메뉴 건너뛰기




Volumn 17, Issue 10, 2014, Pages 1298-1303

Motivational activation: A unifying hypothesis of orexin/hypocretin function

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

EID: 84918823389     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3810     Document Type: Review
Times cited : (291)

References (74)
  • 1
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea, L. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95, 322-327 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 322-327
    • De Lecea, L.1
  • 2
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585 (1998).
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1
  • 4
    • 33847121297 scopus 로고    scopus 로고
    • The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness
    • Sakurai, T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat. Rev. Neurosci. 8, 171-181 (2007).
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 171-181
    • Sakurai, T.1
  • 5
    • 0034255401 scopus 로고    scopus 로고
    • The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders
    • Kilduff, T.S. & Peyron, C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci. 23, 359-365 (2000).
    • (2000) Trends Neurosci , vol.23 , pp. 359-365
    • Kilduff, T.S.1    Peyron, C.2
  • 6
    • 4344609367 scopus 로고    scopus 로고
    • Sleep sleep disorders and hypocretin (orex
    • Mignot, E. Sleep, sleep disorders and hypocretin (orexin). Sleep Med. 5 (suppl. 1), S2-S8 (2004).
    • (2004) Sleep Med , vol.5 , pp. S2-S8
    • Mignot, E.1
  • 7
    • 84891277327 scopus 로고    scopus 로고
    • The hypocretins/orexins: Integrators of multiple physiological functions
    • Li, J., Hu, Z. & de Lecea, L. The hypocretins/orexins: integrators of multiple physiological functions. Br. J. Pharmacol. 171, 332-350 (2014).
    • (2014) Br. J. Pharmacol , vol.171 , pp. 332-350
    • Li, J.1    Hu, Z.2    De Lecea, L.3
  • 8
    • 0033588319 scopus 로고    scopus 로고
    • Narcolepsy a key role for hypocretins (orexins
    • Siegel, J.M. Narcolepsy: a key role for hypocretins (orexins). Cell 98, 409-412 (1999).
    • (1999) Cell , vol.98 , pp. 409-412
    • Siegel, J.M.1
  • 9
    • 75149151138 scopus 로고    scopus 로고
    • Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention
    • Fadel, J. & Burk, J.A. Orexin/hypocretin modulation of the basal forebrain cholinergic system: role in attention. Brain Res. 1314, 112-123 (2010).
    • (2011) Brain Res , vol.1314 , pp. 112-123
    • Fadel, J.1    Burk, J.A.2
  • 10
    • 75449107169 scopus 로고    scopus 로고
    • Hypocretin/orexin in arousal and stress
    • Berridge, C.W., Espana, R.A. & Vittoz, N.M. Hypocretin/orexin in arousal and stress. Brain Res. 1314, 91-102 (2010).
    • (2011) Brain Res , vol.1314 , pp. 91-102
    • Berridge, C.W.1    Espana, R.A.2    Vittoz, N.M.3
  • 12
    • 19544376694 scopus 로고    scopus 로고
    • Behavioral correlates of activity in identified hypocretin/orexin neurons
    • Mileykovskiy, B.Y., Kiyashchenko, L.I. & Siegel, J.M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46, 787-798 (2005).
    • (2005) Neuron , vol.46 , pp. 787-798
    • Mileykovskiy, B.Y.1    Kiyashchenko, L.I.2    Siegel, J.M.3
  • 13
    • 22244443005 scopus 로고    scopus 로고
    • Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    • Lee, M.G., Hassani, O.K. & Jones, B.E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J. Neurosci. 25, 6716-6720 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 6716-6720
    • Lee, M.G.1    Hassani, O.K.2    Jones, B.E.3
  • 14
    • 78649966665 scopus 로고    scopus 로고
    • Dopamine in motivational control: Rewarding, aversive and alerting
    • Bromberg-Martin, E.S., Matsumoto, M. & Hikosaka, O. Dopamine in motivational control: rewarding, aversive and alerting. Neuron 68, 815-834 (2010).
