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Volumn 10, Issue 6, 2010, Pages 424-442

Ten years of improvement in the management of multiple myeloma: 2000-2010

Author keywords

Diagnostics; Disease staging; Genetic changes; Pathophysiology; Serum free light chain assay

Indexed keywords

ACETYLSALICYLIC ACID; ALKYLATING AGENT; ALPHA INTERFERON; ANTHRACYCLINE; ANTHRACYCLINE DERIVATIVE; ANTICOAGULANT AGENT; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DEXAMETHASONE; DOXORUBICIN; FLUORODEOXYGLUCOSE F 18; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; LENALIDOMIDE; LOW MOLECULAR WEIGHT HEPARIN; MELPHALAN; PAMIDRONIC ACID; PLACEBO; PLERIXAFOR; PREDNISONE; THALIDOMIDE; VINCRISTINE; ZOLEDRONIC ACID;

EID: 79952911779     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.3816/CLML.2010.n.076     Document Type: Article
Times cited : (27)

References (199)
  • 2
    • 35748965000 scopus 로고    scopus 로고
    • Value of serum free light chain testing for the diagnosis and monitoring of monoclonal gammopathies in hematology
    • Jagannath S. Value of serum free light chain for diagnosis and monitoring of monoclonal gammopathies in hematology. Clin Lymph Myel 2007; 7:518-23. (Pubitemid 350043489)
    • (2007) Clinical Lymphoma and Myeloma , vol.7 , Issue.8 , pp. 518-523
    • Jagannath, S.1
  • 3
    • 60149096306 scopus 로고    scopus 로고
    • International myeloma working group guidelines for serum-free light chain an analysis in multiple myeloma and related disorders
    • Dispenzieri A, Kyle R, Merlini G, et al. International Myeloma Working Group guidelines for serum-free light chain an analysis in multiple myeloma and related disorders. Leukemia 2009; 23:215-24.
    • (2009) Leukemia , vol.23 , pp. 215-224
    • Dispenzieri, A.1    Kyle, R.2    Merlini, G.3
  • 5
    • 0035353192 scopus 로고    scopus 로고
    • Serum free light-chain measurements for identifying and monitoring patients with non secretory multiple myeloma
    • Drayson M, Tang LX, Drew R, et al. Serum free light-chain measurements for identifying and monitoring patients with non secretory multiple myeloma. Blood 2001; 97:2900-2.
    • (2001) Blood , vol.97 , pp. 2900-2902
    • Drayson, M.1    Tang, L.X.2    Drew, R.3
  • 8
    • 38349136782 scopus 로고    scopus 로고
    • Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma
    • Dispenzieri A, Kyle RA, Katzmann JA, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood 2008; 111:785-9.
    • (2008) Blood , vol.111 , pp. 785-789
    • Dispenzieri, A.1    Kyle, R.A.2    Katzmann, J.A.3
  • 10
    • 34047237093 scopus 로고    scopus 로고
    • Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma
    • Kyrtsonis MC, Vassilakopoulos N, Katasi N, et al. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol 2007; 137:240-3.
    • (2007) Br J Haematol , vol.137 , pp. 240-243
    • Kyrtsonis, M.C.1    Vassilakopoulos, N.2    Katasi, N.3
  • 11
    • 46749104811 scopus 로고    scopus 로고
    • Appraisal for immunogloblin free light chain as marker for response
    • Dispenzieri A, Zhang L, Katzmann JA, et al. Appraisal for immunogloblin free light chain as marker for response. Blood 2008; 111:4908-15.
    • (2008) Blood , vol.111 , pp. 4908-4915
    • Dispenzieri, A.1    Zhang, L.2    Katzmann, J.A.3
  • 13
    • 54049096663 scopus 로고    scopus 로고
    • Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: Proposed incorporation into the international staging system
    • Snozek CLH, Katzmann JA, Kyle RA, et al. prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the international staging system. Leukemia 2008; 22:1933-7.
    • (2008) Leukemia , vol.22 , pp. 1933-1937
    • Snozek, C.L.H.1    Katzmann, J.A.2    Kyle, R.A.3
  • 14
    • 33645748052 scopus 로고    scopus 로고
    • Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation
    • Dispenzieri A, Lacy MQ, Katzmann JA, et al. Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 2006; 107:3378-83.
    • (2006) Blood , vol.107 , pp. 3378-3383
    • Dispenzieri, A.1    Lacy, M.Q.2    Katzmann, J.A.3
  • 15
    • 67651046994 scopus 로고    scopus 로고
    • The relationship between the serum free light chain assay and serum immunofixation electrophoresis, and the definition of concordant and discordant free light chain ratios
    • Singhal S, Vickrey E, Krishnamurthy J, et al. The relationship between the serum free light chain assay and serum immunofixation electrophoresis, and the definition of concordant and discordant free light chain ratios. Blood 2009; 114:38-9.
    • (2009) Blood , vol.114 , pp. 38-39
    • Singhal, S.1    Vickrey, E.2    Krishnamurthy, J.3
  • 16
    • 70349303765 scopus 로고    scopus 로고
    • International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple myeloma
    • Dimopoulos M, Terpos E, Comenzo RL, et al. International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple myeloma. Leukemia 2009; 23:1545-56.
    • (2009) Leukemia , vol.23 , pp. 1545-1556
    • Dimopoulos, M.1    Terpos, E.2    Comenzo, R.L.3
  • 17
    • 63849194015 scopus 로고    scopus 로고
    • Whole-body MRI versus PET in assessment of multiple myeloma activity
    • Shortt CP, Gleeson TG, Breen KA, et al. Whole-body MRI versus PET in assessment of multiple myeloma activity. AJR Am J Roentgenol 2009; 192:980-6.
    • (2009) AJR Am J Roentgenol , vol.192 , pp. 980-986
    • Shortt, C.P.1    Gleeson, T.G.2    Breen, K.A.3
  • 18
    • 70350336824 scopus 로고    scopus 로고
    • Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutic evaluation of patients with multiple myeloma
    • Lutje S, Deooy JW, Croockewit S, et al. Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutic evaluation of patients with multiple myeloma. Ann Hematol 2009; 88:1161-8.
    • (2009) Ann Hematol , vol.88 , pp. 1161-1168
    • Lutje, S.1    Deooy, J.W.2    Croockewit, S.3
  • 20
    • 70349231349 scopus 로고    scopus 로고
    • F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma
    • Bartel TB, Haessler J, Brown TLY, et al. F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma. Blood 2009; 114:2068-76.
    • (2009) Blood , vol.114 , pp. 2068-2076
    • Bartel, T.B.1    Haessler, J.2    Brown, T.L.Y.3
  • 21
    • 20644460600 scopus 로고    scopus 로고
    • International Staging System for Multiple Myeloma
    • Greipp PR, San Miguel J, Durie BGM, et al. International Staging System for Multiple Myeloma. J Clin Oncol 2005; 23:3412-20.
    • (2005) J Clin Oncol , vol.23 , pp. 3412-3420
    • Greipp, P.R.1    San Miguel, J.2    Durie, B.G.M.3
  • 22
    • 68749084622 scopus 로고    scopus 로고
    • Is the International Staging System superior to the Durie Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant
    • Hari PN, Zhang MJ, Roy V, et al. Is the International Staging System superior to the Durie Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant. Leukemia 2009; 23:1528-34.
