메뉴 건너뛰기




Volumn 100, Issue , 2015, Pages 56-67

Contemporary Pacific and Western perspectives on 'awa (Piper methysticum) toxicology

Author keywords

Kava; Kavalactones; Piper methysticum

Indexed keywords

CYTOCHROME P450; FLAVOKAWAIN B; KAVA; UNCLASSIFIED DRUG; LACTONE;

EID: 84918772210     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.11.012     Document Type: Review
Times cited : (29)

References (104)
  • 2
    • 0004252188 scopus 로고
    • L. Lindstrom, M. Merlin, Yale University Press New Haven
    • V. Lebot Kava: the Pacific drug L. Lindstrom, M. Merlin, 1992 Yale University Press New Haven
    • (1992) Kava: The Pacific Drug
    • Lebot, V.1
  • 4
    • 0000158684 scopus 로고
    • Kava in Hawaii
    • M. Titcomb Kava in Hawaii J Polynesian Soc. 57 2 1948 105 117
    • (1948) J Polynesian Soc. , vol.57 , Issue.2 , pp. 105-117
    • Titcomb, M.1
  • 5
    • 85067708705 scopus 로고
    • Du kava ou ava
    • P. Petard Du kava ou ava J Pharm XII 1826 122
    • (1826) J Pharm , vol.12 , pp. 122
    • Petard, P.1
  • 6
    • 84864710619 scopus 로고    scopus 로고
    • Pills, potions, products: Kava's transformations in new and nontraditional contexts
    • J.D. Baker Pills, potions, products: kava's transformations in new and nontraditional contexts Contemp Pac 24 2 2012 233 265
    • (2012) Contemp Pac , vol.24 , Issue.2 , pp. 233-265
    • Baker, J.D.1
  • 8
    • 0036318135 scopus 로고    scopus 로고
    • Kava - The unfolding story: Report on a work-in-progress
    • A. Denham, M. McIntyre, and J. Whitehouse Kava - the unfolding story: report on a work-in-progress J Altern Complement Med 8 3 2002 237 263
    • (2002) J Altern Complement Med , vol.8 , Issue.3 , pp. 237-263
    • Denham, A.1    McIntyre, M.2    Whitehouse, J.3
  • 9
    • 79956225615 scopus 로고    scopus 로고
    • Tradition and toxicity: Evidential cultures in the kava safety debate
    • J.D. Baker Tradition and toxicity: evidential cultures in the kava safety debate Soc Stud Sci 41 3 2011 361 384
    • (2011) Soc Stud Sci , vol.41 , Issue.3 , pp. 361-384
    • Baker, J.D.1
  • 10
    • 5444262664 scopus 로고    scopus 로고
    • Kava ban highly questionable: A brief summary of the main scientific findings presented in the "in depth investigation on EU member states market restrictions on kava products"
    • J. Gruenwald, and J. Skrabal Kava ban highly questionable: a brief summary of the main scientific findings presented in the "in depth investigation on EU member states market restrictions on kava products" Semin Integr Med 1 4 2003 199 210
    • (2003) Semin Integr Med , vol.1 , Issue.4 , pp. 199-210
    • Gruenwald, J.1    Skrabal, J.2
  • 12
    • 55949103189 scopus 로고    scopus 로고
    • High dose of commercial products of kava (Piper methysticum) markedly enhanced hepatic cytochrome P450 1A1 mRNA expression with liver enlargement in rats
    • Y. Yamazaki, H. Hashida, A. Arita, K. Hamaguchi, and F. Shimura High dose of commercial products of kava (Piper methysticum) markedly enhanced hepatic cytochrome P450 1A1 mRNA expression with liver enlargement in rats Food Chem Toxicol 46 12 2008 3732 3738
    • (2008) Food Chem Toxicol , vol.46 , Issue.12 , pp. 3732-3738
    • Yamazaki, Y.1    Hashida, H.2    Arita, A.3    Hamaguchi, K.4    Shimura, F.5
  • 14
    • 34548643763 scopus 로고    scopus 로고
    • The safety of kava: A regulatory perspective
    • W.N. Richardson, and L. Henderson The safety of kava: a regulatory perspective Br J Clin Pharmacol 64 4 2007 418 420
    • (2007) Br J Clin Pharmacol , vol.64 , Issue.4 , pp. 418-420
    • Richardson, W.N.1    Henderson, L.2
  • 15
    • 0037270350 scopus 로고    scopus 로고
    • From the Centers for Disease Control and Prevention. Hepatic toxicity possibly associated with kava-containing products - United States, Germany, and Switzerland, 1999-2002
    • CDC From the Centers for Disease Control and Prevention. Hepatic toxicity possibly associated with kava-containing products - United States, Germany, and Switzerland, 1999-2002 JAMA 289 1 2003 36 37
    • (2003) JAMA , vol.289 , Issue.1 , pp. 36-37
    • Cdc1
  • 17
    • 79251561257 scopus 로고    scopus 로고
    • Herbal medicines in pediatric neuropsychiatry
    • C. Feucht, and D.R. Patel Herbal medicines in pediatric neuropsychiatry Pediatr Clin North Am 58 1 2011 33 54
    • (2011) Pediatr Clin North Am , vol.58 , Issue.1 , pp. 33-54
    • Feucht, C.1    Patel, D.R.2
  • 18