    • (2011) Neuron , vol.68 , pp. 815-834
    • Bromberg-Martin, E.S.1    Matsumoto, M.2    Hikosaka, O.3
  • 15
    • 23244432007 scopus 로고    scopus 로고
    • An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance
    • Aston-Jones, G. & Cohen, J.D. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28, 403-450 (2005).
    • (2005) Annu. Rev. Neurosci , vol.28 , pp. 403-450
    • Aston-Jones, G.1    Cohen, J.D.2
  • 16
    • 3242699614 scopus 로고    scopus 로고
    • Behavioral state instability in orexin knock-out mice
    • Mochizuki, T. et al. Behavioral state instability in orexin knock-out mice. J. Neurosci. 24, 6291-6300 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 6291-6300
    • Mochizuki, T.1
  • 17
    • 84877301467 scopus 로고    scopus 로고
    • Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
    • Bayard, S. & Dauvilliers, Y.A. Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy. Front. Behav. Neurosci. 7, 50 (2013).
    • (2013) Front. Behav. Neurosci , vol.7 , pp. 50
    • Bayard, S.1    Dauvilliers, Y.A.2
  • 18
    • 43049176663 scopus 로고    scopus 로고
    • Neuronal activity of orexin and non-orexin waking-Active neurons during wake-sleep states in the mouse
    • Takahashi, K., Lin, J.S. & Sakai, K. Neuronal activity of orexin and non-orexin waking-Active neurons during wake-sleep states in the mouse. Neuroscience 153, 860-870 (2008).
    • (2008) Neuroscience , vol.153 , pp. 860-870
    • Takahashi, K.1    Lin, J.S.2    Sakai, K.3
  • 19
    • 84885213018 scopus 로고    scopus 로고
    • A unified survival theory of the functioning of the hypocretinergic system
    • Chase, M.H. A unified survival theory of the functioning of the hypocretinergic system. J. Appl. Physiol. 115, 954-971 (2013).
    • (2013) J. Appl. Physiol , vol.115 , pp. 954-971
    • Chase, M.H.1
  • 20
    • 84857433330 scopus 로고    scopus 로고
    • Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes
    • Wu, M.F., Nienhuis, R., Maidment, N., Lam, H.A. & Siegel, J.M. Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes. Arch. Ital. Biol. 149, 492-498 (2011).
    • (2011) Arch. Ital. Biol , vol.149 , pp. 492-498
    • Wu, M.F.1    Nienhuis, R.2    Maidment, N.3    Lam, H.A.4    Siegel, J.M.5
  • 21
    • 77957313794 scopus 로고    scopus 로고
    • Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons
    • Appelbaum, L. et al. Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron 68, 87-98 (2010).
    • (2011) Neuron , vol.68 , pp. 87-98
    • Appelbaum, L.1
  • 22
    • 78650419195 scopus 로고    scopus 로고
    • A role for hypocretin/orexin in motivation
    • Thompson, J.L. & Borgland, S.L. A role for hypocretin/orexin in motivation. Behav. Brain Res. 217, 446-453 (2011).
    • (2011) Behav. Brain Res , vol.217 , pp. 446-453
    • Thompson, J.L.1    Borgland, S.L.2
  • 23
    • 84875486304 scopus 로고    scopus 로고
    • Role of orexin in modulating arousal, feeding and motivation
    • Tsujino, N. & Sakurai, T. Role of orexin in modulating arousal, feeding and motivation. Front. Behav. Neurosci. 7, 28 (2013).
    • (2013) Front. Behav. Neurosci , vol.7 , pp. 28
    • Tsujino, N.1    Sakurai, T.2
  • 24
    • 84904699761 scopus 로고    scopus 로고
    • Function and dysfunction of hypocretin/orexin: An energetics point of view
    • Gao, X.B. & Horvath, T. Function and dysfunction of hypocretin/orexin: an energetics point of view. Annu. Rev. Neurosci. 37, 101-116 (2014).
    • (2014) Annu. Rev. Neurosci , vol.37 , pp. 101-116
    • Gao, X.B.1    Horvath, T.2
  • 25
    • 0020368354 scopus 로고
    • A two process model of sleep regulation
    • Borbély, A.A. A two process model of sleep regulation. Hum. Neurobiol. 1, 195-204 (1982).
