The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model

Osteoarthritis and Cartilage

Volumn 23, Issue 1, 2015, Pages 114-121

  Elsaid, K A ^a   Zhang, L ^b   Shaman, Z ^a   Patel, C ^a   Schmidt, T A ^c   Jay, G D ^b  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Interleukin 1 receptor antagonist; Lubricin; Posttraumatic osteoarthritis

Indexed keywords

CASPASE 3; COLLAGENASE 3; INTERLEUKIN 1; PROTEOGLYCAN; RECOMBINANT HUMAN LUBRICIN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; GLYCOPROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LUBRICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ANTERIOR CRUCIATE LIGAMENT TRANSECTION; APOPTOSIS; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; MALE; NONHUMAN; PROTEIN CLEAVAGE; RAT; RNA ISOLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTICULAR CARTILAGE; INTRAARTICULAR DRUG ADMINISTRATION; LEWIS RAT; METABOLISM; PATHOLOGY; SURGERY; TIME FACTOR;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; APOPTOSIS; CARTILAGE, ARTICULAR; CHONDROCYTES; GLYCOPROTEINS; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MALE; MODELS, ANIMAL; RATS; RATS, INBRED LEW; RECEPTORS, INTERLEUKIN-1; TIME FACTORS;

EID: 84919393952     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.09.006     Document Type: Article

References (40)