    • 0037532873 scopus 로고    scopus 로고
    • "bust enhancing" herbal products
    • A. Fugh-Berman "Bust enhancing" herbal products Obstet Gynecol 101 6 2003 1345 1349
    • (2003) Obstet Gynecol , vol.101 , Issue.6 , pp. 1345-1349
    • Fugh-Berman, A.1
  • 19
    • 0031805139 scopus 로고    scopus 로고
    • Over-the-counter psychotropics: A review of melatonin, St John's wort, valerian, and kava-kava
    • E. Heiligenstein, and G. Guenther Over-the-counter psychotropics: a review of melatonin, St John's wort, valerian, and kava-kava J Am Coll Health 46 6 1998 271 276
    • (1998) J Am Coll Health , vol.46 , Issue.6 , pp. 271-276
    • Heiligenstein, E.1    Guenther, G.2
  • 20
    • 77957327206 scopus 로고    scopus 로고
    • Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review
    • S.E. Lakhan, and K.F. Vieira Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review Nutr J 9 2010 42
    • (2010) Nutr J , vol.9 , pp. 42
    • Lakhan, S.E.1    Vieira, K.F.2
  • 21
    • 0141723557 scopus 로고    scopus 로고
    • Internet marketing of herbal products
    • C.A. Morris, and J. Avorn Internet marketing of herbal products JAMA 290 11 2003 1505 1509
    • (2003) JAMA , vol.290 , Issue.11 , pp. 1505-1509
    • Morris, C.A.1    Avorn, J.2
  • 22
    • 34548301907 scopus 로고    scopus 로고
    • Herbal and dietary supplements for treatment of anxiety disorders
    • S.A. Saeed, R.M. Bloch, and D.J. Antonacci Herbal and dietary supplements for treatment of anxiety disorders Am Fam Physician 76 4 2007 549 556
    • (2007) Am Fam Physician , vol.76 , Issue.4 , pp. 549-556
    • Saeed, S.A.1    Bloch, R.M.2    Antonacci, D.J.3
  • 23
    • 84555196278 scopus 로고    scopus 로고
    • Relaxation drinks and their use in adolescents
    • S. Stacy Relaxation drinks and their use in adolescents J Child Adolesc Psychopharmacol 21 6 2011 605 610
    • (2011) J Child Adolesc Psychopharmacol , vol.21 , Issue.6 , pp. 605-610
    • Stacy, S.1
  • 24
    • 0035296239 scopus 로고    scopus 로고
    • The commercialisation of kava in Vanuatu
    • A. Jowitt, and J. Binihi The commercialisation of kava in Vanuatu Pac Health Dialog 8 1 2001 29 37
    • (2001) Pac Health Dialog , vol.8 , Issue.1 , pp. 29-37
    • Jowitt, A.1    Binihi, J.2
  • 25
    • 76249130686 scopus 로고    scopus 로고
    • Rapid prevalence of kava drinking in Kiribati, Central Pacific
    • K. Kazama Rapid prevalence of kava drinking in Kiribati, Central Pacific People Cult Oceana 22 2006 85 106
    • (2006) People Cult Oceana , vol.22 , pp. 85-106
    • Kazama, K.1
  • 26
    • 18444378432 scopus 로고    scopus 로고
    • Kava cultivation, native species conservation, and integrated watershed resource management on Pohnpei Island
    • M. Merlin, and W. Raynor Kava cultivation, native species conservation, and integrated watershed resource management on Pohnpei Island Pac Sci 59 2 2005 241 260
    • (2005) Pac Sci , vol.59 , Issue.2 , pp. 241-260
    • Merlin, M.1    Raynor, W.2
  • 27
    • 4143093675 scopus 로고    scopus 로고
    • Composition and biological activity of traditional and commercial kava extracts
    • C.S. Côté, C. Kor, J. Cohen, and K. Auclair Composition and biological activity of traditional and commercial kava extracts Biochem Biophys Res Commun 322 1 2004 147 152
    • (2004) Biochem Biophys Res Commun , vol.322 , Issue.1 , pp. 147-152
    • Côté, C.S.1    Kor, C.2    Cohen, J.3    Auclair, K.4
  • 28
    • 40549094283 scopus 로고    scopus 로고
    • Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots
    • T.D. Xuan, M. Fukuta, A.C. Wei, A.A. Elzaawely, T.D. Khanh, and S. Tawata Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots J Nat Med 62 2 2008 188 194
    • (2008) J Nat Med , vol.62 , Issue.2 , pp. 188-194
    • Xuan, T.D.1    Fukuta, M.2    Wei, A.C.3    Elzaawely, A.A.4    Khanh, T.D.5    Tawata, S.6
  • 29
    • 84871296503 scopus 로고    scopus 로고
    • Pacific island 'awa (kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells
    • L.M. Shimoda, C. Park, A.J. Stokes, H.H. Gomes, and H. Turner Pacific island 'awa (kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells Phytother Res 26 12 2012 1934 1941
    • (2012) Phytother Res , vol.26 , Issue.12 , pp. 1934-1941
    • Shimoda, L.M.1    Park, C.2    Stokes, A.J.3    Gomes, H.H.4    Turner, H.5
  • 30
    • 0034331402 scopus 로고    scopus 로고
    • Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol
