Effects of recombinant human growth hormone therapy in obesity in adults: A metaanalysis

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 1, 2009, Pages 130-137

  Mekala, Kavya C ^a,b   Tritos, Nicholas A ^a,b  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN GROWTH HORMONE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ARTHRALGIA; ARTICLE; BIBLIOGRAPHIC DATABASE; BODY COMPOSITION; BODY FAT; BODY FAT DISTRIBUTION; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HEMOGLOBIN BLOOD LEVEL; HORMONAL THERAPY; HUMAN; INSULIN BLOOD LEVEL; INSULINEMIA; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; META ANALYSIS; OBESITY; PARESTHESIA; PERIPHERAL EDEMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYSTEMATIC REVIEW; TREATMENT DURATION; WEIGHT REDUCTION;

EID: 58149387611     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1357     Document Type: Article

References (40)

1. Montague CT, O'Rahilly S 2000 The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49:883-888
2. Scacchi M, Pincelli AI, Cavagnini F 1999 Growth hormone in obesity. Int J Obes Relat Metab Disord 23:260-271
3. Slavin BG, Ong JM, Kern PA 1994 Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J Lipid Res 35:1535-1541
4. Murray RD, Shalet SM 2000 Growth hormone: current and future therapeutic applications. Expert Opin Pharmacother 1:975-990
5. Higgins JP, Thompson SG 2002 Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558
6. DerSimonian R, Laird N 1986 Meta-analysis in clinical trials. Control Clin Trials 7:177-188
7. Ahn CW, Kim CS, Nam JH, Kim HJ, Nam JS, Park JS, Kang ES, Cha BS, Lim SK, Kim KR, Lee HC, Huh KB 2006 Effects of growth hormone on insulin resistance and atherosclerotic risk factors in obese type 2 diabetic patients with poor glycaemic control. Clin Endocrinol (Oxf) 64:444-449
8. Albert SG, Mooradian AD 2004 Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity. J Clin Endocrinol Metab 89:695-701
9. Attallah H, Friedlander AL, Nino-Murcia M, Hoffman AR 2007 Effects of growth hormone and pioglitazone in viscerally obese adults with impaired glucose tolerance: a factorial clinical trial. PLoS Clin Trials 2:e21
10. Clemmons DR, Snyder DK, Williams R, Underwood LE 1987 Growth hormone administration conserves lean body mass during dietary restriction in obese subjects. J Clin Endocrinol Metab 64:878-883
11. Drent ML, Wever LD, Ader HJ, van der Veen EA 1995 Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects. Eur J Endocrinol 132:565-572
12. Franco C, Brandberg J, Lonn L, Andersson B, Bengtsson BA, Johannsson G 2005 Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. J Clin Endocrinol Metab 90:1466-1474
13. Halpern A, Mancini MC, Cercato C, Villares SM, Costa AP 2006 [Effects of growth hormone on anthropometric and metabolic parameters in android obesity]. Arq Bras Endocrinol Metabol 50:68-73 (Portuguese)
14. Herrmann BL, Berg C, Vogel E, Nowak T, Renzing-Koehler K, Mann K, Saller B 2004 Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome. Horm Metab Res 36:54-61
15. Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, Bengtsson BA 1997 Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82:727-734
16. Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB 1999 Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. Horm Res 51:78-84
17. Nam SY, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB 2001 Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int J Obes Relat Metab Disord 25:1101-1107
18. Pasarica M, Zachwieja JJ, Dejonge L, Redman S, Smith SR 2007 Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity. J Clin Endocrinol Metab 92:4265-4270
19. Richelsen B, Pedersen SB, Borglum JD, Moller-Pedersen T, Jorgensen J, Jorgensen JO 1994 Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity. Am J Physiol 266:E211-E216
20. Richelsen B, Pedersen SB, Kristensen K, Borglum JD, Norrelund H, Christiansen JS, Jorgensen JO 2000 Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. Metabolism 49:906-911
