Norbornane-based nucleoside and nucleotide analogues locked in North conformation

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 1, 2015, Pages 184-191

  Dejmek, Milan ^a   Šála, Michal ^a   Hřebabecký, Hubert ^a   Dračínský, Martin ^a   Procházková, Eliška ^a   Chalupská, Dominika ^a   Klíma, Martin ^a   Plačková, Pavla ^a   Hájek, Miroslav ^a   Andrei, Graciela ^b   Naesens, Lieve ^b   Leyssen, Pieter ^b   Neyts, Johan ^b   Balzarini, Jan ^b   Boura, Evzen ^a   Nencka, Radim ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Carbocyclic nucleosides; Norbornane; PI4KII ; Purines

Indexed keywords

(3 AMINOBICYCLO[2.2.1]HEPTAN 1 YL)METHANOL; 1 [4 (HYDROXYMETHYL)BICYCLO[2.2.1]HEPT 2 YL] 5 METHYLPYRIMIDINE 2,4 DIONE; 2 AMINO 9 [4 (HYDROXYMETHYL)BICYCLO[2.2.1]HEPT 2 YL] 1,9 DIHYDRO 6H PURIN 6 ONE; 4 [2 AMINO 6 (CYCLOPROPYLAMINO) 9H PURIN 9 YL]BICYCLO[2.2.1]HEPTAN 2 OL; ABACAVIR; DIDANOSINE; FLUOROURIDINE; METHYL 2 [[[[3 (6 AMINO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTAN 1 YL]METHOXY](PHENOXY)PHOSPHORYL]AMINO]PROPANOATE; METHYL 2 [[[[3 [6 (CYCLOPROPYLAMINO) 9H PURIN 9 YL]BICYCLO[2.2.1]HEPTAN 1 YL]METHOXY](PHENOXY)PHOSPHORYL]AMINO]PROPANOATE; METHYL 3 AZIDOBICYCLO[2.2.1]HEPTANE 1 CARBOXYLATE; METHYL 3 HYDROXYBICYCLO[2.2.1]HEPTANE 1 CARBOXYLATE; METHYL 3 OXOBICYCLO[2.2.1]HEPTANE 1 CARBOXYLATE; NORBORNANE DERIVATIVE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; [3 (2 AMINO 6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPT 1 YL]METHANOL; [3 (6 AMINO CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPT 1 YL]METHANOL; [3 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPT 1 YL]METHANOL; [3 (6 THIO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPT 1 YL]METHANOL; [3 [6 (CYCLOPROPYLAMINO) 9H PURIN 9 YL]BICYCLO[2.2.1]HEPT 1 YL]METHANOL; [3 [6 (DIMETHYLAMINO) 9H PURIN 9 YL]BICYCLO[2.2.1]HEPT 1 YL]METHANOL; ANTIVIRUS AGENT; NUCLEOSIDE; NUCLEOTIDE;

AMMONOLYSIS; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ELECTROSPRAY; HEPATITIS B VIRUS; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MITSUNOBU REACTION; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; CHEMISTRY; CONFORMATION; STEREOISOMERISM; SYNTHESIS;

ANTIVIRAL AGENTS; HUMANS; NORBORNANES; NUCLEIC ACID CONFORMATION; NUCLEOSIDES; NUCLEOTIDES; STEREOISOMERISM;

EID: 84918836443     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.11.011     Document Type: Article

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