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Volumn 174, Issue , 2014, Pages 51-56

Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial

Author keywords

Crocin; Herbal medicine; Major depressive disorder; Saffron (Crocus sativus L.)

Indexed keywords

CITALOPRAM; CROCIN; FLUOXETINE; PLACEBO; SERTRALINE; CAROTENOID; SEROTONIN UPTAKE INHIBITOR;

EID: 84918792426     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.11.035     Document Type: Article
Times cited : (148)

References (54)
  • 1
    • 0036377909 scopus 로고    scopus 로고
    • Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.)
    • FI. Abdullaev Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.) Exp. Biol. Med. 227 2002 20 25
    • (2002) Exp. Biol. Med. , vol.227 , pp. 20-25
    • Abdullaev, F.I.1
  • 2
    • 84878376838 scopus 로고    scopus 로고
    • Effects of emotion recognition training on mood among individuals with high levels of depressive symptoms: Study protocol for a randomised controlled trial
    • S. Adams, I. Penton-Voak, CJ. Harmer, EA. Holmes, and MR. Munafo Effects of emotion recognition training on mood among individuals with high levels of depressive symptoms: study protocol for a randomised controlled trial Trials 14 2013 161 168
    • (2013) Trials , vol.14 , pp. 161-168
    • Adams, S.1    Penton-Voak, I.2    Harmer, C.J.3    Holmes, E.A.4    Munafo, M.R.5
  • 3
    • 38949193873 scopus 로고    scopus 로고
    • Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: A double-blind, randomised and placebo controlled trial
    • M. Agha-Hosseini, L. Kashani, A. Aleyaseen, A. Ghoreishi, H. Rahmanpour, AR. Zarrinara, and S. Akhondzadeh Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo controlled trial BJOG 115 2008 515 519
    • (2008) BJOG , vol.115 , pp. 515-519
    • Agha-Hosseini, M.1    Kashani, L.2    Aleyaseen, A.3    Ghoreishi, A.4    Rahmanpour, H.5    Zarrinara, A.R.6    Akhondzadeh, S.7
  • 6
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L. Extract and its bioactive constituents
    • AN. Assimopoulou, Z. Sinakos, and VP. Papageorgiou Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents Phytother. Res. 19 2005 997 1000
    • (2005) Phytother. Res. , vol.19 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 7
    • 84898005743 scopus 로고    scopus 로고
    • Effect of Crocus sativus L. (Saffron) on coagulation and anticoagulation systems in healthy volunteers
    • H. Ayatollahi, AO. Javan, M. Khajedaluee, M. Shahroodian, and H. Hosseinzadeh Effect of Crocus sativus L. (Saffron) on coagulation and anticoagulation systems in healthy volunteers Phytother. Res. 28 2014 539 543
    • (2014) Phytother. Res. , vol.28 , pp. 539-543
    • Ayatollahi, H.1    Javan, A.O.2    Khajedaluee, M.3    Shahroodian, M.4    Hosseinzadeh, H.5
  • 8
    • 84888641330 scopus 로고    scopus 로고
    • Extended-release quetiapine fumarate (quetiapine XR) monotherapy and quetiapine XR or lithium as add-on to antidepressants in patients with treatment-resistant major depressive disorder
    • M. Bauer, L. Dell'osso, S. Kasper, W. Pitchot, E. Dencker Vansvik, J. Kohler, L. Jørgensen, and SA. Montgomery Extended-release quetiapine fumarate (quetiapine XR) monotherapy and quetiapine XR or lithium as add-on to antidepressants in patients with treatment-resistant major depressive disorder J. Affect. Disord. 151 2013 209 219
    • (2013) J. Affect. Disord. , vol.151 , pp. 209-219
