Biochemical changes and gene expression following traumatic brain injury: Role of spreading depression

Restorative Neurology and Neuroscience

Volumn 14, Issue 2-3, 1999, Pages 103-108

  Hermann, Dirk Matthias ^a   Mies, Günter ^a   Hossmann, Konstantin Alexander ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Cerebral metabolism; Immediate early gene; Neocortical trauma; Tissue acidosis; Transient DC depolarization

Indexed keywords

GLUCOSE; LACTIC ACID; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; COLD INJURY; CONTROLLED STUDY; GENE EXPRESSION; MALE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SPREADING CORTICAL DEPRESSION;

EID: 0032962469     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Dhillon, H S., Dose, J.M., Scheff, S.W. and Renuka Prasad, M. Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. Exp. Neurol. 146 (1997) 240-249.
2. Dietrich, W.D., Alonso, O., Busto, R., Prado, R., Dewanjee, M.K. and Ginsberg, M.D. Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats. J. Cereb. Blood Flow Metab. 16 (1996) 481-489.
3. Edwards, D.R. and Mahadevan, L.C. Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: Lack of evidence for labile repressors. EMBO J. II (1992) 2415-2424.
4. Ginsberg, M.D., Zhao, W., Alonso, O.F., Loor-Estades, J.Y., Dietrich, W.D and Busto, R. Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am. J. Physiol. 272 (1997) H2859-2868.
5. Greenberg, M.E., Hermanowski, A.L. and Ziff, E.B. Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol. Cell. Biol 6 (1986) 1050-1057.
6. Heath, D.L. and Vink, R Impact acceleration-induced severe diffuse axonal injury in rats: characterization of phosphate metabolism and neurologic outcome. J. Neurotrauma 12 (1995) 1027-1034.
7. Hermann, D.M., Mies, G. and Hossmann, K.-A. Effects of a traumatic neocortical lesion on cerebral metabolism and gene expression of rats. Neuroreport 9 (1998) 1249-1253.
8. Hermann, D.M., Mies, G. and Hossmann, K.-A. Expression of c-fos, junB, c-jun, MKP-1 and hsp72 following traumatic neocortical lesions in rats - Relation to spreading depression. Neuroscience (1998) in press.
9. Hovda, D.A., Becker, D.P. and Katayama, Y. Secondary injury and acidosis, J. Neurotrauma 9 Suppl. 1 (1992) 47-60.
10. Inao, S., Marmarou, A., Clarke, G.D., Andersen, B.J., Fatouros, P.P. and Young, H.F. Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury. J. Neurosurg. 69 (1988) 736-744.
11. Kamezawa, T., Asakura, T, Yatsushiro, K., Niiro, M., Kasamo, S. and Fujimoto, T. 3IP-Magnetic resonance spectroscopic study on the effect of glycerol on cold-induced brain edema Acta Neurochir 60 Suppl. (1994) 499-501
12. Kawamata, T., Katayama, Y., Hovda, D.A., Yoshino, A. and Becker, D P. Lactate accumulation following concussive brain injury the role of ionic fluxes induced by excitatory amino acids. Brain Res. 674 (1995) 196-204
13. Lau, L.F. and Nathans, D. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. Proc. Natl. Acad. Sci U.S.A. 84 (1987) 1182-1186
14. Marmarou, A., Holdaway, R., Ward, J.D., Yoshida, K., Choi, S.C. and Muizelaar, J.P. Traumatic brain tissue acidosis: experimental and clinical studies. Acta Neurochir. 57 Suppl. (1993) 160-164
15. 31P nuclear magnetic resonance. J. Neurochem. 49 (1987) 1530-1540.
16. Mies, G Inhibition of protein synthesis during repetitive cortical spreading depression. J Neurochem. 60 (1993) 360-363
17. Mies, G., Iijima, T. and Hossmann, K.-A. Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat. Neuroreport 4 (1993) 709-711.
18. Mikawa, S., Sharp, F.R., Kamii, H., Kinouichi, H., Epstein, C.J. and Chan, P.H. Expression of c-fos and hsp70 mRNA after traumatic brain injury in transgenic mice overexpressing CuZn-superoxide dismutase. Mol Brain Res. 33 (1995) 288-294.
19. Neumann-Haefelin, T., Wiessner, C., Vogel, P., Back, T. and Hossmann, K.-A., Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 14 (1994) 206-216.
20. 2+ levels following cortical compression contusion trauma in rats. J. Cereb. Blood Flow Metab. 13 (1993) 183-192.
21. Raghupathi, R., Welsh, F., Lowenstein, D.H., Gennarelli, T.A. and McIntosh, T.K. Regional induction of c-fos and heat shock protein-72 mRNA following fluid-percussion brain injury in the rat. J. Cereb. Blood Flow Metab. 15 (1995) 467-473.
22. Rahmsdorf, H.J., Schonthal, A., Angel, P., Litfin, M., Ruther, U and Herrlich, P. Posttranscriptional regulation of c-fos mRNA expression. Nucleic Acids Res. 15 (1987) 1643-1659.
23. Renuka Prasad, M., Ramaiah, C., McIntosh, T. K., Dempsey, R.J., Hipkens, S. and Yurek, D. Regional levels of lactate and norepinephrine after experimental brain injury. J. Neurochem. 63 (1994) 1086-1094.
24. Siesjö, B.K., Basic mechanisms of traumatic brain damage. Ann. Emerg. Med. 22 (1993) 11-20
25. Siesjö, B K., Katsura, K.-I. and Kristián, T. Acidosis-related damage Adv. Neurol. 71 (1996) 209-236.
26. Unterberg, A.W., Andersen, B J., Clarke, G.D. and Marmarou, A. Cerebral energy metabolism following fluid-percussion brain injury in cats. J. Neurosurg. 68 (1988) 594-600
27. Wiessner, C., Neumann-Haefelin, T., Vogel, P, Back, T. and Hossmann, K.-A. Transient forebrain ischemia induces an immediate-early gene encoding the mitogen-activated protein kinase phosphatase 3CH134 in the adult rat brain. Neuroscience 64 (1995) 959-966.
28. Wolf, A.L., Levi, L., Marmarou, A., Ward, J.D., Muizelaar, P., Choi, S., Young, H., Rigamonti, D. and Robinson, W.L. Effect of THAM upon outcome in severe head injury. a randomized prospective clinical trial. J. Neurosurg. 78 (1993) 54-59
29. Yamashita, K., Vogel, P., Fritze, K., Back, T. and Hossmann, K.-A. Monitoring the temporal and spatial activation pattern of astrocytes in focal cerebral ischemia using in situ hybridization to GFAP mRNA: comparison with sgp-2 and hsp70 mRNA and the effect of glutamate receptor antagonists Brain Res 735 (1996) 285-297.
30. Yang, K , Mu, X.S., Xue, J.J., Whitson, J., Salminen, A , Dixon, C.E , Liu, P.K. and Hayes, R.L. Increased expression of c-fos mRNA and AP-1 transcription factors after cortical impact injury in rats. Brain Res. 664 (1994) 141-147.