    • (2009) Leukemia , vol.23 , pp. 1528-1534
    • Hari, P.N.1    Zhang, M.J.2    Roy, V.3
  • 23
    • 0035496928 scopus 로고    scopus 로고
    • Fruchart C Hypodiploidy is a major prognostic factor in multiple myeloma
    • Smadja NV, Bastard C, Brigaudeau C, et al. fruchart C Hypodiploidy is a major prognostic factor in multiple myeloma. Blood 2001; 108:2229-38.
    • (2001) Blood , vol.108 , pp. 2229-2238
    • Smadja, N.V.1    Bastard, C.2    Brigaudeau, C.3
  • 26
    • 0036468246 scopus 로고    scopus 로고
    • Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities
    • Fonseca R, Harrington D, Oken MM, et al. Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities. Cancer Res 2002; 62:715-20.
    • (2002) Cancer Res , vol.62 , pp. 715-720
    • Fonseca, R.1    Harrington, D.2    Oken, M.M.3
  • 28
    • 0037217603 scopus 로고    scopus 로고
    • Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization-defined chromosome 13 deletion in multiple myeloma: Early results of total therapy II
    • Shaughnessy J, Jr, Tian E, Sawyer J, et al. Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization-defined chromosome 13 deletion in multiple myeloma: Early results of total therapy II. Br J Haematol 2003; 120:44-52.
    • (2003) Br J Haematol , vol.120 , pp. 44-452
    • Shaughnessy, J.1    Tian Jr., E.2    Sawyer, J.3
  • 30
    • 0036721371 scopus 로고    scopus 로고
    • Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy
    • DOI 10.1182/blood-2002-03-0749
    • Moreau P, Facon T, Leleu X, et al. Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy. Blood 2002; 100:1579-83. (Pubitemid 34925131)
    • (2002) Blood , vol.100 , Issue.5 , pp. 1579-1583
    • Moreau, P.1    Facon, T.2    Leleu, X.3    Morineau, N.4    Huyghe, P.5    Harousseau, J.-L.6    Bataille, R.7    Avet-Loiseau, H.8
  • 33
    • 27244451500 scopus 로고    scopus 로고
    • Cliinical outcomes in t(4;14) mutiple myeloma: A chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance
    • Jaksic W, Trudel S, Chang H, et al. Cliinical outcomes in t(4;14) mutiple myeloma: a chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance. J Clin Oncol 2005; 23:7069-73.
    • (2005) J Clin Oncol , vol.23 , pp. 7069-7073
    • Jaksic, W.1    Trudel, S.2    Chang, H.3
  • 36
    • 11144219996 scopus 로고    scopus 로고
    • P53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation
    • DOI 10.1182/blood-2004-04-1363
    • Chang H, Qi C, Qi-long Y, et al. P53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Blood 2005; 105:358-60. (Pubitemid 40053104)
    • (2005) Blood , vol.105 , Issue.1 , pp. 358-360
    • Chang, H.1    Qi, C.2    Yi, Q.-L.3    Reece, D.4    Stewart, A.K.5
  • 39
    • 34548569309 scopus 로고    scopus 로고
    • Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma
    • DOI 10.1111/j.1365-2141.2007.06750.x
    • Chang H, Ning Y, Qi X. Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma. Br J Haematol 2007; 139:51-4. (Pubitemid 47389925)
    • (2007) British Journal of Haematology , vol.139 , Issue.1 , pp. 51-54
    • Chang, H.1    Ning, Y.2    Qi, X.3    Yeung, J.4    Xu, W.5
  • 41
    • 74049162897 scopus 로고    scopus 로고
    • International MyelomaWorking Group molecular classification of multiple myeloma, Spotlight review
    • Fonseca R, Bergsagel PL, Drach J, et al. International MyelomaWorking Group molecular classification of multiple myeloma. Spotlight review. Leukemia 2009; 23:2210-21.
    • (2009) Leukemia , vol.23 , pp. 2210-2221
    • Fonseca, R.1    Bergsagel, P.L.2    Drach, J.3
  • 43
    • 38349088637 scopus 로고    scopus 로고
    • High-risk myeloma:A gene expression based risk-stratification model for newly diagnosed multiple myeloma treated with high-dose therapy is predictive of outcome in relapsed disease treated with single agent bortezomib or high-dose dexamethasone
    • Zhan F, Barlogie B, Mulligan G, et al. High-risk myeloma:A gene expression based risk-stratification model for newly diagnosed multiple myeloma treated with high-dose therapy is predictive of outcome in relapsed disease treated with single agent bortezomib or high-dose dexamethasone. Blood 2008; 111:968-9.
    • (2008) Blood , vol.111 , pp. 968-969
    • Zhan, F.1    Barlogie, B.2    Mulligan, G.3
  • 44
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the intergroupe francophone du myelome
    • Decaux O, Lode L, Magrangeas F, et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the Intergroupe Francophone du Myelome. J Clin Oncol 2008; 26:4798-805.
    • (2008) J Clin Oncol , vol.26 , pp. 4798-4805
    • Decaux, O.1    Lode, L.2    Magrangeas, F.3
  • 46
    • 74549190701 scopus 로고    scopus 로고
    • Prognostic significance of copy-number alterations in multiple myeloma
    • Avet-Loiseau H, Li C, Magrangeas F, et al. Prognostic significance of copy-number alterations in multiple myeloma. J Clin Oncol 2009; 27:4585-90.
    • (2009) J Clin Oncol , vol.27 , pp. 4585-4590
    • Avet-Loiseau, H.1    Li, C.2    Magrangeas, F.3
  • 47
    • 74049142026 scopus 로고    scopus 로고
    • The use of novel agents in the treatment of relapsed and refractory multiple myeloma
    • Laubach JP, Mahindra A, Mitsiades CS, et al. The use of novel agents in the treatment of relapsed and refractory multiple myeloma. Leukemia 2009; 23:2222-32.
    • (2009) Leukemia , vol.23 , pp. 2222-2232
    • Laubach, J.P.1    Mahindra, A.2    Mitsiades, C.S.3
  • 48
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventionalchemotherapy
    • Hideshima T, Chauhan D, Shima Y, et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventionalchemotherapy. Blood 2000; 96:2943-50.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 51
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999; 341:1565-71.
    • (1999) N Engl J Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 53
    • 5644250621 scopus 로고    scopus 로고
    • A phase 2 study of two doses of bortezomib in relapsed or refractory multiple myeloma
    • Jagannath S, Barlogie B, Berenson J, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory multiple myeloma. Br J Haematol 2004; 127:165-71.
    • (2004) Br J Haematol , vol.127 , pp. 165-171
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 54
    • 33750607347 scopus 로고    scopus 로고
    • A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
    • Richardson PG, Blood E, Mitsiades CS, et al. A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 2006; 108:3458-64.
    • (2006) Blood , vol.108 , pp. 3458-3464
    • Richardson, P.G.1    Blood, E.2    Mitsiades, C.S.3
  • 55
    • 68249135722 scopus 로고    scopus 로고
    • Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma
    • Richardson P, Jagannath S, Hussein M, et al. Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma. Blood 2009; 114:772-8.
