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Volumn 78, Issue 6, 2014, Pages 1441-1452

A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women

Author keywords

GPER; Hypertension

Indexed keywords

G PROTEIN COUPLED RECEPTOR 30; GENOMIC DNA; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPER PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 84919382386     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12471     Document Type: Article
Times cited : (36)

References (54)
  • 1
    • 82155173499 scopus 로고    scopus 로고
    • The G-protein-coupled estrogen receptor GPER in health and disease
    • Prossnitz ER, Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 2011; 7: 715-26.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 715-726
    • Prossnitz, E.R.1    Barton, M.2
  • 2
    • 0031282001 scopus 로고    scopus 로고
    • Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
    • Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 1997; 45: 607-17.
    • (1997) Genomics , vol.45 , pp. 607-617
    • Carmeci, C.1    Thompson, D.A.2    Ring, H.Z.3    Francke, U.4    Weigel, R.J.5
  • 3
    • 67650456863 scopus 로고    scopus 로고
    • Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation
    • Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res 2009; 69: 5415-23.
    • (2009) Cancer Res , vol.69 , pp. 5415-5423
    • Lin, B.C.1    Suzawa, M.2    Blind, R.D.3    Tobias, S.C.4    Bulun, S.E.5    Scanlan, T.S.6    Ingraham, H.A.7
  • 4
    • 67649888455 scopus 로고    scopus 로고
    • Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway
    • He YY, Cai B, Yang YX, Liu XL, Wan XP. Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer Sci 2009; 100: 1051-61.
    • (2009) Cancer Sci , vol.100 , pp. 1051-1061
    • He, Y.Y.1    Cai, B.2    Yang, Y.X.3    Liu, X.L.4    Wan, X.P.5
  • 5
    • 62049084027 scopus 로고    scopus 로고
    • Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
    • Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J 2009; 28: 523-32.
    • (2009) EMBO J , vol.28 , pp. 523-532
    • Pandey, D.P.1    Lappano, R.2    Albanito, L.3    Madeo, A.4    Maggiolini, M.5    Picard, D.6
  • 7
    • 77955711650 scopus 로고    scopus 로고
    • Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest
    • Chan QK, Lam HM, Ng CF, Lee AY, Chan ES, Ng HK, Ho SM, Lau KM. Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ 2010; 17: 1511-23.
    • (2010) Cell Death Differ , vol.17 , pp. 1511-1523
    • Chan, Q.K.1    Lam, H.M.2    Ng, C.F.3    Lee, A.Y.4    Chan, E.S.5    Ng, H.K.6    Ho, S.M.7    Lau, K.M.8
  • 8
    • 70449642979 scopus 로고    scopus 로고
    • Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30
    • Ding Q, Gros R, Limbird LE, Chorazyczewski J, Feldman RD. Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. Am J Physiol Cell Physiol 2009; 297: C1178-C1187.
    • (2009) Am J Physiol Cell Physiol , vol.297 , pp. C1178-C1187
    • Ding, Q.1    Gros, R.2    Limbird, L.E.3    Chorazyczewski, J.4    Feldman, R.D.5
  • 9
    • 84876127855 scopus 로고    scopus 로고
    • Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation
    • Gros R, Ding Q, Liu B, Chorazyczewski J, Feldman RD. Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation. Am J Physiol Cell Physiol 2013; 304: C532-C540.
    • (2013) Am J Physiol Cell Physiol , vol.304 , pp. C532-C540
    • Gros, R.1    Ding, Q.2    Liu, B.3    Chorazyczewski, J.4    Feldman, R.D.5
  • 10
    • 77749242708 scopus 로고    scopus 로고
    • Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries
    • Broughton BR, Miller AA, Sobey CG. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol 2010; 298: H1055-1061.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1055-1061
    • Broughton, B.R.1    Miller, A.A.2    Sobey, C.G.3
  • 12
    • 67651177687 scopus 로고    scopus 로고
    • Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats
    • Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology 2009; 150: 3753-8.
    • (2009) Endocrinology , vol.150 , pp. 3753-3758
    • Lindsey, S.H.1    Cohen, J.A.2    Brosnihan, K.B.3    Gallagher, P.E.4    Chappell, M.C.5
  • 13
    • 78149487334 scopus 로고    scopus 로고
    • Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats
    • Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS ONE 2010; 5: e15433.
    • (2010) PLoS ONE , vol.5 , pp. e15433
    • Jessup, J.A.1    Lindsey, S.H.2    Wang, H.3    Chappell, M.C.4    Groban, L.5
