Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 2, 2010, Pages 451-457

  Hodges, Gary J ^a   Gros, Robert ^a,b   Hegele, Robert A ^a,b   Van Uum, Stan ^a   Shoemaker, J Kevin ^a   Feldman, Ross D ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 6; NORADRENALIN; RENIN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EXERCISE; FEMALE; FOREARM BLOOD FLOW; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAND GRIP; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HETEROZYGOTE; HUMAN; HYPEREMIA; MALE; MEAN ARTERIAL PRESSURE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; ORTHOSTATIC STRESS; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; REST; SYSTOLIC BLOOD PRESSURE; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION;

ADENYLATE CYCLASE; ADOLESCENT; ADULT; ANTHROPOMETRY; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; EXERCISE; FOREARM; GENE FREQUENCY; GENETIC VARIATION; GENOTYPE; HEART RATE; HUMANS; LOWER BODY NEGATIVE PRESSURE; MIDDLE AGED; REGIONAL BLOOD FLOW; VASOCONSTRICTION; VASODILATION; YOUNG ADULT;

EID: 78149263437     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.172700     Document Type: Article

References (35)

1. Betik AC, Luckham VB, and Hughson RL (2004) Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions. Am J Physiol Heart Circ Physiol 286:H442-H448.
2. Cao H and Hegele RA (2003) LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). J Hum Genet 48:271-274.
3. Clifford PS and Hellsten Y (2004) Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97:393-403.
4. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, et al. (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39:257-265.
5. DuBois D and DuBois EF (1916) Clinical calorimetry: tenth paper-a formula to estimate the approximate surface area if height and weight be known. Arch Int Med 17:863-871.
6. Feldman RD and Gros R (1998) Impaired vasodilator function in hypertension: the role of alterations in receptor-G-protein coupling. Trends Cardiovasc Med 8:297-305.
7. Frances MF, Dujic Z, and Shoemaker JK (2008) Splenic constriction during isometric handgrip exercise in humans. Appl Physiol Nutr Metab 33:990-996.
8. Gros R, Ding Q, Cao H, Main T, Hegele RA, and Feldman RD (2005) Identification of a dysfunctional missense single nucleotide variant of human adenylyl cyclase VI. Clin Pharmacol Ther 77:271-278.
9. Gros R, Ding Q, Chorazyczewski J, Pickering JG, Limbird LE, and Feldman RD (2006) Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. Circ Res 99:845-852.
10. Gros R, Van Uum S, Hutchinson-Jaffe A, Ding Q, Pickering JG, Hegele RA, and Feldman RD (2007) Increased enzyme activity and β-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6. Arterioscler Thromb Vasc Biol 27:2657-2663.
11. Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, et al. (2003) Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. J Cardiovasc Pharmacol 42 (Suppl 1):S27-S32.
12. Kimmerly DS and Shoemaker JK (2002) Hypovolemia and neurovascular control during orthostatic stress. Am J Physiol Heart Circ Physiol 282:H645-H655.
13. Ludwig MG and Seuwen K (2002) Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res 22:79-110.
14. Marshall JM (2007) The roles of adenosine and related substances in exercise hyperaemia. J Physiol 583:835-845.
15. Matsumoto T, Wakabayashi K, Kobayashi T, and Kamata K (2005) Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats. Am J Physiol Heart Circ Physiol 289: H2234-H2243.
16. Moxham CM and Malbon CC (1996) Insulin action impaired by deficiency of the G-protein subunit Giα2. Nature 379:840-844.
17. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Circulation 106:3143-3421.
18. Nordman S, Abulaiti A, Hilding A, Långberg EC, Humphreys K, Ostenson CG, Efendic S, and Gu HF (2008) Genetic variation of the adenylyl cyclase 3 (ADCY3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. Int J Obes (Lond) 32:407-412.
19. Ostrom RS, Post SR, and Insel PA (2000) Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther 294:407-412.
20. Patel TB, Du Z, Pierre S, Cartin L, and Scholich K (2001) Molecular biological approaches to unravel adenylyl cyclase signaling and function. Gene 269:13-25.
21. Pouliot MC, Després JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, and Lupien PJ (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 73:460-468.
22. Rana BK, Shiina T, and Insel PA (2001) Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. Annu Rev Pharmacol Toxicol 41:593-624.
23. Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, and Hammond HK (2002) Adenylyl cyclase increases survival in cardiomyopathy. Circulation 105: 1989-1994.
24. Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY, Zhu J, Entrikin D, and Hammond HK (1999) Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 99:3099-3102.
25. Shoemaker JK, Halliwill JR, Hughson RL, and Joyner MJ (1997a) Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery. Am J Physiol Heart Circ Physiol 273:H2388-H2395.
26. Shoemaker JK, Mattar L, Kerbeci P, Trotter S, Arbeille P, and Hughson RL (2007) WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women. J Appl Physiol 103:228-233.
27. Shoemaker JK, Pandey P, Herr MD, Silber DH, Yang QX, Smith MB, Gray K, and Sinoway LI (1997b) Augmented sympathetic tone alters muscle metabolism with exercise: lack of evidence for functional sympatholysis. J Appl Physiol 82:1932-1938.
28. Shoemaker JK, Tiidus PM, and Mader R (1997c) Failure of manual massage to alter limb blood flow: measures by Doppler ultrasound. Med Sci Sports Exerc 29:610-614.
29. Shoemaker JK, Tschakovsky ME, and Hughson RL (1998) Vasodilation contributes to the rapid hyperemia with rhythmic contractions in humans. Can J Physiol Pharmacol 76:418-427.
30. Siffert W (2003) Effects of the G protein β3-subunit gene C825T polymorphism: should hypotheses regarding the molecular mechanisms underlying enhanced G protein activation be revised? Focus on "A splice variant of the G protein β3- subunit implicated in disease states does not modulate ion channels." Physiol Genomics 13:81-84.
31. Small KM, Brown KM, Theiss CT, Seman CA, Weiss ST, and Liggett SB (2003) An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced β2-adrenergic receptor stimulation. Pharmacogenetics 13:535-541.
32. Sunahara RK and Taussig R (2002) Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv 2:168-184.
33. Tepe NM and Liggett SB (1999) Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of β-adrenergic receptor dysfunction in the Gαq overexpressing mouse. FEBS Lett 458:236-240.
34. Wang T and Brown MJ (2004) Differential expression of adenylyl cyclase subtypes in human cardiovascular system. Mol Cell Endocrinol 223:55-62.
35. Wuttke MS, Buck J, and Levin LR (2001) Bicarbonate-regulated soluble adenylyl cyclase. Jop 2 (4 Suppl):154-158. (Pubitemid 38972307)