    • (2009) Blood , vol.114 , pp. 772-778
    • Richardson, P.1    Jagannath, S.2    Hussein, M.3
  • 56
    • 0642276742 scopus 로고    scopus 로고
    • Treatment of plasma cell dyscrasia with thalidomide and its derivates
    • Dimopoulos MA, Anagnostopoulos A, Weber D. Treatment of plasma cell dyscrasia with thalidomide and its derivates. J Clin Oncol 2003; 21:4444-52.
    • (2003) J Clin Oncol , vol.21 , pp. 4444-4452
    • Dimopoulos, M.A.1    Anagnostopoulos, A.2    Weber, D.3
  • 57
    • 43249097561 scopus 로고    scopus 로고
    • Thalidomide for treatment of multiple myeloma: 10 years later
    • Palumbo A, Facon T, Sonnevevld P, et al. Thalidomide for treatment of multiple myeloma: 10 years later. Blood 2008; 111:3968-77.
    • (2008) Blood , vol.111 , pp. 3968-3977
    • Palumbo, A.1    Facon, T.2    Sonnevevld, P.3
  • 59
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natutal killer activity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natutal killer activity in multiple myeloma. Blood 2001; 98:210-6.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 61
    • 76549137222 scopus 로고    scopus 로고
    • Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations
    • Mohty B, El-Cheikh J, Yakoub-Agha I, et al. Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations. Haematologica 2010; 95:311-9.
    • (2010) Haematologica , vol.95 , pp. 311-319
    • Mohty, B.1    El-Cheikh, J.2    Yakoub-Agha, I.3
  • 66
    • 33644823732 scopus 로고    scopus 로고
    • Bortezomib at first relapse is superior to high-dose dexamethasone and more effective that when given later in relapsed multiple myeloma
    • Sonneveld P, Richardson PG, Schuster MW, et al. Bortezomib at first relapse is superior to high-dose dexamethasone and more effective that when given later in relapsed multiple myeloma. Haematologica 2005; 90:146-7.
    • (2005) Haematologica , vol.90 , pp. 146-147
    • Sonneveld, P.1    Richardson, P.G.2    Schuster, M.W.3
  • 71
    • 42349108452 scopus 로고    scopus 로고
    • Efficacy and safety of bortezomib in patients with renal impairment: results from the APEX phase 3 study
    • San Miguel JF, Richardson PG, Sonneveld P, et al. Efficacy and safety of bortezomib in patients with renal impairment: results from the APEX phase 3 study. Leukemia 2008; 22:842-9.
    • (2008) Leukemia , vol.22 , pp. 842-549
    • San Miguel, J.F.1    Richardson, P.G.2    Sonneveld, P.3
  • 77
    • 65349097489 scopus 로고    scopus 로고
    • Lenalidomide in combination with dexamethasone at first relapse in compsrison with its use as salvage therapy in relapsed or refractory multiple myeloma
    • Stadtmauer EA, Weber DM, Niesvitzky R, et al. Lenalidomide in combination with dexamethasone at first relapse in compsrison with its use as salvage therapy in relapsed or refractory multiple myeloma. Eur J Haematol 2009; 82:426-32.
    • (2009) Eur J Haematol , vol.82 , pp. 426-432
    • Stadtmauer, E.A.1    Weber, D.M.2    Niesvitzky, R.3
  • 78
    • 58149384555 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure
    • Wang M, Dimopoulos MA, Chen C, et al. Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure. Blood 2008; 112:4445-51.
    • (2008) Blood , vol.112 , pp. 4445-4451
    • Wang, M.1    Dimopoulos, M.A.2    Chen, C.3
  • 79
    • 67649985917 scopus 로고    scopus 로고
    • Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma
    • Chen C, Reece DE, Siegel D, et al. Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma. Br J Haematol 2009; 146:164-70.
    • (2009) Br J Haematol , vol.146 , pp. 164-170
    • Chen, C.1    Reece, D.E.2    Siegel, D.3
  • 81
    • 77953862198 scopus 로고    scopus 로고
    • The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function
    • Dimopoulos M, Alegre A, Stadtmauer EA, et al. The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer 2010; 115:3807-14.
    • (2010) Cancer , vol.115 , pp. 3807-3814
    • Dimopoulos, M.1    Alegre, A.2    Stadtmauer, E.A.3
  • 84
    • 77952429928 scopus 로고    scopus 로고
    • Lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed or refractory multiple myeloma
    • Palumbo A, Larocca A, Falco P, et al Lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed or refractory multiple myeloma. Leukaemia 2010; 24:1037-42
    • (2010) Leukaemia , vol.24 , pp. 1037-1042
    • Palumbo, A.1    Larocca, A.2    Falco, P.3
  • 85
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter phase I dose escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, et al Multicenter phase I dose escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009; 27:5713-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 86
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008; 111:2516-20.
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 87
    • 67449161589 scopus 로고    scopus 로고
    • Autologous stem-cell transplantation in multiple myeloma
    • Harousseau J-L, Moreau P. Autologous stem-cell transplantation in multiple myeloma. N Engl J Med 2009; 360:2645-54.
    • (2009) N Engl J Med , vol.360 , pp. 2645-2654
    • Harousseau, J.-L.1    Moreau, P.2
  • 95
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the eastern cooperative oncology group
    • DOI 10.1200/JCO.2005.03.0221
    • Rajkumar SV, Blood E, Vesole D, et al. Phase III clinical trial of Thalidomide plus Dexamethasone compared with Dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006; 24:431-6. (Pubitemid 46630462)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.3 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3    Fonseca, R.4    Greipp, P.R.5
  • 97
    • 33847338735 scopus 로고    scopus 로고
    • Dexamethasone + thalidomide compared to VAD as pre-transplant treatment in newly diagnosed multiple myeloma: A randomized trial
    • (abstract)
    • Macro M, Divine M, Uzunban Y, et al. Dexamethasone + thalidomide compared to VAD as pre-transplant treatment in newly diagnosed multiple myeloma: a randomized trial. Blood 2006; 108:22a (abstract).
    • (2006) Blood , vol.108
    • Macro, M.1    Divine, M.2    Uzunban, Y.3
  • 98
    • 78049488759 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: Results of the IFM 2005-01 phase III trial
    • Harousseau J.-L., Attal M, Avet-Loiseau H., et al. Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial. J Clin Oncol 2010; 28:4621-9.
    • (2010) J Clin Oncol , vol.28 , pp. 4621-4629
    • Harousseau, J.-L.1    Attal, M.2    Avet-Loiseau, H.3
  • 100
    • 58149376363 scopus 로고    scopus 로고
    • Thalidomide combinations improve response rates: Results from the MRC IX study
    • (abstract)
    • Morgan GJ, Davies FE, Owen RG, et al. Thalidomide combinations improve response rates: results from the MRC IX study. Blood 2007; 110:1051a (abstract).
