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Volumn 11, Issue 1, 2015, Pages 93-104

Combination of anti-diabetic drug metformin and boswellic acid nanoparticles: A novel strategy for pancreatic cancer therapy

Author keywords

Boswellic acid nanoparticles; Cancer therapy; Metformin; Pancreatic cancer; Synergism

Indexed keywords

CELL CULTURE; CELL DEATH; CELL MEMBRANES; CELL PROLIFERATION; CHEMOTHERAPY; DISEASES; MAGNESIUM PRINTING PLATES; MITOCHONDRIA; NANOPARTICLES; ONCOLOGY;

EID: 84918560373     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2015.1877     Document Type: Article
Times cited : (33)

References (44)
  • 3
    • 75149138953 scopus 로고    scopus 로고
    • Antitumour activity of NK012,SN-38 incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour
    • S. Yohe, Y. Masahiro, K. Jun-Ichiro, K. Yoshikatsu, and M. Yasuhiro, Antitumour activity of NK012,SN-38 incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour. European Journal of Cancer 46, 650 (2010).
    • (2010) European Journal of Cancer , vol.46 , pp. 650
    • Yohe, S.1    Masahiro, Y.2    Yoshikatsu, K.3    Yasuhiro, M.4
  • 5
    • 79952236235 scopus 로고    scopus 로고
    • Pancreatic cancer spheres are more than just aggregates of stem marker positive cells
    • M. Gaviraghi, P. Tunici, S. Valensin, M. Rossi, and C. Giordano, Pancreatic cancer spheres are more than just aggregates of stem marker positive cells. Bioscience Reports 31, 77 (2011).
    • (2011) Bioscience Reports , vol.31 , pp. 77
    • Gaviraghi, M.1    Tunici, P.2    Valensin, S.3    Rossi, M.4    Giordano, C.5
  • 8
    • 0018214433 scopus 로고
    • A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma
    • S. S. Schwarts, A. Zeidler, A. R. Moossa, S. F. Kuku, and A. H. Rubenstein, A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma. Digestive Diseases and Sciences 23, 1107 (1978).
    • (1978) Digestive Diseases and Sciences , vol.23 , pp. 1107
    • Schwarts, S.S.1    Zeidler, A.2    Moossa, A.R.3    Kuku, S.F.4    Rubenstein, A.H.5
  • 9
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • R. J. Shaw, K. A. Lamia, D. Vasquez, S. H. Koo, N. Bardeesy, and R. A. Depinho, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642 (2005).
    • (2005) Science , vol.310 , pp. 1642
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 11
    • 0028332365 scopus 로고
    • Diabetes and the risk of pancreatic cancer: Italian pancreatic cancer study group
    • L. Gullo, R. Pezzilli, and A. M. Morselli, Diabetes and the risk of pancreatic cancer: Italian pancreatic cancer study group. New England Journal of Medicine 331, 84 (1994).
    • (1994) New England Journal of Medicine , vol.331 , pp. 84
    • Gullo, L.1    Pezzilli, R.2    Morselli, A.M.3
  • 12
    • 0029017953 scopus 로고
    • Diabetes mellitus as a risk factor for pancreatic cancer
    • J. Everhart and D. Wright, Diabetes mellitus as a risk factor for pancreatic cancer. JAMA 273, 1605 (1995).
    • (1995) JAMA , vol.273 , pp. 1605
    • Everhart, J.1    Wright, D.2
  • 13
    • 0034679058 scopus 로고    scopus 로고
    • A Abnormal glucose metabolism and pancreatic cancer mortality
    • S. M. Gapstur, P. H. Gann, W. Lowe, K. K. Liu, L. Colangelo, and Dyer, A Abnormal glucose metabolism and pancreatic cancer mortality. JAMA 283, 2558 (2000).
    • (2000) JAMA , vol.283 , pp. 2558
    • Gapstur, S.M.1    Gann, P.H.2    Lowe, W.3    Liu, K.K.4    Colangelo, L.5
  • 14
    • 0031670178 scopus 로고    scopus 로고
    • Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults
    • E. E. Calle, T. K. Murphy, C. Rodriguez, M. J. Thun, and C. W. Heath, Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults. Cancer Causes Control 9, 403 (1998).
