The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(γ-benzyl l-glutamate)-b-hyaluronan polymersomes

Biomaterials

Volumn 31, Issue 10, 2010, Pages 2882-2892

  Upadhyay, Kamal K ^a,b,c   Bhatt, Anant N ^d   Mishra, Anil K ^d   Dwarakanath, Bilikere S ^d   Jain, Sanyog ^e   Schatz, Christophe ^a,b   Le Meins, Jean François ^a,b   Farooque, Abdullah ^d   Chandraiah, Godugu ^e   Jain, Amit K ^e   Misra, Ambikanandan ^c   Lecommandoux, Sébastien ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIVERSITÉ BORDEAUX 1   (France)

^c Faculty of Technology and Engineering   (India)

^d INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^e NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Cell uptake; Cytotoxicity; Doxorubicin; Hyaluronan; Polymersomes; Self assembly

Indexed keywords

ANTI-TUMOR ACTIVITIES; BLOCK COPOLYMER VESICLES; BREAST CANCER; BREAST TUMOR; CANCER CELLS; CARDIOTOXICITY; CD44 EXPRESSION LEVEL; CELL UPTAKE; CONTROL GROUPS; CYTOTOXIC; DOXORUBICIN; EXPOSURE-TIME; HYALURONAN; HYALURONIC ACIDS; IN-CELL; IN-VITRO; INTRACELLULAR DELIVERY; INTRACELLULAR DRUG DELIVERY; L-GLUTAMATE; MCF-7 CELLS; NANOPRECIPITATION METHOD; PHOSPHATE BUFFER SALINES; POLYMERSOMES; REACTIVE OXYGEN SPECIES;

BLOCK COPOLYMERS; CYTOLOGY; DRUG DELIVERY; FLOW CYTOMETRY; ORGANIC ACIDS; OXYGEN; SELF ASSEMBLY; TUMORS;

CELLS;

COPOLYMER; CREATINE KINASE; DOXORUBICIN; HERMES ANTIGEN; HYALURONIC ACID; LACTATE DEHYDROGENASE; POLY(GAMMA BENZYLGLUTAMATE) BETA HYALURONAN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CARDIOTOXICITY; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ANIMALS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; CARDIOTOXINS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CREATINE KINASE; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FEMALE; FLOW CYTOMETRY; HUMANS; HYALURONIC ACID; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; KAPLAN-MEIERS ESTIMATE; L-LACTATE DEHYDROGENASE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; POLYGLUTAMIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 75449112994     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.12.043     Document Type: Article

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