Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

European Journal of Pharmacology

Volumn 743, Issue , 2014, Pages 48-52

  Smeester, Branden A ^a   Lunzer, Mary M ^b   Akgün, Eyup ^b   Beitz, Alvin J ^a   Portoghese, Philip S ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Fibrosarcoma; Hyperalgesia; Inflammatory pain; MPEP

Indexed keywords

METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; MMG 22; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ANALGESIC AGENT; GRM5 PROTEIN, MOUSE; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BONE CANCER; CANCER PAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVATION; HYPERALGESIA; MALE; MOUSE; NONHUMAN; ANIMAL; BONE TUMOR; C3H MOUSE; COMPLICATION; DRUG EFFECTS; DRUG TOLERANCE; METABOLISM; NOCICEPTION; PAIN; TUMOR CELL LINE;

ANALGESICS; ANIMALS; BONE NEOPLASMS; CELL LINE, TUMOR; DRUG TOLERANCE; HYPERALGESIA; LIGANDS; MALE; MICE; MICE, INBRED C3H; MORPHINE; NOCICEPTION; PAIN; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, OPIOID, MU;

EID: 84918795916     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.008     Document Type: Article

References (28)

1. E. Akgün, M.I. Javed, M.M. Lunzer, B.A. Smeester, A.J. Beitz, and P.S. Portoghese Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception Proc. Natl. Acad. Sci. USA 110 2013 11595 11599
2. C.E. Bonferroni Teoria statistica delle classi e calcolo delle probabilit\'{a} Vol. 8 1936 Pubblicazioni del R Istituto Superiore di Scienze Economiche e Commerciali di Firenze 3 62
3. E.A. Cavalheiro, and J.W. Olney Glutamate antagonists: deadly liaisons with cancer Proc. Natl. Acad. Sci. USA 98 2001 5947 5948
4. K.Y. Choi, K. Chang, J.M. Pickel, J.D. Badger II, and K.W. Roche Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice Proc. Natl. Acad. Sci. USA 108 2011 15219 15224
5. C.S. Cleeland, A. O'Mara, M. Zagari, and C. Baas Integrating pain metrics into oncology clinical trials Clin. Cancer Res. 17 2011 6646 6650
6. J.L. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur. J. Pharmacol. 67 1980 313 316
7. E. Kozela, A. Pilc, and P. Popik Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-d-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice Psychopharmacology 165 2003 245 251
8. A. Muralidharan, and M.T. Smith Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments Inflammopharmacology 21 2013 339 363
9. V. Neugebauer Peripheral metabotropic glutamate receptors: fight the pain where it hurts Trends Neurosci. 24 2001 550 552
10. C.M. Niswender, and P.J. Conn Metabotropic glutamate receptors: physiology, pharmacology, and disease Annu. Rev. Pharmacol. Toxicol. 50 2010 295 322
11. S.-Y. Park, S.-A. Lee, I.-H. Han, B.-C. Yoo, S.-H. Lee, J.-Y. Park, I.-H. Cha, J. Kim, and S.-W. Choi Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma Oncol. Rep. 17 2007 81 87
12. J. Perroy, F. Raynaud, V. Homburger, M.-C. Rousset, L. Telley, J. Bockaert, and L. Fagni Direct interaction enables cross-talk between ionotropic and group i metabotropic glutamate receptors J. Biol. Chem. 283 2008 6799 6805
13. T.M. Piers, D.H. Kim, B.C. Kim, P. Regan, D.J. Whitcomb, and K. Cho Translational concepts of mGluR5 in synaptic diseases of the brain Front. Neuropharmacol. 6 2012 199
14. T.M. Piers, D.H. Kim, B.C. Kim, P. Regan, D.J. Whitcomb, and K. Cho Translational concepts of mGluR5 in synaptic diseases of the brain Front. Pharmacol. 3 2012 199
15. T.D. Prickett, and Y. Samuels Molecular pathways: dysregulated glutamatergic signaling pathways in cancer Clin. Cancer Res. 18 2012 4240 4246
16. V. Raghavendra, F.Y. Tanga, and J.A. DeLeo Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats Neuropsychopharmacology 29 2003 327 334
17. B.X. Ren, X.P. Gu, Y.G. Zheng, C.L. Liu, D. Wang, Y.E. Sun, and Z.L. Ma Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model Anesthesiology 116 2012 122 132
18. M. Rodriguez-Munoz, P. Sanchez-Blazquez, A. Vicente-Sanchez, E. Berrocoso, and J. Garzon The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control Neuropsychopharmacology 37 2012 338 349
19. P. Sanchez-Blazquez, M. Rodriguez-Munoz, E. Berrocoso, and J. Garzon The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain Eur. J. Pharmacol. 716 2013 94 105
20. H. Schröder, D.F. Wu, A. Seifert, M. Rankovic, S. Schulz, V. Hölt, and T. Koch Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the [mu]-opioid receptor Neuropharmacology 56 2009 768 778
21. B.A. Smeester, M. Al-Gizawiy, and A.J. Beitz Effects of different electroacupuncture scheduling regimens on murine bone tumor-induced hyperalgesia: sex differences and role of inflammation Evidence-based Complement. Altern. Med. 2012 2012 671386
22. B.A. Smeester, M. Al-Gizawiy, E.E. O'Brien, M.E. Ericson, J.L. Triemstra, and A.J. Beitz The effect of electroacupuncture on osteosarcoma tumor growth and metastasis: analysis of different treatment regimens Evidence-based Complement. Altern. Med. 2013 2013 387169
23. H. Sontheimer Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage Trends Neurosci. 26 2003 543 549
24. M.L. Sotgiu, P. Bellomi, and G.E.M. Biella The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats Neurosci. Lett. 342 2003 85 88
25. B.N. Te, M. Vernooij-Dassen, N. Burger, M. Ijsseldijk, K. Vissers, and Y. Engels Pain and its interference with daily activities in medical oncology outpatients Pain Physician 16 2013 379 389
26. P.W. Wacnik, L.J. Eikmeier, T.R. Ruggles, M.L. Ramnaraine, B.K. Walcheck, A.J. Beitz, and G.L. Wilcox Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain J. Neurosci. 21 2001 9355 9366
27. K. Walker, M. Bowes, M. Panesar, A. Davis, C. Gentry, A. Kesingland, F. Gasparini, W. Spooren, N. Stoehr, A. Pagano, P.J. Flor, I. Vranesic, K. Lingenhoehl, E.C. Johnson, M. Varney, L. Urban, and R. Kuhn Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain Neuropharmacology 40 2001 1 9
28. K. Walker, A. Reeve, M. Bowes, J. Winter, G. Wotherspoon, A. Davis, P. Schmid, F. Gasparini, R. Kuhn, and L. Urban mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia Neuropharmacology 40 2001 10 19