    • C.K. Smith, C.A. Moore, E.N. Elahi, A.T. Smart, and S.A. Hotchkiss Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol Toxicol Appl Pharmacol 168 3 2000 189 199
    • (2000) Toxicol Appl Pharmacol , vol.168 , Issue.3 , pp. 189-199
    • Smith, C.K.1    Moore, C.A.2    Elahi, E.N.3    Smart, A.T.4    Hotchkiss, S.A.5
  • 31
  • 32
    • 79151472205 scopus 로고    scopus 로고
    • TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids
    • L.R. Sadofsky, A.N. Boa, S.A. Maher, M.A. Birrell, M.G. Belvisi, and A.H. Morice TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids Pharmacol Res 63 1 2011 30 36
    • (2011) Pharmacol Res , vol.63 , Issue.1 , pp. 30-36
    • Sadofsky, L.R.1    Boa, A.N.2    Maher, S.A.3    Birrell, M.A.4    Belvisi, M.G.5    Morice, A.H.6
  • 33
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • E. Middleton, C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol Rev 52 4 2000 673
    • (2000) Pharmacol Rev , vol.52 , Issue.4 , pp. 673
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 35
    • 78651231882 scopus 로고    scopus 로고
    • The health and social effects of drinking water-based infusions of kava: A review of the evidence
    • L. Rychetnik, and C.M. Madronio The health and social effects of drinking water-based infusions of kava: a review of the evidence Drug Alcohol Rev 30 1 2011 74 83
    • (2011) Drug Alcohol Rev , vol.30 , Issue.1 , pp. 74-83
    • Rychetnik, L.1    Madronio, C.M.2
  • 36
    • 27144549253 scopus 로고    scopus 로고
    • Kava-induced urticaria
    • R. Grace Kava-induced urticaria J Am Acad Dermatol 53 5 2005 906
    • (2005) J Am Acad Dermatol , vol.53 , Issue.5 , pp. 906
    • Grace, R.1
  • 39
    • 84918771510 scopus 로고    scopus 로고
    • Sebotropic eruption associated with use of oral kava kava supplement
    • J.C. Huynh, M.M. Asgari, and M.M. Moore Sebotropic eruption associated with use of oral kava kava supplement Clin Exp Dermatol 39 7 2014 816 818
    • (2014) Clin Exp Dermatol , vol.39 , Issue.7 , pp. 816-818
    • Huynh, J.C.1    Asgari, M.M.2    Moore, M.M.3
  • 41
    • 0037195459 scopus 로고    scopus 로고
    • Hepatic toxicity possibly associated with kava-containing products - United States, Germany, and Switzerland, 1999-2002
    • CDC Hepatic toxicity possibly associated with kava-containing products - United States, Germany, and Switzerland, 1999-2002 Morb Mortal Wkly Rep 51 47 2002 1065 1067
    • (2002) Morb Mortal Wkly Rep , vol.51 , Issue.47 , pp. 1065-1067
    • Cdc1
  • 43
    • 0036907305 scopus 로고    scopus 로고
    • Meningismus after taking kava-kava
    • I. Sibon, E. Rosier, and J.M. Orgogozo Meningismus after taking kava-kava Rev Neurol (Paris) 158 12 Pt 1 2002 1205 1206
    • (2002) Rev Neurol (Paris) , vol.158 , Issue.12 , pp. 1205-1206
    • Sibon, I.1    Rosier, E.2    Orgogozo, J.M.3
  • 44
    • 83155172756 scopus 로고    scopus 로고
    • Kava drinking associated with suicidal behaviour among young Kanaks using kava in New Caledonia
    • N. Vignier, F. Lert, C. Salomon, and C. Hamelin Kava drinking associated with suicidal behaviour among young Kanaks using kava in New Caledonia Aust N Z J Public Health 35 5 2011 427 433
    • (2011) Aust N Z J Public Health , vol.35 , Issue.5 , pp. 427-433
    • Vignier, N.1    Lert, F.2    Salomon, C.3    Hamelin, C.4
  • 45
    • 79960475169 scopus 로고    scopus 로고
    • Constituents in kava extracts potentially involved in hepatotoxicity: A review
    • L.R. Olsen, M.P. Grillo, and C. Skonberg Constituents in kava extracts potentially involved in hepatotoxicity: a review Chem Res Toxicol 24 7 2011 992 1002
    • (2011) Chem Res Toxicol , vol.24 , Issue.7 , pp. 992-1002
    • Olsen, L.R.1    Grillo, M.P.2    Skonberg, C.3
  • 46
    • 78349260262 scopus 로고    scopus 로고
    • Kava hepatotoxicity - A clinical review
    • R. Teschke Kava hepatotoxicity - a clinical review Ann Hepatol 9 3 2010 251 265
    • (2010) Ann Hepatol , vol.9 , Issue.3 , pp. 251-265
    • Teschke, R.1
  • 47
    • 78651346028 scopus 로고    scopus 로고
    • Kava hepatotoxicity solution: A six-point plan for new kava standardization
    • R. Teschke, J. Sarris, and V. Lebot Kava hepatotoxicity solution: a six-point plan for new kava standardization Phytomedicine 18 2-3 2011 96 103
    • (2011) Phytomedicine , vol.18 , Issue.23 , pp. 96-103
    • Teschke, R.1    Sarris, J.2    Lebot, V.3
  • 48
    • 0038664368 scopus 로고    scopus 로고
    • Kava: Herbal panacea or liver poison?