    • (2007) Blood , vol.110
    • Morgan, G.J.1    Davies, F.E.2    Owen, R.G.3
  • 101
    • 75149129782 scopus 로고    scopus 로고
    • First analysis of Hovon 65/GMMG-HD4 randomized Phase III trial comparing bortezomib, adriamycine,dexamethasone (PAD) vs VAD as induction prior to high dose melphalan in patients with newly diagnosed multiple myeloma
    • (abstract 473)
    • Sonneveld P, Van Der Holt B, Schmidt-Wolf IG, et al. First analysis of Hovon 65/GMMG-HD4 randomized Phase III trial comparing bortezomib, adriamycine,dexamethasone (PAD) vs VAD as induction prior to high dose melphalan in patients with newly diagnosed multiple myeloma. Haematologica 2009; 94: (abstract 473).
    • (2009) Haematologica , vol.94
    • Sonneveld, P.1    Van Der Holt, B.2    Schmidt-Wolf, I.G.3
  • 102
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexaethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma:an open-label randomized controlled trial
    • Rajkumar SV, Jacobus S, Callander NS, et al. Lenalidomide plus high-dose dexaethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma:an open-label randomized controlled trial. Lancet Oncol 2010; 11:29-37.
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 103
    • 77955452192 scopus 로고    scopus 로고
    • Velcade, intravenous cyclophosphamide and dexamethasone induction for previously untreated multiple myeloma (German DSMM Xia trial)
    • (abstract 130)
    • Einsele H, Liebisch P, Langer C, et al. Velcade, intravenous cyclophosphamide and dexamethasone induction for previously untreated multiple myeloma (German DSMM Xia trial). Blood 2009; 114:59-60 (abstract 130).
    • (2009) Blood , vol.114 , pp. 59-60
    • Einsele, H.1    Liebisch, P.2    Langer, C.3
  • 104
    • 77249086780 scopus 로고    scopus 로고
    • A phase III study of double autotransplantation incorporating bortezomib-thalidomide-dexamethasone (VTD) or thalidomide dexamethasone (TD) for multiple myeloma: Superior clinical outcomes with VTD compared to TD
    • (abstract 351)
    • Cavo M, Tacchetti P, Patriarca F, et al. A phase III study of double autotransplantation incorporating bortezomib-thalidomide-dexamethasone (VTD) or thalidomide dexamethasone (TD) for multiple myeloma: Superior clinical outcomes with VTD compared to TD. Blood 2009; 114: (abstract 351).
    • (2009) Blood , vol.114
    • Cavo, M.1    Tacchetti, P.2    Patriarca, F.3
  • 105
    • 77952295503 scopus 로고    scopus 로고
    • Thalidomide/dexamethasone (TD) versus bortezomib (velcade)/thalidomide/ dexamethasone (VTD) versus VBMCP/VBAD velcade as induction regimen prior to autologous stem-cell transplantation in multiple myeloma. Results of a phase III Pethema/Gemm trial
    • (abstract 129)
    • Rosinol L, Cibeira T, Martinez J, et al. Thalidomide/dexamethasone (TD) versus bortezomib (velcade)/thalidomide/dexamethasone (VTD) versus VBMCP/VBAD velcade as induction regimen prior to autologous stem-cell transplantation in multiple myeloma. Results of a phase III Pethema/Gemm trial. Blood 2009; 114:58-9 (abstract 129).
    • (2009) Blood , vol.114 , pp. 58-59
    • Rosinol, L.1    Cibeira, T.2    Martinez, J.3
  • 106
    • 77955980661 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone versus reduced-dose of bortezomib plus thalidomide plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed patients with multiple myeloma
    • (abstract 354)
    • Harousseau J.-L., Avet-Loiseau H., Facon T, et al. Bortezomib plus dexamethasone versus reduced-dose of bortezomib plus thalidomide plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed patients with multiple myeloma. Blood 2009; 114:150 (abstract 354).
    • (2009) Blood , vol.114 , pp. 150
    • Harousseau, J.-L.1    Avet-Loiseau, H.2    Facon, T.3
  • 107
    • 80054086960 scopus 로고    scopus 로고
    • Bortezomib, thalidomide and dexamethasone (VTD) versus VTD plus cyclophosphamide as induction therapy in previously untreatred multiple myeloma patients elgible for HDY-ASCT: A randomized phase 2 trial
    • (abstract 2312)
    • Ludwig H, Viterbo L, Greil R, et al. Bortezomib, thalidomide and dexamethasone (VTD) versus VTD plus cyclophosphamide as induction therapy in previously untreatred multiple myeloma patients elgible for HDY-ASCT: a randomized phase 2 trial. Blood 2009; 114: (abstract 2312).
    • (2009) Blood , vol.114
    • Ludwig, H.1    Viterbo, L.2    Greil, R.3
  • 108
    • 77249145537 scopus 로고    scopus 로고
    • Novel three and four combinations of bortezomib, dexamethasone, cyclophosphamide and lenalidomide for newly diagnosed multiple myeloma: encouraging results from multicenter, randomized, phase 2 Evolution trial
    • (abstract 29)
    • Kumar S, Flin IW, Hari PN, et al. Novel three and four combinations of bortezomib, dexamethasone, cyclophosphamide and lenalidomide for newly diagnosed multiple myeloma: encouraging results from multicenter, randomized, phase 2 Evolution trial. Blood 2009; 114: (abstract 29).
    • (2009) Blood , vol.114
    • Kumar, S.1    Flin, I.W.2    Hari, P.N.3
  • 111
    • 70350091086 scopus 로고    scopus 로고
    • International Working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy in multiple myeloma and the role of plerixafor
    • Giralt S, Stadtmauer EA, Harousseau J.-L., et al. International Working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy in multiple myeloma and the role of plerixafor. Leukemia 2009; 23:1904-12.
    • (2009) Leukemia , vol.23 , pp. 1904-1912
    • Giralt, S.1    Stadtmauer, E.A.2    Harousseau, J.-L.3
  • 112
    • 73349126431 scopus 로고    scopus 로고
    • Achieving at least very good partial remission is a simple and robust prognostic factor in patients with multiple myeloma treated with high-dose therapy. Long-term results of the IFM 99-02 and 99-94 trials
    • Harousseau JL, Avet-Loiseau H., Attal M, et al. Achieving at least very good partial remission is a simple and robust prognostic factor in patients with multiple myeloma treated with high-dose therapy. Long-term results of the IFM 99-02 and 99-94 trials. J Clin Oncol 2009; 27:5720-6.
    • (2009) J Clin Oncol , vol.27 , pp. 5720-5726
    • Harousseau, J.L.1    Avet-Loiseau, H.2    Attal, M.3
  • 113
    • 70350433797 scopus 로고    scopus 로고
    • The role of complete remission in multiple myeloma
    • Harousseau J.-L., Attal M, Avet-Loiseau H.. The role of complete remission in multiple myeloma. Blood 2009; 114:3139-46.
    • (2009) Blood , vol.114 , pp. 3139-3146
    • Harousseau, J.-L.1    Attal, M.2    Avet-Loiseau, H.3
  • 114
    • 57449109100 scopus 로고    scopus 로고
    • Influence of pre- and post-transplantation outcomes of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival
    • Lahuerta JJ, Mateos MV, Rosinol L, et al. Influence of pre- and post-transplantation outcomes of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival. J Clin Oncol 2008; 26:5775-82.
