Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine

Biomaterials

Volumn 39, Issue , 2015, Pages 105-113

  Huang, Jing ^a   Shu, Qing ^a,b   Wang, Liya ^a   Wu, Hui ^a   Wang, Andrew Y ^c   Mao, Hui ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^c OCEAN NANOTECH LLC   (United States)

Author keywords

Casein; Layer by layer; Magnetic resonance; Nanoparticles; Oral drug delivery

Indexed keywords

CASEIN; DRUG DELIVERY; IRON; IRON OXIDES; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; METAL NANOPARTICLES; NANOPARTICLES; PROTEINS;

DRUG DELIVERY SYSTEM; DRUG DELIVERY VEHICLES; GASTRIC CONDITIONS; IRON OXIDE NANOPARTICLE; LAYER-BY-LAYERS; MAGNETIC IRON OXIDE NANOPARTICLES; MAGNETIC NANO-PARTICLES; ORAL DRUG DELIVERY;

NANOMAGNETICS;

CASEIN; DOXORUBICIN; INDOCYANINE GREEN; IRON OXIDE; MAGNETIC NANOPARTICLE; NANOMATERIAL; PROTEINASE; WATER; MAGNETITE NANOPARTICLE; MILK PROTEIN;

ABSORPTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DEGRADATION; DRUG DELIVERY SYSTEM; ENZYME RELEASE; EX VIVO STUDY; IN VIVO STUDY; MICROVILLUS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SMALL INTESTINE; STOMACH; ANIMAL; CACO 2 CELL LINE; CHEMISTRY; HUMAN; METABOLISM; PROCEDURES;

MUS;

ANIMALS; CACO-2 CELLS; CASEINS; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINE, SMALL; MAGNETITE NANOPARTICLES; MICE; MILK PROTEINS; STOMACH;

EID: 84919468152     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.059     Document Type: Article

References (38)

