-
2
-
-
15744377355
-
Phase III southwest oncology group 9415/intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer
-
Poplin EA, Benedetti JK, Estes NC, Haller DG, Mayer RJ, Goldberg RM, et al. Phase III Southwest Oncology Group 9415/Intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer. J Clin Oncol 2005; 23:1819-1825.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1819-1825
-
-
Poplin, E.A.1
Benedetti, J.K.2
Estes, N.C.3
Haller, D.G.4
Mayer, R.J.5
Goldberg, R.M.6
-
3
-
-
67650315187
-
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
-
André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009; 27:3109-3116.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3109-3116
-
-
André, T.1
Boni, C.2
Navarro, M.3
Tabernero, J.4
Hickish, T.5
Topham, C.6
-
4
-
-
34547577217
-
Body mass and colorectal cancer risk in the NIH-AARP cohort
-
Adams KF, Leitzmann MF, Albanes D, Kipnis V, Mouw T, Hollenbeck A, Schatzkin A. Body mass and colorectal cancer risk in the NIH-AARP cohort. Am J Epidemiol 2007; 166:36-45.
-
(2007)
Am J Epidemiol
, vol.166
, pp. 36-45
-
-
Adams, K.F.1
Leitzmann, M.F.2
Albanes, D.3
Kipnis, V.4
Mouw, T.5
Hollenbeck, A.6
Schatzkin, A.7
-
5
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
-
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348:1625-1638.
-
(2003)
N Engl J Med
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
Rodriguez, C.2
Walker-Thurmond, K.3
Thun, M.J.4
-
6
-
-
33751373088
-
Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer
-
Dignam JJ, Polite BN, Yothers G, Raich P, Colangelo L, O'Connell MJ, Wolmark N. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 2006; 98:1647-1654.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1647-1654
-
-
Dignam, J.J.1
Polite, B.N.2
Yothers, G.3
Raich, P.4
Colangelo, L.5
O'Connell, M.J.6
Wolmark, N.7
-
7
-
-
84855530390
-
Impact of body mass index on survival after colorectal cancer diagnosis: The Cancer Prevention Study-II Nutrition Cohort
-
Campbell PT, Newton CC, Dehal AN, Jacobs EJ, Patel AV, Gapstur SM. Impact of body mass index on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol 2012; 30:42-52.
-
(2012)
J Clin Oncol
, vol.30
, pp. 42-52
-
-
Campbell, P.T.1
Newton, C.C.2
Dehal, A.N.3
Jacobs, E.J.4
Patel, A.V.5
Gapstur, S.M.6
-
8
-
-
0037962010
-
Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma
-
Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Benson AB 3rd, Macdonald JS, Fuchs CS. Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma. Cancer 2003; 98:484-495.
-
(2003)
Cancer
, vol.98
, pp. 484-495
-
-
Meyerhardt, J.A.1
Catalano, P.J.2
Haller, D.G.3
Mayer, R.J.4
Benson, A.B.5
Macdonald, J.S.6
Fuchs, C.S.7
-
9
-
-
51649093534
-
Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: Findings from Cancer and Leukemia Group B 89803
-
Cancer and Leukemia Group B 89803
-
Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Nelson H, et al. Cancer and Leukemia Group B 89803. Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol 2008; 26:4109-4115.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4109-4115
-
-
Meyerhardt, J.A.1
Niedzwiecki, D.2
Hollis, D.3
Saltz, L.B.4
Mayer, R.J.5
Nelson, H.6
-
10
-
-
62849109985
-
Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
-
Gao J, Tian J, Lv Y, Shi F, Kong F, Shi H, Zhao L. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci 2009; 100:389-395.
-
(2009)
Cancer Sci
, vol.100
, pp. 389-395
-
-
Gao, J.1
Tian, J.2
Lv, Y.3
Shi, F.4
Kong, F.5
Shi, H.6
Zhao, L.7
-
11
-
-
84897572608
-
Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration
-
Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, et al. Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration. Br J Cancer 2014; 110:1801-1810.
-
(2014)
Br J Cancer
, vol.110
, pp. 1801-1810
-
-
Dong, Z.1
Fu, S.2
Xu, X.3
Yang, Y.4
Du, L.5
Li, W.6
-
12
-
-
56049083633
-
Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways
-
Jaffe T, Schwartz B. Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 2008; 123:2543-2556.
-
(2008)
Int J Cancer
, vol.123
, pp. 2543-2556
-
-
Jaffe, T.1
Schwartz, B.2
-
13
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140:197-208.
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
Lee, J.H.2
Yu, G.Y.3
He, G.4
Ali, S.R.5
Holzer, R.G.6
-
15
-
-
0034693323
-
Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B
-
Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J Biol Chem 2000; 275:32681-32687.
-
(2000)
J Biol Chem
, vol.275
, pp. 32681-32687
-
-
Chung, S.W.1
Kang, B.Y.2
Kim, S.H.3
Pak, Y.K.4
Cho, D.5
Trinchieri, G.6
Kim, T.S.7
-
16
-
-
84879498300
-
A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells
-
Cortez M, Carmo LS, Rogero MM, Borelli P, Fock RA. A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells. Inflammation 2013; 36:379-386.
