Sodium butyrate, a histone deacetylase inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus

Neurological Research

Volumn 37, Issue 1, 2015, Pages 69-76

  Yoo, Dae Young ^a   Kim, Dae Won ^b   Kim, Mi Jin ^c   Choi, Jung Hoon ^d   Jung, Hyo Young ^a   Nam, Sung Min ^a   Kim, Jong Whi ^a   Yoon, Yeo Sung ^a   Choi, Soo Young ^c   Hwang, In Koo ^a  

^a Seoul National University   (South Korea)

^b Gangneung Wonju National University   (South Korea)

^c Hallym University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Dentate gyrus; Histone deacetylation; Neurogenesis; Sirtuin 2; Sodium butyrate

Indexed keywords

BUTYRIC ACID; DOUBLECORTIN; HYBRID PROTEIN; KI 67 ANTIGEN; PEP 1 SIRTUIN 2 FUSION PROTEIN; SIRTUIN 2; UNCLASSIFIED DRUG; DOUBLECORTIN PROTEIN; HISTONE DEACETYLASE INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; NOOTROPIC AGENT; SIRT2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DEACETYLATION; DENTATE GYRUS; HISTONE ACETYLATION; IMMUNOHISTOCHEMISTRY; MALE; MEMORY; MEMORY DISORDER; MOUSE; NEUROBLAST; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; EXPLORATORY BEHAVIOR; MEMORY DISORDERS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BUTYRIC ACID; CELL PROLIFERATION; DENTATE GYRUS; EXPLORATORY BEHAVIOR; HISTONE DEACETYLASE INHIBITORS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MEMORY DISORDERS; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NEURAL STEM CELLS; NEUROGENESIS; NEUROPEPTIDES; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; SIRTUIN 2;

EID: 84919337915     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132814Y.0000000416     Document Type: Article

References (46)