    • (1982) Hum. Neurobiol , vol.1 , pp. 195-204
    • Borbély, A.A.1
  • 26
    • 0037509933 scopus 로고    scopus 로고
    • Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness
    • Zeitzer, J.M. et al. Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J. Neurosci. 23, 3555-3560 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 3555-3560
    • Zeitzer, J.M.1
  • 27
    • 0036865307 scopus 로고    scopus 로고
    • Cataplexy: Tonic immobility rather than REM-sleep atonia?
    • Overeem, S., Lammers, G.J. & van Dijk, J.G. Cataplexy: tonic immobility rather than REM-sleep atonia? Sleep Med. 3, 471-477 (2002).
    • (2002) Sleep Med , vol.3 , pp. 471-477
    • Overeem, S.1    Lammers, G.J.2    Van Dijk, J.G.3
  • 28
    • 84878511803 scopus 로고    scopus 로고
    • Role of the medial prefrontal cortex in cataplexy
    • Oishi, Y. et al. Role of the medial prefrontal cortex in cataplexy. J. Neurosci. 33, 9743-9751 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 9743-9751
    • Oishi, Y.1
  • 30
    • 70349145473 scopus 로고    scopus 로고
    • Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    • Borgland, S.L. et al. Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J. Neurosci. 29, 11215-11225 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 11215-11225
    • Borgland, S.L.1
  • 31
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • Harris, G.C., Wimmer, M. & Aston-Jones, G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437, 556-559 (2005).
    • (2005) Nature , vol.437 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-Jones, G.3
  • 32
    • 79957635337 scopus 로고    scopus 로고
    • The lateral hypothalamus as integrator of metabolic and environmental needs: From electrical self-stimulation to opto-genetics
    • Berthoud, H.R. & Munzberg, H. The lateral hypothalamus as integrator of metabolic and environmental needs: from electrical self-stimulation to opto-genetics. Physiol. Behav. 104, 29-39 (2011).
    • (2011) Physiol. Behav , vol.104 , pp. 29-39
    • Berthoud, H.R.1    Munzberg, H.2
  • 33
    • 84887151444 scopus 로고    scopus 로고
    • Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control
    • Burdakov, D., Karnani, M.M. & Gonzalez, A. Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control. Physiol. Behav. 121, 117-124 (2013).
    • (2013) Physiol. Behav , vol.121 , pp. 117-124
    • Burdakov, D.1    Karnani, M.M.2    Gonzalez, A.3
  • 34
    • 77953710614 scopus 로고    scopus 로고
    • Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity
    • Cason, A.M. et al. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol. Behav. 100, 419-428 (2010).
    • (2011) Physiol. Behav , vol.100 , pp. 419-428
    • Cason, A.M.1
  • 35
    • 84906218386 scopus 로고    scopus 로고
    • Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry
    • 6 August 2014
    • Sheng, Z., Santiago, A.M., Thomas, M.P. & Routh, V.H. Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry. Mol. Cell. Neurosci. published online, doi:10.1016/j.mcn.2014.08.001 (6 August 2014).
    • Mol. Cell. Neurosci. Published Online
    • Sheng, Z.1    Santiago, A.M.2    Thomas, M.P.3    Routh, V.H.4
  • 37
    • 0038521277 scopus 로고    scopus 로고
    • Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    • Yamanaka, A. et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701-713 (2003).
    • (2003) Neuron , vol.38 , pp. 701-713
    • Yamanaka, A.1
  • 38
    • 77950371376 scopus 로고    scopus 로고
    • Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner
    • Perello, M. et al. Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol. Psychiatry 67, 880-886 (2010).
    • (2011) Biol. Psychiatry , vol.67 , pp. 880-886
    • Perello, M.1
  • 39
    • 84864953752 scopus 로고    scopus 로고
    • Hypocretin/orexin regulation of dopamine signaling: Implications for reward and reinforcement mechanisms
    • Calipari, E.S. & Espana, R.A. Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms. Front. Behav. Neurosci. 6, 54 (2012).