    • (1998) Cancer Causes Control , vol.9 , pp. 403
    • Calle, E.E.1    Murphy, T.K.2    Rodriguez, C.3    Thun, M.J.4    Heath, C.W.5
  • 15
    • 79953685303 scopus 로고    scopus 로고
    • The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth
    • Y. H. Feng, G. Velazquez-Torres, C. Gully, J. Chen, M. H. Lee, and S. C. Yeung, The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J. Cell Mol. Med. 15, 825 (2011).
    • (2011) J. Cell Mol. Med , vol.15 , pp. 825
    • Feng, Y.H.1    Gully, C.2    Chen, J.3    Lee, M.H.4    Yeung, S.C.5
  • 16
    • 44649104448 scopus 로고    scopus 로고
    • Targeting AMPK: A new therapeutic opportunity in breast cancer
    • S. M. Hadad, S. Fleming, and A. M. Thompson, Targeting AMPK: A new therapeutic opportunity in breast cancer. Crit. Rev. Oncol. Hematol. 67, 7 (2008).
    • (2008) Crit. Rev. Oncol. Hematol , vol.67 , pp. 7
    • Hadad, S.M.1    Fleming, S.2    Thompson, A.M.3
  • 17
    • 84858745832 scopus 로고    scopus 로고
    • Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
    • K. H. Rabbie, Z. Chunxiao, M. M. Kimberly, S. Li, Z. Yan, A. G. Paola, and L. B. Victoria, Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. Gynecologic Oncology 125, 458 (2012).
    • (2012) Gynecologic Oncology , vol.125 , pp. 458
    • Rabbie, K.H.1    Chunxiao, Z.2    Kimberly, M.M.3    Li, S.4    Yan, Z.5    Paola, A.G.6    Victoria, L.B.7
  • 18
    • 84874310577 scopus 로고    scopus 로고
    • Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells
    • P. S. Heloisa, N. Yang, K. Krisztina, S. S. James, and R. Enrique, Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. Plos One 8, e57289 (2013).
    • (2013) Plos One , vol.8 , pp. e57289
    • Heloisa, P.S.1    Yang, N.2    Krisztina, K.3    James, S.S.4    Enrique, R.5
  • 19
    • 84859463669 scopus 로고    scopus 로고
    • Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells
    • B. Bin, W. Zhiwei, A. Shadan, A. Aamir, S. Asfar, H. S. Sanila, B. Sanjeev, K. Dejuan, L. Yiwei, T. Shivam, and H. S. Fazlul, Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells. Cancer Prev. Res. 5, 355 (2012).
    • (2012) Cancer Prev. Res , vol.5 , pp. 355
    • Bin, B.1    Zhiwei, W.2    Shadan, A.3    Aamir, A.4    Asfar, S.5    Sanila, H.S.6    Sanjeev, B.7    Dejuan, K.8    Yiwei, L.9    Shivam, T.10    Fazlul, H.S.11
  • 20
    • 0036220337 scopus 로고    scopus 로고
    • The evaluation of the radioprotective effect of Triphala (an Ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation
    • G. C. Jagetia, M. S. Baliga, K. J. Malagi, and M. S. Kamath, The evaluation of the radioprotective effect of Triphala (an Ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine 9, 99 (2002).
    • (2002) Phytomedicine , vol.9 , pp. 99
    • Jagetia, G.C.1    Baliga, M.S.2    Malagi, K.J.3    Kamath, M.S.4
  • 21
    • 41349084390 scopus 로고    scopus 로고
    • Bosellia serrata induced apoptosis is related with ER stress and calcium release
    • H. R. Kim, M. S. Kim, D. Y. Kwon, S. W. Chae, and H. J. Chae, Bosellia serrata induced apoptosis is related with ER stress and calcium release. Genes and Nutrition 2, 371 (2008).
    • (2008) Genes and Nutrition , vol.2 , pp. 371
    • Kim, H.R.1    Kim, M.S.2    Kwon, D.Y.3    Chae, S.W.4    Chae, H.J.5
  • 22
    • 3042793289 scopus 로고    scopus 로고
    • An ayurvedic herbal approach to a healthy liver
    • S. Treadway, An ayurvedic herbal approach to a healthy liver. Clinical Nutritional Insights 6, 1 (1998).
    • (1998) Clinical Nutritional Insights , vol.6 , pp. 1
    • Treadway, S.1
  • 23
    • 58749105528 scopus 로고    scopus 로고
    • Successful treatment of schizophrenia requires optimal daily doses of vitamin B3
