-
1
-
-
84867158927
-
Molecular pathogenesis of multiple myeloma and its premalignant precursor
-
Kuehl WM, Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest 2012;122:3456-63.
-
(2012)
J Clin Invest
, vol.122
, pp. 3456-3463
-
-
Kuehl, W.M.1
Bergsagel, P.L.2
-
3
-
-
79952911779
-
Ten years of improvement in the management of multiple myeloma: 2000-2010
-
Harousseau JL. Ten years of improvement in the management of multiple myeloma: 2000-2010. Clin Lymphoma Myeloma Leuk 2010;10:424-42.
-
(2010)
Clin Lymphoma Myeloma Leuk
, vol.10
, pp. 424-442
-
-
Harousseau, J.L.1
-
4
-
-
79953078844
-
Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: Analysis of 1175 patients
-
Gay F, Larocca A, Wijermans P, Cavallo F, Rossi D, Schaafsma R, et al. Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients. Blood 2011;117:3025-31.
-
(2011)
Blood
, vol.117
, pp. 3025-3031
-
-
Gay, F.1
Larocca, A.2
Wijermans, P.3
Cavallo, F.4
Rossi, D.5
Schaafsma, R.6
-
5
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008;111:2516-20.
-
(2008)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
Lacy, M.Q.4
Hayman, S.R.5
Buadi, F.K.6
-
6
-
-
84899630064
-
Limited value of the International Staging System for predicting longterm outcome of transplant-ineligible, newly diagnosed, symptomatic multiple myeloma in the era of novel agents
-
Kuroda J, Shimura Y, Ohta K, Tanaka H, Shibayama H, Kosugi S, et al. Limited value of the International Staging System for predicting longterm outcome of transplant-ineligible, newly diagnosed, symptomatic multiple myeloma in the era of novel agents. Int J Hematol 2014;99:441-9.
-
(2014)
Int J Hematol
, vol.99
, pp. 441-449
-
-
Kuroda, J.1
Shimura, Y.2
Ohta, K.3
Tanaka, H.4
Shibayama, H.5
Kosugi, S.6
-
7
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
Kuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, Sun CM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007;110:3281-90.
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
Strader, J.S.4
Shenk, K.D.5
Sun, C.M.6
-
8
-
-
80052937408
-
Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
-
Lacy MQ, Allred JB, Gertz MA, Hayman SR, Short KD, Buadi F, et al. Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease. Blood 2011;118:2970-5.
-
(2011)
Blood
, vol.118
, pp. 2970-2975
-
-
Lacy, M.Q.1
Allred, J.B.2
Gertz, M.A.3
Hayman, S.R.4
Short, K.D.5
Buadi, F.6
-
9
-
-
84896527916
-
Elotuzumab and daratumumab: Emerging new monoclonal antibodies for multiple myeloma
-
Kuroda J, Nagoshi H, Shimura Y, Taniwaki M. Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma. Expert Rev Anticancer Ther 2013;13:1081-8.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, pp. 1081-1088
-
-
Kuroda, J.1
Nagoshi, H.2
Shimura, Y.3
Taniwaki, M.4
-
10
-
-
79951507143
-
Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival
-
Steinbrunn T, Stühmer T, Gattenlöhner S, Rosenwald A, Mottok A, Unzicker C, et al. Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival. Blood 2011;117:1998-2004.
-
(2011)
Blood
, vol.117
, pp. 1998-2004
-
-
Steinbrunn, T.1
Stühmer, T.2
Gattenlöhner, S.3
Rosenwald, A.4
Mottok, A.5
Unzicker, C.6
-
11
-
-
57849129292
-
Clinical and biological significance of RAS mutations in multiple myeloma
-
Chng WJ, Gonzalez-Paz N, Price-Troska T, Jacobus S, Rajkumar SV, Oken MM,et al. Clinical and biological significance of RAS mutations in multiple myeloma. Leukemia 2008;22:2280-4.