-
(2013)
Inflammation
, vol.36
, pp. 379-386
-
-
Cortez, M.1
Carmo, L.S.2
Rogero, M.M.3
Borelli, P.4
Fock, R.A.5
-
17
-
-
0033972140
-
Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer
-
Guan RJ, Ford HL, Fu Y, Li Y, Shaw LM, Pardee AB. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res 2000; 60:749-755.
-
(2000)
Cancer Res
, vol.60
, pp. 749-755
-
-
Guan, R.J.1
Ford, H.L.2
Fu, Y.3
Li, Y.4
Shaw, L.M.5
Pardee, A.B.6
-
18
-
-
0032588360
-
Pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis
-
Rechreche H, Montalto G, Mallo GV, Vasseur S, Marasa L, Soubeyran P, et al. pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. Int J Cancer 1999; 81:688-694.
-
(1999)
Int J Cancer
, vol.81
, pp. 688-694
-
-
Rechreche, H.1
Montalto, G.2
Mallo, G.V.3
Vasseur, S.4
Marasa, L.5
Soubeyran, P.6
-
19
-
-
0029981266
-
Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases
-
Nielsen BS, Borregaard N, Bundgaard JR, Timshel S, Sehested M, Kjeldsen L. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 1996; 38:414-420.
-
(1996)
Gut
, vol.38
, pp. 414-420
-
-
Nielsen, B.S.1
Borregaard, N.2
Bundgaard, J.R.3
Timshel, S.4
Sehested, M.5
Kjeldsen, L.6
-
20
-
-
34548159455
-
Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells
-
Bush CR, Havens JM, Necela BM, Su W, Chen L, Yanagisawa M, et al. Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. J Biol Chem 2007; 282:23387-23401.
-
(2007)
J Biol Chem
, vol.282
, pp. 23387-23401
-
-
Bush, C.R.1
Havens, J.M.2
Necela, B.M.3
Su, W.4
Chen, L.5
Yanagisawa, M.6
-
21
-
-
34547837548
-
Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer
-
Riemann K, Becker L, Struwe H, Rübben H, Eisenhardt A, Siffert W. Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer. Int J Clin Pharmacol Ther 2007; 45:423-430.
-
(2007)
Int J Clin Pharmacol Ther
, vol.45
, pp. 423-430
-
-
Riemann, K.1
Becker, L.2
Struwe, H.3
Rübben, H.4
Eisenhardt, A.5
Siffert, W.6
-
22
-
-
0036628931
-
A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin
-
Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 2002; 34: 355-359.
-
(2002)
Horm Metab Res
, vol.34
, pp. 355-359
-
-
Hoffstedt, J.1
Eriksson, P.2
Mottagui-Tabar, S.3
Arner, P.4
-
23
-
-
0031595923
-
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20:284-287.
-
(1998)
Nat Genet
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamäki, J.4
Mykkänen, L.5
Kuusisto, J.6
-
24
-
-
0031912333
-
A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans
-
Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Lebel P, Dallongeville J, et al. A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998; 7:435-440.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 435-440
-
-
Meirhaeghe, A.1
Fajas, L.2
Helbecque, N.3
Cottel, D.4
Lebel, P.5
Dallongeville, J.6
-
25
-
-
58849143927
-
Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: Implications for chemoprevention
-
Ondrey F. Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: implications for chemoprevention. Clin Cancer Res 2009; 15:2-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2-8
-
-
Ondrey, F.1
-
26
-
-
1542313738
-
Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone
-
Kato M, Kusumi T, Tsuchida S, Tanaka M, Sasaki M, Kudo H. Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone. J Cancer Res Clin Oncol 2004; 130:73-79.
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 73-79
-
-
Kato, M.1
Kusumi, T.2
Tsuchida, S.3
Tanaka, M.4
Sasaki, M.5
Kudo, H.6
-
27
-
-
0035873953
-
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN
-
Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH. Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 2001; 11:764-768.
-
(2001)
Curr Biol
, vol.11
, pp. 764-768
-
-
Patel, L.1
Pass, I.2
Coxon, P.3
Downes, C.P.4
Smith, S.A.5
Macphee, C.H.6
-
28
-
-
0036606010
-
Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
-
Shao J, Sheng H, DuBois RN. Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res 2002; 62:3282-3288.
-
(2002)
Cancer Res
, vol.62
, pp. 3282-3288
-
-
Shao, J.1
Sheng, H.2
Dubois, R.N.3
-
29
-
-
4143065010
-
Peroxisome proliferatoractivated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway
-
Sharma C, Pradeep A, Wong L, Rana A, Rana B. Peroxisome proliferatoractivated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem 2004; 279:35583-35594.
-
(2004)
J Biol Chem
, vol.279
, pp. 35583-35594
-
-
Sharma, C.1
Pradeep, A.2
Wong, L.3
Rana, A.4
Rana, B.5
-
30
-
-
84867986644
-
Estrogen in obesity-associated colon cancer: Friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer
-
Chen J, Iverson D. Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer. Cancer Causes Control 2012; 23:1767-1773.