    • R.F. Moulds, and J. Malani Kava: herbal panacea or liver poison? Med J Aust 178 9 2003 451 453
    • (2003) Med J Aust , vol.178 , Issue.9 , pp. 451-453
    • Moulds, R.F.1    Malani, J.2
  • 49
    • 78651302770 scopus 로고    scopus 로고
    • Re-introduction of kava (Piper methysticum) to the EU: Is there a way forward?
    • J. Sarris, R. Teschke, C. Stough, A. Scholey, and I. Schweitzer Re-introduction of kava (Piper methysticum) to the EU: is there a way forward? Planta Med 77 2 2011 107 110
    • (2011) Planta Med , vol.77 , Issue.2 , pp. 107-110
    • Sarris, J.1    Teschke, R.2    Stough, C.3    Scholey, A.4    Schweitzer, I.5
  • 50
    • 34247135372 scopus 로고    scopus 로고
    • Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis
    • R.A. DiSilvestro, W. Zhang, and D.J. DiSilvestro Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis Food Chem Toxicol 45 7 2007 1293 1300
    • (2007) Food Chem Toxicol , vol.45 , Issue.7 , pp. 1293-1300
    • Disilvestro, R.A.1    Zhang, W.2    Disilvestro, D.J.3
  • 51
    • 78349302551 scopus 로고    scopus 로고
    • Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways
    • P. Zhou, S. Gross, J.H. Liu, B.Y. Yu, L.L. Feng, and J. Nolta Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways FASEB J 24 12 2010 4722 4732
    • (2010) FASEB J , vol.24 , Issue.12 , pp. 4722-4732
    • Zhou, P.1    Gross, S.2    Liu, J.H.3    Yu, B.Y.4    Feng, L.L.5    Nolta, J.6
  • 52
    • 17144400791 scopus 로고    scopus 로고
    • Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
    • X.L. Zi, and A.R. Simoneau Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice Cancer Res 65 8 2005 3479 3486
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3479-3486
    • Zi, X.L.1    Simoneau, A.R.2
  • 53
    • 0034327338 scopus 로고    scopus 로고
    • The correlation between cancer incidence and kava consumption
    • G.G. Steiner The correlation between cancer incidence and kava consumption Hawaii Med J 59 11 2000 420 422
    • (2000) Hawaii Med J , vol.59 , Issue.11 , pp. 420-422
    • Steiner, G.G.1
  • 54
    • 84863617682 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of kava kava extract (CAS NO. 9000-38-8) in F344/N rats and B6C3F1 mice
    • NTP Toxicology and carcinogenesis studies of kava kava extract (CAS NO. 9000-38-8) in F344/N rats and B6C3F1 mice Natl Toxicol Program Tech Rep Ser 571 2012 1 186
    • (2012) Natl Toxicol Program Tech Rep ser , vol.571 , pp. 1-186
    • Ntp1
  • 55
    • 79960386728 scopus 로고    scopus 로고
    • N-Nitrosodimethylamine in drinking-water; Background document for development of WHO Guidelines for Drinking-water Quality
    • WHO N-Nitrosodimethylamine in drinking-water; background document for development of WHO Guidelines for Drinking-water Quality Concise International Chemical Assessment Document 2006 38
    • (2006) Concise International Chemical Assessment Document , pp. 38
    • Who1
  • 56
    • 0347244522 scopus 로고
    • Chapter 7: Fatty change and steatohepatitis
    • Mosby St. Louis
    • R.G. Lee Chapter 7: fatty change and steatohepatitis Diagnostic liver pathology 1994 Mosby St. Louis
    • (1994) Diagnostic Liver Pathology
    • Lee, R.G.1
  • 57
    • 3242677212 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. F.)