    • Bauer, M.1    Dell'Osso, L.2    Kasper, S.3    Pitchot, W.4    Dencker Vansvik, E.5    Kohler, J.6    Jørgensen, L.7    Montgomery, S.A.8
  • 9
    • 84862287737 scopus 로고    scopus 로고
    • Preclinical and clinical evidence of antioxidant effects of antidepressant agents: Implications for the pathophysiology of major depressive disorder
    • GA. Behr, JC. Moreira, and BN. Frey Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder Oxid. Med. Cell. Longev. 54 2012 421 429
    • (2012) Oxid. Med. Cell. Longev. , vol.54 , pp. 421-429
    • Behr, G.A.1    Moreira, J.C.2    Frey, B.N.3
  • 10
    • 79953198908 scopus 로고    scopus 로고
    • Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices
    • F. Berger, A. Hensel, and K. Nieber Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices Neuroscience 180 2011 238 247
    • (2011) Neuroscience , vol.180 , pp. 238-247
    • Berger, F.1    Hensel, A.2    Nieber, K.3
  • 11
    • 84895918106 scopus 로고    scopus 로고
    • The latent structure and comorbidity patterns of generalized anxiety disorder and major depressive disorder a national study
    • C. Blanco, JM. Rubio, M. Wall, R. Secades-Villa, K. Beesdo-Baum, and S. Wang The latent structure and comorbidity patterns of generalized anxiety disorder and major depressive disorder a national study J. Depress. Anxiety 31 2014 214 222
    • (2014) J. Depress. Anxiety , vol.31 , pp. 214-222
    • Blanco, C.1    Rubio, J.M.2    Wall, M.3    Secades-Villa, R.4    Beesdo-Baum, K.5    Wang, S.6
  • 12
    • 0020032130 scopus 로고
    • Radical intermediates involved in the bleaching of the carotenoid crocin. Hydroxyl radicals, superoxide anions and hydrated electrons
    • W. Bors, M. Saran, and C. Michel Radical intermediates involved in the bleaching of the carotenoid crocin. Hydroxyl radicals, superoxide anions and hydrated electrons Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 41 1982 493 501
    • (1982) Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. , vol.41 , pp. 493-501
    • Bors, W.1    Saran, M.2    Michel, C.3
  • 13
    • 84862280152 scopus 로고    scopus 로고
    • Identity, mood, and quality of life in people with early-stage dementia
    • LS. Caddell, and L. Clare Identity, mood, and quality of life in people with early-stage dementia Int. Psychogeriatr. 24 2012 1306 1315
    • (2012) Int. Psychogeriatr. , vol.24 , pp. 1306-1315
    • Caddell, L.S.1    Clare, L.2
  • 14
    • 65549089208 scopus 로고    scopus 로고
    • Real-world data on ssri antidepressant side effects
    • E. Cascade, AH Kalali, and SH Kennedy Real-world data on ssri antidepressant side effects Psychiatry 6 2009 16 18
    • (2009) Psychiatry , vol.6 , pp. 16-18
    • Cascade, E.1    Kalali, A.H.2    Kennedy, S.H.3
  • 15
    • 84857467292 scopus 로고    scopus 로고
    • Effectiveness of Chinese herbal medicine in treating liver fibrosis: A systematic review and meta-analysis of randomized controlled trials
    • F. Cheung, Y. Feng, N. Wang, MF. Yuen, Y. Tong, and VT. Wong Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials Chin. Med. 7 2012 5 11
    • (2012) Chin. Med. , vol.7 , pp. 5-11
    • Cheung, F.1    Feng, Y.2    Wang, N.3    Yuen, M.F.4    Tong, Y.5    Wong, V.T.6
  • 16
    • 85027924258 scopus 로고    scopus 로고
    • Increased oxidative stress in patients with depression and its relationship to treatment
    • CP. Chung, D. Schmidt, CM. Stein, JD. Morrow, and RM. Salomon Increased oxidative stress in patients with depression and its relationship to treatment Psychiatry Res. 206 2013 213 216