  • 14
    • 80053478893 scopus 로고    scopus 로고
    • Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat
    • Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension 2011; 58: 665-71.
    • (2011) Hypertension , vol.58 , pp. 665-671
    • Lindsey, S.H.1    Yamaleyeva, L.M.2    Brosnihan, K.B.3    Gallagher, P.E.4    Chappell, M.C.5
  • 17
    • 72449174718 scopus 로고    scopus 로고
    • GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients
    • Giess M, Lattrich C, Springwald A, Goerse R, Ortmann O, Treeck O. GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients. J Steroid Biochem Mol Biol 2010; 118: 7-12.
    • (2010) J Steroid Biochem Mol Biol , vol.118 , pp. 7-12
    • Giess, M.1    Lattrich, C.2    Springwald, A.3    Goerse, R.4    Ortmann, O.5    Treeck, O.6
  • 18
    • 0033588351 scopus 로고    scopus 로고
    • Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes
    • Li S, Sims S, Jiao Y, Chow LH, Pickering JG. Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes. Circ Res 1999; 85: 338-48.
    • (1999) Circ Res , vol.85 , pp. 338-348
    • Li, S.1    Sims, S.2    Jiao, Y.3    Chow, L.H.4    Pickering, J.G.5
  • 24
    • 0033709678 scopus 로고    scopus 로고
    • LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration
    • Hegele RA, Cao H, Huff MW, Anderson CM. LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration. J Clin Endocrinol Metab 2000; 85: 3089-93.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3089-3093
    • Hegele, R.A.1    Cao, H.2    Huff, M.W.3    Anderson, C.M.4
  • 25
    • 37349118369 scopus 로고    scopus 로고
    • Analysis of variance
    • Larson MG. Analysis of variance. Circulation 2008; 117: 115-21.
    • (2008) Circulation , vol.117 , pp. 115-121
    • Larson, M.G.1
  • 27
    • 70350448860 scopus 로고    scopus 로고
    • Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
    • Deschamps AM, Murphy E. Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Am J Physiol Heart Circ Physiol 2009; 297: H1806-1813.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H1806-1813
    • Deschamps, A.M.1    Murphy, E.2
  • 28
    • 79959733588 scopus 로고    scopus 로고
    • Unraveling the mechanisms underlying the rapid vascular effects of steroids: Sorting out the receptors and the pathways
    • Feldman RD, Gros R. Unraveling the mechanisms underlying the rapid vascular effects of steroids: sorting out the receptors and the pathways. Br J Pharmacol 2011; 163: 1163-9.
    • (2011) Br J Pharmacol , vol.163 , pp. 1163-1169
    • Feldman, R.D.1    Gros, R.2
  • 29
    • 84934443716 scopus 로고    scopus 로고
    • Pharmacogenomics of G protein-coupled receptor signaling: Insights from health and disease
    • Thompson MD, Cole DE, Jose PA. Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease. Methods Mol Biol (Clifton, N.J.) 2008; 448: 77-107.
    • (2008) Methods Mol Biol (Clifton, N.J. , vol.448 , pp. 77-107
    • Thompson, M.D.1    Cole, D.E.2    Jose, P.A.3
  • 30
    • 1542347133 scopus 로고    scopus 로고
    • Autonomic nervous system pharmacogenomics: A progress report
    • Kirstein SL, Insel PA. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol Rev 2004; 56: 31-52.
    • (2004) Pharmacol Rev , vol.56 , pp. 31-52
    • Kirstein, S.L.1    Insel, P.A.2
  • 31
    • 33644972273 scopus 로고    scopus 로고
    • Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives
    • Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension 2006; 47: 415-20.
    • (2006) Hypertension , vol.47 , pp. 415-420
    • Riddle, E.L.1    Rana, B.K.2    Murthy, K.K.3    Rao, F.4    Eskin, E.5    O'Connor, D.T.6    Insel, P.A.7
  • 32
    • 33644980547 scopus 로고    scopus 로고
    • Regulator of G-protein signaling-2 as a candidate gene: The road to hypertension or just another roadside marker
    • Feldman RD, Gros R. Regulator of G-protein signaling-2 as a candidate gene: the road to hypertension or just another roadside marker? Hypertension 2006; 47: 337-8.
    • (2006) Hypertension , vol.47 , pp. 337-338
    • Feldman, R.D.1    Gros, R.2
  • 33
    • 78149263437 scopus 로고    scopus 로고
    • Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6
    • Hodges GJ, Gros R, Hegele RA, Van Uum S, Shoemaker JK, Feldman RD. Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6. J Pharmacol Exp Ther 2010; 335: 451-7.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 451-457
    • Hodges, G.J.1    Gros, R.2    Hegele, R.A.3    Van Uum, S.4    Shoemaker, J.K.5    Feldman, R.D.6
