Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese Patients: Results of a pilot, open, prospective, randomized, controlled study

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 3, 2009, Pages 817-826

  Savastano, Silvia ^a   Di Somma, Carolina ^a   Angrisani, Luigi ^b   Orio, Francesco ^a,c   Longobardi, Salvatore ^d   Lombardi, Gaetano ^a   Colao, Annamaria ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b General and Laparoscopic Surgery Unit   (Italy)

^c UNIVERSITY OF NAPLES PARTHENOPE   (Italy)

^d Department of Medical Affairs Merck Serono Italia ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN GROWTH HORMONE; INSULIN; RECOMBINANT GROWTH HORMONE;

ARTICLE; BARIATRIC SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; EXERCISE; FEMALE; FOLLOW UP; GASTRIC BANDING; GLUCOSE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LEAN BODY WEIGHT; MORBIDITY; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; TREATMENT OUTCOME; WEIGHT REDUCTION;

EID: 62349133356     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1476     Document Type: Article

References (52)

1. Malnick SD, Knobler H 2006 The medical complications of obesity. QJM 99:565-579
2. Hensrud DD, Klein S 2006 Extreme obesity: a new medical crisis in the United States. Mayo Clin Proc 8l(Suppl):S5-S10
3. 1992 Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference Statement. Am J Clin Nutr 55(Suppl): 615S-619S
4. O'Brien PE, Dixon JB, Laurie C, Skinner S, Proietto J, McNeil J, Strauss B, Marks S, Schachter L, Chapman L, Anderson M 2006 Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program: a randomized trial. Ann Intern Med 144:625-633
5. Krai JG, Näslund E 2007 Surgical treatment of obesity. Nat Clin Pract Endocrinol Metab 3:574-583
6. ShahM, Simha V, Garg A 2006 Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status. J Clin Endocrinol Metab 91:4223-4231
7. Russell-Jones DL, Weissberger AJ, Bowes SB, Kelly JM, Thomason M, Umpleby AM, Jones RH, Sonksen PH 1993 The effects of growth hormone on protein metabolism in adult growth hormone deficient patients. Clin Endocrinol (Oxf) 38:427-431
8. Møller N, Jorgensen JO, Møller J, Orskov L, Ovesen P, Schmitz O, Christiansen JS, Orskov H 1995 Metabolic effects of growth hormone in humans. Metabolism 44{Suppl 4):33-36
9. 1998 Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 83:379-381
10. Frystyk J 2004 Free insulin-like growth factors: measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Horm IGF Res 14:337-375
11. Maccario M, Valetto MR, Savio P, Aimaretti G, Baffoni C, Procopio M, GrottoliS,Oleandri SE, ArvatE, GhigoE 1997 Maximal secretory capacity of somatotrope cells in obesity: comparison with GH deficiency. Int J Obes Relat Metab Disord 21:27-32
12. Scacchi M, Pincelli AI, Cavagnini F 1999 Growth hormone in obesity. Int J Obes 23:262-271
13. Savastano S, Di Somma C, Mentone A, Savanelli MC, De Leo M, Lombardi G, Coalo A 2006 GH insufficiency in obese patients. J Endocrinol Invest 29(Suppl): 42-53
14. Franco C, Bengtsson BA, Johannsson G2001 Visceral obesity and the role of the somatotropic axis in the development of metabolic complications. Growth Horm IGF Res ll(Suppl A):S97-S102
15. Rasmussen MH, Hvidberg A, Juul A, Main KM, Gotfredsen A, Skakkebaek NE, Hilsted J, Skakkebae NE 1995 Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab [Erratum (1995) 80:2446] 80: 1407-1415
16. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rossetto R, SavioP, Aimaretti G, Camanni F, GhigoE 1999 Relationships between 1GF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disord 23:612-618
17. VoorhoevePG, vanRossumEF,TeVelde SJ,KoperJW,KemperHC, Lamberts SW, de Waal HA 2006 Association between an IGF-I gene polymorphism and body fatness: differences between generations. Eur J Endocrinol 154:379-388
18. Savastano S, Di Somma C, Belfiore A, Guida B, Orio Jr F, Rota F, Savanelli MC, Cascella T, Mentone A, AngrisaniL, Lombardi G, Colao A2006 Growth hormone status in morbidly obese subjects and correlation with body composition. J Endocrinol Invest 29:536-543
19. Di Somma C, AngrisaniL., Rota F, Savanelli MC, Cascella T, Belfiore A, Orio F, Lombardi G, Colao A, Savastano S 2008 GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding. Clin Endocrinol (Oxf) 69:393-399
20. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G 2005 The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 153:257-264
21. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F 1996 New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol 134:352-356
22. Lamberts SW, de Herder WW, van der Lely AJ 1998 Pituitary insufficiency. Lancet 352:127-134
23. Hu FB, Rimm E, S Smith-Warner A, Feskanich D, Stampfer MJ, Ascherio A, Sampson L, Willett WC 1999 Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr 69:243-249