    • (2008) J Clin Oncol , vol.26 , pp. 5775-5782
    • Lahuerta, J.J.1    Mateos, M.V.2    Rosinol, L.3
  • 115
    • 77952308211 scopus 로고    scopus 로고
    • High complete and very good partial remission response rates with bortezomib-dexamethasone as induction prior to ASCT in newly diagnosed patients with high-risk myeloma: results of the IFM 2005-01 phase 3 trial
    • (abstract 353)
    • Harousseau J.-L., Avet-Loiseau H., Attal M, et al. High complete and very good partial remission response rates with bortezomib-dexamethasone as induction prior to ASCT in newly diagnosed patients with high-risk myeloma: results of the IFM 2005-01 phase 3 trial. Blood 2009; 114:149-50 (abstract 353).
    • (2009) Blood , vol.114 , pp. 149-150
    • Harousseau, J.-L.1    Avet-Loiseau, H.2    Attal, M.3
  • 117
    • 77950421708 scopus 로고    scopus 로고
    • Melphalan 200mg/m2 versus melphalan 100mg/m2 in newly diagnosed myeloma patients: a prospective, multicenter phase II study
    • Palumbo A, Brighen S, Bruno B, et al. Melphalan 200mg/m2 versus melphalan 100mg/m2 in newly diagnosed myeloma patients: a prospective, multicenter phase II study. Blood 2010; 115:1873-9.
    • (2010) Blood , vol.115 , pp. 1873-1879
    • Palumbo, A.1    Brighen, S.2    Bruno, B.3
  • 118
    • 74949119502 scopus 로고    scopus 로고
    • Bortezomib and high-dose melphalan as conditioning regimen before autologous stem-cell transplantation in patients with de novo multiple myeloma: A phase 2 study of the intergroupe francophone du myelome (IFM)
    • Roussel M, Moreau P, Huinh A, et al. Bortezomib and high-dose melphalan as conditioning regimen before autologous stem-cell transplantation in patients with de novo multiple myeloma: A phase 2 study of the Intergroupe Francophone du Myelome (IFM). Blood 2010; 115:32-7.
    • (2010) Blood , vol.115 , pp. 32-37
    • Roussel, M.1    Moreau, P.2    Huinh, A.3
  • 119
    • 0034933036 scopus 로고    scopus 로고
    • Interferon as therapy for multiple myeloma: Metaanalysis of 24 randomized trials and 4012 patients
    • The Myeloma Trialists'Collaborative Group
    • The Myeloma Trialists'Collaborative Group. Interferon as therapy for multiple myeloma: metaanalysis of 24 randomized trials and 4012 patients. Br J Haematol 2001; 113:1020-34.
    • (2001) Br J Haematol , vol.113 , pp. 1020-1034
  • 121
    • 33751164196 scopus 로고    scopus 로고
    • Maintenance therapy with thalidomide improves survival in multiple myeloma patients
    • Attal M, Harousseau JL, Leyvraz S, et al. Maintenance therapy with thalidomide improves survival in multiple myeloma patients. Blood 2006; 15:3289-94.
    • (2006) Blood , vol.15 , pp. 3289-3294
    • Attal, M.1    Harousseau, J.L.2    Leyvraz, S.3
  • 123
    • 64649083365 scopus 로고    scopus 로고
    • Consolidation therapy with thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single ASCT procedure
    • Spencer A, Prince HM, Roberts A, et al. Consolidation therapy with thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single ASCT procedure. J Clin Oncol 2009; 27:1788-93.
    • (2009) J Clin Oncol , vol.27 , pp. 1788-1793
    • Spencer, A.1    Prince, H.M.2    Roberts, A.3
  • 124
    • 77949521289 scopus 로고    scopus 로고
    • A randomized phase III study on the effect of thalidomide combined with adriamycin, dexamethasone (TAD) and high-dose melphalan followed by thalidomide maintenance in patients with multiple myeloma
    • Lokhorst HM, van der Holt B, Zweegman S, et al. A randomized phase III study on the effect of thalidomide combined with adriamycin, dexamethasone (TAD) and high-dose melphalan followed by thalidomide maintenance in patients with multiple myeloma. Blood 2010; 115:1113-20.
    • (2010) Blood , vol.115 , pp. 1113-1120
    • Lokhorst, H.M.1    Van Der Holt, B.2    Zweegman, S.3
  • 125
    • 60849114852 scopus 로고    scopus 로고
    • Maintenance thalidomide may improve progression free but not overall survival: results from the Myeloma IX maintenance randomization
    • (abstract 656)
    • Morgan GJ, Jackson GH, Davies FE, et al. Maintenance thalidomide may improve progression free but not overall survival: results from the Myeloma IX maintenance randomization. Blood 2008; 112: (abstract 656).
    • (2008) Blood , vol.112
    • Morgan, G.J.1    Jackson, G.H.2    Davies, F.E.3
  • 126
    • 54049148621 scopus 로고    scopus 로고
    • Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with interphase cytogenetic abnormalities
    • Barlogie B, Pineda-Roman M, Van Rhee F., et al. Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with interphase cytogenetic abnormalities. Blood 2008; 112:2999-3000.
    • (2008) Blood , vol.112 , pp. 2999-3000
    • Barlogie, B.1    Pineda-Roman, M.2    Van Rhee, F.3
  • 127
    • 77954465399 scopus 로고    scopus 로고
    • The addition of thalidomide to the induction treatment of newly presenting myeloma patients increases the CR rate which is likely to translate into improved PFS and OS
    • (abstract 352)
    • Morgan GJ, Davies FR, Gregory WM, et al The addition of thalidomide to the induction treatment of newly presenting myeloma patients increases the CR rate which is likely to translate into improved PFS and OS. Blood 2009; 114: (abstract 352).
    • (2009) Blood , vol.114
    • Morgan, G.J.1    Davies, F.R.2    Gregory, W.M.3
  • 128
    • 78650303638 scopus 로고    scopus 로고
    • Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplantation for multple myeloma; CALGB 100104
    • (abstract 8017)
    • McCarthy PL, Owzar K, Anderson KC, et al. Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplantation for multple myeloma; CALGB 100104. J Clin Oncol 2010; 28(15 suppl):577s (abstract 8017).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • McCarthy, P.L.1    Owzar, K.2    Anderson, K.C.3
  • 129
    • 78650333538 scopus 로고    scopus 로고
    • Lenalidomide maintenance after transplantation for myeloma
    • (abstract 8018)
    • Attal M, Cristini C, Marit G, et al. Lenalidomide maintenance after transplantation for myeloma. J Clin Oncol 2010; 28(15 suppl):577s (abstract 8018).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Attal, M.1    Cristini, C.2    Marit, G.3
  • 130
    • 77949894706 scopus 로고    scopus 로고
    • Long-term follow-up of autologous transplantation trials for multiple myeloma: update of protocols conducted by the intergroupe francophone du myelome, southwest oncology group and university of arkansas medical sciences
    • Barlogie B, Attal M, Crowley J, et al. Long-term follow-up of autologous transplantation trials for multiple myeloma: update of protocols conducted by the Intergroupe Francophone du Myelome, Southwest Oncology Group and University of Arkansas Medical Sciences. J Clin Oncol 2010; 28:1209-14.
