Transforming growth factorβ1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and MicroRNAs in renal mesangial cells

Journal of Biological Chemistry

Volumn 289, Issue 42, 2014, Pages 29001-29013

  Castro, Nancy E ^a   Kato, Mitsuo ^a   Park, Jung Tak ^a   Natarajan, Rama ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MESANGIAL CELLS; MICRORNAS; SIGNALING CASCADES; TRANSFORMING GROWTH FACTORS;

CONNECTIVE TISSUE GROWTH FACTOR; MICRORNA; MICRORNA 130B; NF YC PROTEIN; NUCLEAR FACTOR Y; NUCLEIC ACID BINDING PROTEIN; RIK PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CCAAT BINDING FACTOR; COLLAGEN TYPE 4; MIRN130 MICRORNA, MOUSE; MIRNLET7 MICRORNA, MOUSE; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; COL2A1 GENE; COL4A1 GENE; CONTROLLED STUDY; CTGF GENE; DIABETIC NEPHROPATHY; DOWN REGULATION; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING; MESANGIUM CELL; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PAI 1 GENE; PROFIBROTIC GENE; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RIK GENE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE COURSE; FIBROSIS; KIDNEY; METABOLISM; SIGNAL TRANSDUCTION;

3' UNTRANSLATED REGIONS; ANIMALS; CCAAT-BINDING FACTOR; CELLS, CULTURED; COLLAGEN TYPE IV; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; FIBROSIS; GENE EXPRESSION REGULATION; KIDNEY; MESANGIAL CELLS; MICE; MICE, INBRED C57BL; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84908093833     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600783     Document Type: Article

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