    • J. Anke, and I. Ramzan Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.) J Ethnopharmacol 93 2-3 2004 153 160
    • (2004) J Ethnopharmacol , vol.93 , Issue.23 , pp. 153-160
    • Anke, J.1    Ramzan, I.2
  • 58
    • 0036842023 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 activities by kava extract and kavalactones
    • J.M. Mathews, A.S. Etheridge, and S.R. Black Inhibition of human cytochrome P450 activities by kava extract and kavalactones Drug Metab Dispos 30 11 2002 1153 1157
    • (2002) Drug Metab Dispos , vol.30 , Issue.11 , pp. 1153-1157
    • Mathews, J.M.1    Etheridge, A.S.2    Black, S.R.3
  • 59
    • 24944587145 scopus 로고    scopus 로고
    • Pharmacokinetics and disposition of the kavalactone kawain: Interaction with kava extract and kavalactones in vivo and in vitro
    • J.M. Mathews, A.S. Etheridge, J.L. Valentine, S.R. Black, D.P. Coleman, and P. Patel Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro Drug Metab Dispos 33 10 2005 1555 1563
    • (2005) Drug Metab Dispos , vol.33 , Issue.10 , pp. 1555-1563
    • Mathews, J.M.1    Etheridge, A.S.2    Valentine, J.L.3    Black, S.R.4    Coleman, D.P.5    Patel, P.6
  • 60
    • 2442706282 scopus 로고    scopus 로고
    • Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes
    • L. Zou, G.L. Henderson, M.R. Harkey, Y. Sakai, and A. Li Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes Phytomedicine 11 4 2004 285 294
    • (2004) Phytomedicine , vol.11 , Issue.4 , pp. 285-294
    • Zou, L.1    Henderson, G.L.2    Harkey, M.R.3    Sakai, Y.4    Li, A.5
  • 61
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • M. Ingelman-Sundberg Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity Pharmacogenomics J 5 1 2005 6 13
    • (2005) Pharmacogenomics J , vol.5 , Issue.1 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 62
    • 0033929925 scopus 로고    scopus 로고
    • Pharmacogenetics and psychopharmacotherapy
    • N. Poolsup, P. Li Wan, and T. Knight Pharmacogenetics and psychopharmacotherapy J Clin Pharm Ther 25 3 2000 197 220
    • (2000) J Clin Pharm Ther , vol.25 , Issue.3 , pp. 197-220
    • Poolsup, N.1    Li Wan, P.2    Knight, T.3
  • 63
    • 84888099228 scopus 로고    scopus 로고
    • Toxic effects of psychotropics related to possible p450 enzyme inhibition by kava: Report of 2 cases
    • T.P. Toohey, B.Y. Lu, and C. Wada Toxic effects of psychotropics related to possible p450 enzyme inhibition by kava: report of 2 cases Prim Care Companion CNS Disord 15 5 2013
    • (2013) Prim Care Companion CNS Disord , vol.15 , Issue.5
    • Toohey, T.P.1    Lu, B.Y.2    Wada, C.3
  • 64
    • 0031875471 scopus 로고    scopus 로고
    • Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations
    • S. Wanwimolruk, S. Bhawan, P.F. Coville, and S.C. Chalcroft Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations Eur J Clin Pharmacol 54 5 1998 431 435
    • (1998) Eur J Clin Pharmacol , vol.54 , Issue.5 , pp. 431-435
    • Wanwimolruk, S.1    Bhawan, S.2    Coville, P.F.3    Chalcroft, S.C.4
  • 65
    • 28444496691 scopus 로고    scopus 로고
    • Identification of CYP2D6 impaired functional alleles in Mexican Americans
    • H.R. Luo, A. Gaedigk, V. Aloumanis, and Y.J. Wan Identification of CYP2D6 impaired functional alleles in Mexican Americans Eur J Clin Pharmacol 61 11 2005 797 802
    • (2005) Eur J Clin Pharmacol , vol.61 , Issue.11 , pp. 797-802
    • Luo, H.R.1    Gaedigk, A.2    Aloumanis, V.3    Wan, Y.J.4
  • 66
    • 23044503814 scopus 로고    scopus 로고
    • Potential for interaction of kava and St. John's wort with drugs
    • Y.N. Singh Potential for interaction of kava and St. John's wort with drugs J Ethnopharmacol 100 1-2 2005 108 113
    • (2005) J Ethnopharmacol , vol.100 , Issue.12 , pp. 108-113
    • Singh, Y.N.1
  • 67
    • 77950200756 scopus 로고    scopus 로고
    • Stereoselective metabolic and pharmacokinetic analysis of the chiral active components from herbal medicines
    • X. Wang, and S. Zeng Stereoselective metabolic and pharmacokinetic analysis of the chiral active components from herbal medicines Curr Pharm Anal 6 1 2010 39 52