-
(2012)
Cancer Causes Control
, vol.23
, pp. 1767-1773
-
-
Chen, J.1
Iverson, D.2
-
32
-
-
77954380826
-
PPARgamma polymorphisms and cancer risk: A meta-analysis involving 32 138 subjects
-
Xu W, Li Y, Wang X, Chen B, Liu S, Wang Y, et al. PPARgamma polymorphisms and cancer risk: a meta-analysis involving 32 138 subjects. Oncol Rep 2010; 24:579-585.
-
(2010)
Oncol Rep
, vol.24
, pp. 579-585
-
-
Xu, W.1
Li, Y.2
Wang, X.3
Chen, B.4
Liu, S.5
Wang, Y.6
-
33
-
-
0034234543
-
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
-
Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 2000; 9:1681-1690.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 1681-1690
-
-
Fuentes, J.J.1
Genescà, L.2
Kingsbury, T.J.3
Cunningham, K.W.4
Pérez-Riba, M.5
Estivill, X.6
De La Luna, S.7
-
34
-
-
0033605216
-
Characterization of a novel calcium response element in the glucagon gene
-
Fürstenau U, Schwaninger M, Blume R, Jendrusch EM, Knepel W. Characterization of a novel calcium response element in the glucagon gene. J Biol Chem 1999; 274:5851-5860.
-
(1999)
J Biol Chem
, vol.274
, pp. 5851-5860
-
-
Fürstenau, U.1
Schwaninger, M.2
Blume, R.3
Jendrusch, E.M.4
Knepel, W.5
-
35
-
-
29144484163
-
Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease
-
Harris CD, Ermak G, Davies KJ. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci 2005; 62:2477-2486.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 2477-2486
-
-
Harris, C.D.1
Ermak, G.2
Davies, K.J.3
-
36
-
-
0037160991
-
Mortality associated with Down's syndrome in the USA from 1983 to 1997: A population-based study
-
Yang Q, Rasmussen SA, Friedman JM. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 2002; 359:1019-1025.
-
(2002)
Lancet
, vol.359
, pp. 1019-1025
-
-
Yang, Q.1
Rasmussen, S.A.2
Friedman, J.M.3
-
37
-
-
67649506317
-
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
-
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009; 459:1126-1130.
-
(2009)
Nature
, vol.459
, pp. 1126-1130
-
-
Baek, K.H.1
Zaslavsky, A.2
Lynch, R.C.3
Britt, C.4
Okada, Y.5
Siarey, R.J.6
-
38
-
-
4344616593
-
VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: A mechanism for feedback regulation of angiogenesis?
-
Yao YG, Duh EJ. VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis? Biochem Biophys Res Commun 2004; 321:648-656.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 648-656
-
-
Yao, Y.G.1
Duh, E.J.2
-
39
-
-
84859763945
-
Right-side and left-side colon cancer follow different pathways to relapse
-
Bauer KM, Hummon AB, Buechler S. Right-side and left-side colon cancer follow different pathways to relapse. Mol Carcinog 2012; 51:411-421.
-
(2012)
Mol Carcinog
, vol.51
, pp. 411-421
-
-
Bauer, K.M.1
Hummon, A.B.2
Buechler, S.3
-
40
-
-
84879496127
-
Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis
-
Zhu H, Wu TC, Chen WQ, Zhou LJ, Wu Y, Zeng L, Pei HP. Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis. Oncol Lett 2013; 6:353-358.
-
(2013)
Oncol Lett
, vol.6
, pp. 353-358
-
-
Zhu, H.1
Wu, T.C.2
Chen, W.Q.3
Zhou, L.J.4
Wu, Y.5
Zeng, L.6
Pei, H.P.7
-
41
-
-
58149150071
-
VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival
-
Bendardaf R, Buhmeida A, Hilska M, Laato M, Syrjänen S, Syrjänen K, et al. VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival. Anticancer Res 2008; 28 (6B):3865-3870.
-
(2008)
Anticancer Res
, vol.28
, Issue.6
, pp. 3865-3870
-
-
Bendardaf, R.1
Buhmeida, A.2
Hilska, M.3
Laato, M.4
Syrjänen, S.5
Syrjänen, K.6
-
42
-
-
84865712382
-
Annotation of functional variation in personal genomes using RegulomeDB
-
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012; 22:1790-1797.
-
(2012)
Genome Res
, vol.22
, pp. 1790-1797
-
-
Boyle, A.P.1
Hong, E.L.2
Hariharan, M.3
Cheng, Y.4
Schaub, M.A.5
Kasowski, M.6
-
43
-
-
67649982744
-
Diversity and complexity in DNA recognition by transcription factors
-
Badis G, Berger MF, Philippakis AA, Talukder S, Gehrke AR, Jaeger SA, et al. Diversity and complexity in DNA recognition by transcription factors. Science 2009; 324:1720-1723.
-
(2009)
Science
, vol.324
, pp. 1720-1723
-
-
Badis, G.1
Berger, M.F.2
Philippakis, A.A.3
Talukder, S.4
Gehrke, A.R.5
Jaeger, S.A.6
|