinemia in obesity. J Clin Endocrinol Metab 53:618–621
-
(1981)
J Clin Endocrinol Metab
, vol.53
, pp. 618-621
-
-
Faber, O.K.1
Christensen, K.2
Kehlet, H.3
Madsbad, S.4
Binder, C.5
-
28
-
-
84886042353
-
Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels
-
COI: 1:CAS:528:DC%2BC3sXhslSjsrzJ, PID: 24194886
-
Marini MA, Frontoni S, Succurro E et al (2013) Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels. PLoS One 8:e77440
-
(2013)
PLoS One
, vol.8
, pp. e77440
-
-
Marini, M.A.1
Frontoni, S.2
Succurro, E.3
-
29
-
-
0033656589
-
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β cell response
-
COI: 1:CAS:528:DC%2BD3cXos1ejsL8%3D, PID: 11118015
-
Mittelman SD, Van Citters GW, Kim SP et al (2000) Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β cell response. Diabetes 49:2116–2125
-
(2000)
Diabetes
, vol.49
, pp. 2116-2125
-
-
Mittelman, S.D.1
Van Citters, G.W.2
Kim, S.P.3
-
30
-
-
0033531215
-
Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
-
PID: 9878640
-
O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22
-
(1999)
N Engl J Med
, vol.340
, pp. 14-22
-
-
O’Leary, D.H.1
Polak, J.F.2
Kronmal, R.A.3
Manolio, T.A.4
Burke, G.L.5
Wolfson, S.K.6
-
31
-
-
33646501931
-
Insulin resistance and atherosclerosis
-
COI: 1:CAS:528:DC%2BD28XlsFamsL0%3D, PID: 16492903
-
Nigro J, Osman N, Dart AM, Little PJ (2006) Insulin resistance and atherosclerosis. Endocr Rev 27:242–259
-
(2006)
Endocr Rev
, vol.27
, pp. 242-259
-
-
Nigro, J.1
Osman, N.2
Dart, A.M.3
Little, P.J.4
-
32
-
-
1842844426
-
Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen activated protein-kinase
-
COI: 1:CAS:528:DC%2BD2cXis1Ggsbo%3D, PID: 14762656
-
Madonna R, Pandolfi A, Massaro M, Consoli A, De Caterina R (2004) Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen activated protein-kinase. Diabetologia 47:532–536
-
(2004)
Diabetologia
, vol.47
, pp. 532-536
-
-
Madonna, R.1
Pandolfi, A.2
Massaro, M.3
Consoli, A.4
De Caterina, R.5
-
33
-
-
62449320334
-
Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling
-
COI: 1:CAS:528:DC%2BD1MXjtVyrurw%3D, PID: 19190820
-
Madonna R, De Caterina R (2009) Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling. Thromb Haemost 101:345–350
-
(2009)
Thromb Haemost
, vol.101
, pp. 345-350
-
-
Madonna, R.1
De Caterina, R.2
-
34
-
-
75149127688
-
Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues
-
COI: 1:CAS:528:DC%2BC3cXksFakuw%3D%3D, PID: 19745605
-
Koh YJ, Park BH, Park JH, Han J, Lee IK, Park JW, Koh GY (2009) Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues. Exp Mol Med 41:880–895
-
(2009)
Exp Mol Med
, vol.41
, pp. 880-895
-
-
Koh, Y.J.1
Park, B.H.2
Park, J.H.3
Han, J.4
Lee, I.K.5
Park, J.W.6
Koh, G.Y.7
-
35
-
-
84896727271
-
The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus
-
COI: 1:CAS:528:DC%2BC2cXislemsr0%3D, PID: 24370923
-
Daniele G, Guardado Mendoza R et al (2014) The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetol 51:123–131
-
(2014)
Acta Diabetol
, vol.51
, pp. 123-131
-
-
Daniele, G.1
Guardado Mendoza, R.2
-
36
-
-
84890120598
-
Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study
-
COI: 1:CAS:528:DC%2BC3sXhsVeisr3I, PID: 23811853
-
Tripathy D, Daniele G, Fiorentino TV et al (2013) Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study. Diabetologia 56:2153–2163
-
(2013)
Diabetologia
, vol.56
, pp. 2153-2163
-
-
Tripathy, D.1
Daniele, G.2
Fiorentino, T.V.3
|