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Volumn 24, Issue 6, 2014, Pages 221-226

The complex relationship between obesity and the somatropic axis: The long and winding road

Author keywords

Body composition; Cardio metabolic risk; Obesity and GH IGF 1 axis

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C; HUMAN GROWTH HORMONE;

EID: 84919483077     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2014.09.002     Document Type: Review
Times cited : (64)

References (66)
  • 1
    • 78149366451 scopus 로고    scopus 로고
    • The GH/IGF-1 axis in growth and development: new insights derived from animal models
    • Cannata D., Vijayakumar A., Fierz Y., LeRoith D. The GH/IGF-1 axis in growth and development: new insights derived from animal models. Adv. Pediatr. 2010, 57:331-351.
    • (2010) Adv. Pediatr. , vol.57 , pp. 331-351
    • Cannata, D.1    Vijayakumar, A.2    Fierz, Y.3    LeRoith, D.4
  • 2
    • 0028922330 scopus 로고
    • Influence of metabolic substrates and obesity on growth hormone secretion
    • Dieguez C., Casanueva F.F. Influence of metabolic substrates and obesity on growth hormone secretion. Trends Endocrinol. Metab. 1995, 6:55-59.
    • (1995) Trends Endocrinol. Metab. , vol.6 , pp. 55-59
    • Dieguez, C.1    Casanueva, F.F.2
  • 3
    • 84555183257 scopus 로고    scopus 로고
    • The intricate role of growth hormone in metabolism
    • (Lausanne)
    • Vijayakumar A., Yakar S., LeRoith D. The intricate role of growth hormone in metabolism. Front. Endocrinol. 2011, 2:1-11. (Lausanne).
    • (2011) Front. Endocrinol. , vol.2 , pp. 1-11
    • Vijayakumar, A.1    Yakar, S.2    LeRoith, D.3
  • 4
    • 0008193290 scopus 로고
    • Growth hormone content of pituitaries from rats with hypothalamic lesions
    • Reichlin S. Growth hormone content of pituitaries from rats with hypothalamic lesions. Endocrinology 1961, 69:225-230.
    • (1961) Endocrinology , vol.69 , pp. 225-230
    • Reichlin, S.1
  • 8
    • 72449124122 scopus 로고    scopus 로고
    • Obesity, growth hormone and weight loss
    • Rasmussen M.H. Obesity, growth hormone and weight loss. Mol. Cell. Endocrinol. 2010, 316:147-153.
    • (2010) Mol. Cell. Endocrinol. , vol.316 , pp. 147-153
    • Rasmussen, M.H.1
  • 9
    • 84879117813 scopus 로고    scopus 로고
    • The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
    • Berryman D.E., Gla C.A., List E.O., Johannsson G. The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat. Rev. Endocrinol. 2013, 9:346-356.
    • (2013) Nat. Rev. Endocrinol. , vol.9 , pp. 346-356
    • Berryman, D.E.1    Gla, C.A.2    List, E.O.3    Johannsson, G.4
  • 10
    • 79956291628 scopus 로고    scopus 로고
    • Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline
    • Molitch M.E., Clemmons D.R., Malozowski S., Merriam G.R., Vance M.L., Endocrine Society Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011, 96:1587-1609.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1587-1609
    • Molitch, M.E.1    Clemmons, D.R.2    Malozowski, S.3    Merriam, G.R.4    Vance, M.L.5
  • 11
    • 84875468539 scopus 로고    scopus 로고
    • New aspects of the physiology of the GH-IGF-1 axis
    • Vottero A., Guzzetti C., Loche S. New aspects of the physiology of the GH-IGF-1 axis. Endocr. Dev. 2013, 24:96-105.
    • (2013) Endocr. Dev. , vol.24 , pp. 96-105
    • Vottero, A.1    Guzzetti, C.2    Loche, S.3
  • 13
    • 4444284454 scopus 로고    scopus 로고
    • Free insulin-like growth factors: measurements and relationships to growth hormone secretion and glucose homeostasis
    • Frystyk J. Free insulin-like growth factors: measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Hormon. IGF Res. 2004, 14:337-375.
    • (2004) Growth Hormon. IGF Res. , vol.14 , pp. 337-375
    • Frystyk, J.1
  • 15
    • 84903576507 scopus 로고    scopus 로고
    • Minireview: mechanisms of growth hormone-mediated gene regulation
    • Chia D.J. Minireview: mechanisms of growth hormone-mediated gene regulation. Mol. Endocrinol. 2014, 28:1012-1025.
    • (2014) Mol. Endocrinol. , vol.28 , pp. 1012-1025
    • Chia, D.J.1
  • 16
    • 77955613356 scopus 로고    scopus 로고
    • The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins
    • Ahmed S.F., Farquharson C. The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins. J. Endocrinol. 2010, 206:249-259.