    • H. Abram and P. Jonathan, Successful treatment of schizophrenia requires optimal daily doses of vitamin B3. Alternative Medicine Review 13, 2 (2008).
    • (2008) Alternative Medicine Review , vol.13 , pp. 2
    • Abram, H.1    Jonathan, P.2
  • 24
    • 77955983183 scopus 로고    scopus 로고
    • Modulation of the immune system by Boswellia serrata extracts and boswellic acids
    • H. P. Ammon, Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine 17, 862 (2010).
    • (2010) Phytomedicine , vol.17 , pp. 862
    • Ammon, H.P.1
  • 26
    • 0036780654 scopus 로고    scopus 로고
    • Keto-And acetylketo-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway
    • J. J. Liu, A. Nilsson, S. Oredsson, V. Badmaev, and R. D. Duan. Keto- and acetylketo-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int. J. Mol. Med. 10, 501 (2002).
    • (2002) Int. J. Mol. Med , vol.10 , pp. 501
    • Liu, J.J.1    Nilsson, A.2    Oredsson, S.3    Badmaev, V.4    Duan, R.D.5
  • 27
    • 33747099596 scopus 로고    scopus 로고
    • Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells
    • J. J. Liu, B. Huang, and S. C. Hooi, Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells. Br. J. Pharmacol. 148, 1099 (2006).
    • (2006) Br. J. Pharmacol , vol.148 , pp. 1099
    • Liu, J.J.1    Huang, B.2    Hooi, S.C.3
  • 28
    • 68549111000 scopus 로고    scopus 로고
    • LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells
    • J. J. Liu and R. D. Duan, LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells. Anticancer. Res. 29, 2987 (2009).
    • (2009) Anticancer. Res , vol.29 , pp. 2987
    • Liu, J.J.1    Duan, R.D.2
  • 29
    • 0034492409 scopus 로고    scopus 로고
    • Anti-tumor and anti-carcinogenic activities of triterpenoid, betaboswellic acid
    • M. T. Huang, V. Badmaev, Y. Ding, Y. Liu, J. G. Xie, and C. T. Ho, Anti-tumor and anti-carcinogenic activities of triterpenoid, betaboswellic acid. Biofactors 13, 225 (2000).
    • (2000) Biofactors , vol.13 , pp. 225
    • Huang, M.T.1    Badmaev, V.2    Ding, Y.3    Liu, Y.4    Xie, J.G.5    Ho, C.T.6
  • 30
    • 0031802980 scopus 로고    scopus 로고
    • Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture
    • Y. Shao, C. T. Ho, C. K. Chin, V. Badmaev, W. Ma, and M. T. Huang, Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Med. 64, 328 (1998).
    • (1998) Planta Med , vol.64 , pp. 328
    • Shao, Y.1    Ho, C.T.2    Chin, C.K.3    Badmaev, V.4    Ma, W.5    Huang, M.T.6
  • 32
    • 15944422555 scopus 로고    scopus 로고
    • Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells
    • L. Xia, D. Chen, R. Han, Q. Fang, S. Waxman, and Y. Jing. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol. Cancer Ther. 4, 381 (2005).
    • (2005) Mol. Cancer Ther , vol.4 , pp. 381
    • Xia, L.1    Chen, D.2    Han, R.3    Fang, Q.4    Waxman, S.5    Jing, Y.6
  • 33
    • 34848927498 scopus 로고    scopus 로고
    • A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
    • S. Bhushan, A. Kumar, F. Malik, S. S. Andotra, V. K. Sethi, I. P. Kaur, S. C. Taneja, G. N. Qazi, and J. Singh, A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells. Apoptosis 12, 1911 (2007).
    • (2007) Apoptosis , vol.12 , pp. 1911
    • Bhushan, S.1    Kumar, A.2    Malik, F.3    Andotra, S.S.4    Sethi, V.K.5    Kaur, I.P.6    Taneja, S.C.7    Qazi, G.N.8    Singh, J.9
  • 34
    • 0242500941 scopus 로고    scopus 로고
    • Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells
    • W. Zhao, F. Entschladen, H. Liu, B. Niggemann, Q. Fang, K. S. Zaenker, and R. Han, Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detect Prev. 27, 67 (2003).
    • (2003) Cancer Detect Prev , vol.27 , pp. 67
    • Zhao, W.1    Entschladen, F.2    Liu, H.3    Niggemann, B.4    Fang, Q.5    Zaenker, K.S.6    Han, R.7
