Changes of early post-traumatic osteoarthritis in an ovine model of simulated ACL reconstruction are associated with transient acute post-injury synovial inflammation and tissue catabolism

Osteoarthritis and Cartilage

Volumn 21, Issue 12, 2013, Pages 1942-1949

  Heard, B J ^a   Solbak, N M ^a   Achari, Y ^a   Chung, M ^a   Hart, D A ^a   Shrive, N G ^a,b   Frank, C B ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

ACL; Inflammation; Osteoarthritis; Ovine; Synovium

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; MESSENGER RNA; STROMELYSIN; VERSICAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; ARTICULAR CARTILAGE; AUTOGRAFT; CONNECTIVE TISSUE; CONTROLLED STUDY; FEMALE; NONHUMAN; OSTEOARTHRITIS; OSTEOPHYTE; OVINE MODEL; PLASTIC SURGERY; POSTTRAUMATIC ARTHROPATHY; POSTTRAUMATIC OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SYNOVITIS; TISSUE METABOLISM;

ACL; INFLAMMATION; OSTEOARTHRITIS; OVINE; SYNOVIUM;

AGGRECANS; ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; OSTEOARTHRITIS, KNEE; POSTOPERATIVE COMPLICATIONS; RNA, MESSENGER; SHEEP; SYNOVIAL MEMBRANE; SYNOVITIS; VERSICANS;

EID: 84888878364     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.08.019     Document Type: Article

References (31)

1. Brophy R.H., Wright R.W., Matava M.J. Cost analysis of converting from single-bundle to double-bundle anterior cruciate ligament reconstruction. Am J Sports Med 2009, 37:683-687.
2. Spindler K.P., Parker R.D., Andrish J.T., Kaeding C.C., Wright R.W., Marx R.G., et al. Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies. JOrthop Res 2012, 31:2-9.
3. Asano H., Muneta T., Ikeda H., Yagishita K., Kurihara Y., Sekiya I. Arthroscopic evaluation of the articular cartilage after anterior cruciate ligament reconstruction: a short-term prospective study of 105 patients. Arthroscopy 2004, 20:474-481.
4. Lohmander L.S., Ostenberg A., Englund M., Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum 2004, 50:3145-3152.
5. Seol D., McCabe D.J., Choe H., Zheng H., Yu Y., Jang K., et al. Chondrogenic progenitor cells respond to cartilage injury. Arthritis Rheum 2012, 64:3626-3637.
6. Frank C.B., Beveridge J.E., Huebner K.D., Heard B.J., Tapper J.E., O'Brien E.J., et al. Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis. JOrthop Res 2011, 30:384-392.
7. Lotz M.K., Kraus V.B. New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options. Arthritis Res Ther 2010, 12:211.
8. Sellam J., Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010, 6:625-635.
9. Scanzello C.R., Goldring S.R. The role of synovitis in osteoarthritis pathogenesis. Bone 2012, 51:249-257.
10. Lohmander L.S., Englund P.M., Dahl L.L., Roos E.M. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 2007, 35:1756-1769.
11. Oehler S., Neureiter D., Meyer-Scholten C., Aigner T. Subtyping of osteoarthritic synoviopathy. Clin Exp Rheumatol 2002, 20:633-640.
12. Wassilew G.I., Lehnigk U., Duda G.N., Taylor W.R., Matziolis G., Dynybil C. The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 2010, 26:1096-1104.
13. Piccinini A.M., Midwood K.S. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010, 2010.
14. Scanzello C.R., Plaas A., Crow M.K. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?. Curr Opin Rheumatol 2008, 20:565-572.
15. Schinhan M., Gruber M., Vavken P., Dorotka R., Samouh L., Chiari C., et al. Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee. JOrthop Res 2012, 30:214-220.
16. Cake M.A., Smith M.M., Young A.A., Smith S.M., Ghosh P., Read R.A. Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clin Exp Rheumatol 2008, 26:561-567.
17. Heard B.J., Achari Y., Chung M., Shrive N.G., Frank C.B. Early joint tissue changes are highly correlated with a set of inflammatory and degradative synovial biomarkers after ACL autograft and its sham surgery in an ovine model. JOrthop Res 2011, 29:1185-1192.
18. Drez D.J., DeLee J., Holden J.P., Arnoczky S., Noyes F.R., Roberts T.S. Anterior cruciate ligament reconstruction using bone-patellar tendon-bone allografts. A biological and biomechanical evaluation in goats. Am J Sports Med 1991, 19:256-263.
19. Cummings J.F., Grood E.S., Levy M.S., Korvick D.L., Wyatt R., Noyes F.R. The effects of graft width and graft laxity on the outcome of caprine anterior cruciate ligament reconstruction. JOrthop Res 2002, 20:338-345.
20. Adams M.E., Billingham M.E., Muir H. The glycosaminoglycans in menisci in experimental and natural osteoarthritis. Arthritis Rheum 1983, 26:69-76.
21. Smith M.M., Cake M.A., Ghosh P., Schiavinato A., Read R.A., Little C.B. Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Oxford) 2008, 47:1172-1178.
22. Reno C., Marchuk L., Sciore P., Frank C.B., Hart D.A. Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. Biotechniques 1997, 22:1082-1086.
23. Rieu I., Powers S.J. Real-time quantitative RT-PCR: design, calculations, and statistics. Plant Cell 2009, 21:1031-1033.
24. Wang J.F., Olson M.E., Reno C.R., Wright J.B., Hart D.A. The pig as a model for excisional skin wound healing: characterization of the molecular and cellular biology, and bacteriology of the healing process. Comp Med 2001, 51:341-348.
25. O'Brien E.J., Beveridge J.E., Huebner K.D., Heard B.J., Tapper J.E., Shrive N.G., et al. Osteoarthritis develops in the operated joint of an ovine model following ACL reconstruction with immediate anatomic reattachment of the native ACL. JOrthop Res 2012, 31:35-43.
26. Ahn J.H., Chang M.J., Lee Y.S., Koh K.H., Park Y.S., Eun S.S. Non-operative treatment of ACL rupture with mild instability. Arch Orthop Trauma Surg 2010, 130:1001-1006.
27. Butler R.J., Minick K.I., Ferber R., Underwood F. Gait mechanics after ACL reconstruction: implications for the early onset of knee osteoarthritis. Br J Sports Med 2009, 43:366-370.
28. Nelson F., Billinghurst R.C., Pidoux I., Reiner A., Langworthy M., McDermott M., et al. Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthritis Cartilage 2006, 14:114-119.
29. Tashman S., Anderst W., Kolowich P., Havstad S., Arnoczky S. Kinematics of the ACL-deficient canine knee during gait: serial changes over two years. JOrthop Res 2004, 22:931-941.
30. Kessler M.A., Behrend H., Henz S., Stutz G., Rukavina A., Kuster M.S. Function, osteoarthritis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment. Knee Surg Sports Traumatol Arthrosc 2008, 16:442-448.
31. Myklebust G., Holm I., Maehlum S., Engebretsen L., Bahr R. Clinical, functional, and radiologic outcome in team handball players 6 to 11 years after anterior cruciate ligament injury: a follow-up study. Am J Sports Med 2003, 31:981-989.