    • (2010) Curr Pharm Anal , vol.6 , Issue.1 , pp. 39-52
    • Wang, X.1    Zeng, S.2
  • 68
    • 42049115630 scopus 로고    scopus 로고
    • Pharmacokinetics of selected chiral flavonoids: Hesperetin, naringenin and eriodictyol in rats and their content in fruit juices
    • J.A. Yáñez, C.M. Remsberg, N.D. Miranda, K.R. Vega-Villa, P.K. Andrews, and N.M. Davies Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices Biopharm Drug Dispos 29 2 2008 63 82
    • (2008) Biopharm Drug Dispos , vol.29 , Issue.2 , pp. 63-82
    • Yáñez, J.A.1    Remsberg, C.M.2    Miranda, N.D.3    Vega-Villa, K.R.4    Andrews, P.K.5    Davies, N.M.6
  • 69
    • 38549121938 scopus 로고    scopus 로고
    • Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats
    • Z. Hong, J. Le, M. Lin, G. Fan, Y. Chai, and X. Yin Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats Chirality 20 2 2008 119 124
    • (2008) Chirality , vol.20 , Issue.2 , pp. 119-124
    • Hong, Z.1    Le, J.2    Lin, M.3    Fan, G.4    Chai, Y.5    Yin, X.6
  • 70
    • 80051895129 scopus 로고    scopus 로고
    • Proposal for a kava quality standardization code
    • R. Teschke, and V. Lebot Proposal for a kava quality standardization code Food Chem Toxicol 49 10 2011 2503 2516
    • (2011) Food Chem Toxicol , vol.49 , Issue.10 , pp. 2503-2516
    • Teschke, R.1    Lebot, V.2
  • 71
    • 0036315161 scopus 로고    scopus 로고
    • Traditional use of sakau (kava) in Pohnpei: Lessons for integrative medicine
    • M.J. Balick, and R. Lee Traditional use of sakau (kava) in Pohnpei: lessons for integrative medicine Altern Ther Health Med 8 4 2002 96 98
    • (2002) Altern Ther Health Med , vol.8 , Issue.4 , pp. 96-98
    • Balick, M.J.1    Lee, R.2
  • 72
    • 79958772932 scopus 로고    scopus 로고
    • Is the quality of kava (Piper methysticum Forst. F.) responsible for different geographical patternS?
    • V. Lebot, and P. Simeoni Is the quality of kava (Piper methysticum Forst. f.) responsible for different geographical patternS? Ethnobot Res Appl 2 2004 19 28
    • (2004) Ethnobot Res Appl , vol.2 , pp. 19-28
    • Lebot, V.1    Simeoni, P.2
  • 76
    • 0034749234 scopus 로고    scopus 로고
    • Is kava extract effective for treating anxiety?
    • S. Abadi, C. Papoushek, and M.F. Evans Is kava extract effective for treating anxiety? Can Fam Physician 47 2001 1745 1747
    • (2001) Can Fam Physician , vol.47 , pp. 1745-1747
    • Abadi, S.1    Papoushek, C.2    Evans, M.F.3
  • 77
    • 3042818418 scopus 로고    scopus 로고
    • Explanatory attributions of anxiety and recovery in a study of kava
    • K.C. Abraham, K.M. Connor, and J.R. Davidson Explanatory attributions of anxiety and recovery in a study of kava J Altern Complement Med 10 3 2004 556 559
    • (2004) J Altern Complement Med , vol.10 , Issue.3 , pp. 556-559
    • Abraham, K.C.1    Connor, K.M.2    Davidson, J.R.3
  • 78
    • 0034754047 scopus 로고    scopus 로고
    • Kava kava in the treatment of generalized anxiety disorder, simple phobia and specific social phobia
    • R.J. Boerner Kava kava in the treatment of generalized anxiety disorder, simple phobia and specific social phobia Phytother Res 15 7 2001 646 647
    • (2001) Phytother Res , vol.15 , Issue.7 , pp. 646-647
    • Boerner, R.J.1
  • 79
    • 13244255206 scopus 로고    scopus 로고
    • Attenuation of neuroleptic-induced extrapyramidal side effects by Kava special extract WS 1490
    • R.J. Boerner, and S. Klement Attenuation of neuroleptic-induced extrapyramidal side effects by Kava special extract WS 1490 Wien Med Wochenschr 154 21-22 2004 508 510
    • (2004) Wien Med Wochenschr , vol.154 , Issue.2122 , pp. 508-510
    • Boerner, R.J.1    Klement, S.2
  • 80
    • 0037911537 scopus 로고    scopus 로고
    • Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder - An 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients
    • R.J. Boerner, H. Sommer, W. Berger, U. Kuhn, U. Schmidt, and M. Mannel Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder - an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients Phytomedicine 10 Suppl. 4 2003 38 49
    • (2003) Phytomedicine , vol.10 , pp. 38-49