  • 35
    • 14044268207 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo
    • T. Syrovets, J. E. Gschwend, B. Buchele, Y. Laumonnier, W. Zugmaier, F. Genze, and T. Simmet, Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. J. Biol. Chem. 280, 6170 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 6170
    • Syrovets, T.1    Gschwend, J.E.2    Buchele, B.3    Laumonnier, Y.4    Zugmaier, W.5    Genze, F.6    Simmet, T.7
  • 36
    • 84918566096 scopus 로고    scopus 로고
    • Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets
    • P. Byoungduck, P. Sahdeo, Y. Vivek, S. Bokyung, and B. A. Bharat, Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets. Plos one 6, 1 (2011).
    • (2011) Plos one , vol.6 , pp. 1
    • Byoungduck, P.1    Sahdeo, P.2    Vivek, Y.3    Bokyung, S.4    Bharat, B.A.5
  • 37
    • 84870882544 scopus 로고    scopus 로고
    • Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model
    • X. Ni, M. M. Suhail, Q. Yang, A. Cao, K. M. Fung, R. G. Postier, C. Woolley, G. Young, J. Zhang, and H. K. Lin, Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complement Altern Med. 12, 235 (2012).
    • (2012) BMC Complement Altern Med , vol.12 , pp. 235
    • Ni, X.1    Suhail, M.M.2    Yang, Q.3    Cao, A.4    Fung, K.M.5    Postier, R.G.6    Woolley, C.7    Young, G.8    Zhang, J.9    Lin, H.K.10
  • 40
    • 0035957969 scopus 로고    scopus 로고
    • The mitochondrion: Is it central to apoptosis?
    • E. Finkel, The mitochondrion: Is it central to apoptosis? Science 292, 624 (2001).
    • (2001) Science , vol.292 , pp. 624
    • Finkel, E.1
  • 41
    • 80054777735 scopus 로고    scopus 로고
    • The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2
    • H. Dorian, M. Marco, L. Cristina, and C. S. Charles, The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2. J. Eur. Ceram. Soc. 32, 235 (2012).
    • (2012) J. Eur. Ceram. Soc , vol.32 , pp. 235
    • Dorian, H.1    Marco, M.2    Cristina, L.3    Charles, C.S.4
  • 42
    • 0028881848 scopus 로고
    • Mitochondrial membrane potential monitored by JC-1 dye
    • M. Reers, S. T. Smiley, C. Mottola-Hartshorn, A. Chen, M. Lin, and L. B. Chen, Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol 260, 406 (1995).
    • (1995) Methods Enzymol , vol.260 , pp. 406
    • Reers, M.1    Smiley, S.T.2    Chen, A.3    Lin, M.4    Chen, L.B.5
  • 43
    • 0027374638 scopus 로고
    • A method for the cytofluorimetric analysis of mitochondrial membrane potential using J-aggregate forming cationic 5,5,6,6tetrachloro-1.1 ,3,3tetraethylbenzimidazolcarbocyanine iodide (JC-1
    • A. Cossariza, M. Baccarani-Contri, G. Kalashinikova, and C. Franceschi, A method for the cytofluorimetric analysis of mitochondrial membrane potential using J-aggregate forming cationic 5,5,6,6tetrachloro-1.1,3,3tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem. Biophs. Res. Comm. 197, 40 (1993).
    • (1993) Biochem. Biophs. Res. Comm , vol.197 , pp. 40
    • Cossariza, A.1    Kalashinikova, G.2    Franceschi, C.3
  • 44
    • 84918542618 scopus 로고    scopus 로고
    • Synergistic inhibition of pancreatic cancer cell proliferation by metformin and rapamycin: Identification of a novel combinatorial drug strategy
    • S. S. James, K. Krisztina, K. K. Robert, H. Y. Steven, and R. Enrique, Synergistic inhibition of pancreatic cancer cell proliferation by metformin and rapamycin: Identification of a novel combinatorial drug strategy. Gastroenterology 142, S-129 (2012).
    • (2012) Gastroenterology , vol.142 , pp. S-129
    • James, S.S.1    Krisztina, K.2    Robert, K.K.3    Steven, H.Y.4    Enrique, R.5


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