    • (2010) J Clin Oncol , vol.28 , pp. 1209-1214
    • Barlogie, B.1    Attal, M.2    Crowley, J.3
  • 132
    • 70350001654 scopus 로고    scopus 로고
    • TP53 deletion is not an adverse feature in multiple myeloma treated with total therapy 3
    • Shaughnessy JD, Zhou Y, Haessler J, et al. TP53 deletion is not an adverse feature in multiple myeloma treated with total therapy 3. Br J Haematol 2009; 147:347-51.
    • (2009) Br J Haematol , vol.147 , pp. 347-351
    • Shaughnessy, J.D.1    Zhou, Y.2    Haessler, J.3
  • 135
    • 34147144964 scopus 로고    scopus 로고
    • Reduced-intensity conditioning for myeloma: Lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning
    • DOI 10.1182/blood-2006-07-036848
    • Crawley C, Iacobelli S, Björkstrand B, et al. Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning. Blood 2007; 109:3588-94. (Pubitemid 46572554)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3588-3594
    • Crawley, C.1    Iacobelli, S.2    Bjorkstrand, B.3    Apperley, J.F.4    Niederwieser, D.5    Gahrton, G.6
  • 136
    • 65149104407 scopus 로고    scopus 로고
    • Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting
    • Rotta M, Storer BE, Sahebi F, et al. Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting. Blood 2009; 113:3383-91.
    • (2009) Blood , vol.113 , pp. 3383-3391
    • Rotta, M.1    Storer, B.E.2    Sahebi, F.3
  • 138
    • 55749090051 scopus 로고    scopus 로고
    • Long-term follow-up results of IFM 99-03 and IFM 99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma
    • Moreau P, Garban F, Attal M, et al. Long-term follow-up results of IFM 99-03 and IFM 99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma. Blood 2008; 112:3914-5.
    • (2008) Blood , vol.112 , pp. 3914-3915
    • Moreau, P.1    Garban, F.2    Attal, M.3
  • 139
    • 55749099328 scopus 로고    scopus 로고
    • A prospective Pethema study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in multiple myeloma
    • Rosinol L, Perez-Simon JA, Sureda A, et al. A prospective Pethema study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in multiple myeloma. Blood 2008; 112:3591-2.
    • (2008) Blood , vol.112 , pp. 3591-3592
    • Rosinol, L.1    Perez-Simon, J.A.2    Sureda, A.3
  • 140
    • 65149096403 scopus 로고    scopus 로고
    • Nonmyeloablative allografting for newly diagnosed multiple myeloma:the experience of the Gruppo Intaliano Trapianti di Medolla
    • Bruno B, Rotta M, Patriarca F, et al. Nonmyeloablative allografting for newly diagnosed multiple myeloma:the experience of the Gruppo Intaliano Trapianti di Medolla. Blood 2009; 113:3375-82.
    • (2009) Blood , vol.113 , pp. 3375-3382
    • Bruno, B.1    Rotta, M.2    Patriarca, F.3
  • 141
    • 33646685024 scopus 로고    scopus 로고
    • Bortezomib after dose-reduced allogeneic stem cell transplantation for multiple myeloma to enhance or maintain remission status
    • DOI 10.1016/j.exphem.2006.02.020, PII S0301472X06001275
    • Kroger N, Zabelina T, Ayuk T, et al. Bortezomib after dose-reduced allogeneic stem cell transplantation for multipe myeloma to enhance or maintain remission status. Exp Hematol 2006; 34:770-5. (Pubitemid 43737100)
    • (2006) Experimental Hematology , vol.34 , Issue.6 , pp. 770-775
    • Kroger, N.1    Zabelina, T.2    Ayuk, F.3    Atanackovic, D.4    Schieder, H.5    Renges, H.6    Zander, A.7
  • 142
    • 41949114641 scopus 로고    scopus 로고
    • Recent major improvement in long-term survival of younger patients with multiple myeloma
    • Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008; 111:2521-6.
    • (2008) Blood , vol.111 , pp. 2521-2526
    • Brenner, H.1    Gondos, A.2    Pulte, D.3
  • 145
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan prednisone and thalidomide in elderly patients with multiple myeloma: Updated results of a randomized, controlled trial
    • Palumbo A, Bringhen S, Liberati A, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma:updated results of a randomized, controlled trial. Blood 2008; 112:3107-14.
    • (2008) Blood , vol.112 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.3
  • 147
    • 68949137225 scopus 로고    scopus 로고
    • Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma; IFM 01/01 trial
    • Hulin C, Facon T, Rodon P, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma; IFM 01/01 trial. J Clin Oncol 2009; 27:3664-70.
    • (2009) J Clin Oncol , vol.27 , pp. 3664-3670
    • Hulin, C.1    Facon, T.2    Rodon, P.3
  • 148
    • 77955495783 scopus 로고    scopus 로고
    • Phase III study of the value of thalidomide added to melphalan prednisone in elderly patients with newly diagnosed multiple myeloma: The Hovon 49 study
    • Wijermans P, Schaafsma M, Termorhuizen et al. Phase III study of the value of thalidomide added to melphalan prednisone in elderly patients with newly diagnosed multiple myeloma: the Hovon 49 study. J Clin Oncol 2010; 28:3160-6.
    • (2010) J Clin Oncol , vol.28 , pp. 3160-3166
    • Wijermans, P.1    Schaafsma, M.2    Termorhuizen3
  • 149
    • 77956599686 scopus 로고    scopus 로고
    • Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
    • May 6 [Epub ahead of print]
    • Waage A, Gimsing P, Fayers P, et al. Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma. Blood 2010; May 6 [Epub ahead of print].
    • (2010) Blood
    • Waage, A.1    Gimsing, P.2    Fayers, P.3
  • 150
    • 33748287079 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase 1/2 study
    • Mateos MV, Hernandez JM, Hernandez MT, et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood 2006; 108:2165-72.
    • (2006) Blood , vol.108 , pp. 2165-2172
    • Mateos, M.V.1    Hernandez, J.M.2    Hernandez, M.T.3
  • 151
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008; 35:906-17.
    • (2008) N Engl J Med , vol.35 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 152
    • 77952310929 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III vista trial
    • Mateos MV, Richardson PG, Schlag R, et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the Phase III Vista trial. J Clin Oncol 2010; 28:2258-66.
    • (2010) J Clin Oncol , vol.28 , pp. 2258-2266
    • Mateos, M.V.1    Richardson, P.G.2    Schlag, R.3
  • 154
    • 78649686966 scopus 로고    scopus 로고
    • A Phase 3 study to determine the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients = 65 years with newly diagnosed myeloma
    • (abstract)
    • Palumbo A, Dimopoulos M, Delforge M. A Phase 3 study to determine the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients = 65 years with newly diagnosed myeloma. Hematologica 2010; 95:566 (abstract).
    • (2010) Hematologica , vol.95 , pp. 566
    • Palumbo, A.1    Dimopoulos, M.2    Delforge, M.3
  • 155
    • 65349142006 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma
    • Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma. Blood 2008; 113:3435-42.