1. Mei L., Zhang Z., Zhao L., Huang L., Yang X.-L., Tang J., et al. Pharmaceutical nanotechnology for oral delivery of anticancer drugs. Adv Drug Deliv Rev 2013, 65:880-890.
2. Leong K.W., Sung H.W. Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy preface. Adv Drug Deliv Rev 2013, 65:757-758.
3. Feng S.S., Zhao L., Tang J. Nanomedicine for oral chemotherapy. Nanomedicine 2011, 6:407-410.
4. Thanki K., Gangwal R.P., Sangamwar A.T., Jain S. Oral delivery of anticancer drugs: challenges and opportunities. JControl Release 2013, 170:15-40.
5. Gamboa J.M., Leong K.W. Invitro and invivo models for the study of oral delivery of nanoparticles. Adv Drug Deliv Rev 2013, 65:800-810.
6. Lautenschlaeger C., Schmidt C., Fischer D., Stallmach A. Drug delivery strategies in the therapy of inflammatory bowel disease. Adv Drug Deliv Rev 2014, 71:58-76.
7. Zhang Z., Ma L., Jiang S., Liu Z., Huang J., Chen L., et al. Aself-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor. JControl Release 2013, 166:30-37.
8. Li X., Guo S., Zhu C., Zhu Q., Gan Y., Rantanen J., et al. Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles. Biomaterials 2013, 34:9678-9687.
9. Semo E., Kesselman E., Danino D., Livney Y.D. Casein micelle as a natural nano-capsular vehicle for nutraceuticals. Food Hydrocoll 2007, 21:936-942.
10. Mohan M.S., Jurat-Fuentes J.L., Harte F. Binding of vitamin A by casein micelles in commercial skim milk. JDairy Sci 2013, 96:790-798.
11. Livney Y.D. Milk proteins as vehicles for bioactives. Curr Opin Colloid Interface Sci 2010, 15:73-83.
12. Elzoghby A.O., Samy W.M., Elgindy N.A. Protein-based nanocarriers as promising drug and gene delivery systems. JControl Release 2012, 161:38-49.
13. Elzoghby A.O., El-Fotoh W.S.A., Elgindy N.A. Casein-based formulations as promising controlled release drug delivery systems. JControl Release 2011, 153:206-216.
14. Bachar M., Mandelbaum A., Portnaya I., Perlstein H., Even-Chen S., Barenholz Y., et al. Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled beta-casein micelles. JControl Release 2012, 160:164-171.
15. Huang J., Wang L., Lin R., Wang A.Y., Yang L., Kuang M., et al. Casein-coated iron oxide nanoparticles for high MRI contrast enhancement and efficient cell targeting. ACS Appl Mater Interfaces 2013, 5:4632-4639.
16. Shapira A., Davidson I., Avni N., Assaraf Y.G., Livney Y.D. Beta-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: stability, target-activated release and cytotoxicity. Eur J Pharm Biopharm 2012, 80:298-305.
17. Chen K., Xie J., Xu H., Behera D., Michalski M.H., Biswal S., et al. Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials 2009, 30:6912-6919.
18. Duan H., Kuang M., Wang X., Wang Y.A., Mao H., Nie S. Reexamining the effects of particle size and surface chemistry on the magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. JPhys Chem C 2008, 112:8127-8131.
19. Win K.Y., Feng S.S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005, 26:2713-2722.
20. Kenzaoui B.H., Vila M.R., Miquel J.M., Cengelli F., Juillerat-Jeanneret L. Evaluation of uptake and transport of cationic and anionic ultrasmall iron oxide nanoparticles by human colon cells. Int J Nanomedicine 2012, 7:1275-1286.
21. Park M.Y., Kwon H.J., Sung M.K. Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two invitro absorption models. Nutr Res Pract 2009, 3:9-14.
22. Hillman E.M.C., Moore A. All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast. Nat Photonics 2007, 1:526-530.
23. Liu Z., Sun X., Nakayama-Ratchford N., Dai H. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 2007, 1:50-56.
24. Jin Y.H., Hu H.Y., Qiao M.X., Zhu J., Qi J.W., Hu C.J., et al. pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and invitro evaluation. Colloids Surf, B 2012, 94:184-191.
25. Goren D., Horowitz A.T., Tzemach D., Tarshish M., Zalipsky S., Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000, 6:1949-1957.
26. Ren D., Kratz F., Wang S.-W. Protein nanocapsules containing doxorubicin as a pH-responsive delivery system. Small 2011, 7:1051-1060.
27. Upadhyay K.K., Bhatt A.N., Mishra A.K., Dwarakanath B.S., Jain S., Schatz C., et al. The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(gamma-benzyl L-glutamate)-b-hyaluronan polymersomes. Biomaterials 2010, 31:2882-2892.
28. Chaturvedi K., Ganguly K., Nadagouda M.N., Aminabhavi T.M. Polymeric hydrogels for oral insulin delivery. JControl Release 2013, 165:129-138.
29. Han L., Tang C., Yin C. Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy. Biomaterials 2014, 35:4589-4600.
30. Wang Xiaoying, Chen Yihang, Dahmani Fatima Zohra, Yin Lifang, Zhou Jianping, Yao J. Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Biomaterials 2014, 35:7654-7665.
31. Lin C., Chen F., Ye T., Zhang L., Zhang W., Liu D., et al. Anovel oral delivery system consisting in "drug-in cyclodextrin-in nanostructured lipid carriers" for poorly water-soluble drug: vinpocetine. Int J Pharm 2014, 465:90-96.
32. Zuo Q., Lu J., Hong A., Zhong D., Xie S., Liu Q., et al. Preparation and characterization of PEM-coated alginate microgels for controlled release of protein. Biomed Mater 2012, 7.
33. Liu C., Yao W., Zhang L., Qian H., Wu W., Jiang X. Cell-penetrating hollow spheres based on milk protein. Chem Comm 2010, 46:7566-7568.
34. Groo A.C., Saulnier P., Gimel J.C., Gravier J., Ailhas C., Benoit J.P., et al. Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery. Int J Nanomedicine 2013, 8:4291-4302.
35. Panthani M.G., Khan T.A., Reid D.K., Hellebusch D.J., Rasch M.R., Maynard J.A., et al. Invivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSexS2-x)/ZnS core/shell quantum dots. Nano Lett 2013, 13:4294-4298.
36. Sonaje K., Lin K.-J., Wey S.-P., Lin C.-K., Yeh T.-H., Nguyen H.-N., et al. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010, 31:6849-6858.
37. Sakkinen M., Marvola J., Kanerva H., Lindevall K., Ahonen A., Marvola M. Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy. Int J Pharm 2006, 307:285-291.
38. Lee C.M., Jeong H.J., Yun K.N., Kim D.W., Sohn M.H., Lee J.K., et al. Optical imaging to trace near infrared fluorescent zinc oxide nanoparticles following oral exposure. Int J Nanomedicine 2012, 7:3203-3209.