  • 34
    • 76749092615 scopus 로고    scopus 로고
    • Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: The CUMAGAS-HYPERT database
    • Kitsios GD, Zintzaras E. Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database. Am J Hypertens 2010; 23: 305-13.
    • (2010) Am J Hypertens , vol.23 , pp. 305-313
    • Kitsios, G.D.1    Zintzaras, E.2
  • 35
    • 77954544185 scopus 로고    scopus 로고
    • Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780
    • Meyer MR, Baretella O, Prossnitz ER, Barton M. Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780. Pharmacology 2010; 86: 58-64.
    • (2010) Pharmacology , vol.86 , pp. 58-64
    • Meyer, M.R.1    Baretella, O.2    Prossnitz, E.R.3    Barton, M.4
  • 37
    • 80052080394 scopus 로고    scopus 로고
    • Association of the aldosterone synthase gene-344TC polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population
    • Li XM, Ling Y, Lu DR, Lu ZQ, Yi QL, Liu Y, Chen HY, Gao X. Association of the aldosterone synthase gene-344TC polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population. Clin Exp Pharmacol Physiol 2011; 38: 598-604.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 598-604
    • Li, X.M.1    Ling, Y.2    Lu, D.R.3    Lu, Z.Q.4    Yi, Q.L.5    Liu, Y.6    Chen, H.Y.7    Gao, X.8
  • 38
    • 80052025365 scopus 로고    scopus 로고
    • Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: Interaction with dietary energy intake
    • Htun NC, Miyaki K, Song Y, Ikeda S, Shimbo T, Muramatsu M. Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake. Am J Hypertens 2011; 24: 1022-6.
    • (2011) Am J Hypertens , vol.24 , pp. 1022-1026
    • Htun, N.C.1    Miyaki, K.2    Song, Y.3    Ikeda, S.4    Shimbo, T.5    Muramatsu, M.6
  • 39
    • 33846815156 scopus 로고    scopus 로고
    • The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of studies including 14,094 cases and 17,760 controls
    • Bagos PG, Elefsinioti AL, Nikolopoulos GK, Hamodrakas SJ. The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of studies including 14,094 cases and 17,760 controls. J Hypertens 2007; 25: 487-500.
    • (2007) J Hypertens , vol.25 , pp. 487-500
    • Bagos, P.G.1    Elefsinioti, A.L.2    Nikolopoulos, G.K.3    Hamodrakas, S.J.4
  • 44
    • 82555194123 scopus 로고    scopus 로고
    • Two-marker association tests yield new disease associations for coronary artery disease and hypertension
    • Slavin TP, Feng T, Schnell A, Zhu X, Elston RC. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet 2011; 130: 725-33.
    • (2011) Hum Genet , vol.130 , pp. 725-733
    • Slavin, T.P.1    Feng, T.2    Schnell, A.3    Zhu, X.4    Elston, R.C.5
  • 46
    • 78349244412 scopus 로고    scopus 로고
    • A genome-wide association study of hypertension-related phenotypes in a Japanese population
    • Hiura Y, Tabara Y, Kokubo Y, Okamura T, Miki T, Tomoike H, Iwai N. A genome-wide association study of hypertension-related phenotypes in a Japanese population. Circ J 2010; 74: 2353-9.
    • (2010) Circ J , vol.74 , pp. 2353-2359
    • Hiura, Y.1    Tabara, Y.2    Kokubo, Y.3    Okamura, T.4    Miki, T.5    Tomoike, H.6    Iwai, N.7
  • 50
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wideassociation study of 14,000 cases of seven common diseasesand 3,000 shared controls
    • The Wellcome Trust Case Control Consortium
    • The Wellcome Trust Case Control Consortium. Genome-wideassociation study of 14,000 cases of seven common diseasesand 3,000 shared controls. Nature 2007; 447: 61-78
    • (2007) Nature , vol.447 , pp. 61-78
  • 52
    • 33644623295 scopus 로고    scopus 로고
    • Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population
    • Pollex RL, Hanley AJ, Zinman B, Harris SB, Hegele RA. Clinicaland genetic associations with hypertriglyceridemic waist ina Canadian aboriginal population. Int J Obes (Lond) 2006;30: 484-91.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 484-491
    • Pollex, R.L.1    Hanley, A.J.2    Zinman, B.3    Harris, S.B.4    Hegele, R.A.5
  • 53
    • 0142025121 scopus 로고    scopus 로고
    • Association studies of genetic polymorphismsin central obesity: A critical review
    • Rosmond R. Association studies of genetic polymorphismsin central obesity: a critical review. Int J Obes Relat MetabDisord 2003; 27: 1141-51.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1141-1151
    • Rosmond, R.1


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