    • (2008) Blood , vol.113 , pp. 3435-3442
    • Ludwig, H.1    Hajek, R.2    Tothova, E.3
  • 156
    • 78650349052 scopus 로고    scopus 로고
    • Outcome of elderly patients 70 years and older with newly diagnosed myeloma in the ECOG randomized trial of lenalidomide/high-dose dexamethasone versus lenalidomide/low-dose dexamethasone
    • (abstract)
    • Jacobus S, Callander N, Siegel D et al Outcome of elderly patients 70 years and older with newly diagnosed myeloma in the ECOG randomized trial of lenalidomide /high-dose dexamethasone versus lenalidomide/ low-dose dexamethasone. Hematologica 2010 95:370 (abstract).
    • (2010) Hematologica , vol.95 , pp. 370
    • Jacobus, S.1    Callander, N.2    Siegel, D.3
  • 157
    • 78650993336 scopus 로고    scopus 로고
    • Bortezomib, melphalan, prednisone and thalidomide followed by maintenance with bortezomib thalidomide compared with bortezomid, melphalan, prednisone for initial treatment of multiple myeloma: A randomized controlled trial
    • Oct 12 [Epub ahead of print]
    • Palumbo A, Bringhen S, Rossi D, et al. Bortezomib, melphalan, prednisone and thalidomide followed by maintenance with bortezomib thalidomide compared with bortezomid, melphalan, prednisone for initial treatment of multiple myeloma: a randomized controlled trial. J Clin Oncol 2010; Oct 12 [Epub ahead of print].
    • (2010) J Clin Oncol
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3
  • 158
    • 77957344540 scopus 로고    scopus 로고
    • A prospective, randomized trial of Bortezomib, melphalan, prednisone versus bortezomib, thalidomide, prednisone as induction therapy followed by maintenance treatment with bortezomib, thalidomide versus bortezomib, prednisone in elderly patients with untreated multiple myeloma: A randomized trial
    • Mateos MV, Oriol A, Martinez Lopez J, et al. A prospective, randomized trial of Bortezomib, melphalan, prednisone versus bortezomib, thalidomide, prednisone as induction therapy followed by maintenance treatment with bortezomib, thalidomide versus bortezomib, prednisone in elderly patients with untreated multiple myeloma: a randomized trial. Lancet Oncol 2010; 10:934-41.
    • (2010) Lancet Oncol , vol.10 , pp. 934-941
    • Mateos, M.V.1    Oriol, A.2    Martinez Lopez J3
  • 160
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once weekly bortezomib in multiple myeloma patients
    • Aug 31 [Epub ahead of print]
    • Bringhen S, Larocca A, Rossi D et al Efficacy and safety of once weekly bortezomib in multiple myeloma patients. Blood 2010; Aug 31 [Epub ahead of print]
    • (2010) Blood
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3
  • 162
    • 0142025453 scopus 로고    scopus 로고
    • Beitz Renal failure with the use of zoledronic acid
    • Chang JT, Green L. Beitz Renal failure with the use of zoledronic acid. N Engl J Med 2005; 349:1676-9.
    • (2005) N Engl J Med , vol.349 , pp. 1676-1679
    • Chang, J.T.1    Green, L.2
  • 165
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 clinical practice guidelines update on the role of bisphoposphonates in multiple myeloma
    • Kyle RA, Yee GC, Sornefield MR, et al. American Society of Clinical Oncology 2007 clinical practice guidelines update on the role of bisphoposphonates in multiple myeloma. J Clin Oncol 2007; 25:2454-72.
    • (2007) J Clin Oncol , vol.25 , pp. 2454-2472
    • Kyle, R.A.1    Yee, G.C.2    Sornefield, M.R.3
  • 166
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma: Recommendations of an expert panel on behalf of the european myeloma network
    • Terpos E, Sezer O, Croucher P, et al. The use of bisphosphonates in multiple myeloma:: recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009; 8:1303-17.
    • (2009) Ann Oncol , vol.8 , pp. 1303-1317
    • Terpos, E.1    Sezer, O.2    Croucher, P.3
  • 167
    • 77957332677 scopus 로고    scopus 로고
    • Effect of pamidronate 30mg versus 90mg on physical finction in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): A double-blind, randomized controlled trial
    • Gimsing P, Carlson K, Turesson I, et al. Effect of pamidronate 30mg versus 90mg on physical finction in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): A double-blind, randomized controlled trial. Lancet Oncol 2010; 10:973-82.
    • (2010) Lancet Oncol , vol.10 , pp. 973-982
    • Gimsing, P.1    Carlson, K.2    Turesson, I.3
  • 168
    • 36349031205 scopus 로고    scopus 로고
    • Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma
    • DOI 10.3324/haematol.11534
    • Van De Velde HJ, Xiangyang L, Chen G, et al. Complete response correlates with long-term survival in high-dose therapy in multiple myeloma. Haematologica 2007; 92:1399-406. (Pubitemid 350144158)
    • (2007) Haematologica , vol.92 , Issue.10 , pp. 1399-1406
    • Van De Velde, H.J.K.1    Liu, X.2    Chen, G.3    Cakana, A.4    Deraedt, W.5    Bayssas, M.6
  • 169
    • 77956259865 scopus 로고    scopus 로고
    • Importance of achieving a complete response in multiple myeloma and the impact of novel agents
    • Chanan-Khan AA, Giralt S. Importance of achieving a complete response in multiple myeloma and the impact of novel agents. J Clin Oncol 2010; 28:2612-24.
    • (2010) J Clin Oncol , vol.28 , pp. 2612-2624
    • Chanan-Khan, A.A.1    Giralt, S.2
  • 172
    • 49449085862 scopus 로고    scopus 로고
    • Making progress in treating multiple myeloma with total therapies: issue of complete remission and more
    • Barlogie B, Van Rhee F., Shaughnessy JD, et al. Making progress in treating multiple myeloma with total therapies: issue of complete remission and more. Leukemia 2008; 22:1633-6.
    • (2008) Leukemia , vol.22 , pp. 1633-1636
    • Barlogie, B.1    Van Rhee, F.2    Shaughnessy, J.D.3
  • 175
    • 59449099316 scopus 로고    scopus 로고
    • Multiparameter flow cytometry is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
    • Paiva B, Vidriales MB, Cervero J, et al. Multiparameter flow cytometry is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Blood 2008; 112:4017-40.
    • (2008) Blood , vol.112 , pp. 4017-4040
    • Paiva, B.1    Vidriales, M.B.2    Cervero, J.3
  • 176
    • 85031237804 scopus 로고    scopus 로고
    • The quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcome in patients with relapsed or refractory myeloma
    • May 11 [Epub ahead of print]
    • Harousseau JL, Dimopoulos MA, Wang M, et al. The quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcome in patients with relapsed or refractory myeloma. Haematologica 2010; May 11 [Epub ahead of print].
    • (2010) Haematologica
    • Harousseau, J.L.1    Dimopoulos, M.A.2    Wang, M.3
  • 177
    • 78149443734 scopus 로고    scopus 로고
    • Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with non-intensive therapy: Analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone
    • Jul 13 [Epub ahead of print]
    • Harousseau JL, Palumbo A, Richardson PG, et al. Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with non-intensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone. Blood 2010; Jul 13 [Epub ahead of print].