    • (2013) Psychiatry Res. , vol.206 , pp. 213-216
    • Chung, C.P.1    Schmidt, D.2    Stein, C.M.3    Morrow, J.D.4    Salomon, R.M.5
  • 17
    • 84885577161 scopus 로고    scopus 로고
    • Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: A 24-wk randomized, controlled, double-blind trial
    • E. Corruble, C. de Bodinat, C. Belaidi, and GM Goodwin Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-wk randomized, controlled, double-blind trial Int. J. Neuropsychopharmacol. 16 2013 2219 2234
    • (2013) Int. J. Neuropsychopharmacol. , vol.16 , pp. 2219-2234
    • Corruble, E.1    De Bodinat, C.2    Belaidi, C.3    Goodwin, G.M.4
  • 18
    • 0011145384 scopus 로고    scopus 로고
    • SSRI antidepressant medications: Adverse effects and tolerability
    • JM. Ferguson SSRI antidepressant medications: adverse effects and tolerability Prim. Care Companion J. Clin. Psychiatry 3 2001 22 27
    • (2001) Prim. Care Companion J. Clin. Psychiatry , vol.3 , pp. 22-27
    • Ferguson, J.M.1
  • 19
    • 84867146021 scopus 로고    scopus 로고
    • Prevalence of DSM-IV major depression among U.S. Military personnel: Meta-analysis and simulation
    • AM. Gadermann, CC. Engel, JA. Naifeh, MK. Nock, M. Petukhova, and PN. Santiago Prevalence of DSM-IV major depression among U.S. military personnel: meta-analysis and simulation Mil. Med. 177 2012 47 59
    • (2012) Mil. Med. , vol.177 , pp. 47-59
    • Gadermann, A.M.1    Engel, C.C.2    Naifeh, J.A.3    Nock, M.K.4    Petukhova, M.5    Santiago, P.N.6
  • 20
    • 84870017532 scopus 로고    scopus 로고
    • Role of antioxidants in generalised anxiety disorder and depression
    • M. Gautam, Agrawal Mukta, P. Sharma, and AS. Gautam Role of antioxidants in generalised anxiety disorder and depression Indian J. Psychiatry 54 2012 244 247
    • (2012) Indian J. Psychiatry , vol.54 , pp. 244-247
    • Gautam, M.1    Mukta, A.2    Sharma, P.3    Gautam, A.S.4
  • 21
    • 84880374083 scopus 로고    scopus 로고
    • Is there a cerebellar compensatory effort in first-episode, treatment-naive major depressive disorder at rest
    • W. Guo, F. Liu, J. Liu, L. Yu, Z. Zhang, and J. Zhang Is there a cerebellar compensatory effort in first-episode, treatment-naive major depressive disorder at rest Prog. Neuropsychopharmacol. Biol. Psychiatry 46 2010 13 18
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.46 , pp. 13-18
    • Guo, W.1    Liu, F.2    Liu, J.3    Yu, L.4    Zhang, Z.5    Zhang, J.6
  • 22
    • 77957274588 scopus 로고    scopus 로고
    • Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method
    • F. Hadizadeh, SA. Mohajeri, and M. Seifi Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method Pak. J. Biol. Sci. 13 2010 691 698
    • (2010) Pak. J. Biol. Sci. , vol.13 , pp. 691-698
    • Hadizadeh, F.1    Mohajeri, S.A.2    Seifi, M.3
  • 23
    • 0032962469 scopus 로고    scopus 로고
    • Biochemical changes and gene expression following traumatic brain injury: Role of spreading depression
    • DM. Hermann, G. Mies, and KA. Hossmann Biochemical changes and gene expression following traumatic brain injury: role of spreading depression Restor. Neurol. Neurosci. 14 1999 103 108
    • (1999) Restor. Neurol. Neurosci. , vol.14 , pp. 103-108
    • Hermann, D.M.1    Mies, G.2    Hossmann, K.A.3
  • 24
    • 84879591654 scopus 로고    scopus 로고
    • The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: A placebo-controlled study