-
(2008)
Leukemia
, vol.22
, pp. 2280-2284
-
-
Chng, W.J.1
Gonzalez-Paz, N.2
Price-Troska, T.3
Jacobus, S.4
Rajkumar, S.V.5
Oken, M.M.6
-
12
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, et al. Initial genome sequencing and analysis of multiple myeloma. Nature 2011;471:467-72.
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
Cibulskis, K.4
Sougnez, C.5
Schinzel, A.C.6
-
13
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009;137:873-86.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
14
-
-
54049150430
-
Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Aktdependent and Akt-independent multiple myeloma
-
Zöllinger A, Stühmer T, Chatterjee M, Gattenlöhner S, Haralambieva E, Müller-Hermelink HK, et al. Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Aktdependent and Akt-independent multiple myeloma. Blood 2008;112:3403-11.
-
(2008)
Blood
, vol.112
, pp. 3403-3411
-
-
Zöllinger, A.1
Stühmer, T.2
Chatterjee, M.3
Gattenlöhner, S.4
Haralambieva, E.5
Müller-Hermelink, H.K.6
-
15
-
-
0029819604
-
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group Phase III Trial
-
Liu P, Leong T, Quam L, Billadeau D, Kay NE, Greipp P, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood 1996;88:2699-706.
-
(1996)
Blood
, vol.88
, pp. 2699-2706
-
-
Liu, P.1
Leong, T.2
Quam, L.3
Billadeau, D.4
Kay, N.E.5
Greipp, P.6
-
16
-
-
84869785019
-
Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway
-
Ramakrishnan V, Kimlinger T, Haug J, Painuly U, Wellik L, Halling T, et al. Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway. PLoS ONE2012;7:e50005.
-
(2012)
PLoS ONE
, vol.7
, pp. e50005
-
-
Ramakrishnan, V.1
Kimlinger, T.2
Haug, J.3
Painuly, U.4
Wellik, L.5
Halling, T.6
-
17
-
-
0037158513
-
Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
-
Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, et al. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 2002; 21:5673-83.
-
(2002)
Oncogene
, vol.21
, pp. 5673-5683
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Poulaki, V.3
Schlossman, R.4
Akiyama, M.5
Chauhan, D.6
-
18
-
-
56449128746
-
New drugs in multiple myeloma: Mechanisms of action and phase I/II clinical findings
-
Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF. New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol 2008;9:1157-65.
-
(2008)
Lancet Oncol
, vol.9
, pp. 1157-1165
-
-
Ocio, E.M.1
Mateos, M.V.2
Maiso, P.3
Pandiella, A.4
San-Miguel, J.F.5
-
19
-
-
81155151824
-
Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
-
Richardson PG, Wolf J, Jakubowiak A, Zonder J, Lonial S, Irwin D, et al. Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. J Clin Oncol 2011;29:4243-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4243-4249
-
-
Richardson, P.G.1
Wolf, J.2
Jakubowiak, A.3
Zonder, J.4
Lonial, S.5
Irwin, D.6
-
20
-
-
78851472038
-
Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers
-
Richardson PG, Mitsiades CS, Laubach JP, Lonial S, Chanan-Khan AA, Anderson KC. Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers. Br J Haematol 2011;152:367-79.
-
(2011)
Br J Haematol
, vol.152
, pp. 367-379
-
-
Richardson, P.G.1
Mitsiades, C.S.2
Laubach, J.P.3
Lonial, S.4
Chanan-Khan, A.A.5
Anderson, K.C.6
-
21
-
-
79952042047
-
Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: A multicentre, phase 1/2, open-label, dose-escalation study
-
Ghobrial IM, Weller E, Vij R, Munshi NC, Banwait R, Bagshaw M, et al. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Lancet Oncol 2011;12:263-72.