    • (2010) Blood
    • Harousseau, J.L.1    Palumbo, A.2    Richardson, P.G.3
  • 179
    • 78049501226 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone induction improves outcome of patients with t(4:14) myeloma but not outcome of patients with del(17p)
    • Avet-Loiseau H., Leleu X, Roussel M. Bortezomib plus dexamethasone induction improves outcome of patients with t(4:14) myeloma but not outcome of patients with del(17p). J Clin Oncol 2010; 28:4630-4.
    • (2010) J Clin Oncol , vol.28 , pp. 4630-4634
    • Avet-Loiseau, H.1    Leleu, X.2    Roussel, M.3
  • 180
    • 77949423941 scopus 로고    scopus 로고
    • Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone
    • Avet-Loiseau H., Soulier J, Fermand JP, et al. Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone. Leukemia 2010; 24:623-8.
    • (2010) Leukemia , vol.24 , pp. 623-628
    • Avet-Loiseau, H.1    Soulier, J.2    Fermand, J.P.3
  • 181
    • 70149113290 scopus 로고    scopus 로고
    • Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone:adverse effect of deletion 17p13
    • Reece D, Song KW, Fu T, et al. Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone:adverse effect of deletion 17p13. Blood 2009; 114:522-5.
    • (2009) Blood , vol.114 , pp. 522-525
    • Reece, D.1    Song, K.W.2    Fu, T.3
  • 182
    • 70149107680 scopus 로고    scopus 로고
    • Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
    • Kapoor P, Kumar S, Fonseca R, et al. Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone. Blood 2009; 114:518-21.
    • (2009) Blood , vol.114 , pp. 518-521
    • Kapoor, P.1    Kumar, S.2    Fonseca, R.3
  • 184
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib and dexamethasone combination therapy in newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib and dexamethasone combination therapy in newly diagnosed multiple myeloma. Blood 2010; 116:679-86.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 186
    • 77649215631 scopus 로고    scopus 로고
    • Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    • Palumbo A, Gay F, Falco P, et al. Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation- maintenance in untreated multiple myeloma patients. J Clin Oncol 2010; 28:800-7.
    • (2010) J Clin Oncol , vol.28 , pp. 800-807
    • Palumbo, A.1    Gay, F.2    Falco, P.3
  • 187
    • 79951786255 scopus 로고    scopus 로고
    • Improved response rate with consolidation after high-dose melphalan: first results of a Nordic Myeloma Study Group randomized Phase III TRIAL 536
    • (abstract)
    • Mellqvist UH, Westin J, Gimsing P, et al. Improved response rate with consolidation after high-dose melphalan: first results of a Nordic Myeloma Study Group randomized Phase III TRIAL 536. Blood 2009; 114: (abstract).
    • (2009) Blood , vol.114
    • Mellqvist, U.H.1    Westin, J.2    Gimsing, P.3
  • 188
    • 79952915202 scopus 로고    scopus 로고
    • Lenalidomide after autologous transplantation for myeloma. First analysis of a prospective randomized study of the Intergroupe Francophone du Myelome (IFM 2005602)
    • (abstract 529)
    • Attal M, Harousseau J.-L. Marit G, et al. Lenalidomide after autologous transplantation for myeloma. First analysis of a prospective randomized study of the Intergroupe Francophone du Myelome (IFM 2005602). Blood 2009; 114: (abstract 529).
    • (2009) Blood , vol.114
    • Attal, M.1    Harousseau, J.-L.2    Marit, G.3
  • 189
    • 77951625298 scopus 로고    scopus 로고
    • Major shrinking and persistant molecular remissions after consolidation with bortezomib, thalidomide and dexamethasone in patients with autografted myeloma
    • Ladetto M, Pagliano G, Ferrero, et al. Major shrinking and persistant molecular remissions after consolidation with bortezomib, thalidomide and dexamethasone in patients with autografted myeloma. J Clin Oncol 2010; 28:2077-84.
    • (2010) J Clin Oncol , vol.28 , pp. 2077-2084
    • Ladetto, M.1    Pagliano, G.2    Ferrero3
  • 191
    • 73849086725 scopus 로고    scopus 로고
    • Pomalidomied (CC4047) plus low-dose dexamethasone therapy for relapsed multiple myeloma
    • Lacy MQ, Haymann SR, Gertz MA, et al. Pomalidomied (CC4047) plus low-dose dexamethasone therapy for relapsed multiple myeloma. J Clin Oncol 2009; 27:5008-14.
    • (2009) J Clin Oncol , vol.27 , pp. 5008-5014
    • Lacy, M.Q.1    Haymann, S.R.2    Gertz, M.A.3
  • 192
    • 79955743503 scopus 로고    scopus 로고
    • Activity of pomalidomide plus dexamethasone in dual lenalidomide/ bortezomib refractory multiple myeloma
    • (abstract 8002)
    • Lacy M, Gertz MA, Haymann SR, et al. Activity of pomalidomide plus dexamethasone in dual lenalidomide/bortezomib refractory multiple myeloma. J Clin Oncol 2010; 28(15 suppl):573s (abstract 8002).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Lacy, M.1    Gertz, M.A.2    Haymann, S.R.3
  • 193
    • 72549116835 scopus 로고    scopus 로고
    • A phase I dose escalation study of the safety and pharmacokinetics of the novel proteasome-inhibitor carfilzomib (PP171) in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M, et al. A phase I dose escalation study of the safety and pharmacokinetics of the novel proteasome-inhibitor carfilzomib (PP171) in patients with hematologic malignancies. Clin Cancer Res 2009; 15:7085-91.
    • (2009) Clin Cancer Res , vol.15 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 194
    • 78649237411 scopus 로고    scopus 로고
    • Results of an ongoing open-label phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma
    • (abstract 8000)
    • Vij R, Siegel DS, Kaufmann JL, et al. Results of an ongoing open-label phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma. J Clin Oncol 2010; 28(15 suppl):573s (abstract 8000).
    • (2010) J Clin Oncol , Issue.15 SUPPL.
    • Vij, R.1    Siegel, D.S.2    Kaufmann, J.L.3
  • 195
    • 77949475477 scopus 로고    scopus 로고
    • Novel therapies for relapsed myeloma
    • Stewart AK. Novel therapies for relapsed myeloma. ASH Educationnal Program 2009:578-86.
    • (2009) ASH Educationnal Program , pp. 578-586
    • Stewart, A.K.1
  • 197
    • 51649083849 scopus 로고    scopus 로고
    • Anti CS1 humanized monoclonal antibody HuLuc 63 inhibits myeloma cell adhesion, and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai YT, Dillon M, Song W, et al. Anti CS1 humanized monoclonal antibody HuLuc 63 inhibits myeloma cell adhesion, and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 2008; 112:1329-37.
    • (2008) Blood , vol.112 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 199
    • 77952306482 scopus 로고    scopus 로고
    • In vitro and in vivo rationale for the triple combination of panobinostat (LBH 589) and dexamethasone plus either bortezomib or lenalidomide in multiple myeloma
    • Ocio EM, Villanova D, Atadja P, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH 589) and dexamethasone plus either bortezomib or lenalidomide in multiple myeloma. Haematologica 2010; 95:794-803.
    • (2010) Haematologica , vol.95 , pp. 794-803
    • Ocio, E.M.1    Villanova, D.2    Atadja, P.3


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