Dipeptidyl peptidase 8/9-like activity in human leukocytes

Journal of Leukocyte Biology

Volumn 81, Issue 5, 2007, Pages 1252-1257

  Maes, Marie Berthe ^a   Dubois, Véronique ^a   Brandt, Inger ^a   Lambeir, Anne Marie ^a   Van Der Veken, Pieter ^a   Augustyns, Koen ^a   Cheng, Jonathan D ^b   Chen, Xin ^c   Scharpé, Simon ^a   De Meester, Ingrid ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b FOX CHASE CANCER CENTER   (United States)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

DPP8; DPP9; DPPIV; Fibroblast activation protein; Vildagliptin

Indexed keywords

2,6 DIAMINO 1 (ISOINDOLIN 2 YL)HEXAN 1 ONE; AB 192; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE 9; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV; PEPTIDE HYDROLASE INHIBITOR; UAMC 00039; UAMC 00132; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL STRAIN U937; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKOCYTE; LYMPHOCYTE; MONOCYTE; PRIORITY JOURNAL;

ADAMANTANE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD26; DIPEPTIDASES; DIPEPTIDYL PEPTIDASES; ENZYME ACTIVATION; HUMANS; INDOLES; ISOLEUCINE; LEUKOCYTES; MOLECULAR CONFORMATION; NITRILES; PHOSPHONIC ACIDS; PIPERIDINES; PROLINE; PROTEASE INHIBITORS; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247898818     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0906546     Document Type: Article

References (26)

1. Rosenblum, J. S., Kozarich, J. W. (2003) Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Curr. Opin. Chem. Biol. 7, 496-504.
2. Lambeir, A. M., Durinx, C., Scharpé, S., De Meester, I. (2003) Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit. Rev. Clin. Lab. Sci. 40, 209-294.
3. Weber, A. E. (2004) Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. J. Med. Chem. 47, 4135-4141.
4. McIntyre, J. A., Castaner, J. (2004) Talabostat. Oncolytic, hematopoietic agent, dipeptidyl-peptidase IV (CD26) inhibitor, fibroblast activation protein inhibitor. Drugs of the Future 29, 882-886.
5. Abbott, C. A., Yu, D. M., Woollatt, E., Sutherland, G. R., McCaughan, G. W., Gorrell, M. D. (2000) Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur. J. Biochem. 267, 6140-6150.
6. Olsen, C., Wagtmann, N. (2002) Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. Gene 299, 185-193.
7. Gorrell, M. D. (2005) Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin. Sci. (Lond.) 108, 277-292.
8. Lankas, G. R., Leiting, B., Roy, R. S., Eiermann, G. J., Beconi, M. G., Biftu, T., Chan, C. C., Edmondson, S., Feeney, W. P., He, H., et al. (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54, 2988-2994.
9. Jones, B., Dinarello, C. A. (2006) Research and Development Day, Boston, MA, USA, Point Therapeutics, www.pther.com.
10. Ajami, K., Abbott, C. A., McCaughan, G. W., Gorrell, M. D. (2004) Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Biochim. Biophys. Acta 1679, 18-28.
11. Jiaang, W. T., Chen, Y. S., Hsu, T., Wu, S. H., Chien, C. H., Chang, C. N., Chang, S. P., Lee, S. J., Chen, X. (2005) Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg. Med. Chem. Lett. 15, 687-691.
12. Senten, K., Van Der Veken, P., De Meester, I., Lambeir, A. M., Scharpé, S., Haemers, A., Augustyns, K. (2004) γ-Amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl] piperidine as highly potent and selective dipeptidyl peptidase II inhibitors. J. Med. Chem. 47, 2906-2916.
13. Maes, M. B., Martinet, W., Schrijvers, D. M., Van der Veken, P., De Meyer, G. R. Y., Augustyns, K., Lambeir, A. M., Scharpé, S., De Meester, I. (2006) Dipeptidyl peptidase II and leukocyte cell death. Biochem. Pharmacol. 72, 70-79.
14. Villhauer, E. B., Brinkman, J. A., Naderi, G. B., Burkey, B. F., Dunning, B. E., Prasad, K., Mangold, B. L., Russell, M. E., Hughes, T. E. (2003) 1-[[(3-Hydroxy-1- adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J. Med. Chem. 46, 2774-2789.
15. Brandt, I., Joossens, J., Chen, X., Maes, M. B., Scharpé, S., De Meester, I., Lambeir, A. M. (2005) Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3- hydroxyadamantan-1-yl) amino] acetyl}-pyrrolidine-2-carbonitrile). Biochem. Pharmacol. 70, 134-143.
16. Belyaev, A., Zhang, X., Augustyns, K., Lambeir, A. M., De Meester, I., Vedernikova, I., Scharpé, S., Haemers, A. (1999) Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors. J. Med. Chem. 42, 1041-1052.
17. Maes, M. B., Lambeir, A. M., Gilany, K., Senten, K., Van der Veken, P., Leiting, B., Augustyns, K., Scharpé, S., De Meester, I. (2005) Kinetic investigation of human dipeptidyl peptidase II mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase/dipeptidyl peptidase 7. Biochem. J. 386, 315-324.
18. De Meester, I., Vanhoof, G., Lambeir, A. M., Scharpé, S. (1996) Use of immobilized adenosine deaminase (EC 3.5.4.4) for the rapid purification of native human CD26/dipeptidyl peptidase IV (EC 3.4.14.5). J. Immunol. Methods 189, 99-105.
19. Chen, Y. S., Chien, C. H., Goparaju, C. M., Hsu, J. T. A., Liang, P. H., Chen, X. (2004) Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells. Protein Expr. Purif. 35, 142-146.
20. Cheng, J. D., Dunbrack, R. L., Vilianou, M., Rogatko, A., Alpaugh, R. K., Weiner, L. M. (2002) Promotion of tumor growth by murine fibroblast activation protein (FAP), a serine protease, in an animal model. Cancer Res. 62, 4767-4772.
21. Bjelke, J. R., Christensen, J., Nielsen, P. F., Branner, S., Kanstrup, A. B., Wagtmann, N., Rasmussen, H. B. (2006) Dipeptidyl peptidase 8 and 9 specificity and molecular characterization compared to dipeptidyl peptidase IV. Biochem. J. 396, 391-399.
22. Cooper, G. M. (2000) The Cell, A Molecular Approach, Sunderland, MA, USA, Sinauer Associates.
23. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
24. De Meester, I., Scharpé, S., Vanham, G., Bosmans, E., Heyligen, H., Vanhoof, G., Corte, G. (1993) Antibody binding profile of purified and cell-bound CD26. Designation of BT5/9 and TA5.9 to the CD26 cluster. Immunobiology 188, 145-158.
25. Abbott, C. A., McCaughan, G. W., Levy, M. T., Church, W. B., Gorrell, M. D. (1999) Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain. Eur. J. Biochem. 266, 798-810.
26. Aertgeerts, K., Levin, I., Shi, L., Snell, G. P., Jennings, A., Prasad, G. S., Zhang, Y., Kraus, M. L., Salakian, S., Sridhar, V., Wijnands, R., Tennant, M. G. (2005) Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein α. J. Biol. Chem. 280, 19441-19444.