메뉴 건너뛰기




Volumn 51, Issue 5, 2014, Pages 705-713

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

Author keywords

Insulin sensitivity; Intima media thickness; Irisin; Vascular atherosclerosis

Indexed keywords

CYTOKINE; INSULIN; IRISIN; UNCLASSIFIED DRUG; FIBRONECTIN; FNDC5 PROTEIN, HUMAN; GLUCOSE BLOOD LEVEL;

EID: 84919487162     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-014-0576-0     Document Type: Article
Times cited : (119)

References (36)
  • 1
  • 2
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • COI: 1:CAS:528:DC%2BD1MXht1OrtrrK, PID: 19805654
    • Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 3
    • 62849107573 scopus 로고    scopus 로고
    • Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
    • Prospective Studies Collaboration, Whitlock G, Lewington S et al (2009) Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 73:1083–1096
    • (2009) Lancet , vol.73 , pp. 1083-1096
    • Prospective Studies Collaboration1    Whitlock, G.2    Lewington, S.3
  • 4
    • 33747739430 scopus 로고    scopus 로고
    • Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    • COI: 1:CAS:528:DC%2BD28XosFGhs7s%3D, PID: 16735483
    • Meigs JB, Wilson PW, Fox CS et al (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91:2906–2912
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2906-2912
    • Meigs, J.B.1    Wilson, P.W.2    Fox, C.S.3
  • 5
    • 74949084667 scopus 로고    scopus 로고
    • Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
    • PID: 20038741
    • Arnlöv J, Ingelsson E, Sundström J, Lind L (2010) Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121(2):230–236
    • (2010) Circulation , vol.121 , Issue.2 , pp. 230-236
    • Arnlöv, J.1    Ingelsson, E.2    Sundström, J.3    Lind, L.4
  • 6
    • 21544462572 scopus 로고    scopus 로고
    • Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence
    • PID: 15983333
    • Ford ES (2005) Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 28:1769–1778
    • (2005) Diabetes Care , vol.28 , pp. 1769-1778
    • Ford, E.S.1
  • 7
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • COI: 1:STN:280:DyaL1M%2Flt12msQ%3D%3D, PID: 3056758
    • Reaven G (1988) Role of insulin resistance in human disease. Diabetes 37:1595–1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.1
  • 8
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • COI: 1:STN:280:DC%2BD3M3kvFejsA%3D%3D, PID: 11333990
    • Tuomilehto J, Lindström J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindström, J.2    Eriksson, J.G.3
  • 9
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: skeletal muscle as a secretory organ
    • COI: 1:CAS:528:DC%2BC38XhtVOmtLrJ, PID: 22473333
    • Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457–465
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 10
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • PID: 22237023
    • Boström P, Wu J, Jedrychowski MP et al (2012) A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
    • (2012) Nature , vol.481 , pp. 463-468
    • Boström, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 11
    • 84865512723 scopus 로고    scopus 로고
    • Is irisin a human exercise gene?
    • COI: 1:CAS:528:DC%2BC38Xht1yntbrK, PID: 22932392
    • Timmons JA, Baar K, Davidsen PK, Atherton PJ (2012) Is irisin a human exercise gene? Nature 488:E9–E10
    • (2012) Nature , vol.488 , pp. E9-E10
    • Timmons, J.A.1    Baar, K.2    Davidsen, P.K.3    Atherton, P.J.4
  • 12
    • 84869497609 scopus 로고    scopus 로고
    • FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    • COI: 1:CAS:528:DC%2BC38XhsVSlt7bK, PID: 23018146
    • Huh JY, Panagiotou G, Mougios V et al (2012) FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61:1725–1738
    • (2012) Metabolism , vol.61 , pp. 1725-1738
    • Huh, J.Y.1    Panagiotou, G.2    Mougios, V.3
  • 13
    • 84888879117 scopus 로고    scopus 로고
    • Circulating irisin in relation to insulin resistance and the metabolic syndrome
    • Hee Park K, Zaichenko L, Brinkoetter M et al (2013) Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 98:4899–4907
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4899-4907
    • Hee Park, K.1    Zaichenko, L.2    Brinkoetter, M.3
  • 14
    • 84871587312 scopus 로고    scopus 로고
    • Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index
    • COI: 1:CAS:528:DC%2BC3sXitlejsLc%3D, PID: 23219488
    • Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides 39:125–130
