Saffron for treatment of fluoxetine-induced sexual dysfunction in women: Randomized double-blind placebo-controlled study

Human Psychopharmacology

Volumn 28, Issue 1, 2013, Pages 54-60

  Kashani, Ladan ^a   Raisi, Firoozeh ^b   Saroukhani, Sepideh ^b   Sohrabi, Hamid ^b   Modabbernia, Amirhossein ^b   Nasehi, Abbas Ali ^b   Jamshidi, Amirhossein ^b   Ashrafi, Mandana ^b   Mansouri, Parisa ^b   Ghaeli, Padideh ^b   Akhondzadeh, Shahin ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocus sativus L; fluoxetine; saffron; sexual dysfunction; SSRI; women

Indexed keywords

CROCUS SATIVUS EXTRACT; FLUOXETINE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; DECREASED APPETITE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG INDUCED HEADACHE; DRUG SAFETY; DYSPAREUNIA; FEMALE; FEMALE SEXUAL DYSFUNCTION; FEMALE SEXUAL FUNCTION INDEX; HUMAN; INCREASED APPETITE; INSOMNIA; MAJOR DEPRESSION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NAUSEA; ORGASM; OUTCOME ASSESSMENT; PARALLEL DESIGN; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUAL SATISFACTION; SIDE EFFECT; SORE THROAT; TREATMENT DURATION; TREATMENT RESPONSE; VAGINAL LUBRICATION;

ADOLESCENT; ADULT; CROCUS; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; FLUOXETINE; HUMANS; MIDDLE AGED; PLANT EXTRACTS; SEROTONIN UPTAKE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84873099006     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.2282     Document Type: Article

References (32)

1. Agha-Hosseini M, Kashani L, Aleyaseen A,. 2008. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG 115 (4): 515-519.
2. Aizenberg D, Zemishlany Z, Weizman A,. 1995. Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors. Clin Neuropharmacol 18 (4): 320-324.
3. Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S,. 2007. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 31 (2): 439-442.
4. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F,. 2004. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 4: 12.
5. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al,. 2005. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 19 (2): 148-151.
6. Akhondzadeh S, Sabet MS, Harirchian MH, et al,. 2010a. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther 35 (5): 581-588.
7. Akhondzadeh S, Shafiee Sabet M, Harirchian MH, et al,. 2010b. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease. Psychopharmacology (Berl) 207 (4): 637-643.
8. Balon R,. 1993. Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry 54 (4): 161-162.
9. Clayton AH, McGarvey EL, Abouesh AI, Pinkerton RC,. 2001. Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction. J Clin Psychiatry 62 (3): 185-190.
10. Feder R,. 1991. Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients. J Clin Psychiatry 52 (4): 163-164.
11. Gupta S, Droney T, Masand P, Ashton AK,. 1999. SSRI-induced sexual dysfunction treated with sildenafil. Depress Anxiety 9 (4): 180-182.
12. Hensley PL, Nurnberg HG,. 2002. SSRI sexual dysfunction: a female perspective. J Sex Marital Ther 28 Suppl 1: 143-153.
13. Hosseinzadeh H, Jahanian Z,. 2010. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res 24 (5): 726-730.
14. Hosseinzadeh H, Sadeghnia HR,. 2005. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci 8 (3): 394-399.
15. Hosseinzadeh H, Sadeghnia HR,. 2007. Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay. DNA Cell Biol 26 (12): 841-846.
16. Hosseinzadeh H, Younesi HM,. 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2: 7.
17. Hosseinzadeh H, Ziaee T, Sadeghi A,. 2008. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 15 (6-7): 491-495.
18. Hosseinzadeh H, Modaghegh MH, Saffari Z,. 2009. Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med 6 (3): 343-350.
19. Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA,. 2012. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res 26 (3): 381-386.
20. Landen M, Eriksson E, Agren H, Fahlen T,. 1999. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol 19 (3): 268-271.
21. Lane RM,. 1997. A critical review of selective serotonin reuptake inhibitor-related sexual dysfunction; incidence, possible aetiology and implications for management. J Psychopharmacol 11 (1): 72-82.
22. Modabbernia A, Sohrabi H, Nasehi AA, et al,. 2012. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 223 (4): 381-8.
23. Montejo A, Majadas S, Rizvi SJ, Kennedy SH,. 2011. The effects of agomelatine on sexual function in depressed patients and healthy volunteers. Hum Psychopharmacol 26 (8): 537-42.
24. Montejo-Gonzalez AL, Llorca G, Izquierdo JA, et al,. 1997. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 23 (3): 176-194.
25. Nahid K, Fariborz M, Ataolah G, Solokian S,. 2009. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 54 (5): 401-404.
26. Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH,. 2005. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol 97 (2): 281-284.
27. Rosen R, Brown C, Heiman J, et al,. 2000. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 26 (2): 191-208.
28. Serretti A, Chiesa A,. 2009. Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. J Clin Psychopharmac 29 (3): 259-66.
29. Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O,. 2009. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine 16 (8): 690-693.
30. Sidi H, Asmidar D, Hod R, Jaafar NR, Guan NC,. 2012. Hypoactive sexual desire among depressed female patients treated with selective serotonin reuptake inhibitors: a comparison between escitalopram and fluoxetine. Int J Psychiatry Clin Pract 16 (1): 41-47.
31. Wilson LA, Wayman CP, Jackson VM,. 2009. Neuropeptide modulation of a lumbar spinal reflex: potential implications for female sexual function. J Sex Med 6 (4): 947-957.
32. Woodrum ST, Brown CS,. 1998. Management of SSRI-induced sexual dysfunction. Ann Pharmacother 32 (11): 1209-1215.