    • (2010) J. Endocrinol. , vol.206 , pp. 249-259
    • Ahmed, S.F.1    Farquharson, C.2
  • 17
    • 84904700684 scopus 로고    scopus 로고
    • Growth hormone (GH) differentially regulates NF-kB activity in preadipocytes and macrophages: implications for GH's role in adipose tissue homeostasis in obesity
    • Kumar P.A., Chitra P.S., Lu C., Sobhanaditya J., Menon R. Growth hormone (GH) differentially regulates NF-kB activity in preadipocytes and macrophages: implications for GH's role in adipose tissue homeostasis in obesity. J. Physiol. Biochem. 2014, 70:433-440.
    • (2014) J. Physiol. Biochem. , vol.70 , pp. 433-440
    • Kumar, P.A.1    Chitra, P.S.2    Lu, C.3    Sobhanaditya, J.4    Menon, R.5
  • 18
    • 77956988551 scopus 로고    scopus 로고
    • The IGF-I regulatory system and its impact on skeletal and energy homeostasis
    • Kawai M., Rosen C.J. The IGF-I regulatory system and its impact on skeletal and energy homeostasis. J. Cell. Biochem. 2010, 111:14-19.
    • (2010) J. Cell. Biochem. , vol.111 , pp. 14-19
    • Kawai, M.1    Rosen, C.J.2
  • 22
    • 10344237010 scopus 로고    scopus 로고
    • The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study
    • Colao A., Di Somma C., Cuocolo A., Filippella M., Rota F., Acampa W., Savastano S., Salvatore M., Lombardi G. The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. J. Clin. Endocrinol. Metab. 2004, 89:5998-6004.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5998-6004
    • Colao, A.1    Di Somma, C.2    Cuocolo, A.3    Filippella, M.4    Rota, F.5    Acampa, W.6    Savastano, S.7    Salvatore, M.8    Lombardi, G.9
  • 23
    • 84902493825 scopus 로고    scopus 로고
    • Efficacy and safety of growth hormone treatment in adults with growth hormone deficiency: a systematic review of studies on morbidity
    • (Oxf)
    • van Bunderen C.C., van Varsseveld N.C., Erfurth E.M., Ket J.C., Drent M.L. Efficacy and safety of growth hormone treatment in adults with growth hormone deficiency: a systematic review of studies on morbidity. Clin. Endocrinol. 2014, 81:1-14. (Oxf).
    • (2014) Clin. Endocrinol. , vol.81 , pp. 1-14
    • van Bunderen, C.C.1    van Varsseveld, N.C.2    Erfurth, E.M.3    Ket, J.C.4    Drent, M.L.5
  • 24
    • 0347720717 scopus 로고    scopus 로고
    • Endocrine and metabolic aspects of adult Prader-Willi syndrome with special emphasis on the effect of growth hormone treatment
    • Höybye C. Endocrine and metabolic aspects of adult Prader-Willi syndrome with special emphasis on the effect of growth hormone treatment. Growth Hormon. IGF Res. 2004, 14:1-15.
    • (2004) Growth Hormon. IGF Res. , vol.14 , pp. 1-15
    • Höybye, C.1
  • 25
    • 42249094576 scopus 로고    scopus 로고
    • Prader-Willi syndrome: who can have growth hormone?
    • Stafler P., Wallis C. Prader-Willi syndrome: who can have growth hormone?. Arch. Dis. Child. 2008, 93:341-345.
    • (2008) Arch. Dis. Child. , vol.93 , pp. 341-345
    • Stafler, P.1    Wallis, C.2
  • 28
    • 47549103137 scopus 로고    scopus 로고
    • Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women
    • Utz A.L., Yamamoto A., Hemphill L., Miller K.K. Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. J. Clin. Endocrinol. Metab. 2008, 93:2507-2514.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 2507-2514
    • Utz, A.L.1    Yamamoto, A.2    Hemphill, L.3    Miller, K.K.4
  • 30
    • 84855428936 scopus 로고    scopus 로고
    • Reduced growth hormone secretion in obesity is associated with smaller LDL and HDL particle size
    • (Oxf)
    • Makimura H., Feldpausch M.N., Stanley T.L., Sun N., Grinspoon S.K. Reduced growth hormone secretion in obesity is associated with smaller LDL and HDL particle size. Clin. Endocrinol. 2012, 76:220-227. (Oxf).