    • Boerner, R.J.1    Sommer, H.2    Berger, W.3    Kuhn, U.4    Schmidt, U.5    Mannel, M.6
  • 83
    • 12944302609 scopus 로고    scopus 로고
    • Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination
    • A. Capasso, and L. Sorrentino Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination Phytomedicine 12 1-2 2005 39 45
    • (2005) Phytomedicine , vol.12 , Issue.12 , pp. 39-45
    • Capasso, A.1    Sorrentino, L.2
  • 84
    • 0035985915 scopus 로고    scopus 로고
    • A placebo-controlled study of Kava kava in generalized anxiety disorder
    • K.M. Connor, and J.R. Davidson A placebo-controlled study of Kava kava in generalized anxiety disorder Int Clin Psychopharmacol 17 4 2002 185 188
    • (2002) Int Clin Psychopharmacol , vol.17 , Issue.4 , pp. 185-188
    • Connor, K.M.1    Davidson, J.R.2
  • 85
    • 0344629271 scopus 로고    scopus 로고
    • Treatment of anxiety, tension and restlessness states with Kava special extract WS 1490 in general practice: A randomized placebo-controlled double-blind multicenter trial
    • M. Gastpar, and H.D. Klimm Treatment of anxiety, tension and restlessness states with Kava special extract WS 1490 in general practice: a randomized placebo-controlled double-blind multicenter trial Phytomedicine 10 8 2003 631 639
    • (2003) Phytomedicine , vol.10 , Issue.8 , pp. 631-639
    • Gastpar, M.1    Klimm, H.D.2
  • 86
    • 2442461009 scopus 로고    scopus 로고
    • Kava treatment in patients with anxiety
    • F.P. Geier, and T. Konstantinowicz Kava treatment in patients with anxiety Phytother Res 18 4 2004 297 300
    • (2004) Phytother Res , vol.18 , Issue.4 , pp. 297-300
    • Geier, F.P.1    Konstantinowicz, T.2
  • 87
    • 0025337433 scopus 로고
    • The antinociceptive actions of kava components in mice
    • D.D. Jamieson, and P.H. Duffield The antinociceptive actions of kava components in mice Clin Exp Pharmacol Physiol 17 7 1990 495 507
    • (1990) Clin Exp Pharmacol Physiol , vol.17 , Issue.7 , pp. 495-507
    • Jamieson, D.D.1    Duffield, P.H.2
  • 88
    • 79956264661 scopus 로고    scopus 로고
    • Neurocognitive effects of kava (Piper methysticum): A systematic review
    • E. LaPorte, J. Sarris, C. Stough, and A. Scholey Neurocognitive effects of kava (Piper methysticum): a systematic review Hum Psychopharmacol 26 2 2011 102 111
    • (2011) Hum Psychopharmacol , vol.26 , Issue.2 , pp. 102-111
    • Laporte, E.1    Sarris, J.2    Stough, C.3    Scholey, A.4
  • 89
    • 65049085570 scopus 로고    scopus 로고
    • Time for a reassessment of the use of Kava in anxiety?
    • J. Sarris, J. Adams, and J.L. Wardle Time for a reassessment of the use of Kava in anxiety? Complement Ther Med 17 3 2009 121 122
    • (2009) Complement Ther Med , vol.17 , Issue.3 , pp. 121-122
    • Sarris, J.1    Adams, J.2    Wardle, J.L.3
  • 90
    • 65049083084 scopus 로고    scopus 로고
    • Kava Anxiety Depression Spectrum Study (KADSS): A mixed methods RCT using an aqueous extract of Piper methysticum
    • J. Sarris, D.J. Kavanagh, G. Byrne, K.M. Bone, J. Adams, and G. Deed Kava Anxiety Depression Spectrum Study (KADSS): a mixed methods RCT using an aqueous extract of Piper methysticum Complement Ther Med 17 3 2009 176 178
    • (2009) Complement Ther Med , vol.17 , Issue.3 , pp. 176-178
    • Sarris, J.1    Kavanagh, D.J.2    Byrne, G.3    Bone, K.M.4    Adams, J.5    Deed, G.6
  • 91
    • 84883757118 scopus 로고    scopus 로고
    • Kava in the treatment of generalized anxiety disorder: A double-blind, randomized, placebo-controlled study
    • J. Sarris, C. Stough, C.A. Bousman, Z.T. Wahid, G. Murray, and R. Teschke Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study J Clin Psychopharmacol 33 5 2013 643 648
    • (2013) J Clin Psychopharmacol , vol.33 , Issue.5 , pp. 643-648
    • Sarris, J.1    Stough, C.2    Bousman, C.A.3    Wahid, Z.T.4    Murray, G.5    Teschke, R.6
  • 92
    • 84886244381 scopus 로고    scopus 로고
    • Kava for the treatment of generalized anxiety disorder RCT: Analysis of adverse reactions, liver function, addiction, and sexual effects