-
(2011)
Lancet Oncol
, vol.12
, pp. 263-272
-
-
Ghobrial, I.M.1
Weller, E.2
Vij, R.3
Munshi, N.C.4
Banwait, R.5
Bagshaw, M.6
-
22
-
-
84894557306
-
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling
-
Will M, Qin AC, Toy W, Yao Z, Rodrik-Outmezguine V, Schneider C, et al. Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov 2014;4:334-47.
-
(2014)
Cancer Discov
, vol.4
, pp. 334-347
-
-
Will, M.1
Qin, A.C.2
Toy, W.3
Yao, Z.4
Rodrik-Outmezguine, V.5
Schneider, C.6
-
23
-
-
0033607633
-
Phosphorylation and regulation of Raf by Akt (protein kinase B)
-
Zimmermann S, Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999;286:1741-4.
-
(1999)
Science
, vol.286
, pp. 1741-1744
-
-
Zimmermann, S.1
Moelling, K.2
-
24
-
-
84868198690
-
Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma
-
Steinbrunn T, Stühmer T, Sayehli C, Chatterjee M, Einsele H, Bargou RC. Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma. Br J Haematol 2012;159:430-40.
-
(2012)
Br J Haematol
, vol.159
, pp. 430-440
-
-
Steinbrunn, T.1
Stühmer, T.2
Sayehli, C.3
Chatterjee, M.4
Einsele, H.5
Bargou, R.C.6
-
25
-
-
84871375573
-
RSK2(Ser227) at N-terminal kinase domain is a potential therapeutic target for multiple myeloma
-
Shimura Y, Kuroda J, Ri M, Nagoshi H, Yamamoto-Sugitani M, Kobayashi T, et al. RSK2(Ser227) at N-terminal kinase domain is a potential therapeutic target for multiple myeloma. Mol Cancer Ther 2012;11:2600-9.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2600-2609
-
-
Shimura, Y.1
Kuroda, J.2
Ri, M.3
Nagoshi, H.4
Yamamoto-Sugitani, M.5
Kobayashi, T.6
-
26
-
-
52449095361
-
The RSK family of kinases: Emerging roles in cellular signalling
-
Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 2008;9:747-58.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 747-758
-
-
Anjum, R.1
Blenis, J.2
-
27
-
-
57549101230
-
Small-molecule inhibitors of PDK1
-
Peifer C, Alessi DR. Small-molecule inhibitors of PDK1. Chem Med Chem 2008;3:1810-38.
-
(2008)
Chem Med Chem
, vol.3
, pp. 1810-1838
-
-
Peifer, C.1
Alessi, D.R.2
-
28
-
-
0028963195
-
Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes
-
Roecklein BA, Torok-Storb B. Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. Blood 1995;85:997-1005.
-
(1995)
Blood
, vol.85
, pp. 997-1005
-
-
Roecklein, B.A.1
Torok-Storb, B.2
-
29
-
-
77955712506
-
Bortezomibresistant myeloma cell lines: A role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress
-
Ri M, Iida S, Nakashima T, Miyazaki H, Mori F, Ito A, et al. Bortezomibresistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 2010;24:1506-12.
-
(2010)
Leukemia
, vol.24
, pp. 1506-1512
-
-
Ri, M.1
Iida, S.2
Nakashima, T.3
Miyazaki, H.4
Mori, F.5
Ito, A.6
-
30
-
-
84862905349
-
Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma
-
Kiyota M, Kobayashi T, Fuchida S, Yamamoto-Sugitani M, Ohshiro M, Shimura Y, et al. Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma. Int J Hematol 2012; 95:516-26.
-
(2012)
Int J Hematol
, vol.95
, pp. 516-526
-
-
Kiyota, M.1
Kobayashi, T.2
Fuchida, S.3
Yamamoto-Sugitani, M.4
Ohshiro, M.5
Shimura, Y.6
-
31
-
-
21244435590
-
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1
-
Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem 2005;280:19867-74.