    • (2012) Clin. Endocrinol. , vol.76 , pp. 220-227
    • Makimura, H.1    Feldpausch, M.N.2    Stanley, T.L.3    Sun, N.4    Grinspoon, S.K.5
  • 33
    • 57349141683 scopus 로고    scopus 로고
    • The effects of central adiposity on growth hormone (GH) response to GH-releasing hormone-arginine stimulation testing in men
    • Makimura H., Stanley T.L., Mun D., You S.M., Grinspoon S.K. The effects of central adiposity on growth hormone (GH) response to GH-releasing hormone-arginine stimulation testing in men. J. Clin. Endocrinol. Metab. 2008, 93:4254-4260.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4254-4260
    • Makimura, H.1    Stanley, T.L.2    Mun, D.3    You, S.M.4    Grinspoon, S.K.5
  • 34
    • 0029935185 scopus 로고    scopus 로고
    • Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression
    • Cordido F., Peino R., Peñalva A., Alvarez C.V., Casanueva F.F., Dieguez C. Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression. J. Clin. Endocrinol. Metab. 1996, 81:914-918.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 914-918
    • Cordido, F.1    Peino, R.2    Peñalva, A.3    Alvarez, C.V.4    Casanueva, F.F.5    Dieguez, C.6
  • 37
    • 0025787687 scopus 로고
    • Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
    • Iranmanesh A., Lizarralde G., Veldhuis J.D. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J. Clin. Endocrinol. Metab. 1991, 73:1081-1088.
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 1081-1088
    • Iranmanesh, A.1    Lizarralde, G.2    Veldhuis, J.D.3
  • 38
    • 54049143241 scopus 로고    scopus 로고
    • Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects
    • Colao A., Di Somma C., Cascella T., Pivonello R., Vitale G., Grasso L.F., Lombardi G., Savastano S. Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects. Eur. J. Endocrinol. 2008, 159:389-397.
    • (2008) Eur. J. Endocrinol. , vol.159 , pp. 389-397
    • Colao, A.1    Di Somma, C.2    Cascella, T.3    Pivonello, R.4    Vitale, G.5    Grasso, L.F.6    Lombardi, G.7    Savastano, S.8
  • 39
    • 84862909334 scopus 로고    scopus 로고
    • The insulin-like growth factor system, metabolic syndrome, and cardiovascular disease risk
    • Akanji A.O., Smith R.J. The insulin-like growth factor system, metabolic syndrome, and cardiovascular disease risk. Metab. Syndr. Relat. Disord. 2012, 10:3-13.
    • (2012) Metab. Syndr. Relat. Disord. , vol.10 , pp. 3-13
    • Akanji, A.O.1    Smith, R.J.2
  • 40
    • 0043198265 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factor I and its binding proteins in health and disease
    • Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Hormon. IGF Res. 2003, 13:113-170.
    • (2003) Growth Hormon. IGF Res. , vol.13 , pp. 113-170
    • Juul, A.1
  • 42
    • 34248350385 scopus 로고    scopus 로고
    • Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism
    • Rasmussen M.H., Juul A., Hilsted J. Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism. Obesity (Silver Spring) 2007, 15:879-886.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 879-886
    • Rasmussen, M.H.1    Juul, A.2    Hilsted, J.3
  • 45
    • 78049503241 scopus 로고    scopus 로고
    • Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance
    • Tarantino G., Savastano S., Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J. Gastroenterol. 2010, 16:4773-4783.
    • (2010) World J. Gastroenterol. , vol.16 , pp. 4773-4783
    • Tarantino, G.1    Savastano, S.2    Colao, A.3
  • 49
    • 77949271602 scopus 로고    scopus 로고
    • Relationship between growth hormone/insulin-like growth factor-1 axis integrity and voluntary weight loss after gastric banding surgery for severe obesity
    • Savastano S., Angrisani L., Di Somma C., Rota F., Savanelli M.C., Cascella T., Orio F., Lombardi G., Colao A. Relationship between growth hormone/insulin-like growth factor-1 axis integrity and voluntary weight loss after gastric banding surgery for severe obesity. Obes. Surg. 2010, 20:211-220.
    • (2010) Obes. Surg. , vol.20 , pp. 211-220
    • Savastano, S.1    Angrisani, L.2    Di Somma, C.3    Rota, F.4    Savanelli, M.C.5    Cascella, T.6    Orio, F.7    Lombardi, G.8    Colao, A.9
  • 53
    • 84876491565 scopus 로고    scopus 로고
    • Preoperative prediction of growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis modification and postoperative changes in candidates for bariatric surgery
    • Mittempergher F., Pata G., Crea N., Di Betta E., Vilardi A., Chiesa D., Nascimbeni R. Preoperative prediction of growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis modification and postoperative changes in candidates for bariatric surgery. Obes. Surg. 2013, 23:594-601.
