The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis

International Journal of Oncology

Volumn 42, Issue 1, 2013, Pages 338-348

  Unger, Christine ^a   Popescu, Ruxandra ^c   Giessrigl, Benedikt ^a   Laimer, Daniela ^a   Heider, Susanne ^a   Seelinger, Mareike ^a   Diaz, Rene ^d   Wallnöfer, Bruno ^e   Egger, Gerda ^a   Hassler, Melanie ^a   Knöfler, Martin ^b   Saleh, Leila ^b   Sahin, Emine ^f   Grusch, Michael ^f   Fritzer Szekeres, Monika ^a   Dolznig, Helmut ^a   Frisch, Richard ^d   Kenner, Lukas ^a   Kopp, Brigitte ^c   Krupitza, Georg ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Reproductive Biology Unit   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d Institute for Ethnobiology   (Guatemala)

^e NATURHISTORISCHES MUSEUM WIEN   (Austria)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anaplastic large cell lymphoma; Ethno pharmacology; JunB; Neurolaena lobata; NPM ALK; PDGF R

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; CASPASE 3; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; NEUROLAENA LOBATA EXTRACT; NUCLEOPHOSMIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; TRANSCRIPTION FACTOR JUNB;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTERACEAE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; LARGE CELL LYMPHOMA; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NEUROLAENA LOBATA; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TRADITIONAL MEDICINE;

ANIMALS; APOPTOSIS; ASTERACEAE; BLOTTING, WESTERN; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOMA, LARGE-CELL, ANAPLASTIC; METHYLENE CHLORIDE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTEIN-TYROSINE KINASES; TUMOR CELLS, CULTURED;

EID: 84873627858     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1690     Document Type: Article

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