Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 12, 2014, Pages F1390-F1403

  Park, Jung Tak ^a,b   Kato, Mitsuo ^b   Lanting, Linda ^b   Castro, Nancy ^b   Nam, Bo Young ^a   Wang, Mei ^b   Kang, Shin Wook ^a   Natarajan, Rama ^b  

^a Yonsei University College of Medicine   (South Korea)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Diabetic nephropathy; Let 7; Lin28b; MicroRNA; Transforming growth factor

Indexed keywords

COLLAGEN; COLLAGEN TYPE 2; COLLAGEN TYPE 4; LIN28B PROTEIN; LUCIFERASE; MICRORNA; MICRORNA LET 7; RNA BINDING PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ALPHA 2(I) COLLAGEN; COLLAGEN TYPE 1; LIN-28 PROTEIN, MOUSE; MIRNLET7 MICRORNA, MOUSE; RECOMBINANT PROTEIN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; STREPTOZOCIN; TGFB1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE EXPRESSION REGULATION; LUCIFERASE ASSAY; MESANGIUM CELL; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; BINDING SITES; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE IV; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROSIS; HUMANS; MESANGIAL CELLS; MICE, INBRED C57BL; MICRORNAS; MUTATION; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; STREPTOZOCIN; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84918834795     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00458.2014     Document Type: Article

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