1. Oliveira SL, Pillat MM, Cheffer A, Lameu C, Schwindt TT, Ulrich H. Functions of neurotrophins and growth factors in neurogenesis and brain repair. Cytometry Part A. 2013;83:76-89.
2. Crepaldi L, Riccio A. Chromatin learns to behave. Epigenetics. 2009;4:23-6.
3. Morrison BE, Majdzadeh N, D’Mello SR. Histone deacetylases: focus on the nervous system. Cell Mol Life Sci. 2007;64:2258-69.
4. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009;459:55-60.
5. Jawerka M, Colak D, Dimou L, Spiller C, Lagger S, Montgomery RL, et al. The specific role of histone deacetylase 2 in adult neurogenesis. Neuron Glia Biol. 2010;6:93-107.
6. Gan L, Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008;58:10-4.
7. Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 2007;26:5489-504.
8. Hashiramoto M, Kaku K. Sirtuin 1 as a key player of ‘metabolic memory’. J Diabetes Invest. 2013;4:34-6.
9. Maxwell MM, Tomkinson EM, Nobles J, Wizeman JW, Amore AM, Quinti L, et al. The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Hum Mol Genet. 2011;20:3986-96.
10. Yao X, Zhang JR, Huang HR, Dai LC, Liu QJ, Zhang M. Histone deacetylase inhibitor promotes differentiation of embryonic stem cells into neural cells in adherent monoculture. Chin Med J (Engl). 2010;123:734-8.
11. Yu IT, Park JY, Kim SH, Lee JS, Kim YS, Son H. Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation. Neuropharmacology. 2009;56:473-80.
12. George S, Kadam SD, Irving ND, Markowitz GJ, Raja S, Kwan A, et al. Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice. Front Cell Neurosci. 2013;7:123.
13. Yoo DY, Kim W, Nam SM, Kim DW, Chung JY, Choi SY, et al. Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrus. Neurochem Res. 2011;36:1850-7.
14. Kim HJ, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009;110:1226-40.
15. Saharan S, Jhaveri DJ, Bartlett PF. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. J Neurosci Res. 2013;91:642-59.
16. Pandithage R, Lilischkis R, Harting K, Wolf A, Jedamzik B, Lüscher-Firzlaff J, et al. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol. 2008;180:915-29.
17. Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, et al. Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson’s disease. Science. 2007;317:516-9.
18. Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, et al. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci USA. 2010;107:7927-32.
19. Fonseca SB, Pereira MP, Kelley SO. Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv Drug Deliv Rev. 2009;61:953-64.
20. Ding B, Chen Z. Molecular interactions between cell penetrating peptide Pep-1 and model cell membranes. J Phys Chem B. 2012;116:2545-52.
21. Deshayes S, Heitz A, Morris MC, Charnet P, Divita G, Heitz F. Insight into the mechanism of internalization of the cellpenetrating carrier peptide Pep-1 through conformational analysis. Biochemistry. 2004;43:1449-57.
22. Cho JH, Hwang IK, Yoo KY, Kim SY, Kim DW, Kwon YG, et al. Effective delivery of Pep-1-cargo protein into ischemic neurons and long-term neuroprotection of Pep-1-SOD1 against ischemic injury in the gerbil hippocampus. Neurochem Int. 2008;52:659-68.
23. Meloni BP, Craig AJ, Milech N, Hopkins RM, Watt PM, Knuckey NW. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014;34:173-81.
24. Kim MJ, Kim DW, Park JH, Kim SJ, Lee CH, Yong JI, et al. PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 2013;63:432-445.
25. Kim W, Kim DW, Shin BN, Yoo DY, Nam SM, Kim MJ, et al. PEP-1-frataxin significantly increases cell proliferation and neuroblast differentiation by reducing lipid peroxidation in the mouse dentate gyrus. Neurochem Res. 2011;36:2452-8.
26. Brown JP, Couillard-Després S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol. 2003;467:1-10.
27. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, et al. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci. 2005;21:1-14.
28. Franklin KBJ, Paxinos G. The mouse brain in stereotaxic coordinates. San Diego, CA: Academic Press; 1997.
29. North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NADz-dependent tubulin deacetylase. Mol Cell. 2003;11:437-44.
30. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, et al. Elongator controls the migration and differentiation of cortical neurons through acetylation of atubulin. Cell. 2009;136:551-64.
31. Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, et al. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun. 2003;309:558-66.
32. Harting K, Knöll B. SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology. Eur J Cell Biol. 2010;89:262-9.
33. Li Y, Dai D, Lu Q, Fei M, Li M, Wu X. Sirt2 suppresses glioma cell growth through targeting NF-kB-miR-21 axis. Biochem Biophys Res Commun. 2013;441:661-7.
34. Pfister JA, Ma C, Morrison BE, D’Mello SR. Opposing effects of sirtuins on neuronal survival: SIRT1-meidated neuroprotection is independent of its deacetylase activity. PLoS One. 2008;3:e4090.
35. Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 2012;492:199-204.
36. Suzuki K, Koike T. Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. Neuroscience. 2007;147:599-612.
37. Fessler EB, Chibane FL, Wang Z, Chuang DM. Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery. Curr Pharm Des. 2013;19:5105-20.
38. Levenson JM, O’Riordan KJ, Brown KD, Trinh MA, Molfese DL, Sweatt JD. Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem. 2004;279:40545-59.
39. Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci. 2007;27:6128-40.
40. Broadbent NJ, Gaskin S, Squire LR, Clark RE. Object recognition memory and the rodent hippocampus. Learn Mem. 2010;17:5-11.
41. Broadbent NJ, Squire LR, Clark RE. Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci USA. 2004;101:14515-20.
42. Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’. Nat Protoc. 2006;1:1306-11.
43. Ennaceur A. One-trial object recognition in rats and mice: methodological and theoretical issues. Behav Brain Res. 2010;215:244-54.
44. Rane P, Shields J, Heffernan M, Guo Y, Akbarian S, King JA. The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology. 2012;62:2409-12.
45. Silva PF, Garcia VA, Dornelles Ada S, Silva VK, Maurmann N, Portal BC, et al. Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate. Neuroscience. 2012;200:42-9.
46. Yoo DY, Kim W, Kim IH, Nam SM, Chung JY, Choi JH, et al. Combination effects of sodium butyrate and pyridoxine treatment on cell proliferation and neuroblast differentiation in the dentate gyrus of D-galactose-induced aging model mice. Neurochem Res. 2012;37:223-31.