21. Sartorio A, Maffiuletti NA, Agosti F, Marinone PG, Ottolini S, Lafortuna CL 2004 Body mass reduction markedly improves muscle performance and body composition in obese females aged 61-75 years: comparison between the effects exerted by energy-restricted diet plus moderate aerobic-strength training alone or associated with rGH or nandrolone undecanoate. Eur J Endocrinol 150:511-515
22. Skaggs SR, Crist DM 1991 Exogenous human growth hormone reduces body fat in obese women. Horm Res 35:19-24
23. Snyder DK, Clemmons DR, Underwood LE 1988 Treatment of obese, diet-restricted subjects with growth hormone for 11 weeks: effects on anabolism, lipolysis, and body composition. J Clin Endocrinol Metab 67:54-61
24. Snyder DK, Clemmons DR, Underwood LE 1989 Dietary carbohydrate content determines responsiveness to growth hormone in energy-restricted humans. J Clin Endocrinol Metab 69:745-752
25. Snyder DK, Underwood LE, Clemmons DR 1990 Anabolic effects of growth hormone in obese diet-restricted subjects are dose dependent. Am J Clin Nutr 52:431-437
26. Snyder DK, Underwood LE, Clemmons DR 1995 Persistent lipolytic effect of exogenous growth hormone during caloric restriction. Am J Med 98:129-134
27. Tagliaferri M, Scacchi M, Pincelli AI, Berselli ME, Silvestri P, Montesano A, Ortolani S, Dubini A, Cavagnini F 1998 Metabolic effects of biosynthetic growth hormone treatment in severely energy-restricted obese women. Int J Obes Relat Metab Disord 22:836-841
28. Thompson JL, Butterfield GE, Gylfadottir UK, Yesavage J, Marcus R, Hintz RL, Pearman A, Hoffman AR 1998 Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. J Clin Endocrinol Metab 83:1477-1484
29. Tomlinson JW, Crabtree N, Clark PM, Holder G, Toogood AA, Shackleton CH, Stewart PM 2003 Low-dose growth hormone inhibits 11β-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity. J Clin Endocrinol Metab 88:2113-2118
30. Vestergaard P, Borglum J, Heickendorff L, Mosekilde L, Richelsen B 2000 Artifact in bone mineral measurements during a very low calorie diet: short-term effects of growth hormone. J Clin Densitom 3:63-71
31. Martin RJ, Drewry M, Jewell D, Harris RB, Young R, Patton JS 1989 Growth hormone treatment reduces total body fat accumulation in Zucker obese rats. Int J Obes 13:327-335
32. Johansen T, Laurino C, Barreca A, Malmlof K 2005 Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling. Growth Horm IGF Res 15:55-63
33. Azain MJ, Broderson JR, Martin RJ 2006 Effect of long-term somatotropin treatment on body composition and life span in aging obese Zucker rats. Exp Biol Med (Maywood) 231:76-83
34. Azain MJ, Hausman DB, Kasser TR, Martin RJ 1995 Effect of somatotropin and feed restriction on body composition and adipose metabolism in obese Zucker rats. Am J Physiol 269:E137-E144
35. Dieguez C, Carro E, Seoane LM, Garcia M, Camina JP, Senaris R, Popovic V, Casanueva FF 2000 Regulation of somatotroph cell function by the adipose tissue. Int J Obes Relat Metab Disord 24(Suppl 2):S100-S103
36. Iranmanesh A, Lizarralde G, Veldhuis JD 1991 Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 73:1081-1088
37. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sonksen PH, Tanaka T, Thorne M 1998 Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 83:382-395
38. Carroll PV, Christ ER, Sonksen PH 2000 Growth hormone replacement in adults with growth hormone deficiency: assessment of current knowledge. Trends Endocrinol Metab 11:231-238
39. Beauregard C, Utz A, Schaub AE, Nachtigall L, Biller BM, Miller KK, Klibanski A 2008 Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study. J Clin Endocrinol Metab 93:2063-2071
40. Falutz J, Allas S, Blot K, Potvin D, Kotler D, Somero M, Berger D, Brown S, Richmond G, Fessel J, Turner R, Grinspoon S 2007 Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med 357:2359-2370