Rhabdomyolysis associated with kava ingestion

American Journal of Emergency Medicine

Volumn 30, Issue 4, 2012, Pages 635.e1-635.e3

  Bodkin, Ryan ^a   Schneider, Sandra ^a   Rekkerth, Donna ^b   Spillane, Linda ^a   Kamali, Michael ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b Greer Labs   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; CREATINE KINASE; HALOPERIDOL; KAVA; LORAZEPAM;

ADULT; ARTICLE; CASE REPORT; CONSCIOUSNESS LEVEL; CREATINE KINASE BLOOD LEVEL; DISEASE ASSOCIATION; EMERGENCY CARE; EMERGENCY WARD; FLUID THERAPY; FOOD INTAKE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; KIDNEY FUNCTION; MALE; PRIORITY JOURNAL; RHABDOMYOLYSIS; TACHYCARDIA; UREA NITROGEN BLOOD LEVEL;

EID: 84861176896     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2011.01.030     Document Type: Article

References (18)

1. Singh Y.N. Kava: an overview J Ethopharmacol 37 1992 13 45
2. Donadio V., Bonsi P., Zele I., Monari L., Liguori R., and Vetrugno R. Myoglobinuria after ingestion of extracts of guarana, Ginkgo biloba and kava Neurol Sci 21 2000 124
3. Raduege K.M., Kleshinski J.F., Ryckman J.V., and Tetzlaff J.E. Anesthetic considerations of the herbal kava J Clin Anesth 16 2004 305 311
4. Gleitz J., Friese J., Beile A., Ameri A., and Peters T. Anticonvulsive action of (+/-)-kavain estimated from its properties on stimulated synaptosomes and Na+ channel receptor sites Eur J Pharmacol 315 1996 89 97
5. Anke J., and Ramzan I. Pharmacokinetic and pharmacodynamic drug interactions with kava. J Ethnopharm 93 2004 153 160
6. Zou L., Henderson G.L., Harkey M.R., Sakai Y., and Li A. Effects of kava (kava-kava, 'awa, yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes Phytomedicine 11 2004 285 294
7. Sarris J., Kavanagh D.J., and Bryne G. The Kava Anxiety Depression Sprectrum Study (KADSS): a randomized, placebo controlled crossover trial using an aqueous extract of Piper methysticum Psycopharmacology 205 2009 399 407
8. Pittler M.H., and Ernst E. Kava extract for treating anxiety Cochrane Database Syst Rev 1 2003 CD003383
9. Baum S.S., Hill R., and Rommelspacher H. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats Prog Neuro-Psychopharmacol Biol Psychiatry 22 1998 1105 1120
10. Seitz U., Ameri A., and Pelzer H. Relaxation of evoked contractile activity of isolated guinea-pig ileum by (+/-)-kavain Planta Med 63 1997 303 306
11. Hashimoto T., Suganuma M., Fujiki H., Yamada M., Kohno T., and Asakawa Y. Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum) Phytomedicine 10 2003 309 317
12. Steiner G.G. The correlation between cancer incidence and kava consumption Hawaii Med J 59 2000 420 422
13. Norton S.A., and Ruze P. Kava dermopathy J Am Acad Dermatol 31 1994 89 97
14. Thomsen M., Vitetta L., Schmidt M., and Salil A. Fatal fulminant hepatic failure induced by a natural therapy containing kava Med J Aust 180 2004 198 199
15. Humberston C.L., Akhtar J., and Krenzelok E.P. Acute hepatitis induced by kava kava J Toxicol Clin Toxicol 41 2003 109 113
16. Anonymous From the Centers for Disease Control and Prevention. Hepatic toxicity possibly associated with kava-containing products - United States, Germany, and Switzerland, 1999-2002 JAMA 289 2003 36 37
17. Teschke R., and Schulze J. Risk of kava hepatotoxicity and the FDA consumer advisory JAMA 304 2010 2174 2175
18. Mathews J.M., Etheridge A.S., Valentine J.L., Black S.R., Coleman D.P., and Patel P. Pharmacokinetics and disposition of the kavalactone Kawain: interaction with kava extract and kavalactones in vivo and in vitro Drug Metab Dispos 33 2005 1555 1563