    • (2013) Peptides , vol.39 , pp. 125-130
    • Stengel, A.1    Hofmann, T.2    Goebel-Stengel, M.3    Elbelt, U.4    Kobelt, P.5    Klapp, B.F.6
  • 15
    • 84879915581 scopus 로고    scopus 로고
    • Lower circulating irisin is associated with type 2 diabetes mellitus
    • PID: 23619195
    • Liu JJ, Wong MD, Toy WC et al (2013) Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complicat 27:365–369
    • (2013) J Diabetes Complicat , vol.27 , pp. 365-369
    • Liu, J.J.1    Wong, M.D.2    Toy, W.C.3
  • 16
    • 84876222786 scopus 로고    scopus 로고
    • Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    • COI: 1:CAS:528:DC%2BC3sXmtFegsr0%3D, PID: 23436919
    • Moreno-Navarrete JM, Ortega F, Serrano M et al (2013) Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 98:E769–E778
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E769-E778
    • Moreno-Navarrete, J.M.1    Ortega, F.2    Serrano, M.3
  • 17
    • 84876736157 scopus 로고    scopus 로고
    • Serum irisin levels in new-onset type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFSqtbc%3D, PID: 23369227
    • Choi YK, Kim MK, Bae KH et al (2013) Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 100:96–101
    • (2013) Diabetes Res Clin Pract , vol.100 , pp. 96-101
    • Choi, Y.K.1    Kim, M.K.2    Bae, K.H.3
  • 18
    • 84876744461 scopus 로고    scopus 로고
    • Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity
    • Staiger H, Böhm A, Scheler M et al (2013) Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity. PLoS One 25(8):e61903
    • (2013) PLoS One , vol.25 , Issue.8 , pp. e61903
    • Staiger, H.1    Böhm, A.2    Scheler, M.3
  • 19
    • 40749087319 scopus 로고    scopus 로고
    • A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    • COI: 1:CAS:528:DC%2BD1cXhvVOktLc%3D, PID: 18039816
    • Staiger H, Stančáková A, Zilinskaite J et al (2008) A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 57:514–517
    • (2008) Diabetes , vol.57 , pp. 514-517
    • Staiger, H.1    Stančáková, A.2    Zilinskaite, J.3
  • 20
    • 43249095915 scopus 로고    scopus 로고
    • SNP rs7754840 of CDKAL1 is associated with impaired insulin secretion in non-diabetic offspring of type 2 diabetic subjects (the EUGENE2 study) and in a large sample of men with normal glucose tolerance
    • PID: 18285412
    • Stancáková A, Pihlajamäki J, Kuusisto J et al (2008) SNP rs7754840 of CDKAL1 is associated with impaired insulin secretion in non-diabetic offspring of type 2 diabetic subjects (the EUGENE2 study) and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924–1930
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1924-1930
    • Stancáková, A.1    Pihlajamäki, J.2    Kuusisto, J.3
  • 21
    • 84862089177 scopus 로고    scopus 로고
    • Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-h postload plasma glucose levels
    • COI: 1:CAS:528:DC%2BC38Xmt1Chsbk%3D, PID: 22357182
    • Marini MA, Succurro E, Frontoni S et al (2012) Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-h postload plasma glucose levels. Diabetes Care 35:868–872
    • (2012) Diabetes Care , vol.35 , pp. 868-872
    • Marini, M.A.1    Succurro, E.2    Frontoni, S.3
  • 22
    • 0037622751 scopus 로고    scopus 로고
    • The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BD3sXlslaiurw%3D, PID: 12843189
    • Marini MA, Frontoni S, Mineo D et al (2003) The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab 88:3368–3371
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3368-3371
    • Marini, M.A.1    Frontoni, S.2    Mineo, D.3
  • 23
    • 70350574189 scopus 로고    scopus 로고
    • Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis
    • COI: 1:CAS:528:DC%2BD1MXhtlyrur7P, PID: 19410252
    • Succurro E, Marini MA, Arturi F et al (2009) Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis. Atherosclerosis 207:245–249
    • (2009) Atherosclerosis , vol.207 , pp. 245-249
    • Succurro, E.1    Marini, M.A.2    Arturi, F.3
  • 24
    • 84880640561 scopus 로고    scopus 로고
    • Insulin clearance is associated with carotid artery intima–media thickness
    • COI: 1:CAS:528:DC%2BC3sXhtFCrsr%2FK, PID: 23880204
    • Marini MA, Frontoni S, Succurro E et al (2013) Insulin clearance is associated with carotid artery intima–media thickness. Atherosclerosis 229:453–458
    • (2013) Atherosclerosis , vol.229 , pp. 453-458
    • Marini, M.A.1    Frontoni, S.2    Succurro, E.3
  • 25
    • 33846031943 scopus 로고    scopus 로고
    • Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
