Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

Cancer Letters

Volumn 356, Issue 2, 2015, Pages 994-1006

  Kiss, Izabella ^a   Unger, Christine ^a   Huu, Chi Nguyen ^a   Atanasov, Atanas Georgiev ^b   Kramer, Nina ^a   Chatruphonprasert, Waranya ^a,c   Brenner, Stefan ^a   McKinnon, Ruxandra ^b   Peschel, Andrea ^a   Vasas, Andrea ^d   Lajter, Ildiko ^d   Kain, Renate ^a   Saiko, Philipp ^a   Szekeres, Thomas ^a   Kenner, Lukas ^a,e,f   Hassler, Melanie R ^a   Diaz, Rene ^g   Frisch, Richard ^g   Dirsch, Verena M ^b   Jäger, Walter ^a   de Martin, Rainer ^a   Bochkov, Valery N ^h   Passreiter, Claus M ⁱ   Peter Vörösmarty, Barbara ^a   Mader, Robert M ^a   Grusch, Michael ^a   Dolznig, Helmut ^a   Kopp, Brigitte ^b   Zupko, Istvan ^d   Hohmann, Judit ^d   Krupitza, Georg ^a   more..

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c MAHASARAKHAM UNIVERSITY   (Thailand)

^d UNIVERSITY OF SZEGED   (Hungary)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^g Institute for Ethnobiology   (Guatemala)

^h UNIVERSITY OF GRAZ   (Austria)

ⁱ HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

3D compound testing; ALCL; Lobatin; Lymphendothelial intravasation; NPM ALK

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 5 CHLORO 4 [[2 (ISOPROPYLSULFONYL)PHENYL]AMINO] 2 [[2 METHOXY 4 [4 (4 METHYL 1 PIPERAZINYL) 1 PIPERIDINYL]PHENYL]AMINO]PYRIMIDINE; ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CYTOCHROME P450 1A1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOBATIN B; MESSENGER RNA; NUCLEOPHOSMIN; PROTEIN TYROSINE KINASE INHIBITOR; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG; CASPASE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; P80(NPM-ALK) PROTEIN; PLANT EXTRACT; PROTEIN C JUN; PROTEIN TYROSINE KINASE; SESQUITERPENE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CELL CYCLE PROGRESSION; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE PRODUCT; HL 60 CELL LINE; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; LYMPH NODE METASTASIS; LYMPH VESSEL ENDOTHELIUM; LYMPHOMA CELL LINE; METASTASIS INHIBITION; MITOCHONDRION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; APOPTOSIS; ASTERACEAE; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; GENETICS; LYMPHOMA, LARGE-CELL, ANAPLASTIC; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; TUMOR INVASION;

NEUROLAENA LOBATA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASTERACEAE; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENDOTHELIUM, LYMPHATIC; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOMA, LARGE-CELL, ANAPLASTIC; MITOCHONDRIA; NEOPLASM INVASIVENESS; NF-KAPPA B; PLANT EXTRACTS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-JUN; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SESQUITERPENES; TUMOR CELLS, CULTURED;

EID: 84919459458     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.019     Document Type: Article

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