    • R. Heun, A. Ahokas, P. Boyer, N. Gimenez-Montesinos, F. Pontes-Soares, and V. Olivier The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: a placebo-controlled study J. Clin. Psychiatry 74 2013 587 594
    • (2013) J. Clin. Psychiatry , vol.74 , pp. 587-594
    • Heun, R.1    Ahokas, A.2    Boyer, P.3    Gimenez-Montesinos, N.4    Pontes-Soares, F.5    Olivier, V.6
  • 25
    • 27444432701 scopus 로고    scopus 로고
    • Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice
    • H. Hosseinzadeh, G. Karimi, and M. Niapoor Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice Acta Hortic. 650 2004 435 445
    • (2004) Acta Hortic. , vol.650 , pp. 435-445
    • Hosseinzadeh, H.1    Karimi, G.2    Niapoor, M.3
  • 26
    • 0036271283 scopus 로고    scopus 로고
    • Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus stigmas in mice
    • H. Hosseinzadeh, and V. Khosravan Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus stigmas in mice Arch. Iran. Med. 5 2002 44 47
    • (2002) Arch. Iran. Med. , vol.5 , pp. 44-47
    • Hosseinzadeh, H.1    Khosravan, V.2
  • 27
    • 34548616031 scopus 로고    scopus 로고
    • Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats
    • H. Hosseinzadeh, V. Motamedshariaty, and F. Hadizadeh Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats Pharmacologyonline 2 2007 367 370
    • (2007) Pharmacologyonline , vol.2 , pp. 367-370
    • Hosseinzadeh, H.1    Motamedshariaty, V.2    Hadizadeh, F.3
  • 28
    • 84858005351 scopus 로고    scopus 로고
    • Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats
    • H. Hosseinzadeh, HR. Sadeghnia, FA. Ghaeni, VS. Motamedshariaty, and SA. Mohajeri Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats Phytother. Res. 26 2012 381 386
    • (2012) Phytother. Res. , vol.26 , pp. 381-386
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2    Ghaeni, F.A.3    Motamedshariaty, V.S.4    Mohajeri, S.A.5
  • 29
    • 0141746538 scopus 로고    scopus 로고
    • Antinociceptive and anti-inflammatory effects of Crocus sativus L. Stigma and petal extracts in mice
    • H. Hosseinzadeh, and HM. Younesi Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice BMC Pharmacol. 15 2002 2 7
    • (2002) BMC Pharmacol. , vol.15 , pp. 2-7
    • Hosseinzadeh, H.1    Younesi, H.M.2
  • 30
    • 0027204635 scopus 로고
    • The utility of the beck anxiety inventory with inpatient adolescents
    • J. Jolly, JF. Aruffo, J. Wherry, and R. Livingston The utility of the beck anxiety inventory with inpatient adolescents J. Anxiety Disord. 7 1993 95 106
    • (1993) J. Anxiety Disord. , vol.7 , pp. 95-106
    • Jolly, J.1    Aruffo, J.F.2    Wherry, J.3    Livingston, R.4
  • 31
    • 0029558356 scopus 로고
    • Mood disorders in the general population represent an important and worldwide public health problem
    • LL. Judd Mood disorders in the general population represent an important and worldwide public health problem Int. Clin. Psychopharmacol. 4 1995 5 10
    • (1995) Int. Clin. Psychopharmacol. , vol.4 , pp. 5-10
    • Judd, L.L.1
  • 34
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of twelve-month dsm-iv disorders in the national comorbidity survey replication
    • RC. Kessler, WT. Chiu, O. Demler, KR. Merikangas, and EE. Walters Prevalence, severity, and comorbidity of twelve-month dsm-iv disorders in the national comorbidity survey replication Arch. Gen. Psychiatry 62 2005 617 627
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3    Merikangas, K.R.4    Walters, E.E.5