    • COI: 1:CAS:528:DC%2BD2sXhsFWqtb4%3D, PID: 17192339
    • Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA (2007) Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care 30:89–94
    • (2007) Diabetes Care , vol.30 , pp. 89-94
    • Abdul-Ghani, M.A.1    Matsuda, M.2    Balas, B.3    DeFronzo, R.A.4
  • 27
    • 0019721421 scopus 로고
    • Decreased insulin removal contributes to hyperinsulinemia in obesity
    • COI: 1:STN:280:DyaL3M3msVGqug%3D%3D, PID: 7021583
    • Faber OK, Christensen K, Kehlet H, Madsbad S, Binder C (1981) Decreased insulin removal contributes to hyperinsulinemia in obesity. J Clin Endocrinol Metab 53:618–621
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 618-621
    • Faber, O.K.1    Christensen, K.2    Kehlet, H.3    Madsbad, S.4    Binder, C.5
  • 28
    • 84886042353 scopus 로고    scopus 로고
    • Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels
    • COI: 1:CAS:528:DC%2BC3sXhslSjsrzJ, PID: 24194886
    • Marini MA, Frontoni S, Succurro E et al (2013) Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels. PLoS One 8:e77440
    • (2013) PLoS One , vol.8 , pp. e77440
    • Marini, M.A.1    Frontoni, S.2    Succurro, E.3
  • 29
    • 0033656589 scopus 로고    scopus 로고
    • Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β cell response
    • COI: 1:CAS:528:DC%2BD3cXos1ejsL8%3D, PID: 11118015
    • Mittelman SD, Van Citters GW, Kim SP et al (2000) Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β cell response. Diabetes 49:2116–2125
    • (2000) Diabetes , vol.49 , pp. 2116-2125
    • Mittelman, S.D.1    Van Citters, G.W.2    Kim, S.P.3
  • 30
    • 0033531215 scopus 로고    scopus 로고
    • Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    • PID: 9878640
    • O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22
    • (1999) N Engl J Med , vol.340 , pp. 14-22
    • O’Leary, D.H.1    Polak, J.F.2    Kronmal, R.A.3    Manolio, T.A.4    Burke, G.L.5    Wolfson, S.K.6
  • 31
    • 33646501931 scopus 로고    scopus 로고
    • Insulin resistance and atherosclerosis
    • COI: 1:CAS:528:DC%2BD28XlsFamsL0%3D, PID: 16492903
    • Nigro J, Osman N, Dart AM, Little PJ (2006) Insulin resistance and atherosclerosis. Endocr Rev 27:242–259
    • (2006) Endocr Rev , vol.27 , pp. 242-259
    • Nigro, J.1    Osman, N.2    Dart, A.M.3    Little, P.J.4
  • 32
    • 1842844426 scopus 로고    scopus 로고
    • Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen activated protein-kinase
    • COI: 1:CAS:528:DC%2BD2cXis1Ggsbo%3D, PID: 14762656
    • Madonna R, Pandolfi A, Massaro M, Consoli A, De Caterina R (2004) Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen activated protein-kinase. Diabetologia 47:532–536
    • (2004) Diabetologia , vol.47 , pp. 532-536
    • Madonna, R.1    Pandolfi, A.2    Massaro, M.3    Consoli, A.4    De Caterina, R.5
  • 33
    • 62449320334 scopus 로고    scopus 로고
    • Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling
    • COI: 1:CAS:528:DC%2BD1MXjtVyrurw%3D, PID: 19190820
    • Madonna R, De Caterina R (2009) Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling. Thromb Haemost 101:345–350
    • (2009) Thromb Haemost , vol.101 , pp. 345-350
    • Madonna, R.1    De Caterina, R.2
  • 34
    • 75149127688 scopus 로고    scopus 로고
    • Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues
    • COI: 1:CAS:528:DC%2BC3cXksFakuw%3D%3D, PID: 19745605
    • Koh YJ, Park BH, Park JH, Han J, Lee IK, Park JW, Koh GY (2009) Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues. Exp Mol Med 41:880–895
    • (2009) Exp Mol Med , vol.41 , pp. 880-895
    • Koh, Y.J.1    Park, B.H.2    Park, J.H.3    Han, J.4    Lee, I.K.5    Park, J.W.6    Koh, G.Y.7
  • 35
    • 84896727271 scopus 로고    scopus 로고
    • The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXislemsr0%3D, PID: 24370923
    • Daniele G, Guardado Mendoza R et al (2014) The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetol 51:123–131
    • (2014) Acta Diabetol , vol.51 , pp. 123-131
    • Daniele, G.1    Guardado Mendoza, R.2
  • 36
    • 84890120598 scopus 로고    scopus 로고
    • Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study
    • COI: 1:CAS:528:DC%2BC3sXhsVeisr3I, PID: 23811853
    • Tripathy D, Daniele G, Fiorentino TV et al (2013) Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study. Diabetologia 56:2153–2163
    • (2013) Diabetologia , vol.56 , pp. 2153-2163
    • Tripathy, D.1    Daniele, G.2    Fiorentino, T.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.