The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2262-2272

  Bachran, Diana ^a   Schneider, Stefanie ^a   Bachran, Christopher ^a   Weng, Alexander ^a   Melzig, Matthias F ^b   Fuchs, Hendrik ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

dynamin 2; EGFR; endocytosis; endosomes; intracellular trafficking; retrograde transport; saponins; saporin; targeted toxins

Indexed keywords

ACTIN; BAFILOMYCIN A1; CHLOROQUINE; CHLORPROMAZINE; CLATHRIN; DYNASORE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FILIPIN; LATRUNCULIN A; SAPONIN DERIVATIVE; SAPORIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ARTICLE; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; GYPSOPHILA PANICULATA; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL;

BLOTTING, WESTERN; CARYOPHYLLACEAE; CELL LINE, TUMOR; DRUG SYNERGISM; ENDOCYTOSIS; FLOW CYTOMETRY; HELA CELLS; HUMANS; IMMUNOTOXINS; MODELS, BIOLOGICAL; SAPONINS; SIGNAL TRANSDUCTION;

EID: 82955169671     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200130j     Document Type: Article

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