  • 36
    • 34548160924 scopus 로고    scopus 로고
    • The beck depression inventory ii and the beck anxiety inventory in people with intellectual disabilities: Factor analyses and group data
    • WR. Lindsay, and D. Skene The beck depression inventory ii and the beck anxiety inventory in people with intellectual disabilities: factor analyses and group data J. Appl. Res. Intellect. Disabil. 20 2007 401 408
    • (2007) J. Appl. Res. Intellect. Disabil. , vol.20 , pp. 401-408
    • Lindsay, W.R.1    Skene, D.2
  • 37
    • 84885862322 scopus 로고    scopus 로고
    • Association between physical activity and major depressive disorder among current or former smokers with pulmonary disease
    • PD. Loprinzi, C. Kane, and JF. Walker Association between physical activity and major depressive disorder among current or former smokers with pulmonary disease Prev. Med. 57 2013 545 549
    • (2013) Prev. Med. , vol.57 , pp. 545-549
    • Loprinzi, P.D.1    Kane, C.2    Walker, J.F.3
  • 38
    • 84893125653 scopus 로고    scopus 로고
    • Relationship between mental health and spiritual wellbeing among hemodialysis patients: A correlation study
    • BB. Martínez, and RP. Custódio Relationship between mental health and spiritual wellbeing among hemodialysis patients: a correlation study Sao Paulo Med. J. 132 2014 23 27
    • (2014) Sao Paulo Med. J. , vol.132 , pp. 23-27
    • Martínez, B.B.1    Custódio, R.P.2
  • 39
    • 84892411110 scopus 로고    scopus 로고
    • Mental health status among younger generation around Chernobyl
    • T. Masunaga, A. Kozlovsky, N. Takamura, and S. Yamashit Mental health status among younger generation around Chernobyl Arch. Med. Sci. 9 2013 1114 1116
    • (2013) Arch. Med. Sci. , vol.9 , pp. 1114-1116
    • Masunaga, T.1    Kozlovsky, A.2    Takamura, N.3    Yamashit, S.4
  • 40
    • 84867696554 scopus 로고    scopus 로고
    • The role of oxidative stress in depressive disorders
    • TM. Michel, D. Pülschen, and J. Thome The role of oxidative stress in depressive disorders Curr. Pharm. 18 2012 5890 5899
    • (2012) Curr. Pharm. , vol.18 , pp. 5890-5899
    • Michel, T.M.1    Pülschen, D.2    Thome, J.3
  • 43
    • 13544274008 scopus 로고    scopus 로고
    • Hydroalcoholic extract of Crocus sativus L. Versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial
    • AA. Noorbala, S. Akhondzadeh, N. Tahmacebi-Pour, and AH. Jamshidi Hydroalcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial J. Ethnopharmacol. 97 2005 281 284
    • (2005) J. Ethnopharmacol. , vol.97 , pp. 281-284
    • Noorbala, A.A.1    Akhondzadeh, S.2    Tahmacebi-Pour, N.3    Jamshidi, A.H.4
  • 44
    • 33751305217 scopus 로고    scopus 로고
    • Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents
    • MA. Papandreou, CD. Kanakis, MG. Polissiou, S. Efthimiopoulos, P. Cordopatis, and M. Margarity Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents J. Agric. Food Chem. 54 2006 8762 8768
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 8762-8768
    • Papandreou, M.A.1    Kanakis, C.D.2    Polissiou, M.G.3    Efthimiopoulos, S.4    Cordopatis, P.5    Margarity, M.6
  • 45
  • 46
    • 70349972975 scopus 로고    scopus 로고
    • Differences in adverse effect reporting in placebo groups in SSRI and tricyclic antidepressant trials: A systematic review and meta-analysis
