Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control

Circulation Journal

Volumn 76, Issue 1, 2012, Pages 152-159

  Shimizu, Shuji ^a   Akiyama, Tsuyoshi ^b   Kawada, Toru ^a   Sata, Yusuke ^a   Mizuno, Masaki ^a   Kamiya, Atsunori ^a   Shishido, Toshiaki ^a   Inagaki, Masashi ^a   Shirai, Mikiyasu ^b   Sano, Shunji ^c   Sugimachi, Masaru ^a  

^a Department of Cardiovascular Dynamics ^*  (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Norepinephrine; Sinoatrial node; Sympathetic nervous system; Vagus nerve

Indexed keywords

ACETYLCHOLINE; MEDETOMIDINE; NORADRENALIN; PHENYLEPHRINE; PHYSOSTIGMINE; RINGER SOLUTION;

ACETYLCHOLINE RELEASE; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; CARDIAC VAGUS NERVE; CONTROLLED STUDY; DIALYSATE LEVEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; HEART NERVE; HEART RATE; HEART RIGHT ATRIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LOW DRUG DOSE; MEAN ARTERIAL PRESSURE; MECHANICAL PROBE; MICRODIALYSIS; NEUROMODULATION; NONHUMAN; NORADRENALIN RELEASE; PRESSORECEPTOR REFLEX; RABBIT; SINUS NODE; VAGUS NERVE STIMULATION;

ACETYLCHOLINE; ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BAROREFLEX; BLOOD PRESSURE; HEART; MEDETOMIDINE; MICRODIALYSIS; MODELS, ANIMAL; NERVE ENDINGS; NOREPINEPHRINE; PHENYLEPHRINE; RABBITS; VAGUS NERVE;

EID: 84255183862     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-11-0574     Document Type: Article

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