Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4374-4384

  Šála, Michal ^a   De Palma, Armando M ^b   Hřebabecký, Hubert ^a   Nencka, Radim ^a   Dračínský, Martin ^a   Leyssen, Pieter ^b   Neyts, Johan ^b   Holý, Antonín ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

6 Chloropurine; Bicyclo 2.2.1 heptane; Coxsackievirus B3; Fluorination; Mitsunobu reaction

Indexed keywords

5 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTAN 2 OL; 5 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTAN 2 ONE; 5 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTANE 2,3 DIOL; 6 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTAN 2 OL; 6 (6 CHLORO 9H PURIN 9 YL)BICYCLO[2.2.1]HEPTAN 2 ONE; 6 CHLORO 9 (1,2,3,4 TETRAHYDROANTHRACEN 2 YL) 9H PURINE; 6 CHLORO 9 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPT 2 YL] 9H PURINE; 6 CHLORO 9 (3 OXATRICYCLO[3.2.1.0]OCT 6 YL) 9H PURINE; 6 CHLORO 9 (3,3 DIMETHYLBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (4 OXATRICYCLO[4.2.1.0]NON 2 YL) 9H PURINE; 6 CHLORO 9 (4 OXATRICYCLO[4.2.1.0]NON 9 YL] 9H PURINE; 6 CHLORO 9 (5 FLUOROBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (5 PHENYLBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (5,5 DIFLUOROBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (6 FLUOROBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (6 PHENYLBICYCLO[2.2.1]HEPT 2 YL) 9H PURINE; 6 CHLORO 9 (6,6 DIFLUOROBICYCLO[2.2.1]HEPT 2 YL] 9H PURINE; 6 CHLORO 9 (TRICYCLO[2.2.1.0]HEPT 3 YL) 9H PURINE; 6 CHLORO 9 (TRICYCLO[5.2.1.0]DEC 8 YL] 9H PURINE; 6 CHLORO 9 (TRICYCLO[6.2.1.0]UNDECA 2,4,6 TRIEN 9 YL] 9H PURINE; 9 (BICYCLO[2.2.1]HEPT 2 YL) 6 CHLORO 9H PURINE; 9 (BICYCLO[2.2.1]HEPT 2 YLMETHYL) 6 CHLORO 9H PURINE; 9 (BICYCLO[2.2.1]HEPT 5 EN 2 YL) 6 CHLORO 9H PURINE; 9 (BICYCLO[2.2.1]HEPT 5 EN 2 YLMETHYL) 6 CHLORO 9H PURINE; 9,9' BICYCLO[2.2.1]HEPT 5 ENE 2,3 DIYLBIS (6 CHLORO 9H PURINE); 9,9' BICYCLO[2.2.1]HEPTANE 2,3 DIYLBIS(6 CHLORO 9H PURINE); 9,9' BICYCLO[2.2.1]HEPTANE 2,5 DIYLBIS (6 CHLORO 9H PURINE); 9,9' BICYCLO[2.2.1]HEPTANE 2,6 DIYLBIS(6 CHLORO 9H PURINE); ANTIVIRUS AGENT; PURINE DERIVATIVE; UNCLASSIFIED DRUG; 6-CHLOROPURINE; BICYCLO COMPOUND; BICYCLO(2.2.1)HEPTENE;

ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B3; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; VIRUS INHIBITION; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; ENTEROVIRUS; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VERO CELL LINE;

ANIMALS; ANTIVIRAL AGENTS; BICYCLO COMPOUNDS; CERCOPITHECUS AETHIOPS; DRUG DESIGN; ENTEROVIRUS B, HUMAN; HUMANS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

COXSACKIEVIRUS;

EID: 77953130838     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.081     Document Type: Article

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