The effect of water-soluble polymers on aqueous solubility of drugs

International Journal of Pharmaceutics

Volumn 127, Issue 2, 1996, Pages 293-296

  Loftsson, Thorsteinn ^a   Fririksdóttir, Hafrún ^a   Gumundsdóttir, Thrórunn K ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

Author keywords

aqueous solution; complexation; drugs; incompatibility; polymer; solubility

Indexed keywords

ACETAZOLAMIDE; HYDROCORTISONE; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; POVIDONE; PRAZEPAM; SULFAMETHOXAZOLE;

ARTICLE; COMPLEX FORMATION; DRUG BINDING; DRUG FORMULATION; DRUG INCOMPATIBILITY; DRUG MIXTURE; DRUG SOLUBILITY; PRIORITY JOURNAL;

EID: 0342561507     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04207-5     Document Type: Article

References (9)

1. Attwood, D. and Florence, A.T., Surfactant Systems. Their Chemistry, Pharmacy and Biology, Chapman and Hall, London, 1983, pp. 361-365.
2. Dox, T. et al. Iyakirkin Kenkyn, 9 (1978) 205 (through Chem. Abstr. 88: 141601a, 1978).
3. Dox, T. et al. Iyakirkin Kenkyn, 9 (1978) 205 (through Chem. Abstr. 88: 141601a, 1978).
4. Loftsson, T., Fri∂riksdóttir, H., Sigur∂ardóttir, A.M. and Ueda, H., The effect of water-soluble polymers on drug-cyclodextrin complexation. Int. J. Pharm., 10 (1994) 169-177.
5. Loftsson, T. and Sigur∂ardóttir, A.M., The effect of polyvinylpyrrolidone and hydroxypropyl methylcellulose on HPbCD complexation of hydrocortisone and its permeability through hairless mouse skin. Eur. J. Pharm. Sci., 2 (1994) 297-301.
6. Marcus, A.D., Complexation incompatibilities. Drug Cosmet. Ind., 79 (1956) 456-457, 554, 560-561 and 564.
7. Myers, D., Surfactant Science and Technology, VCH Publishers, New York, 1988, pp. 142-145.
8. Rácz, I. Drug Formulation, John Wiley and Sons, Budapest, 1989, pp. 212-242.
9. Riley, C.M., Rytting, J.H. and Kral, M.A. (Eds.), Takeru Higuchi, a Memorial Tribute, Volume 3. Equilibria and Thermodynamics. Allen Press, Lawrence (Kansas), 1991, pp. 220-272.