    • W. Rief, Y. Nestoriuc, A. von Lilienfeld-Toal, I. Dogan, F. Schreiber, and SG. Hofmann Differences in adverse effect reporting in placebo groups in SSRI and tricyclic antidepressant trials: a systematic review and meta-analysis Drug Saf. 32 2009 1041 1056
    • (2009) Drug Saf. , vol.32 , pp. 1041-1056
    • Rief, W.1    Nestoriuc, Y.2    Von Lilienfeld-Toal, A.3    Dogan, I.4    Schreiber, F.5    Hofmann, S.G.6
  • 47
    • 0026356751 scopus 로고
    • The current clinical practice of herbal medicine in psychiatry in mainland China: A review of literature
    • M. Saku The current clinical practice of herbal medicine in psychiatry in mainland China: a review of literature Jpn. J. Psychiatry Neurol. 45 1991 825 832
    • (1991) Jpn. J. Psychiatry Neurol. , vol.45 , pp. 825-832
    • Saku, M.1
  • 48
    • 84878512829 scopus 로고    scopus 로고
    • Pattern of psychotropic prescription in a tertiary care center: A critical analysis
    • P. Sarkar, K. Chakraborty, A. Misra, R. Shukla, and SP. Swain Pattern of psychotropic prescription in a tertiary care center: a critical analysis Indian J. Pharmacol. 45 2013 270 273
    • (2013) Indian J. Pharmacol. , vol.45 , pp. 270-273
    • Sarkar, P.1    Chakraborty, K.2    Misra, A.3    Shukla, R.4    Swain, S.P.5
  • 49
    • 82855175265 scopus 로고    scopus 로고
    • Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence
    • J. Sarris, A. Panossian, I. Schweitzer, C. Stough, and A. Scholey Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence Eur. Neuropsychopharmacol. 21 2011 841 860
    • (2011) Eur. Neuropsychopharmacol. , vol.21 , pp. 841-860
    • Sarris, J.1    Panossian, A.2    Schweitzer, I.3    Stough, C.4    Scholey, A.5
  • 50
    • 85016284685 scopus 로고    scopus 로고
    • Comparative validity of DSM-IV and alternative empirically derived approaches for the assessment of ADHD
    • SK. Shemmassian, and SS. Lee Comparative validity of DSM-IV and alternative empirically derived approaches for the assessment of ADHD J. Atten. Disord. 8 2014 111 118
    • (2014) J. Atten. Disord. , vol.8 , pp. 111-118
    • Shemmassian, S.K.1    Lee, S.S.2
  • 52
    • 0028314443 scopus 로고
    • Effects of Crocus sativus L. on the ethanolinduced impairment of passive avoidanceperformances in mice
    • Y. Zhang, Y. Shoyama, M. Sugiura, and H. Saito Effects of Crocus sativus L. on the ethanolinduced impairment of passive avoidanceperformances in mice Biol. Pharm. Bull. 17 1994 217 221
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 217-221
    • Zhang, Y.1    Shoyama, Y.2    Sugiura, M.3    Saito, H.4
  • 53
    • 38049088926 scopus 로고    scopus 로고
    • Relationship between oxidative stress and depression in patients with acute leukemia
    • FL. Zhou, WG. Zhang, ZX. Su, X. Meng, and W. Tian Relationship between oxidative stress and depression in patients with acute leukemia Zhongguo Shi Yan Xue Ye Xue Za Zhi 14 2006 872 875
    • (2006) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.14 , pp. 872-875
    • Zhou, F.L.1    Zhang, W.G.2    Su, Z.X.3    Meng, X.4    Tian, W.5
  • 54
    • 11144300165 scopus 로고    scopus 로고
    • Increased risk of gastrointestinal adverse effects under SSRI/NSAID combination may be due to pharmacokinetic interactions
    • DF. Zullino, and Y. Khazaal Increased risk of gastrointestinal adverse effects under SSRI/NSAID combination may be due to pharmacokinetic interactions Br. J. Clin. Pharmacol. 59 2005 118 119
    • (2005) Br. J. Clin. Pharmacol. , vol.59 , pp. 118-119
    • Zullino, D.F.1    Khazaal, Y.2


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