    • J. Sarris, C. Stough, R. Teschke, Z.T. Wahid, C.A. Bousman, and G. Murray Kava for the treatment of generalized anxiety disorder RCT: analysis of adverse reactions, liver function, addiction, and sexual effects Phytother Res 27 11 2013 1723 1728
    • (2013) Phytother Res , vol.27 , Issue.11 , pp. 1723-1728
    • Sarris, J.1    Stough, C.2    Teschke, R.3    Wahid, Z.T.4    Bousman, C.A.5    Murray, G.6
  • 93
    • 0037186674 scopus 로고    scopus 로고
    • Kava-kava-extrakt
    • D. Loew Kava-kava-extrakt Dtsch Apoth Ztg 142 9 2002 1012 1020
    • (2002) Dtsch Apoth Ztg , vol.142 , Issue.9 , pp. 1012-1020
    • Loew, D.1
  • 94
    • 0030809916 scopus 로고    scopus 로고
    • Kava and alcohol
    • C. Cantor Kava and alcohol Med J Aust 167 10 1997 560
    • (1997) Med J Aust , vol.167 , Issue.10 , pp. 560
    • Cantor, C.1
  • 95
    • 61749084029 scopus 로고    scopus 로고
    • Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice
    • T.E. Johnson, F. Kassie, M.G. O'Sullivan, M. Negia, T.E. Hanson, and P. Upadhyaya Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice Cancer Prev Res (Phila) 1 6 2008 430 438
    • (2008) Cancer Prev Res (Phila) , vol.1 , Issue.6 , pp. 430-438
    • Johnson, T.E.1    Kassie, F.2    O'Sullivan, M.G.3    Negia, M.4    Hanson, T.E.5    Upadhyaya, P.6
  • 96
    • 79959950118 scopus 로고    scopus 로고
    • Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice
    • T.E. Johnson, D. Hermanson, L. Wang, F. Kassie, P. Upadhyaya, and M.G. O'Sullivan Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice Am J Chin Med 39 4 2011 727 742
    • (2011) Am J Chin Med , vol.39 , Issue.4 , pp. 727-742
    • Johnson, T.E.1    Hermanson, D.2    Wang, L.3    Kassie, F.4    Upadhyaya, P.5    O'Sullivan, M.G.6
  • 97
    • 84892385065 scopus 로고    scopus 로고
    • Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice
    • P. Leitzman, S.C. Narayanapillai, S. Balbo, B. Zhou, P. Upadhyaya, and A.A. Shaik Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice Cancer Prev Res (Phila) 7 1 2014 86 96
    • (2014) Cancer Prev Res (Phila) , vol.7 , Issue.1 , pp. 86-96
    • Leitzman, P.1    Narayanapillai, S.C.2    Balbo, S.3    Zhou, B.4    Upadhyaya, P.5    Shaik, A.A.6
  • 99
    • 0014182444 scopus 로고
    • Pharmacology of Kava
    • H.J. Meyer Pharmacology of Kava Psychopharmacol Bull 4 3 1967 10
    • (1967) Psychopharmacol Bull , vol.4 , Issue.3 , pp. 10
    • Meyer, H.J.1
  • 101
    • 0026808928 scopus 로고
    • Kava pyrones and resin: Studies on GABA A, GABA B and benzodiazepine binding sites in rodent brain
    • L.P. Davies, C.A. Drew, P. Duffield, G.A. Johnston, and D.D. Jamieson Kava pyrones and resin: studies on GABA A, GABA B and benzodiazepine binding sites in rodent brain Pharmacol Toxicol 71 2 1992 120 126
    • (1992) Pharmacol Toxicol , vol.71 , Issue.2 , pp. 120-126
    • Davies, L.P.1    Drew, C.A.2    Duffield, P.3    Johnston, G.A.4    Jamieson, D.D.5
  • 102
    • 0036970141 scopus 로고    scopus 로고
    • Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation
    • C.S. Yuan, L. Dey, A. Wang, S. Mehendale, J.T. Xie, and H.H. Aung Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation Planta Med 68 12 2002 1092 1096
    • (2002) Planta Med , vol.68 , Issue.12 , pp. 1092-1096
    • Yuan, C.S.1    Dey, L.2    Wang, A.3    Mehendale, S.4    Xie, J.T.5    Aung, H.H.6
  • 103
    • 0031830516 scopus 로고    scopus 로고
    • An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
    • S. Ben-Shabat, E. Fride, T. Sheskin, T. Tamiri, M.H. Rhee, and Z. Vogel An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity Eur J Pharmacol 353 1 1998 23 31
    • (1998) Eur J Pharmacol , vol.353 , Issue.1 , pp. 23-31
    • Ben-Shabat, S.1    Fride, E.2    Sheskin, T.3    Tamiri, T.4    Rhee, M.H.5    Vogel, Z.6
  • 104
    • 79960306559 scopus 로고    scopus 로고
    • Taming THC: Potential cannabis synergy and phytocannabinoidâ€terpenoid entourage effects.
    • E.B. Russo Taming THC: potential cannabis synergy and phytocannabinoidâ€FOR VERIFICATION>terpenoid entourage effects Br. J. Pharmacol. 163 7 2011 1344 1364
    • (2011) Br. J. Pharmacol. , vol.163 , Issue.7 , pp. 1344-1364
    • Russo, E.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.