    • (2012) Front. Behav. Neurosci , vol.6 , pp. 54
    • Calipari, E.S.1    Espana, R.A.2
  • 40
    • 84876469527 scopus 로고    scopus 로고
    • Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats
    • Mahler, S.V., Smith, R.J. & Aston-Jones, G. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl.) 226, 687-698 (2013).
    • (2013) Psychopharmacology (Berl , vol.226 , pp. 687-698
    • Mahler, S.V.1    Smith, R.J.2    Aston-Jones, G.3
  • 41
    • 84898046033 scopus 로고    scopus 로고
    • Orexin antagonists for neuropsychiatric disease: Progress and potential pitfalls
    • Yeoh, J.W., Campbell, E.J., James, M.H., Graham, B.A. & Dayas, C.V. Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls. Front. Neurosci. 8, 36 (2014).
    • (2014) Front. Neurosci , vol.8 , pp. 36
    • Yeoh, J.W.1    Campbell, E.J.2    James, M.H.3    Graham, B.A.4    Dayas, C.V.5
  • 42
    • 85172037420 scopus 로고    scopus 로고
    • The hypocretins and the reward function: What have we learned so far?
    • Boutrel, B., Steiner, N. & Halfon, O. The hypocretins and the reward function: what have we learned so far? Front. Behav. Neurosci. 7, 59 (2013).
    • (2013) Front. Behav. Neurosci , vol.7 , pp. 59
    • Boutrel, B.1    Steiner, N.2    Halfon, O.3
  • 43
    • 84857036336 scopus 로고    scopus 로고
    • The hypothalamus and the neurobiology of drug seeking
    • Marchant, N.J., Millan, E.Z. & McNally, G.P. The hypothalamus and the neurobiology of drug seeking. Cell. Mol. Life Sci. 69, 581-597 (2012).
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 581-597
    • Marchant, N.J.1    Millan, E.Z.2    McNally, G.P.3
  • 44
    • 78049402675 scopus 로고    scopus 로고
    • Orexin neurons as arousal-Associated modulators of central cardiorespiratory regulation
    • Kuwaki, T. & Zhang, W. Orexin neurons as arousal-Associated modulators of central cardiorespiratory regulation. Respir. Physiol. Neurobiol. 174, 43-54 (2010).
    • (2011) Respir. Physiol. Neurobiol , vol.174 , pp. 43-54
    • Kuwaki, T.1    Zhang, W.2
  • 45
    • 84898036066 scopus 로고    scopus 로고
    • Orex orexin receptor antagonists and central cardiovascular control
    • Carrive, P. Orexin, orexin receptor antagonists and central cardiovascular control. Front. Neurosci. 7, 257 (2013).
    • (2013) Front. Neurosci , vol.7 , pp. 257
    • Carrive, P.1
  • 47
    • 10644267749 scopus 로고    scopus 로고
    • Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response
    • Winsky-Sommerer, R. et al. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J. Neurosci. 24, 11439-11448 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 11439-11448
    • Winsky-Sommerer, R.1
  • 48
    • 38349116509 scopus 로고    scopus 로고
    • Stress blunts serotonin-And hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
    • Liu, R.J. & Aghajanian, G.K. Stress blunts serotonin-And hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proc. Natl. Acad. Sci. USA 105, 359-364 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 359-364
    • Liu, R.J.1    Aghajanian, G.K.2
  • 49
    • 0038600674 scopus 로고    scopus 로고
    • Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects
    • Salomon, R.M. et al. Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol. Psychiatry 54, 96-104 (2003).
    • (2003) Biol. Psychiatry , vol.54 , pp. 96-104
    • Salomon, R.M.1
  • 50
    • 41149167542 scopus 로고    scopus 로고
    • Orexin signaling mediates the antidepressant-like effect of calorie restriction
    • Lutter, M. et al. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J. Neurosci. 28, 3071-3075 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 3071-3075
    • Lutter, M.1
  • 51
    • 84904597218 scopus 로고    scopus 로고
    • Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats
    • James, M.H. et al. Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats. Front. Behav. Neurosci. 8, 244 (2014).