24. Kuzmak LI 1991 A review of seven years' experience with silicone gastric banding. Obes Surg 1:403-408
25. Angrisani L, Lorenzo M, Esposito G, Romano G, Puzziello A, Belfiore A, Santoro T, Roina G, Petito A, Falconi C, Tesauro B 1997 Laparoscopic adjustable silicone gastric banding: preliminary results of Naples experience. Obes Surg 7:19-21
26. Busetto L, Pisent C, Segato G, De Marchi F, Favretti F, Lise M, Enzi G 1997 The influence of a new timing strategy of band adjustment on the vomiting frequency and the food consumption of obese women operated with laparoscopic adjustable silicone gastric banding (LAP-BAND). Obes Surg 7:505-512
27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
28. MatsudaM,DeFronzoRA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
29. Castelli WP 1996 Lipids, risk factors and ischaemic heart disease. Atherosclerosis 124(Suppl):Sl-S9
30. 1997 Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197
31. Van Gaal LF, Vansant GA, De Leeuw IH 1992 Factors determining energy expenditure during very-low-calorie diets. Am J Clin Nutr 56(Suppl):224S-229S
32. AndersonJW,KonzEC, FrederichRC, Wood CL 2001 Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr 74:579-5784
33. Chaston TB, Dixon JB, O'Brien PE 2006 Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes (Lond) 31:743-750
34. Coupaye M, Bouillot JL, Poitou C, Schutz Y, Basdevant A, Oppert JM 2007 Is lean body mass decreased after obesity treatment by adjustable gastric banding? Obes Surg 17:427-433
35. Møtier N, Gjedsted J, Gormsen L, Fuglsang J, Djurhuus C 2003 Effects of growth hormone on lipid metabolism in humans. Growth Horm IGF Res 13(Suppl A):S18-S21
36. Colao A, Di Somma C, Savanelli MC, De Leo M, Lombardi G 2006 Beginning to end: cardiovascular implications of growth hormone (GH) deficiency and GH therapy. Growth Horm IGF Res 16(Suppl A):S41-S48
37. JohannssonG, Marin P, Lonn L, Ottosson M, StenlofK, Bjorntorp P, Sjostrom L, Bengtsson BA 1997 Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82:727-734
38. Shadid S, Jensen MD 2003 Effects of growth hormone administration in human obesity. Obes Res 11:170-175
39. Albert SG, Mooradian D 2004 Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity. J Clin Endocrinol Metab 89:695-701
40. Attallah H, Friedlander AL, Hoffman AR 2006 Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy. Growth Horm IGF Res 16(Suppl A):S62-S67
41. Tagliaferri M, Scacchi M, Pincelli AI, Berselli ME, Silvestri P, Montesano A, Ortolani S, Dubini A, Cavagnini F 1998 Metabolic effects of biosynthetic growth hormone treatment in severely energy-restricted obese women. Int J Obes Relat Metab Disord 22:836-841
42. Laron Z, Ginsberg S, Lilos P. Arbiv M, Vaisman N 2006 Long-term IGF-I treatment of children with Laron syndrome increases adiposity. Growth Horm IGF Res 16:61-64
43. Lund S, Flyvbjerg A, Holman GD, Larsen FS, Pedersen O, Schmitz O 1994 Comparative effects of IGF-I and insulin on the glucose transporter system in rat muscle. Am J Physiol 267(3 Pt 1):E461-E466
44. Rosenbaum M, Gertner JM, Leibel RL 1989 Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J Clin Endocrinol Metab 69:1274-1281
45. Franco C, Brandberg J, Lönn L, Andersson B, Bengtsson BA, Johannsson G 2005 Growth hormone treatment reduces abdominal visceral fatin postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. J Clin Endocrinol Metab 90:1466-1474
46. Pasarica M, Zachwieja JJ, Dejonge L, Redman S, Smith SR 2007 Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity. J Clin Endocrinol Metab 92:4265-4270
47. Holdstock C, Engstrom BE, Ohrvall M, Lind L, Sundbom M, Karlsson FA 2003 Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab 88:3177-3183
48. Mancini MC, Costa AP, de Melo ME, Cercato C, Giannella-Neto D, Garrido Jr AB, Rosberg S, Albertsson-Wikland K, Villares SM, Halpern A 2006 Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles. Obesity 14:383-387
49. Ram E, Vishna T, Diker D, Gal-Ad I, Maayan R, Lerner I, Dreznik Z, Seror D, Vardi P, Weizman A 2005 Impact of gastric banding on plasma ghrelin, growth hormone, Cortisol, DHEA and DHEA-S levels. Obes Surg 15:1115-1123
50. Engström BE, Burman P, Holdstock C 2006 Effects of gastric bypass on the GH/IGF-I axis in severe obesity and a comparison with GH deficiency. Eur J Endocrinol 154:53-59
51. Mauras N, Haymond MW 2005 Are the metabolic effects of GH and IGF-I separable? Growth Horm IGF Res 15:19-27
52. De Marinis L, Bianchi A, Mancini A, Gentilella R, Perrelli M, Giampietro A, Porcelli T, Tilaro L, Fusco A, Valle D, Tacchino RM 2004 Growth hormone secretion and leptin in morbid obesity before and after biliopancreatic diversion: relationships with insulin and body composition. J Clin Endocrinol Metab 89:174-180