-
(2005)
J Biol Chem
, vol.280
, pp. 19867-19874
-
-
Feldman, R.I.1
Wu, J.M.2
Polokoff, M.A.3
Kochanny, M.J.4
Dinter, H.5
Zhu, D.6
-
32
-
-
34548060313
-
OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms
-
Zhang S, Suvannasankha A, Crean CD, White VL, Johnson A, Chen CS, et al. OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. Clin Cancer Res 2007;13:4750-8.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4750-4758
-
-
Zhang, S.1
Suvannasankha, A.2
Crean, C.D.3
White, V.L.4
Johnson, A.5
Chen, C.S.6
-
33
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005;106:296-303.
-
(2005)
Blood
, vol.106
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy, J.6
-
34
-
-
47749122567
-
PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
-
Nakamura K, Sakaue H, Nishizawa A, Matsuki Y, Gomi H, Watanabe E, et al. PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression. J Biol Chem 2008;283:17702-11.
-
(2008)
J Biol Chem
, vol.283
, pp. 17702-17711
-
-
Nakamura, K.1
Sakaue, H.2
Nishizawa, A.3
Matsuki, Y.4
Gomi, H.5
Watanabe, E.6
-
35
-
-
23044512143
-
The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
-
Moreaux J, Cremer FW, Reme T, Raab M, Mahtouk K, Kaukel P, et al. The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature. Blood 2005;106:1021-30
-
(2005)
Blood
, vol.106
, pp. 1021-1030
-
-
Moreaux, J.1
Cremer, F.W.2
Reme, T.3
Raab, M.4
Mahtouk, K.5
Kaukel, P.6
-
36
-
-
84877603442
-
Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma
-
Huo J, Xu S, Lin B, Chng WJ, Lam KP. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. Leukemia 2013;27:1165-71.
-
(2013)
Leukemia
, vol.27
, pp. 1165-1171
-
-
Huo, J.1
Xu, S.2
Lin, B.3
Chng, W.J.4
Lam, K.P.5
-
37
-
-
0033199841
-
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identi fication of five sites of phosphorylation in vivo
-
Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identi fication of five sites of phosphorylation in vivo. Biochem J 1999;342:287-92.
-
(1999)
Biochem J
, vol.342
, pp. 287-292
-
-
Casamayor, A.1
Morrice, N.A.2
Alessi, D.R.3
-
38
-
-
84875960670
-
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development
-
Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, et al. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J 2013;32:1008-22.
-
(2013)
EMBO J
, vol.32
, pp. 1008-1022
-
-
Venigalla, R.K.1
McGuire, V.A.2
Clarke, R.3
Patterson-Kane, J.C.4
Najafov, A.5
Toth, R.6
-
39
-
-
84873487984
-
The kinase PDK1 is essential for B-cell receptor mediated survival signaling
-
Park SG, Long M, Kang JA, Kim WS, Lee CR, Im SH, et al. The kinase PDK1 is essential for B-cell receptor mediated survival signaling. PLoS ONE 2013;8:e55378.
-
(2013)
PLoS ONE
, vol.8
, pp. e55378
-
-
Park, S.G.1
Long, M.2
Kang, J.A.3
Kim, W.S.4
Lee, C.R.5
Im, S.H.6
-
40
-
-
84876437832
-
Selective requirement of PI3K/PDK1 signaling for Kras oncogenedriven pancreatic cell plasticity and cancer
-
Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, et al. Selective requirement of PI3K/PDK1 signaling for Kras oncogenedriven pancreatic cell plasticity and cancer. Cancer Cell 2013;23:406-20.
-
(2013)
Cancer Cell
, vol.23
, pp. 406-420
-
-
Eser, S.1
Reiff, N.2
Messer, M.3
Seidler, B.4
Gottschalk, K.5
Dobler, M.6
-
41
-
-
77949732137
-
3-phosphoinositidedependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway
-
Lu Z, Cox-Hipkin MA, Windsor WT, Boyapati A. 3-phosphoinositidedependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Mol Cancer Res 2010;8:421-32.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 421-432
-
-
Lu, Z.1
Cox-Hipkin, M.A.2
Windsor, W.T.3
Boyapati, A.4
-
42
-
-
84899745758
-
The PDK1 master kinase is overexpressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts
-
Zabkiewicz J, Pearn L, Hills RK, Morgan RG, Tonks A, Burnett AK, et al. The PDK1 master kinase is overexpressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica 2014;99:858-64.