1. Flannery C.R., Hughes C.E., Schumacher B.L., Tudor D., Aydelotte M.B., Kuettner K.E., et al. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun 1999, 254:535-541.
2. Jay G.D., Britt D.E., Cha C.J. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. JRheumatol 2000, 26:2454-2457.
3. Schmidt T.A., Schumacher B.L., Klein T.J., Voegtline M.S., Sah R.L. Synthesis of proteoglycan 4 by chondrocyte subpopulations in cartilage explants, monolayer cultures, and resurfaced cartilage cultures. Arthritis Rheum 2004, 50:2849-2857.
4. Schmidt T.A., Gastelum N.S., Nguyen Q.T., Schumacher B.L., Sah R.L. Boundary lubrication of articular cartilage; role of synovial fluid constituents. Arthritis Rheum 2007, 56:882-891.
5. Jones A.R., Flannery C.R. Bioregulation of lubricin expression by growth factors and cytokines. Eur Cell Mater 2007, 13:40-45.
6. Lee S.Y., Niikura T., Reddi A.H. Superficial zone protein (lubricin) in the different tissue compartments of the knee joint: modulation by transforming growth factor beta 1 and interleukin-1 beta. Tissue Eng Part A 2008, 14:1799-1808.
7. DuRaine G., Neu C.P., Chan S.M., Komvopoulos K., June R.K., Reddi A.H. Regulation of the friction coefficient of articular cartilage by TGF-beta and IL-1beta. JOrthop Res 2009, 27:249-256.
8. Elsaid K.A., Jay G.D., Chichester C.O. Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis. Arthritis Rheum 2007, 56:108-116.
9. Elsaid K.A., Machan J.T., Waller K., Fleming B.C., Jay G.D. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Arthritis Rheum 2009, 60:2997-3006.
10. Catterall J.B., Stabler T.V., Flannery C.R., Kraus V.B. Changes in serum and synovial fluid biomarkers after acute injury. Arthritis Res Ther 2010, 12:R229.
11. Elsaid K.A., Fleming B.C., Oksendahl H.L., Machan J.T., Fadale P.D., Hulstyn M.J., et al. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 2008, 58:1707-1715.
12. Elsaid K.A., Zhang L., Waller K., Tofte J., Teeple E., Fleming B.C., et al. The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection. Osteoarthritis Cartilage 2012, 20:940-948.
13. Teeple E., Elsaid K.A., Jay G.D., Zhang L., Badger G.J., Akelman M., et al. Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee. Am J Sports Med 2011, 39:164-172.
14. Jay G.D., Elsaid K.A., Kelly K.A., Anderson S.C., Zhang L., Teeple E., et al. Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 2012, 64:1162-1171.
15. Jay G.D., Fleming B.C., Watkins B.A., McHugh K.A., Anderson S.C., Zhang L.X., et al. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 2010, 62:2382-2391.
16. Flannery C.R., Zollner R., Corcoran C., Jones A.R., Root A., Rivera-Bermudez M.A., et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 2009, 60:840-847.
17. Waller K., Zhang L., Elsaid K.A., Fleming B.C., Warman M., Jay G.D. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A 2013, 110:5852-5857.
18. Samson M.L., Morrison S., Masala N., Sullivan B.D., Sullivan D.A., Sheardown H., et al. Characterization of full-length recombinant human proteoglycan 4 as an ocular surface boundary lubricant. Exp Eye Res 2014, 127:14-19. pii: S0014-4835(14)00176-6. 10.1016/j.exer.2014.06.015.
19. Kraus V.B., Huebner J.L., Fink C., King J.B., Brown S., Vail T.P., et al. Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum 2002, 46:420-427.
20. Chockalingam P.S., Sun W., Rivera-Bermudez M.A., Zeng W., Dufield D.R., Larsson S., et al. Elevated aggrecanases activity in a rat model of joint injury is attenuated by an aggrecanases specific inhibitor. Osteoarthritis Cartilage 2011, 19:315-323.
21. Pritzker K.P., Gay S., Jiminez S.A., Ostergaard K., Pelletier J.P., Revell Pa, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006, 14:13-29.
22. Cake M.A., Smith M.M., Young A.A., Smith S.M., Ghosh P., Read R.A. Synovial pathology in an ovine model of osteoarthritis: effect of intra-articular hyaluronan. Clin Exper Rheumatol 2008, 26:561-567.
23. Gelber A.C., Hochberg M.C., Mead L.A., Wang N.Y., Wigley F.M., Klag M.J. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000, 133:321-328.
24. Louboutin H., Debarge R., Richuo J., Selmi T.A., Donell S.T., Neyret P., et al. Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors. Knee 2009, 16:239-244.
25. Neuman P., Kostogiannis I., Friden T., Roos H., Dahlberg L.E., Englund M. Patellofemoral osteoarthritis 15 years after anterior cruciate ligament injury-a prospective cohort study. Osteoarthritis Cartilage 2009, 17:284-290.
26. Friel N.A., Chu C.R. The role of ACL injury in the development of posttraumatic knee osteoarthritis. Clin Sports Med 2013, 32:1-12.
27. Heard B.J., Solbak N.M., Achari Y., Chung M., Hart D.A., Shrive N.G., et al. Changes of early post-traumatic osteoarthritis in an ovine model of simulated ACL reconstruction are associated with transient post-injury synovial inflammation and tissue catabolism. Osteoarthritis Cartilage 2013, 21:1942-1949.
28. Song E.K., Seon J.K., Yim J.H., Woo S.H., Seo H.Y., Lee K.B. Progression of osteoarthritis after double- and single-bundle anterior cruciate ligament reconstruction. Am J sports Med 2013, 41:2340-2346.
29. Øiestad B.E., Holm I., Engebretsen L., Aune A.K., Gunderson R., Risberg M.A. The prevalence of patellofemoral osteoarthritis 12 years after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 2013, 21:942-949.
30. Wassilew G.I., Lehnigk U., Duda G.N., Taylor W.R., Matziolis G., Dynybil C. The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 2010, 26:1096-1104.
31. Cameron M.L., Fu F.H., Paessler H.H., Schneider M., Evans C.H. Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee. Knee Surg Sports Traumatol Arthrosc 1994, 2:38-44.
32. Cameron M., Buchgraber A., Passler H., Vogt M., Thonar E., Fu F., et al. The natural history of anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokines and keratin sulfate concentrations. Am J Sports Med 1997, 25:751-754.
33. Hashimoto S., Takahashi K., Amiel D., Coutts R.D., Lotz M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998, 41:1266-1274.
34. D'Lima D., Hermida J., Hashimoto S., Colwell C., Lotz M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 2006, 54:1814-1821.
35. Pelletier J.P., Fernandes J.C., Jovanovic D.V., Reboul P., Martel-Pelletier J. Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxidase synthase. JRheumatol 2001, 28:2509-2519.
36. Csaki C., Mobasheri A., Shakibaei M. Synergistic chondroprotective effect of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis. Arthritis Res Ther 2009, 11:R165.
37. Jomphe C., Gabriac M., Hale T.M., Heroux L., Trudeau L.E., Deblois D., et al. Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1 beta-stimulated chondrocytes. Basic Clin Pharmacol Toxicol 2008, 102:59-65.
38. Allen K., Adams S.B., Setton L.A. Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. Tissue Eng Part B 2010, 16:81-92.
39. Caron J.P., Fernandes J.C., Martel-Pelletier J., Tardif G., Mineau F., Geng C., et al. Chondroprotective effect of intraarticular injection of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 1996, 39:1535-1544.
40. Anderson D.D., Chubinskaya S., Guilak F., Martin J.A., Oegema T.R., Olson S.A., et al. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. JOrthop Res 2011, 29:802-809.