Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 3, 2010, Pages

  Broughton, Brad R S ^a   Miller, Alyson A ^a   Sobey, Christopher G ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

5408 0877; G protein estrogen receptor; G 1; Nitric oxide; Superoxide

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5408 0877; ANTIOXIDANT; ESTROGEN; ESTROGEN RECEPTOR; G 1; G PROTEIN COUPLED RECEPTOR 30; G PROTEIN COUPLED RECEPTOR 30 AGONIST; LUCIGENIN; N(G) NITROARGININE METHYL ESTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT; XANTHINE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY WALL; ARTICLE; CAROTID ARTERY; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; CAROTID ARTERIES; CYCLOPENTANES; ENDOTHELIUM, VASCULAR; FEMALE; MALE; MODELS, ANIMAL; NADP; NITRIC OXIDE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SUPEROXIDES; VASODILATION;

EID: 77749242708     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00878.2009     Document Type: Article

References (37)

1. 2+ entry. Am J Physiol Cell Physiol 288: C872-C880, 2005.
2. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulinrequiring enzyme. Proc Natl Acad Sci USA 87: 682-685, 1990.
3. Chan EC, Drummond GR, Woodman OL. 3′,4′- Dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat. J Cardiovasc Pharmacol 42: 727-735, 2003.
4. Chin-Dusting JP, Boak L, Husband A, Nestel PJ. The isoflavone metabolite dehydroequol produces vasodilatation in human resistance arteries via a nitric oxide-dependent mechanism. Atherosclerosis 176: 45-48, 2004.
5. Chin-Dusting JP, Fisher LJ, Lewis TV, Piekarska A, Nestel PJ, Husband A. The vascular activity of some isoflavone metabolites: implications for a cardioprotective role. Br J Pharmacol 133: 595-605, 2001.
6. Christopoulos A, El Fakahany EE. The generation of nitric oxide by G protein-coupled receptors. Life Sci 64: 1-15, 1998.
7. Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest 116: 561-570, 2006.
8. Haas E, Bhattacharya I, Brailoiu E, Damjanovic M, Brailoiu GC, Gao X, Mueller-Guerre L, Marjon NA, Gut A, Minotti R, Meyer MR, Amann K, Ammann E, Perez-Dominguez A, Genoni M, Clegg DJ, Dun NJ, Resta TC, Prossnitz ER, Barton M. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res 104: 288-291, 2009.
9. Haas E, Meyer MR, Schurr U, Bhattacharya I, Minotti R, Nguyen HH, Heigl A, Lachat M, Genoni M, Barton M. Differential effects of 17beta-estradiol on function and expression of estrogen receptor alpha, estrogen receptor beta, and GPR30 in arteries and veins of patients with atherosclerosis. Hypertension 49: 1358-1363, 2007.
10. Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D, Adler T, de Angelis MH, Irgang M, Otto C, Noppinger PR. Expression pattern of G proteincoupled receptor 30 in LacZ reporter mice. Endocrinology 150: 1722-1730, 2009.
11. Jackman KA, Woodman OL, Chrissobolis S, Sobey CG. Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Res 1141: 99-107, 2007.
12. Jackman KA, Woodman OL, Sobey CG. Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights. Curr Med Chem 14: 2824-2830, 2007.
13. Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2. Lewis rats Endocrinology 150: 3753-3758, 2009.
14. Luksha L, Kublickiene K. The role of estrogen receptor subtypes for vascular maintenance. Gynecol Endocrinol 25: 82-95, 2009.
15. Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, Montanaro D, Musti AM, Picard D, Ando S. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem 279: 27008-27016, 2004.
16. Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Vina J, Aaronson PI, Mann GE. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J 19: 1755-1757, 2005.
17. Martensson UE, Salehi SA, Windahl S, Gomez MF, Sward K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grande PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM. Deletion of the G proteincoupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology 150: 687-698, 2009.
18. Martin DS, Breitkopf NP, Eyster KM, Williams JL. Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats. Am J Physiol Regul Integr Comp Physiol 281: R553-R560, 2001.
19. Martin DS, Williams JL, Breitkopf NP, Eyster KM. Pressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats. Can J Physiol Pharmacol 80: 1180-1186, 2002.
20. Miller AA, Drummond GR, Schmidt HH, Sobey CG. NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res 97: 1055-1062, 2005.
21. Muller-Delp JM, Lubahn DB, Nichol KE, Philips BJ, Price EM, Curran EM, Laughlin MH. Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-α-deficient mice. Am J Physiol Heart Circ Physiol 285: H2150-H2157, 2003.
22. Nevala R, Korpela R, Vapaatalo H. Plant derived estrogens relax rat mesenteric artery in vitro. Life Sci 63: L-100, 1998.
23. Nevala R, Vaskonen T, Vehniainen J, Korpela R, Vapaatalo H. Soy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat. Life Sci 66: 115-124, 2000.
24. Paravicini TM, Gulluyan LM, Dusting GJ, Drummond GR. Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits. Circ Res 91: 54-61, 2002.
25. Park E, Shin JI, Park OJ, Kang MH. Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 51: 254-259, 2005.
26. Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 70: 165-190, 2008.
27. Prossnitz ER, Barton M. Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. Prostaglandins Other Lipid Mediat 89: 89-97, 2009.
28. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307: 1625-1630, 2005.
29. Rosenfeld CR, Cox BE, Roy T, Magness RR. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 98: 2158-2166, 1996.
30. Rubanyi GM, Freay AD, Kauser K, Sukovich D, Burton G, Lubahn DB, Couse JF, Curtis SW, Korach KS. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption. J Clin Invest 99: 2429-2437, 1997.
31. Sobey CG, Weiler JM, Boujaoude M, Woodman OL. Effect of shortterm phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17beta-estradiol. J Pharmacol Exp Ther 310: 135-140, 2004.
32. Tang G, Wang R. Differential expression of KV and KCa channels in vascular smooth muscle cells during 1-day culture. Pflugers Arch 442: 124-135, 2001.
33. Thomas P, Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol 102: 175-179, 2006.
34. Thompson LP, Pinkas G, Weiner CP. Chronic 17beta-estradiol replacement increases nitric oxide-mediated vasodilation of guinea pig coronary microcirculation. Circulation 102: 445-451, 2000.
35. Traupe T, Stettler CD, Li H, Haas E, Bhattacharya I, Minotti R, Barton M. Distinct roles of estrogen receptors alpha and beta mediating acute vasodilation of epicardial coronary arteries. Hypertension 49: 1364-1370, 2007.
36. 2+ influx and contraction in murine cardiomyocytes. Am J Physiol Heart Circ Physiol 294: H2421-H2427, 2008.
37. Walker HA, Dean TS, Sanders TA, Jackson G, Ritter JM, Chowienczyk PJ. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol. Circulation 103: 258-262, 2001.