    • (2014) Front. Behav. Neurosci , vol.8 , pp. 244
    • James, M.H.1
  • 52
    • 80155147930 scopus 로고    scopus 로고
    • An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis
    • Tupone, D., Madden, C.J., Cano, G. & Morrison, S.F. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J. Neurosci. 31, 15944-15955 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 15944-15955
    • Tupone, D.1    Madden, C.J.2    Cano, G.3    Morrison, S.F.4
  • 53
    • 84904605023 scopus 로고    scopus 로고
    • Role of lateral hypothalamus in two aspects of attention in associative learning
    • Wheeler, D.S. et al. Role of lateral hypothalamus in two aspects of attention in associative learning. Eur. J. Neurosci. 40, 2359-2377 (2014).
    • (2014) Eur. J. Neurosci , vol.40 , pp. 2359-2377
    • Wheeler, D.S.1
  • 54
    • 19444377722 scopus 로고    scopus 로고
    • Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: Correlation with improved attention in rat
    • Lambe, E.K., Olausson, P., Horst, N.K., Taylor, J.R. & Aghajanian, G.K. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. J. Neurosci. 25, 5225-5229 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 5225-5229
    • Lambe, E.K.1    Olausson, P.2    Horst, N.K.3    Taylor, J.R.4    Aghajanian, G.K.5
  • 55
    • 84899103938 scopus 로고    scopus 로고
    • Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area
    • Muschamp, J.W. et al. Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area. Proc. Natl. Acad. Sci. USA 111, E1648-E1655 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. E1648-E1655
    • Muschamp, J.W.1
  • 56
    • 84890284400 scopus 로고    scopus 로고
    • Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus
    • Sears, R.M. et al. Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc. Natl. Acad. Sci. USA 110, 20260-20265 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 20260-20265
    • Sears, R.M.1
  • 57
    • 33750027158 scopus 로고    scopus 로고
    • Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task
    • Akbari, E., Naghdi, N. & Motamedi, F. Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task. Behav. Brain Res. 173, 47-52 (2006).
    • (2006) Behav. Brain Res , vol.173 , pp. 47-52
    • Akbari, E.1    Naghdi, N.2    Motamedi, F.3
  • 58
    • 68249087462 scopus 로고    scopus 로고
    • Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking
    • Smith, R.J., See, R.E. & Aston-Jones, G. Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Eur. J. Neurosci. 30, 493-503 (2009).
    • (2009) Eur. J. Neurosci , vol.30 , pp. 493-503
    • Smith, R.J.1    See, R.E.2    Aston-Jones, G.3
  • 59
    • 33748806552 scopus 로고    scopus 로고
    • Arousal and reward: A dichotomy in orexin function
    • Harris, G.C. & Aston-Jones, G. Arousal and reward: a dichotomy in orexin function. Trends Neurosci. 29, 571-577 (2006).
    • (2006) Trends Neurosci , vol.29 , pp. 571-577
    • Harris, G.C.1    Aston-Jones, G.2
  • 61
    • 35648985743 scopus 로고    scopus 로고
    • The orexins/hypocretins and schizophrenia
    • Deutch, A.Y. & Bubser, M. The orexins/hypocretins and schizophrenia. Schizophr. Bull. 33, 1277-1283 (2007).
    • (2007) Schizophr. Bull , vol.33 , pp. 1277-1283
    • Deutch, A.Y.1    Bubser, M.2
  • 62
    • 4243302729 scopus 로고    scopus 로고
    • Orexin (hypocretin) neurons contain dynorph
    • Chou, T.C. et al. Orexin (hypocretin) neurons contain dynorphin. J. Neurosci. 21, RC168 (2001).
    • (2001) J. Neurosci , vol.21 , pp. RC168
    • Chou, T.C.1
  • 63
    • 84891278490 scopus 로고    scopus 로고
    • Orexin/hypocretin receptor signaling cascades
    • Kukkonen, J.P. & Leonard, C.S. Orexin/hypocretin receptor signaling cascades. Br. J. Pharmacol. 171, 314-331 (2014).