-
(2014)
Haematologica
, vol.99
, pp. 858-864
-
-
Zabkiewicz, J.1
Pearn, L.2
Hills, R.K.3
Morgan, R.G.4
Tonks, A.5
Burnett, A.K.6
-
43
-
-
84885646157
-
PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy
-
Tan J, Li Z, Lee PL, Guan P, Aau MY, Lee ST, et al. PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. Cancer Discov 2013;3:1156-71.
-
(2013)
Cancer Discov
, vol.3
, pp. 1156-1171
-
-
Tan, J.1
Li, Z.2
Lee, P.L.3
Guan, P.4
Aau, M.Y.5
Lee, S.T.6
-
44
-
-
47049120726
-
IRF4 addiction in multiple myeloma
-
Shaffer AL, Emre NC, Lamy L, Ngo VN, Wright G, Xiao W, et al. IRF4 addiction in multiple myeloma. Nature 2008;454:226-31.
-
(2008)
Nature
, vol.454
, pp. 226-231
-
-
Shaffer, A.L.1
Emre, N.C.2
Lamy, L.3
Ngo, V.N.4
Wright, G.5
Xiao, W.6
-
45
-
-
0141737071
-
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
-
Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 2003;22:4666-76.
-
(2003)
EMBO J
, vol.22
, pp. 4666-4676
-
-
Mora, A.1
Davies, A.M.2
Bertrand, L.3
Sharif, I.4
Budas, G.R.5
Jovanović, S.6
-
46
-
-
79954588932
-
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models
-
Ellwood-Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, et al. PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. Cancer Res 2011;71:3052-65.
-
(2011)
Cancer Res
, vol.71
, pp. 3052-3065
-
-
Ellwood-Yen, K.1
Keilhack, H.2
Kunii, K.3
Dolinski, B.4
Connor, Y.5
Hu, K.6
-
47
-
-
31544452150
-
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: A Princess Margaret Hospital Phase II Consortium study
-
Hotte SJ, Oza A, Winquist EW, Moore M, Chen EX, Brown S, et al. Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study. Ann Oncol 2006;17:334-40.
-
(2006)
Ann Oncol
, vol.17
, pp. 334-340
-
-
Hotte, S.J.1
Oza, A.2
Winquist, E.W.3
Moore, M.4
Chen, E.X.5
Brown, S.6
-
48
-
-
0037099658
-
Essential role of PDK1 in regulating cell size and development in mice
-
Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J 2002;21:3728-38.
-
(2002)
EMBO J
, vol.21
, pp. 3728-3738
-
-
Lawlor, M.A.1
Mora, A.2
Ashby, P.R.3
Williams, M.R.4
Murray-Tait, V.5
Malone, L.6
-
49
-
-
84902548164
-
The emerging role of miR-375 in cancer
-
Yan JW, Lin JS, He XX. The emerging role of miR-375 in cancer. Int J Cancer 2014;135:1011-8.
-
(2014)
Int J Cancer
, vol.135
, pp. 1011-1018
-
-
Yan, J.W.1
Lin, J.S.2
He, X.X.3
-
50
-
-
77949423427
-
Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
-
Gutiérrez NC, Sarasquete ME, Misiewicz-Krzeminska I, Delgado M, De Las Rivas J, Ticona FV, et al. Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling. Leukemia 2010;24:629-37.
-
(2010)
Leukemia
, vol.24
, pp. 629-637
-
-
Gutiérrez, N.C.1
Sarasquete, M.E.2
Misiewicz-Krzeminska, I.3
Delgado, M.4
De Las Rivas, J.5
Ticona, F.V.6
|