    • (2013) Obes. Surg. , vol.23 , pp. 594-601
    • Mittempergher, F.1    Pata, G.2    Crea, N.3    Di Betta, E.4    Vilardi, A.5    Chiesa, D.6    Nascimbeni, R.7
  • 56
    • 73249117063 scopus 로고    scopus 로고
    • Effect of body mass index on peak growth hormone response to provocative testing in children with short stature
    • Stanley T.L., Levitsky L.L., Grinspoon S.K., Misra M. Effect of body mass index on peak growth hormone response to provocative testing in children with short stature. J. Clin. Endocrinol. Metab. 2009, 94:4875-4881.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 4875-4881
    • Stanley, T.L.1    Levitsky, L.L.2    Grinspoon, S.K.3    Misra, M.4
  • 57
    • 61949335122 scopus 로고    scopus 로고
    • Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis
    • Bredella M.A., Utz A.L., Torriani M., Thomas B., Schoenfeld D.A., Miller K.K. Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis. J. Appl. Physiol. 2009, 106:418-422.
    • (2009) J. Appl. Physiol. , vol.106 , pp. 418-422
    • Bredella, M.A.1    Utz, A.L.2    Torriani, M.3    Thomas, B.4    Schoenfeld, D.A.5    Miller, K.K.6
  • 60
    • 84916640280 scopus 로고    scopus 로고
    • Overweight/obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency
    • (Sep 11:jc20142830. [Epub ahead of print])
    • Dichtel L.E., Yuen K.C., Bredella M.A., Gerweck A.V., Russell B.M., Riccio A.D., Gurel M.H., Sluss P.M., Biller B.M., Miller K.K. Overweight/obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency. Clin. Endocrinol. Metab. 2014, (Sep 11:jc20142830. [Epub ahead of print]).
    • (2014) Clin. Endocrinol. Metab.
    • Dichtel, L.E.1    Yuen, K.C.2    Bredella, M.A.3    Gerweck, A.V.4    Russell, B.M.5    Riccio, A.D.6    Gurel, M.H.7    Sluss, P.M.8    Biller, B.M.9    Miller, K.K.10
  • 61
    • 84877699941 scopus 로고    scopus 로고
    • Approach to testing growth hormone (GH) secretion in obese subjects
    • Popovic V. Approach to testing growth hormone (GH) secretion in obese subjects. J. Clin. Endocrinol. Metab. 2013, 98:1789-1796.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1789-1796
    • Popovic, V.1
  • 62
    • 84901019548 scopus 로고    scopus 로고
    • The relationship between subnormal peak-stimulated growth hormone levels and auxological characteristics in obese children
    • (Lausanne)
    • Barrett J., Maranda L., Nwosu B.U. The relationship between subnormal peak-stimulated growth hormone levels and auxological characteristics in obese children. Front. Endocrinol. 2014, 5:35-41. (Lausanne).
    • (2014) Front. Endocrinol. , vol.5 , pp. 35-41
    • Barrett, J.1    Maranda, L.2    Nwosu, B.U.3
  • 63
    • 58149387611 scopus 로고    scopus 로고
    • Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis
    • Mekala K.C., Tritos N.A. Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis. J. Clin. Endocrinol. Metab. 2009, 94:130-137.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 130-137
    • Mekala, K.C.1    Tritos, N.A.2
  • 64
    • 84907660082 scopus 로고    scopus 로고
    • Short-term low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency
    • Yuen K.C., Jr Roberts C.T., Frystyk J., Rooney W.D., Pollaro J.R., Klopfenstein B.J., Purnell J.Q. Short-term low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency. J. Clin. Endocrinol. Metab. 2014, 99:1862-1869.
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. 1862-1869
    • Yuen, K.C.1    Jr Roberts, C.T.2    Frystyk, J.3    Rooney, W.D.4    Pollaro, J.R.5    Klopfenstein, B.J.6    Purnell, J.Q.7
  • 65
    • 62349133356 scopus 로고    scopus 로고
    • Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese patients: results of a pilot, open, prospective, randomized, controlled study
    • Savastano S., Di Somma C., Angrisani L., Orio F., Longobardi S., Lombardi G., Colao A. Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese patients: results of a pilot, open, prospective, randomized, controlled study. J. Clin. Endocrinol. Metab. 2009, 94:817-826.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 817-826
    • Savastano, S.1    Di Somma, C.2    Angrisani, L.3    Orio, F.4    Longobardi, S.5    Lombardi, G.6    Colao, A.7
  • 66
    • 84870753316 scopus 로고    scopus 로고
    • Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial
    • Makimura H., Feldpausch M.H., Rope A.M., Hemphill L.C., Torriani M., Lee H., Grinspoon S.K. Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial. J. Clin. Endocrinol. Metab. 2012, 97:4769-4779.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 4769-4779
    • Makimura, H.1    Feldpausch, M.H.2    Rope, A.M.3    Hemphill, L.C.4    Torriani, M.5    Lee, H.6    Grinspoon, S.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.