    • (2014) Br. J. Pharmacol , vol.171 , pp. 314-331
    • Kukkonen, J.P.1    Leonard, C.S.2
  • 64
    • 84869061342 scopus 로고    scopus 로고
    • Glutamate and GABA as rapid effectors of hypothalamic peptidergic" neurons
    • Schöne, C. & Burdakov, D. Glutamate and GABA as rapid effectors of hypothalamic "peptidergic" neurons. Front. Behav. Neurosci. 6, 81 (2012).
    • (2012) Front. Behav. Neurosci , vol.6 , pp. 81
    • Schöne, C.1    Burdakov, D.2
  • 65
    • 84904699761 scopus 로고    scopus 로고
    • Function and dysfunction of hypocretin/orexin: An energetics point of view
    • Gao, X.B. & Horvath, T. Function and dysfunction of hypocretin/orexin: an energetics point of view. Annu. Rev. Neurosci. 37, 101-116 (2014).
    • (2014) Annu. Rev. Neurosci , vol.37 , pp. 101-116
    • Gao, X.B.1    Horvath, T.2
  • 66
    • 84895498899 scopus 로고    scopus 로고
    • Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock
    • Belle, M.D. et al. Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. J. Neurosci. 34, 3607-3621 (2014).
    • (2014) J. Neurosci , vol.34 , pp. 3607-3621
    • Belle, M.D.1
  • 67
    • 75149159966 scopus 로고    scopus 로고
    • Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction
    • Borgland, S.L., Ungless, M.A. & Bonci, A. Convergent actions of orexin/hypocretin and CRF on dopamine neurons: emerging players in addiction. Brain Res. 1314, 139-144 (2010).
    • (2011) Brain Res , vol.1314 , pp. 139-144
    • Borgland, S.L.1    Ungless, M.A.2    Bonci, A.3
  • 68
    • 84899855138 scopus 로고    scopus 로고
    • Conditional ablation of orexin/hypocretin neurons: A new mouse model for the study of narcolepsy and orexin system function
    • Tabuchi, S. et al. Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J. Neurosci. 34, 6495-6509 (2014).
    • (2014) J. Neurosci , vol.34 , pp. 6495-6509
    • Tabuchi, S.1
  • 70
    • 34249822199 scopus 로고    scopus 로고
    • Amygdala dysfunction in narcolepsy-cataplexy
    • Khatami, R., Birkmann, S. & Bassetti, C.L. Amygdala dysfunction in narcolepsy-cataplexy. J. Sleep Res. 16, 226-229 (2007).
    • (2007) J. Sleep Res , vol.16 , pp. 226-229
    • Khatami, R.1    Birkmann, S.2    Bassetti, C.L.3
  • 71
    • 77950522133 scopus 로고    scopus 로고
    • Reduced amygdala activity during aversive conditioning in human narcolepsy
    • Ponz, A. et al. Reduced amygdala activity during aversive conditioning in human narcolepsy. Ann. Neurol. 67, 394-398 (2010).
    • (2011) Ann. Neurol , vol.67 , pp. 394-398
    • Ponz, A.1
  • 72
    • 35648933581 scopus 로고    scopus 로고
    • A review of the effects of modafinil on cognition in schizophrenia
    • Morein-Zamir, S., Turner, D.C. & Sahakian, B.J. A review of the effects of modafinil on cognition in schizophrenia. Schizophr. Bull. 33, 1298-1306 (2007).
    • (2007) Schizophr. Bull , vol.33 , pp. 1298-1306
    • Morein-Zamir, S.1    Turner, D.C.2    Sahakian, B.J.3
  • 73
    • 84875134387 scopus 로고    scopus 로고
    • Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction
    • Blouin, A.M. et al. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat. Commun. 4, 1547 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 1547
    • Blouin, A.M.1
  • 74
    • 0026434566 scopus 로고
    • Neuronal activity in narcolepsy: Identification of cataplexy-related cells in the medial medulla
    • Siegel, J.M. et al. Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla. Science 252, 1315-1318 (1991).
    • (1991) Science , vol.252 , pp. 1315-1318
    • Siegel, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.